The potential of monitoring the movement of typhoons using the precipitable water vapor(PWV) has been confirmed. However, monitoring the movement of typhoon is focused on PWV, making it difficult to describe the movem...The potential of monitoring the movement of typhoons using the precipitable water vapor(PWV) has been confirmed. However, monitoring the movement of typhoon is focused on PWV, making it difficult to describe the movement of a typhoon in detail minutely and resulting in insufficient accuracy. Hence,based on PWV and meteorological data, we propose an improved typhoon monitoring mode. First, the European Centre for Medium-Range Weather Forecasts Reanalysis 5-derived PWV(ERA5-PWV) and the Global Navigation Satellite System-derived PWV(GNSS-PWV) were compared with the reference radiosonde PWV(RS-PWV). Then, using the PWV and atmospheric parameters derived from ERA5, we discussed the anomalous variations of PWV, pressure(P), precipitation, and wind speed during different typhoons. Finally, we compiled a list of critical factors related to typhoon movement, PWV and P. We developed an improved multi-factor typhoon monitoring mode(IMTM) with different models(i.e.,IMTM-I and IMTM-II) in different cases with a higher density of GNSS observation or only Numerical Weather Prediction(NWP) data. The IMTM was evaluated through the reference movement speeds of HATO and Mangkhut from the China Meteorological Observatory Typhoon Network(CMOTN). The results show that the root mean square(RMS) of the IMTM-I is 1.26 km/h based on ERA5-P and ERA5-PWV,and the absolute bias values are mostly within 2 km/h. Compared with the models considering the single factor ERA5-P/ERA5-PWV, the RMS of the IMTM-I is improved by 26.3% and 38.5%, respectively. The IMTM-II model manifests a residual of only 0.35 km/h. Compared with the single-factor model based on GNSS-PWV/P, the residual of the IMTM-II model is reduced by 90.8% and 84.1%, respectively. These results propose that the typhoon movement monitoring approach combining PWV and P has evident advantages over the single-factor model and is expected to supplement traditional typhoon monitoring.展开更多
Drone or unmanned aerial vehicle(UAV)technology has undergone significant changes.The technology allows UAV to carry out a wide range of tasks with an increasing level of sophistication,since drones can cover a large ...Drone or unmanned aerial vehicle(UAV)technology has undergone significant changes.The technology allows UAV to carry out a wide range of tasks with an increasing level of sophistication,since drones can cover a large area with cameras.Meanwhile,the increasing number of computer vision applications utilizing deep learning provides a unique insight into such applications.The primary target in UAV-based detection applications is humans,yet aerial recordings are not included in the massive datasets used to train object detectors,which makes it necessary to gather the model data from such platforms.You only look once(YOLO)version 4,RetinaNet,faster region-based convolutional neural network(R-CNN),and cascade R-CNN are several well-known detectors that have been studied in the past using a variety of datasets to replicate rescue scenes.Here,we used the search and rescue(SAR)dataset to train the you only look once version 5(YOLOv5)algorithm to validate its speed,accuracy,and low false detection rate.In comparison to YOLOv4 and R-CNN,the highest mean average accuracy of 96.9%is obtained by YOLOv5.For comparison,experimental findings utilizing the SAR and the human rescue imaging database on land(HERIDAL)datasets are presented.The results show that the YOLOv5-based approach is the most successful human detection model for SAR missions.展开更多
This paper describes an extension and a new foundation of the Standard Model of particle physics based on a SU(4)-force called hyper-color, and on preon subparticles. The hyper-color force is a generalization of the S...This paper describes an extension and a new foundation of the Standard Model of particle physics based on a SU(4)-force called hyper-color, and on preon subparticles. The hyper-color force is a generalization of the SU(2)-based weak interaction and the SU(1)-based right-chiral self-interaction, in which the W-and the Z-bosons are Yukawa residual-field-carriers of the hyper-color force, in the same sense as the pions are the residual-field-carriers of the color SU(3) interaction. Using the method of numerical minimization of the SU(4)-action based on this model, the masses and the inner structure of leptons, quarks and weak bosons are calculated: the mass results are very close to the experimental values. We calculate also precisely the value of the Cabibbo angle, so the mixing matrices of the Standard model, CKM matrix for quarks and PMNS matrix for neutrinos can also be calculated. In total, we reduce the 29 parameters of the Standard Model to a total of 7 parameters.展开更多
Objective:To construct a scientific and feasible teaching mode based on 5C caring theory and evaluate it,so as to provide a reference basis for future study about nursing humanistic quality education.Methods:Based on ...Objective:To construct a scientific and feasible teaching mode based on 5C caring theory and evaluate it,so as to provide a reference basis for future study about nursing humanistic quality education.Methods:Based on the 5C caring theory,the teaching design and teaching content were revising and implementing in the intervention group.Before and after the implementation of the course,a questionnaire survey was conducted using the Caring Ability Inventory(CAI).The results of the surveys were collected,and the data were statistically analysis using SPSS.Results:After the implementation of the course,the cognitive dimension,patience dimension,and humanistic caring ability scores of the nursing students in the intervention group improved compared with those before the implementation of the course(P<0.05).There were no significant difference in the control group(P>0.05).Conclusion:The humanistic caring teaching model based on 5C caring theory has a positive effect on improving nursing students'humanistic caring ability.In the future nursing teaching,the modules with the characteristics of humanistic caring ability can be increased,and carry out the educational reform throughout the humanistic caring ability.Actively guiding nursing students to establish the awareness of humanistic caring,so as to lay a solid foundation for high-quality clinical nursing work.展开更多
目的:研究溶质载体家族6成员9(solute carrier family 6 member 9,SLC6A9)表达对结直肠癌细胞增殖、迁移和5-氟尿嘧啶(5-fluorouracil,5-FU)药物敏感性的影响。方法:TCGA数据库分析、实时荧光定量PCR和Western blot分析检测SLC6A9在结...目的:研究溶质载体家族6成员9(solute carrier family 6 member 9,SLC6A9)表达对结直肠癌细胞增殖、迁移和5-氟尿嘧啶(5-fluorouracil,5-FU)药物敏感性的影响。方法:TCGA数据库分析、实时荧光定量PCR和Western blot分析检测SLC6A9在结肠癌组织、正常结肠细胞系(NCM460)和结直肠癌细胞系(SW620、HCT116、HT29、Lovo和SW480)中的表达。将SCL6A9过表达质粒及阴性对照(SLC6A9 OE、Vector)转染HT29细胞,将SCL6A9小干扰RNA及阴性对照(SLC6A9 siRNA1#、siRNA2#和Scramble)转染SW620细胞。划痕愈合实验和Transwell实验检测各组细胞的迁移、侵袭能力。Western blot和细胞免疫荧光检测EMT相关蛋白E-cadherin、Vimentin的表达水平。利用CCK-8法和构建裸鼠移植瘤模型检测SLC6A9过表达对结直肠癌细胞5-FU药物敏感性的影响。结果:与正常结肠组织和NCM460细胞相比,SLC6A9在结肠癌组织和结直肠癌细胞系中低表达(均P<0.05)。SLC6A9过表达引起E-cadherin蛋白表达增加,Vimentin蛋白水平降低,抑制结直肠癌细胞的迁移、侵袭(P<0.05)。SLC6A9低表达引起E-cadherin蛋白表达降低,Vimentin蛋白水平增加,促进结直肠癌细胞的迁移、侵袭能力(P<0.05)。SLC6A9过表达提高了5-FU的药物敏感性,并使肿瘤生长缓慢,质量减轻(P<0.05)。而SLC6A9低表达降低了5-FU的药物敏感性(P<0.05)。结论:SLC6A9过表达能够抑制结直肠癌细胞的迁移、侵袭和EMT进程,并增强5-FU对结直肠癌细胞的药物敏感性。展开更多
With the development of the rail transit industry,more attention has been paid to the passive safety of rail vehicles.Structural damage is one of the main failure behaviors in a rail vehicle collision,but it has been ...With the development of the rail transit industry,more attention has been paid to the passive safety of rail vehicles.Structural damage is one of the main failure behaviors in a rail vehicle collision,but it has been paid little attention to in past research.In this paper,the quasi-static fracture experiments of SUS301L-MT under different stress states were carried out.The mechanical fracture properties of this material were studied,and the corresponding finite element simulation accuracy was improved to guide the design of vehicle crashworthiness.Through the tests,the fracture behavior of materials with wide stress triaxiality was obtained,and each specimen’s fracture locations and fracture strains were determined.Parameters of a generalized incremental stress state dependent damage model(GISSMO)of the material were calibrated,and the model’s accuracy was verified with test results from a 45°shear specimen.The GISSMO failure model accurately reflected the fracture characteristics of the material.The mesh dependency of this model was modified and discussed.The results show that the simulation agrees well with experimental data for the force-displacement curve after correction,but the strain distribution needs to be further studied and improved.展开更多
The solubility of 2,3,4-trichloro-1,5-dinitrobenzene(TCDNB) was measured by a laser dynamic method over the temperature range from 278.15 K to 323.15 K under 0.1 MPa in fifteen mono-solvents(methanol,ethanol,isopropan...The solubility of 2,3,4-trichloro-1,5-dinitrobenzene(TCDNB) was measured by a laser dynamic method over the temperature range from 278.15 K to 323.15 K under 0.1 MPa in fifteen mono-solvents(methanol,ethanol,isopropanol,n-butanol,toluene,dichloromethane,chloroform,tetrachloromethane,1,2-dichloroethane,acetone,ethyl acetate,acetonitrile,N-methylpyrrolidone(NMP),N,Ndimethylformamide dimethyl sulfoxide(DMF),dimethyl sulfoxide(DMSO).The solubility of TCDNB could be increased with increasing temperature in fifteen mono-solvents.TCDNB solubility is in the following order at 298.15 K:NMP>DMF>DMSO>toluene>acetone>ethyl acetate>dichloromethane>1,2-dich loroethane>chloroform>acetonitrile>tetrachloromethane>methanol>ethanol>n-butanol>isopropanol.The KAT-LSER model was used to investigate the solvent effect,which revealed that the hydrogen bond acidity of solvents has a greater effect on TCDNB solubility.The van't Hoff model,the modified Apelblat model,theλh model,and the non-random two liquid(NRTL)model were used to correlate the solubility of TCDNB.The calculated solubility data agreed well with the experimental data,and the modified Apelblat model fit best.Furthermore,the van't Hoff and Gibbs equations were also used to calculate the dissolution thermodynamic properties of TCDNB in various solvents.TCDNB dissolution could be an enthalpy-driven,non-spontaneous,and endothermic process in fifteen mono-solvents.The determination and fitting solubility of TCDNB,as well as the calculation of its thermodynamic properties,would be critical in the purification and crystallization of its preparation process research.展开更多
Precipitation and surface temperature are two important quantities whose variations are closely related through various physical processes. In the present study, we evaluated the precipitation-surface temperature (P-...Precipitation and surface temperature are two important quantities whose variations are closely related through various physical processes. In the present study, we evaluated the precipitation-surface temperature (P-T) relationship in 17 climate models involved in the Coupled Model Intercomparison Project Phase 5 (CMIP5) for the IPCC Assessment Report version 5. Most models performed reasonably well at simulat- ing the large-scale features of the P-T correlation distribution. Based on the pattern correlation of the P-T correlation distribution, the models performed better in November-December-January-February-March (NDJFM) than in May-June-July-August-September (MJJAS) except for the mid-latitudes of the North- ern Hemisphere, and the performance was generally better over the land than over the ocean. Seasonal dependence was more obvious over the land than over the ocean and was more obvious over the mid- and high-latitudes than over the tropics. All of the models appear to have had difficulty capturing the P-T correlation distribution over the mid-latitudes of the Southern Hemisphere in MJJAS. The spatial variabil- ity of the P-T correlation in the models was overestimated compared to observations. This overestimation tended to be larger over the land than over the ocean and larger over the mid- and high-latitudes than over the tropics. Based on analyses of selected model ensemble simulations, the spread of the P-T correlation among the ensemble members appears to have been small. While the performance in the P-T correlation provides a general direction for future improvement of climate models, the specific reasons for the discrep- ancies between models and observations remain to be revealed with detailed and comprehensive evaluations in various aspects.展开更多
The multi-model ensemble (MME) of 20 models from the Coupled Model Intercomparison Project Phase Five (CMIP5) was used to analyze surface climate change in the 21st century under the representative con- centration...The multi-model ensemble (MME) of 20 models from the Coupled Model Intercomparison Project Phase Five (CMIP5) was used to analyze surface climate change in the 21st century under the representative con- centration pathway RCP2.6, to reflect emission mitigation efforts. The maximum increase of surface air temperature (SAT) is 1.86℃ relative to the pre-industrial level, achieving the target to limit the global warming to 2℃. Associated with the "increase-peak-decline" greenhouse gases (GHGs) concentration path- way of RCP2.6, the global mean SAT of MME shows opposite trends during two time periods: warming during 2006-55 and cooling during 2056-2100. Our results indicate that spatial distribution of the linear trend of SAT during the warming period exhibited asymmetrical features compared to that during the cool- ing period. The warming during 2006-55 is distributed globally, while the cooling during 2056-2100 mainly occurred in the NH, the South Indian Ocean, and the tropical South Atlantic Ocean. Different dominant roles of heat flux in the two time periods partly explain the asymmetry. During the warming period, the latent heat flux and shortwave radiation both play major roles in heating the surface air. During the cooling period, the increase of net longwave radiation partly explains the cooling in the tropics and subtropics, which is associated with the decrease of total cloud amount. The decrease of the shortwave radiation accounts for the prominent cooling in the high latitudes of the NH. The surface sensible heat flux, latent heat flux, and shortwave radiation collectively contribute to the especial warming phenomenon in the high-latitude of the SH during the cooling period.展开更多
Entanglement in quantum theory is a peculiar concept to scientists. With this concept we are forced to re-consider the cluster property which means that one event is irrelevant to another event when they are fully far...Entanglement in quantum theory is a peculiar concept to scientists. With this concept we are forced to re-consider the cluster property which means that one event is irrelevant to another event when they are fully far away. In the recent works we showed that the quasi-degenerate states induce the violation of cluster property in antiferromagnets when the continuous symmetry breaks spontaneously. We expect that the violation of cluster property will be observed in other materials too, because the spontaneous symmetry breaking is found in many systems such as the high temperature superconductors and the superfluidity. In order to examine the cluster property for these materials, we studied a quantum nonlinear sigma model with U(1) symmetry in the previous work. There we showed that the model does have quasi-degenerate states. In this paper we study the quantum nonlinear sigma model with SU(2) symmetry. In our approach we first define the quantum system on the lattice and then adopt the representation where the kinetic term is diagonalized. Since we have no definition on the conjugate variable to the angle variable, we use the angular momentum operators instead for the kinetic term. In this representation we introduce the states with the fixed quantum numbers and carry out numerical calculations using quantum Monte Carlo methods and other methods. Through analytical and numerical studies, we conclude that the energy of the quasi-degenerate state is proportional to the squared total angular momentum as well as to the inverse of the lattice size.展开更多
The railway mobile communication system is undergoing a smooth transition from the Global System for Mobile Communications-Railway(GSM-R)to the Railway 5G.In this paper,an empirical path loss model based on a large am...The railway mobile communication system is undergoing a smooth transition from the Global System for Mobile Communications-Railway(GSM-R)to the Railway 5G.In this paper,an empirical path loss model based on a large amount of measured data is established to predict the path loss in the Railway 5G marshalling yard scenario.According to the different characteristics of base station directional antennas,the antenna gain is verified.Then we propose the position of the breakpoint in the antenna propagation area,and based on the breakpoint segmentation,a large-scale statistical model for marshalling yards is established.展开更多
The present study evaluates the precipitation variability over the South China Sea(SCS) and its relationship to tropical Indo-Pacific SST anomalies during spring-to-summer transition(April–May–June,AMJ) simulate...The present study evaluates the precipitation variability over the South China Sea(SCS) and its relationship to tropical Indo-Pacific SST anomalies during spring-to-summer transition(April–May–June,AMJ) simulated by 23 Intergovernmental Panel on Climate Change Coupled Model Intercomparison Project Phase 5 coupled models.Most of the models have the capacity to capture the AMJ precipitation variability in the SCS.The precipitation and SST anomaly(SSTA) distribution in the SCS,tropical Pacific Ocean(TPO),and tropical Indian Ocean(TIO) domains is evaluated based on the pattern correlation coefficients between model simulations and observations.The analysis leads to several points of note.First,the performance of the SCS precipitation anomaly pattern in AMJ is model dependent.Second,the SSTA pattern in the TPO and TIO is important for capturing the AMJ SCS precipitation variability.Third,a realistic simulation of the western equatorial Pacific(WEP) and local SST impacts is necessary for reproducing the AMJ SCS precipitation variability in some models.Fourth,the overly strong WEP SST impacts may disrupt the relationship between the SCS precipitation and the TPO–TIO SST.Further work remains to be conducted to unravel the specific reasons for the discrepancies between models and observations in various aspects.展开更多
Based on the data of daily precipitation in Lianyungang area from 1951 to 2012 and various climate signal data from the National Climate Center website and the NOAA website,a model for predicting whether the number of...Based on the data of daily precipitation in Lianyungang area from 1951 to 2012 and various climate signal data from the National Climate Center website and the NOAA website,a model for predicting whether the number of rainstorm days in summer in Lianyungang area is large was established by the classical C5. 0 decision tree algorithm. The data samples in 48 years( accounting for about 80% of total number of samples)was as the training set of a model,and the training accuracy rate of the model was 95. 83%. The data samples in the remaining 14 years( accounting for about 20% of total number of samples) were used as the test set of the model to test the model,and the test accuracy of the model was 85. 71%. The results showed that the prediction model of number of rainstorm days in summer constructed by C5. 0 algorithm had high accuracy and was easy to explain. Moreover,it is convenient for meteorological staff to use directly. At the same time,this study provides a new idea for short-term climate prediction of number of rainstorm days in summer.展开更多
基金supported by the Guangxi Natural Science Foundation of China (2020GXNSFBA297145,Guike AD23026177)the Foundation of Guilin University of Technology(GUTQDJJ6616032)+3 种基金Guangxi Key Laboratory of Spatial Information and Geomatics (21-238-21-05)the National Natural Science Foundation of China (42064002,42004025,42074035,42204006)the Innovative Training Program Foundation (202210596015,202210596402)the Open Fund of Hubei Luojia Laboratory(gran 230100020,230100019)。
文摘The potential of monitoring the movement of typhoons using the precipitable water vapor(PWV) has been confirmed. However, monitoring the movement of typhoon is focused on PWV, making it difficult to describe the movement of a typhoon in detail minutely and resulting in insufficient accuracy. Hence,based on PWV and meteorological data, we propose an improved typhoon monitoring mode. First, the European Centre for Medium-Range Weather Forecasts Reanalysis 5-derived PWV(ERA5-PWV) and the Global Navigation Satellite System-derived PWV(GNSS-PWV) were compared with the reference radiosonde PWV(RS-PWV). Then, using the PWV and atmospheric parameters derived from ERA5, we discussed the anomalous variations of PWV, pressure(P), precipitation, and wind speed during different typhoons. Finally, we compiled a list of critical factors related to typhoon movement, PWV and P. We developed an improved multi-factor typhoon monitoring mode(IMTM) with different models(i.e.,IMTM-I and IMTM-II) in different cases with a higher density of GNSS observation or only Numerical Weather Prediction(NWP) data. The IMTM was evaluated through the reference movement speeds of HATO and Mangkhut from the China Meteorological Observatory Typhoon Network(CMOTN). The results show that the root mean square(RMS) of the IMTM-I is 1.26 km/h based on ERA5-P and ERA5-PWV,and the absolute bias values are mostly within 2 km/h. Compared with the models considering the single factor ERA5-P/ERA5-PWV, the RMS of the IMTM-I is improved by 26.3% and 38.5%, respectively. The IMTM-II model manifests a residual of only 0.35 km/h. Compared with the single-factor model based on GNSS-PWV/P, the residual of the IMTM-II model is reduced by 90.8% and 84.1%, respectively. These results propose that the typhoon movement monitoring approach combining PWV and P has evident advantages over the single-factor model and is expected to supplement traditional typhoon monitoring.
文摘Drone or unmanned aerial vehicle(UAV)technology has undergone significant changes.The technology allows UAV to carry out a wide range of tasks with an increasing level of sophistication,since drones can cover a large area with cameras.Meanwhile,the increasing number of computer vision applications utilizing deep learning provides a unique insight into such applications.The primary target in UAV-based detection applications is humans,yet aerial recordings are not included in the massive datasets used to train object detectors,which makes it necessary to gather the model data from such platforms.You only look once(YOLO)version 4,RetinaNet,faster region-based convolutional neural network(R-CNN),and cascade R-CNN are several well-known detectors that have been studied in the past using a variety of datasets to replicate rescue scenes.Here,we used the search and rescue(SAR)dataset to train the you only look once version 5(YOLOv5)algorithm to validate its speed,accuracy,and low false detection rate.In comparison to YOLOv4 and R-CNN,the highest mean average accuracy of 96.9%is obtained by YOLOv5.For comparison,experimental findings utilizing the SAR and the human rescue imaging database on land(HERIDAL)datasets are presented.The results show that the YOLOv5-based approach is the most successful human detection model for SAR missions.
文摘This paper describes an extension and a new foundation of the Standard Model of particle physics based on a SU(4)-force called hyper-color, and on preon subparticles. The hyper-color force is a generalization of the SU(2)-based weak interaction and the SU(1)-based right-chiral self-interaction, in which the W-and the Z-bosons are Yukawa residual-field-carriers of the hyper-color force, in the same sense as the pions are the residual-field-carriers of the color SU(3) interaction. Using the method of numerical minimization of the SU(4)-action based on this model, the masses and the inner structure of leptons, quarks and weak bosons are calculated: the mass results are very close to the experimental values. We calculate also precisely the value of the Cabibbo angle, so the mixing matrices of the Standard model, CKM matrix for quarks and PMNS matrix for neutrinos can also be calculated. In total, we reduce the 29 parameters of the Standard Model to a total of 7 parameters.
基金supported by the Research Program on Educational Teaching Reform of Tianjin University of Traditional Chinese Medicine(2020JY041)。
文摘Objective:To construct a scientific and feasible teaching mode based on 5C caring theory and evaluate it,so as to provide a reference basis for future study about nursing humanistic quality education.Methods:Based on the 5C caring theory,the teaching design and teaching content were revising and implementing in the intervention group.Before and after the implementation of the course,a questionnaire survey was conducted using the Caring Ability Inventory(CAI).The results of the surveys were collected,and the data were statistically analysis using SPSS.Results:After the implementation of the course,the cognitive dimension,patience dimension,and humanistic caring ability scores of the nursing students in the intervention group improved compared with those before the implementation of the course(P<0.05).There were no significant difference in the control group(P>0.05).Conclusion:The humanistic caring teaching model based on 5C caring theory has a positive effect on improving nursing students'humanistic caring ability.In the future nursing teaching,the modules with the characteristics of humanistic caring ability can be increased,and carry out the educational reform throughout the humanistic caring ability.Actively guiding nursing students to establish the awareness of humanistic caring,so as to lay a solid foundation for high-quality clinical nursing work.
文摘目的:研究溶质载体家族6成员9(solute carrier family 6 member 9,SLC6A9)表达对结直肠癌细胞增殖、迁移和5-氟尿嘧啶(5-fluorouracil,5-FU)药物敏感性的影响。方法:TCGA数据库分析、实时荧光定量PCR和Western blot分析检测SLC6A9在结肠癌组织、正常结肠细胞系(NCM460)和结直肠癌细胞系(SW620、HCT116、HT29、Lovo和SW480)中的表达。将SCL6A9过表达质粒及阴性对照(SLC6A9 OE、Vector)转染HT29细胞,将SCL6A9小干扰RNA及阴性对照(SLC6A9 siRNA1#、siRNA2#和Scramble)转染SW620细胞。划痕愈合实验和Transwell实验检测各组细胞的迁移、侵袭能力。Western blot和细胞免疫荧光检测EMT相关蛋白E-cadherin、Vimentin的表达水平。利用CCK-8法和构建裸鼠移植瘤模型检测SLC6A9过表达对结直肠癌细胞5-FU药物敏感性的影响。结果:与正常结肠组织和NCM460细胞相比,SLC6A9在结肠癌组织和结直肠癌细胞系中低表达(均P<0.05)。SLC6A9过表达引起E-cadherin蛋白表达增加,Vimentin蛋白水平降低,抑制结直肠癌细胞的迁移、侵袭(P<0.05)。SLC6A9低表达引起E-cadherin蛋白表达降低,Vimentin蛋白水平增加,促进结直肠癌细胞的迁移、侵袭能力(P<0.05)。SLC6A9过表达提高了5-FU的药物敏感性,并使肿瘤生长缓慢,质量减轻(P<0.05)。而SLC6A9低表达降低了5-FU的药物敏感性(P<0.05)。结论:SLC6A9过表达能够抑制结直肠癌细胞的迁移、侵袭和EMT进程,并增强5-FU对结直肠癌细胞的药物敏感性。
基金National Natural Scienceof China(Grant No.52172409)Sichuan Provincial Outstanding Youth Fund of China(Grant No.2022JDJQ0025)。
文摘With the development of the rail transit industry,more attention has been paid to the passive safety of rail vehicles.Structural damage is one of the main failure behaviors in a rail vehicle collision,but it has been paid little attention to in past research.In this paper,the quasi-static fracture experiments of SUS301L-MT under different stress states were carried out.The mechanical fracture properties of this material were studied,and the corresponding finite element simulation accuracy was improved to guide the design of vehicle crashworthiness.Through the tests,the fracture behavior of materials with wide stress triaxiality was obtained,and each specimen’s fracture locations and fracture strains were determined.Parameters of a generalized incremental stress state dependent damage model(GISSMO)of the material were calibrated,and the model’s accuracy was verified with test results from a 45°shear specimen.The GISSMO failure model accurately reflected the fracture characteristics of the material.The mesh dependency of this model was modified and discussed.The results show that the simulation agrees well with experimental data for the force-displacement curve after correction,but the strain distribution needs to be further studied and improved.
文摘The solubility of 2,3,4-trichloro-1,5-dinitrobenzene(TCDNB) was measured by a laser dynamic method over the temperature range from 278.15 K to 323.15 K under 0.1 MPa in fifteen mono-solvents(methanol,ethanol,isopropanol,n-butanol,toluene,dichloromethane,chloroform,tetrachloromethane,1,2-dichloroethane,acetone,ethyl acetate,acetonitrile,N-methylpyrrolidone(NMP),N,Ndimethylformamide dimethyl sulfoxide(DMF),dimethyl sulfoxide(DMSO).The solubility of TCDNB could be increased with increasing temperature in fifteen mono-solvents.TCDNB solubility is in the following order at 298.15 K:NMP>DMF>DMSO>toluene>acetone>ethyl acetate>dichloromethane>1,2-dich loroethane>chloroform>acetonitrile>tetrachloromethane>methanol>ethanol>n-butanol>isopropanol.The KAT-LSER model was used to investigate the solvent effect,which revealed that the hydrogen bond acidity of solvents has a greater effect on TCDNB solubility.The van't Hoff model,the modified Apelblat model,theλh model,and the non-random two liquid(NRTL)model were used to correlate the solubility of TCDNB.The calculated solubility data agreed well with the experimental data,and the modified Apelblat model fit best.Furthermore,the van't Hoff and Gibbs equations were also used to calculate the dissolution thermodynamic properties of TCDNB in various solvents.TCDNB dissolution could be an enthalpy-driven,non-spontaneous,and endothermic process in fifteen mono-solvents.The determination and fitting solubility of TCDNB,as well as the calculation of its thermodynamic properties,would be critical in the purification and crystallization of its preparation process research.
基金supported by the National Key Basic Research Program of China(Grant No.2009CB421404)the National Natural Science Foundation of China(Grant No.41175076)+2 种基金the Fundamental Research Funds for the Central Universities(Grant No.11lgjc10)the support of a Direct Grant of the Chinese University of Hong Kong(Grant No.2021105)a Hong Kong Research Grants Council Project(CUHK No.403612)
文摘Precipitation and surface temperature are two important quantities whose variations are closely related through various physical processes. In the present study, we evaluated the precipitation-surface temperature (P-T) relationship in 17 climate models involved in the Coupled Model Intercomparison Project Phase 5 (CMIP5) for the IPCC Assessment Report version 5. Most models performed reasonably well at simulat- ing the large-scale features of the P-T correlation distribution. Based on the pattern correlation of the P-T correlation distribution, the models performed better in November-December-January-February-March (NDJFM) than in May-June-July-August-September (MJJAS) except for the mid-latitudes of the North- ern Hemisphere, and the performance was generally better over the land than over the ocean. Seasonal dependence was more obvious over the land than over the ocean and was more obvious over the mid- and high-latitudes than over the tropics. All of the models appear to have had difficulty capturing the P-T correlation distribution over the mid-latitudes of the Southern Hemisphere in MJJAS. The spatial variabil- ity of the P-T correlation in the models was overestimated compared to observations. This overestimation tended to be larger over the land than over the ocean and larger over the mid- and high-latitudes than over the tropics. Based on analyses of selected model ensemble simulations, the spread of the P-T correlation among the ensemble members appears to have been small. While the performance in the P-T correlation provides a general direction for future improvement of climate models, the specific reasons for the discrep- ancies between models and observations remain to be revealed with detailed and comprehensive evaluations in various aspects.
基金supported by National Basic Research Program of China(973 Program,Grant No.2010CB951903)the National Natural Science Foundation of China(Grant Nos.41105054,41175074,and 41205043)China Meteorological Administration(Grant No.GYHY201306048 and CMAYBY2012-001)
文摘The multi-model ensemble (MME) of 20 models from the Coupled Model Intercomparison Project Phase Five (CMIP5) was used to analyze surface climate change in the 21st century under the representative con- centration pathway RCP2.6, to reflect emission mitigation efforts. The maximum increase of surface air temperature (SAT) is 1.86℃ relative to the pre-industrial level, achieving the target to limit the global warming to 2℃. Associated with the "increase-peak-decline" greenhouse gases (GHGs) concentration path- way of RCP2.6, the global mean SAT of MME shows opposite trends during two time periods: warming during 2006-55 and cooling during 2056-2100. Our results indicate that spatial distribution of the linear trend of SAT during the warming period exhibited asymmetrical features compared to that during the cool- ing period. The warming during 2006-55 is distributed globally, while the cooling during 2056-2100 mainly occurred in the NH, the South Indian Ocean, and the tropical South Atlantic Ocean. Different dominant roles of heat flux in the two time periods partly explain the asymmetry. During the warming period, the latent heat flux and shortwave radiation both play major roles in heating the surface air. During the cooling period, the increase of net longwave radiation partly explains the cooling in the tropics and subtropics, which is associated with the decrease of total cloud amount. The decrease of the shortwave radiation accounts for the prominent cooling in the high latitudes of the NH. The surface sensible heat flux, latent heat flux, and shortwave radiation collectively contribute to the especial warming phenomenon in the high-latitude of the SH during the cooling period.
文摘Entanglement in quantum theory is a peculiar concept to scientists. With this concept we are forced to re-consider the cluster property which means that one event is irrelevant to another event when they are fully far away. In the recent works we showed that the quasi-degenerate states induce the violation of cluster property in antiferromagnets when the continuous symmetry breaks spontaneously. We expect that the violation of cluster property will be observed in other materials too, because the spontaneous symmetry breaking is found in many systems such as the high temperature superconductors and the superfluidity. In order to examine the cluster property for these materials, we studied a quantum nonlinear sigma model with U(1) symmetry in the previous work. There we showed that the model does have quasi-degenerate states. In this paper we study the quantum nonlinear sigma model with SU(2) symmetry. In our approach we first define the quantum system on the lattice and then adopt the representation where the kinetic term is diagonalized. Since we have no definition on the conjugate variable to the angle variable, we use the angular momentum operators instead for the kinetic term. In this representation we introduce the states with the fixed quantum numbers and carry out numerical calculations using quantum Monte Carlo methods and other methods. Through analytical and numerical studies, we conclude that the energy of the quasi-degenerate state is proportional to the squared total angular momentum as well as to the inverse of the lattice size.
基金supported in part by the Fundamental Research Funds for the Central Universities under Grant No.2022JBXT001in part by NS⁃FC under Grant No.62171021+1 种基金in part by the Project of China State Rail⁃way Group under Grant No.P2021G012in part by ZTE Industry⁃University⁃Institute Cooperation Funds under Grant No.I21L00220.
文摘The railway mobile communication system is undergoing a smooth transition from the Global System for Mobile Communications-Railway(GSM-R)to the Railway 5G.In this paper,an empirical path loss model based on a large amount of measured data is established to predict the path loss in the Railway 5G marshalling yard scenario.According to the different characteristics of base station directional antennas,the antenna gain is verified.Then we propose the position of the breakpoint in the antenna propagation area,and based on the breakpoint segmentation,a large-scale statistical model for marshalling yards is established.
基金supported by the National Key Basic Research Program of China(Grant No.2014CB953902)the support of the Hong Kong Research Grants Council(Grant No.CUHK403612)+4 种基金the National Natural Science Foundation of China(Grants Nos.41275081 and 41475081)a Chinese University of Hong Kong direct grant(Grant No.4052057)the support of a Chinese Academy of Sciences project(Grant No.XDA11010402)the National Natural Science Foundation of China(Grant Nos.41305065 and 41305068)the support of the State Key Laboratory of Tropical Oceanography,South China Sea Institute of Oceanology of Chinese Academy of Sciences(Grant No.LTO1203)
文摘The present study evaluates the precipitation variability over the South China Sea(SCS) and its relationship to tropical Indo-Pacific SST anomalies during spring-to-summer transition(April–May–June,AMJ) simulated by 23 Intergovernmental Panel on Climate Change Coupled Model Intercomparison Project Phase 5 coupled models.Most of the models have the capacity to capture the AMJ precipitation variability in the SCS.The precipitation and SST anomaly(SSTA) distribution in the SCS,tropical Pacific Ocean(TPO),and tropical Indian Ocean(TIO) domains is evaluated based on the pattern correlation coefficients between model simulations and observations.The analysis leads to several points of note.First,the performance of the SCS precipitation anomaly pattern in AMJ is model dependent.Second,the SSTA pattern in the TPO and TIO is important for capturing the AMJ SCS precipitation variability.Third,a realistic simulation of the western equatorial Pacific(WEP) and local SST impacts is necessary for reproducing the AMJ SCS precipitation variability in some models.Fourth,the overly strong WEP SST impacts may disrupt the relationship between the SCS precipitation and the TPO–TIO SST.Further work remains to be conducted to unravel the specific reasons for the discrepancies between models and observations in various aspects.
基金Support by Meteorological Open Research Foundation for the Huaihe River Basin(HRM201602)Foundation for Young Scholars of Jiangsu Meteorological Bureau(Q201708,KQ201802)+2 种基金Science and Technology Innovation Team Foundation for Marine Meteorological Forecast Technology of Lianyungang Meteorological BureauKey Technology R&D Program Project of Lianyungang City(SH1634)Special Project for Forecasters of Jiangsu Meteorological Bureau(JSYBY201811,JSYBY201812,JSYBY201810)
文摘Based on the data of daily precipitation in Lianyungang area from 1951 to 2012 and various climate signal data from the National Climate Center website and the NOAA website,a model for predicting whether the number of rainstorm days in summer in Lianyungang area is large was established by the classical C5. 0 decision tree algorithm. The data samples in 48 years( accounting for about 80% of total number of samples)was as the training set of a model,and the training accuracy rate of the model was 95. 83%. The data samples in the remaining 14 years( accounting for about 20% of total number of samples) were used as the test set of the model to test the model,and the test accuracy of the model was 85. 71%. The results showed that the prediction model of number of rainstorm days in summer constructed by C5. 0 algorithm had high accuracy and was easy to explain. Moreover,it is convenient for meteorological staff to use directly. At the same time,this study provides a new idea for short-term climate prediction of number of rainstorm days in summer.