BACKGROUND Cold-dampness-type knee osteoarthritis is a common middle-aged and elderly disease,but its pathogenesis is not fully understood,and its clinical treatment has limitations.Glucosamine sulfate capsules are co...BACKGROUND Cold-dampness-type knee osteoarthritis is a common middle-aged and elderly disease,but its pathogenesis is not fully understood,and its clinical treatment has limitations.Glucosamine sulfate capsules are commonly used for treating arthritis,and San Bi Tang is a classic formula of traditional Chinese medicine(TCM)that has the effects of warming yang,dispelling dampness,relaxing muscles,and activating collaterals.This research hypothesized that the combination of modified San Bi Tang and glucosamine sulfate capsules could enhance the clinical efficacy of treating cold-dampness-type knee osteoarthritis through complementary effects.AIM To analyze the clinical efficacy of San Bi Tang combined with glucosamine sulfate capsules when treating cold-dampness-type knee osteoarthritis.METHODS A total of 110 patients with cold-dampness-type knee osteoarthritis were selected as research subjects and randomly divided into a control group and an experimental group of 55 cases each.The control group received only treatment with glucosamine sulfate capsules,while the experimental group received additional treatment with modified San Bi Tang for a duration of 5 wk.The patients’knee joint functions,liver and kidney function indicators,adverse reactions,and vital signs were evaluated and analyzed using SPSS 26.0 software.RESULTS Before treatment,the two groups’genders,ages,and scores were not significantly different,indicating comparability.Both groups’scores improved after treatment,which could indicate pain and knee joint function improvement,but the test group had better scores.The TCM-specific symptoms and the clinical efficacy of the treatment in the test group were higher.Before and after treatment,there were no abnormalities in the patients’liver and kidney function indicators.CONCLUSION The combination of modified San Bi Tang and glucosamine sulfate capsules is superior to treatment with sulfated glucosamine alone and has high safety.展开更多
AIM: To investigate the effects of San-Huang-Xie-XinTang(SHXXT), a herbal product used in traditional Chinese medicine, on gastrointestinal(GI) motility in mice.METHODS: The in vivo effects of SHXXT on GI motility wer...AIM: To investigate the effects of San-Huang-Xie-XinTang(SHXXT), a herbal product used in traditional Chinese medicine, on gastrointestinal(GI) motility in mice.METHODS: The in vivo effects of SHXXT on GI motility were investigated by measuring the intestinal transit rates(ITRs) using Evans blue in normal mice and in mice with experimentally induced GI motility dysfunction(GMD).RESULTS: In normal ICR mice, ITRs were significantly and dose-dependently increased by SHXXT(0.1-1 g/kg). GMD was induced by injecting acetic acid or streptozotocin intraperitoneally. The ITRs of GMD mice were significantly reduced compared to normal mice, and these reductions were significantly and dose-dependently inhibited by SHXXT(0.1-1 g/kg).CONCLUSION: These results suggest that SHXXT is a novel candidate for the development of a prokinetic agent that may prevent or alleviate GMD.展开更多
The purpose is to research compound prescribe compatibility of medicines have some influence on anthraquinone which is the gentleman medicine CRC’s valid composition dissolution rate in San Cheng Qi Tang.The method:A...The purpose is to research compound prescribe compatibility of medicines have some influence on anthraquinone which is the gentleman medicine CRC’s valid composition dissolution rate in San Cheng Qi Tang.The method:Adopting respectively RP-HPLC and colorimetric method,measure the content of liberation3-methylchrysazin and 3-methylchrysazin and combined 3-methylchrysazin and 3-methylchrysazin total liberation anthraquinone and total combined anthraquinone in the different decoction water liquid coming from single CRC the different decoction and compatibility of medicines method of San Cheng Qi Tang.The result: Compared with CRC single flavor decoction water,liberation anthraquinone and combined anthraquinone content show differently in the most decoction water liquid,Combined 3-methylchrysazin and combined anthraquinone content in decoction prescribe as follows in proper order decrease:Da Cheng Qi Tang > Xiao San Cheng Qi Tang > Tiao Wei Cheng Qi Tang.The conclusion :Because CRC mate with different medicine material .different decoction method,liberation anthraquinone and combined anthraquinone content in San Cheng Qi Tang change.The combined 3-methylchrysazin and combined anthraquinon content variety order in accordance with its decanta bottom function.展开更多
文摘BACKGROUND Cold-dampness-type knee osteoarthritis is a common middle-aged and elderly disease,but its pathogenesis is not fully understood,and its clinical treatment has limitations.Glucosamine sulfate capsules are commonly used for treating arthritis,and San Bi Tang is a classic formula of traditional Chinese medicine(TCM)that has the effects of warming yang,dispelling dampness,relaxing muscles,and activating collaterals.This research hypothesized that the combination of modified San Bi Tang and glucosamine sulfate capsules could enhance the clinical efficacy of treating cold-dampness-type knee osteoarthritis through complementary effects.AIM To analyze the clinical efficacy of San Bi Tang combined with glucosamine sulfate capsules when treating cold-dampness-type knee osteoarthritis.METHODS A total of 110 patients with cold-dampness-type knee osteoarthritis were selected as research subjects and randomly divided into a control group and an experimental group of 55 cases each.The control group received only treatment with glucosamine sulfate capsules,while the experimental group received additional treatment with modified San Bi Tang for a duration of 5 wk.The patients’knee joint functions,liver and kidney function indicators,adverse reactions,and vital signs were evaluated and analyzed using SPSS 26.0 software.RESULTS Before treatment,the two groups’genders,ages,and scores were not significantly different,indicating comparability.Both groups’scores improved after treatment,which could indicate pain and knee joint function improvement,but the test group had better scores.The TCM-specific symptoms and the clinical efficacy of the treatment in the test group were higher.Before and after treatment,there were no abnormalities in the patients’liver and kidney function indicators.CONCLUSION The combination of modified San Bi Tang and glucosamine sulfate capsules is superior to treatment with sulfated glucosamine alone and has high safety.
基金Supported by National Research Foundation of Korea Grant funded by the Korean government,No.2014R1A5A2009936
文摘AIM: To investigate the effects of San-Huang-Xie-XinTang(SHXXT), a herbal product used in traditional Chinese medicine, on gastrointestinal(GI) motility in mice.METHODS: The in vivo effects of SHXXT on GI motility were investigated by measuring the intestinal transit rates(ITRs) using Evans blue in normal mice and in mice with experimentally induced GI motility dysfunction(GMD).RESULTS: In normal ICR mice, ITRs were significantly and dose-dependently increased by SHXXT(0.1-1 g/kg). GMD was induced by injecting acetic acid or streptozotocin intraperitoneally. The ITRs of GMD mice were significantly reduced compared to normal mice, and these reductions were significantly and dose-dependently inhibited by SHXXT(0.1-1 g/kg).CONCLUSION: These results suggest that SHXXT is a novel candidate for the development of a prokinetic agent that may prevent or alleviate GMD.
文摘The purpose is to research compound prescribe compatibility of medicines have some influence on anthraquinone which is the gentleman medicine CRC’s valid composition dissolution rate in San Cheng Qi Tang.The method:Adopting respectively RP-HPLC and colorimetric method,measure the content of liberation3-methylchrysazin and 3-methylchrysazin and combined 3-methylchrysazin and 3-methylchrysazin total liberation anthraquinone and total combined anthraquinone in the different decoction water liquid coming from single CRC the different decoction and compatibility of medicines method of San Cheng Qi Tang.The result: Compared with CRC single flavor decoction water,liberation anthraquinone and combined anthraquinone content show differently in the most decoction water liquid,Combined 3-methylchrysazin and combined anthraquinone content in decoction prescribe as follows in proper order decrease:Da Cheng Qi Tang > Xiao San Cheng Qi Tang > Tiao Wei Cheng Qi Tang.The conclusion :Because CRC mate with different medicine material .different decoction method,liberation anthraquinone and combined anthraquinone content in San Cheng Qi Tang change.The combined 3-methylchrysazin and combined anthraquinon content variety order in accordance with its decanta bottom function.
