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Experimental investigation on effective aerosol scavenging using different spray configurations with pre-injection of water mist for Fukushima Daiichi decommissioning
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作者 Rui-Cong Xu Avadhesh Kumar Sharma +2 位作者 Erdal Ozdemir Shuichiro Miwa Shunichi Suzuki 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第5期154-172,共19页
During the decommissioning of the Fukushima Daiichi nuclear power plant,it is important to consider the retrieval of resolidified debris both in air and underwater configurations.For the subsequent retrieval of debris... During the decommissioning of the Fukushima Daiichi nuclear power plant,it is important to consider the retrieval of resolidified debris both in air and underwater configurations.For the subsequent retrieval of debris from the reactor building,the resolidified debris must be cut into smaller pieces using various cutting methods.During the cutting process,aerosol particles are expected to be generated at the submicron scale.It has been noted that such aerosols sizing within the Greenfield gap(0.1-1μm)are difficult to remove effectively using traditional spraying methods.Therefore,to improve the aerosol removal efficiency of the spray system,a new aerosol agglomeration method was recently proposed,which involves injecting water mist to enlarge the sizes of the aerosol particles before removing them using water sprays.In this study,a series of experiments were performed to clarify the proper spray configurations for effective aerosol scavenging and to improve the performance of the water mist.The experimental results showed that the spray flow rate and droplet characteristics are important factors for the aerosol-scavenging efficiency and performance of the water mist.The results obtained from this study will be helpful for the optimization of the spray system design for effective aerosol scavenging during the decommissioning of the Fukushima Daiichi plant. 展开更多
关键词 Fukushima Daiichi decommissioning Aerosol scavenging Multiphase flow Spray system Aerosol-mist agglomeration
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Enterococcus faecalis provides protection during scavenging in carrion crow (Corvus corone)
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作者 Bin Hu Jia-Min Wang +5 位作者 Qing-Xun Zhang Jing Xu Ya-Nan Xing Bo Wang Shu-Yi Han Hong-Xuan He 《Zoological Research》 SCIE CSCD 2024年第3期451-463,共13页
The gut microbiota significantly influences host physiology and provides essential ecosystem services.While diet can affect the composition of the gut microbiota,the gut microbiota can also help the host adapt to spec... The gut microbiota significantly influences host physiology and provides essential ecosystem services.While diet can affect the composition of the gut microbiota,the gut microbiota can also help the host adapt to specific dietary habits.The carrion crow(Corvus corone),an urban facultative scavenger bird,hosts an abundance of pathogens due to its scavenging behavior.Despite this,carrion crows infrequently exhibit illness,a phenomenon related to their unique physiological adaptability.At present,however,the role of the gut microbiota remains incompletely understood.In this study,we performed a comparative analysis using 16S rRNA amplicon sequencing technology to assess colonic content in carrion crows and 16 other bird species with different diets in Beijing,China.Our findings revealed that the dominant gut microbiota in carrion crows was primarily composed of Proteobacteria(75.51%)and Firmicutes(22.37%).Significant differences were observed in the relative abundance of Enterococcus faecalis among groups,highlighting its potential as a biomarker of facultative scavenging behavior in carrion crows.Subsequently,E.faecalis isolated from carrion crows was transplanted into model mice to explore the protective effects of this bacterial community against Salmonella enterica infection.Results showed that E.faecalis down-regulated the expression of pro-inflammatory cytokines tumor necrosis factor alpha(TNF-α),interferon gamma(IFN-γ),and interleukin 6(IL-6),prevented S.enterica colonization,and regulated the composition of gut microbiota in mice,thereby modulating the host’s immune regulatory capacity.Therefore,E.faecalis exerts immunoregulatory and anti-pathogenic functions in carrion crows engaged in scavenging behavior,offering a representative case of how the gut microbiota contributes to the protection of hosts with specialized diets. 展开更多
关键词 Carrion crow Facultative scavenger Gut microbiota Enterococcus faecalis 16S rRNA sequencing
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Control of the Dust Vertical Distribution over Western Africa by Convection and Scavenging
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作者 H.Senghor R.Pilon +7 位作者 B.Diallo J.Escribano F.Hourdin J.Y.Grandpeix O.Boucher M.Gueye A.T.Gaye E.Machu 《Journal of Atmospheric Science Research》 2024年第1期19-39,共21页
Saharan dust represents more than 50%of the total desert dust emitted around the globe and its radiative effect significantly affects the atmospheric circulation at a continental scale.Previous studies on dust vertica... Saharan dust represents more than 50%of the total desert dust emitted around the globe and its radiative effect significantly affects the atmospheric circulation at a continental scale.Previous studies on dust vertical distribution and the Saharan Air Layer(SAL)showed some shortcomings that could be attributed to imperfect representation of the effects of deep convection and scavenging.The authors investigate here the role of deep convective transport and scavenging on the vertical distribution of mineral dust over Western Africa.Using multi-year(2006-2010)simulations performed with the variable-resolution(zoomed)version of the LMDZ climate model.Simulations are compared with aerosol amounts recorded by the Aerosol Robotic Network(AERONET)and with vertical profiles of the Cloud-Aerosol Lidar with Orthogonal Polarization(CALIOP)measurements.LMDZ allows a thorough examination of the respective roles of deep convective transport,convective and stratiform scavenging,boundary layer transport,and advection processes on the vertical mineral dust distribution over Western Africa.The comparison of simulated dust Aerosol Optical Depth(AOD)and distribution with measurements suggest that scavenging in deep convection and subsequent re-evaporation of dusty rainfall in the lower troposphere are critical processes for explaining the vertical distribution of desert dust.These processes play a key role in maintaining a well-defined dust layer with a sharp transition at the top of the SAL and in establishing the seasonal cycle of dust distribution.This vertical distribution is further reshaped offshore in the Inter-Tropical Convergence Zone(ITCZ)over the Atlantic Ocean by marine boundary layer turbulent and convective transport and wet deposition at the surface. 展开更多
关键词 DUST Vertical distribution Sahara SAHEL West Africa Climate model CONVECTION scavengING ITCZ
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Scavenger receptor BI: A multi-purpose player in cholesterol and steroid metabolism 被引量:11
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作者 Menno Hoekstra Theo JC Van Berkel Miranda Van Eck 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第47期591-5924,共9页
Scavenger receptor class B type Ⅰ (SR-BI) is an important member of the scavenger receptor family of integral membrane glycoproteins. This review highlights studies in SR-BI knockout mice, which concern the role of S... Scavenger receptor class B type Ⅰ (SR-BI) is an important member of the scavenger receptor family of integral membrane glycoproteins. This review highlights studies in SR-BI knockout mice, which concern the role of SR-BI in cholesterol and steroid metabolism. SR-BI in hepatocytes is the sole molecule involved in selective uptake of cholesteryl esters from high-density lipoprotein (HDL). SR-BI plays a physiological role in binding and uptake of native apolipoprotein B (apoB)-containing lipoproteins by hepatocytes, which identif ies SR-BI as a multipurpose player in lipid uptake from the blood circulation into hepatocytes in mice. In adrenocortical cells, SR-BI mediates the selective uptake of HDL-cholesteryl esters, which is eff iciently coupled to the synthesis of glucocorticoids (i.e. corticosterone). SR-BI knockout mice suffer from adrenal glucocorticoid insuff iciency, which suggests that functional SR-BI protein is necessary for optimal adrenal steroidogenesis in mice. SR-BI in macrophages plays a dual role in cholesterol metabolism as it is able to take up cholesterol associated with HDL and apoBcontaining lipoproteins and can possibly facilitate cholesterol efflux to HDL. Absence of SR-BI is associated with thrombocytopenia and altered thrombosis susceptibility, which suggests a novel role for SR-BI in regulating platelet number and function in mice. Transgenic expression of cholesteryl ester transfer protein in humanized SR-BI knockout mice normalizes hepatic delivery of HDL-cholesteryl esters. However, other pathologies associated with SR-BI def iciency, i.e. increased atherosclerosis susceptibility, adrenal glucocorticoid insuffi ciency, and impaired platelet function are not normalized, which suggests an important role for SR-BI in cholesterol and steroid metabolism in man. In conclusion, generation of SR-BI knockout mice has signif icantly contributed to our knowledge of the physiological role of SR-BI. Studies using these mice have identif ied SR-BI as a multi-purpose player in cholesterol and steroid metabolism because it has distinct roles in reverse cholesterol transport, adrenal steroidogenesis, and platelet function. 展开更多
关键词 scavenger receptor class B type Highdensity lipoprotein CHOLESTEROL Lipoprotein metabolism Liver MACROPHAGES Adrenal gland PLATELETS Steroido- genesis
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Synergistic impact of cocatalysts and hole scavenger for promoted photocatalytic H2 evolution in mesoporous TiO2–NiSx hybrid 被引量:3
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作者 Yi Wei Gang Cheng +5 位作者 Jinyan Xiong Jiaxin Zhu Yixin Gan Mengmeng Zhang Zhen Li Shixue Dou 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2019年第5期45-56,共12页
Photocatalytic solar energy conversion to hydrogen is sustainable and attractive for addressing the global energy and environmental issue. Herein, a novel photocatalytic system (NiS/Ni3S4 cocatalysts modified mesoporo... Photocatalytic solar energy conversion to hydrogen is sustainable and attractive for addressing the global energy and environmental issue. Herein, a novel photocatalytic system (NiS/Ni3S4 cocatalysts modified mesoporous TiO2) with superior photocatalytic hydrogen evolution capability through the synergistic impact of NiS/Ni3S4 (NiSx) cocatalyst and efficient hole scavenger has been demonstrated. The photocatalytic hydrogen evolution of TiO2-NiSx hybrids with the different content of NiSx and upon different organic hole scavengers was both investigated. The hybrid of TiO2 decorated with 3%(mole ratio of Ni^2+) NiSx cocatalyst in methanol solution showed the optimal photocatalytic hydrogen evolution rate of 981.59 μmol h^-1 g^-1 which was about 20 times higher than that of bare mesoporous TiO2. Our results suggested that the boosted hydrogen production performance is attributed to both the improved photoinduced electrons migration between NiS and Ni3S4 in cocatalyst and the high hole captured efficiency by hole scavengers of methanol. 展开更多
关键词 NiS/Ni3S4 COCATALYST PHOTOCATALYTIC hydrogen EVOLUTION Mesoporous TiO2 HOLE scavenger
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Effects of a nitric oxide donor and nitric oxide scavengers on Sorbus pohuashanensis embryo germination 被引量:2
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作者 Ling Yang Dongyan Zhang +3 位作者 Hongnan Liu Cheng Wei Jianan Wang Hailong Shen 《Journal of Forestry Research》 SCIE CAS CSCD 2018年第3期628-635,共8页
The effects of an exogenous nitric oxide donor(sodium nitroprusside, SNP), a NO scavenger 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxode(PTIO) and carboxy-PTIO potassium salt(c PTIO) on the embryo germination ... The effects of an exogenous nitric oxide donor(sodium nitroprusside, SNP), a NO scavenger 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxode(PTIO) and carboxy-PTIO potassium salt(c PTIO) on the embryo germination of Sorbus pohuashanensis were studied in a petri dish test. SNP at 0.5–5 mmol L-1 increased germination percentage, mean time to germination, germination index and germination energy compared with the control to different degrees. Treatment with 2 mmol L-1 SNP improved germination most significantly; embryo germination percentage for mother tree 1(91.11%) and mother tree 2(64.44%) were much higher than the control. In addition,excessive SNP levels did not enhance embryo germination.Combined treatment with SNP and an NO scavenger delayed embryo germination. Treatment with c PTIO inhibited embryo germination; germination percentage was 42.22% and was lower than that of the control. These results show that low concentrations of exogenous NO can enhance the embryo germination of S. pohuashanensis,providing a simple, effective way for promoting germination of S. pohuashanensis. 展开更多
关键词 Mountain ash Embryo germination Nitric oxide Sodium nitroprusside Nitric oxide scavenger
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The gut microbiome and metabolome of Himalayan Griffons(Gyps himalayensis):insights into the adaptation to carrion-feeding habits in avian scavengers 被引量:2
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作者 Wen Wang Xiaolong Gao +9 位作者 Sisi Zheng Zhuoma Lancuo Ying Li Lilin Zhu Jianping Hou Jiayi Hai Xin Long Hanxi Chen Alexey Druzyaka Kirill Sharshov 《Avian Research》 SCIE CSCD 2021年第4期682-698,共17页
Background:Himalayan Griffons(Gyps himalayensis),large scavenging raptors widely distributed in Qinghai-Tibetan Plateau,have evolved a remarkable ability to feed on carcasses without suffering any adverse effects.The ... Background:Himalayan Griffons(Gyps himalayensis),large scavenging raptors widely distributed in Qinghai-Tibetan Plateau,have evolved a remarkable ability to feed on carcasses without suffering any adverse effects.The gut microbiome plays an important role in animal physiological and pathological processes,and has also been found to play a health protective role in the vulture adaptation to scavenging.However,the microbial taxonomic diversity(including nonculturable and culturable microbes),functions,and metabolites related to Himalayan Griffons have not been fully explored.Methods:In the present study,the 28 fecal samples of the Himalayan Griffons and 8 carrion samples were collected and sequenced using high-throughput 16 S rRNA gene sequencing methods to analyze the composition and functional structures of the microbiomes.Twelve fecal samples of the Himalayan Griffons were analyzed using untargeted Liquid Chromatography Mass Spectroscopy(LC-MS)to identify metabolites.We used different culture conditions to grow Himalayan Griffons gut microbes.Inhibitory effects of gut beneficial bacteria on 5 common pathogenic bacteria were also tested using the Oxford cup method.Results:According to the results of the culture-independent method,a high abundance of four major phyla in Himalayan Griffons were identified,including Fusobacteria,Firmicutes,Bacteroidetes,and Proteobacteria.The most abundant genera were Fusobacterium,followed by Clostridium_sensu_stricto_1,Cetobacterium,Epulopiscium,and Bacteroides.The predicted primary functional categories of the Himalayan Griffons'gut microbiome were associated with carbohydrate and amino acid metabolism,replication and repair,and membrane transport.LC-MS metabolomic analysis showed a total of 154 metabolites in all the fecal samples.Cultivation yielded 184 bacterial isolates with Escherichia coli,Enterococcus faecium,Enterococcus hirae,and Paeniclostridium sordellii as most common isolates.Moreover,7 potential beneficial gut bacteria isolated showed certain inhibition to 5 common pathogenic bacteria.Conclusions:Our findings broaden and deepen the understanding of Himalayan Griffons'gut microbiome,and highlighted the importance of gut microbiome-mediated adaptation to scavenging habits.In particular,our results highlighted the protective role of gut beneficial bacteria in the Himalayan Griffons against pathogenic bacteria that appear in rotten food resources. 展开更多
关键词 Avian scavengers Culture MICROBIOME Pathogens VULTURES
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Non-peptidyl low molecular weight radical scavenger IAC attenuates DSS-induced colitis in rats 被引量:1
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作者 Valentina Vasina Massimiliano Broccoli +5 位作者 Maria Grazia Ursino Donatella Canistro Luca Valgimigli Antonio Soleti Moreno Paolini Fabrizio De Ponti 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第29期3642-3650,共9页
AIM:To investigate the effects of the free radical scavenger bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl) decandioate(IAC) in the dextran sodium sulphate(DSS) experimental model of ulcerative colitis.METHODS:Colit... AIM:To investigate the effects of the free radical scavenger bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl) decandioate(IAC) in the dextran sodium sulphate(DSS) experimental model of ulcerative colitis.METHODS:Colitis was induced in Sprague Dawley male rats by administration of 5% DSS in drinking water.IAC(30 mg/kg,lipophilic or hydrophilic form) was administered daily(orally or ip) for 6 d until sacrifice.Colonic damage was assessed by means of indirect(Disease Activity Index score) and direct measures(macroscopic and microscopic scores) and myeloperoxidase(MPO)activity.Neutrophil infiltration within the tissue and glutathione S-transferase activity were also investigated.RESULTS:DSS-induced colitis impaired body weight gain and markedly increased all inflammatory parameters.Six-day treatment with lipophilic IAC significantly reduced intestinal damage caused by inflammation,induced a down-regulation in MPO activity(0.72 ± 0.12 and 0.45 ± 0.12 with lipophilic IAC po and ip,respectively,vs 1.10 ± 0.27 in untreated DSS colitis animals) and minimized DSS-induced neutrophil infiltration,while hydrophilic IAC administered orally did not ameliorate DSS-induced damage.CONCLUSION:These results support the hypothesis that reactive oxygen metabolites contribute to inflammation and that the radical scavenger IAC has therapeutic potential in inflammatory bowel disease. 展开更多
关键词 Dextran sodium sulphate-induced colitis Oxidative damage Inflammatory bowel disease Bis(1-hydroxy-2 2 6 6-tetramethyl-4-piperidinyl)decandioate Radical scavenger Animal models
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Berberine promotes the development of atherosclerosis and foam cell formation by inducing scavenger receptor A expression in macrophage 被引量:18
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作者 Ke Li Wenqi Yao Xiudan Zheng Kan Liao 《Cell Research》 SCIE CAS CSCD 2009年第8期1006-1017,共12页
Berberine 被识别通过低密度脂蛋白(LDL ) 的正式就职在人和仓鼠降低浆液胆固醇水平在肝的房间的受体。在阻止动脉粥样硬化评估它的潜力,在在 apolipoprotein 电子 deficient 的动脉粥样硬化开发的 berberine 的效果(apoE ?/?) 老鼠被... Berberine 被识别通过低密度脂蛋白(LDL ) 的正式就职在人和仓鼠降低浆液胆固醇水平在肝的房间的受体。在阻止动脉粥样硬化评估它的潜力,在在 apolipoprotein 电子 deficient 的动脉粥样硬化开发的 berberine 的效果(apoE ?/?) 老鼠被调查。在 apoE ?/ ?鼠标,在 vivo 导致的 berberine 泡沫房间形成和支持的动脉粥样硬化开发。berberine 导致的泡沫房间形成也在老鼠 RAW264.7 房间,以及在老鼠和人的主要巨噬细胞被观察。由导致 scavenger 受体 A (SR -- 一) 在巨噬细胞的表示, berberine 增加了修改 LDL (DiO-Ac-LDL ) 的举起。导致 Berberine 的 SR -- 表情也在动脉粥样硬化患者在 vivo 并且在房间在巨噬细胞泡沫房间被观察损害。在 RAW264.7 房间的分析显示 berberine 导致了 SR -- 由压制 PTEN 表示的表情,它导致了持续 Akt 激活。我们的结果建议那在减轻动脉粥样硬化评估减少胆固醇的混合物的潜力,它涉及动脉粥样硬化开发的房间上的效果例如巨噬细胞,应该也被考虑。泡沫房间形成的提升能抵销阴沉的浆液胆固醇的有益的效果。 展开更多
关键词 动脉粥样硬化 清道夫受体A 泡沫细胞 小檗碱 诱导 RAW264.7细胞 细胞表达 低密度脂蛋白
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Increase the Degradation Efficiency of Organic Pollutants with a Radical Scavenger (Cl) in a Novel Photoelectrocatalytic Reactor
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作者 TaiChengAN WenBingZHANG GuiYingLI JiaMoFU GuoYingSHENG 《Chinese Chemical Letters》 SCIE CAS CSCD 2004年第4期455-458,共4页
Photoelectrocatalytic degradation performance of quinoline in saline water was investigated using a new-designed continuous flow three-dimensional electrode-packed bed photocatalytic reactor. It is interesting to find... Photoelectrocatalytic degradation performance of quinoline in saline water was investigated using a new-designed continuous flow three-dimensional electrode-packed bed photocatalytic reactor. It is interesting to find that chloride ion has an obvious enhancement effect rather than a scavenging effect on the photoelectrocatalytic degradation of quinoline, and create a kinetic synergetic effect in the photoelectrocatalytic reactor. 展开更多
关键词 Photoelectrocatalytic reactor PHOTOCATALYTIC radical scavenger chloride ion quioline.
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Genetic variants of the class A scavenger receptor gene are associated with coronary artery disease in Chinese
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作者 Min Zhang Yan Zhang +4 位作者 Shuaishuai Zhu Xiaoyu Li Qing Yang Hui Bai Qi Chen 《The Journal of Biomedical Research》 CAS 2012年第6期418-424,共7页
The class A scavenger receptor, encoded by the macrophage scavenger receptor 1 (MSR1) gene, is a pattern recognition receptor (PPR) primarily expressed in macrophages. It has been reported that genetic polymorphis... The class A scavenger receptor, encoded by the macrophage scavenger receptor 1 (MSR1) gene, is a pattern recognition receptor (PPR) primarily expressed in macrophages. It has been reported that genetic polymorphisms of MSR1 are significantly associated with the number of diseased vessels and coronary artery narrowing greater than 20% in Caucasians. However, whether it links genetically to coronary artery disease (CAD) in Chinese is not defined. Here, we performed an independent case-control study in a Chinese population consisting of 402 CAD cases and 400 controls by genotyping ten single nucleotide polymorphisms (SNPs) of MSR1. We found that rs416748 and rs13306541 were significantly associated with an increased risk of CAD with per allele odds ratio (OR) of 1.56 [95% confidence interval (CI) = 1.28-1.90; P 〈 0.001] and 1.70 (95% CI = 1.27-2.27; P 〈 0.001), re- spectively. Our results indicate that genetic variants of MSR1 may serve as predictive markers for the risk of CAD / in combination with traditional risk factors of CAD in Chinese population. 展开更多
关键词 class A scavenger receptor gene single nucleotide polymorphisms (SNPs) coronary artery disease Chinese population
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Assessment of the Activities of Scavengers in Obio/Akpor Local Government, Rivers State, Nigeria
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作者 Elenwo Ephraim Ikechukwu 《Journal of Environmental Protection》 2015年第3期272-280,共9页
This study was carried out based on consistent observations on the activities of scavengers of scrap metal in Obio/Akpor local government Rivers State. The study was carried out to ascertain the profitability of scrap... This study was carried out based on consistent observations on the activities of scavengers of scrap metal in Obio/Akpor local government Rivers State. The study was carried out to ascertain the profitability of scrap metal scavenging and how scrap metal waste can generate wealth to the public and the government. The study made use of primary and secondary data with the former being the main focus. The data were analyzed using the simple percentage, while the hypothesis was tested by means of the chi-square. The study findings revealed that there was a relationship between waste and wealth in relation to scrap metal scavenging. The researches therefore make the following recommendations;that scavengers should form co-operatives so that they can pull their efforts and resources together and bargain collectively. Government and nongovernmental organization should enlighten them through seminars, workshops, etc., on how to carry out their activities in an environmentally safe manner. The state government should encourage scavenging by enacting a law to back the profession and make it attractive for the teaming youths to venture into. 展开更多
关键词 ASSESSMENT Activities scavengerS Obio/Akpor
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Hyperglycemia promotes overexpression of SR-BII isoform of the scavenger receptor class B type I in type 2 diabetes mellitus: A study in Juana Koslay City, San Luis, Argentina
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作者 Gisela V. Mendoza Susana Siewert +3 位作者 Irma González María C. Della Vedova Gustavo Fernandez Marta S. Ojeda 《Journal of Diabetes Mellitus》 2013年第4期172-183,共12页
The scavenger receptor class B type I (SR-BI) is a high-density lipoprotein (HDL) receptor involved in reverse cholesterol transport. Some studies reported the association to be stronger in the presence of diabetes. T... The scavenger receptor class B type I (SR-BI) is a high-density lipoprotein (HDL) receptor involved in reverse cholesterol transport. Some studies reported the association to be stronger in the presence of diabetes. The full length gene encoding SR-BI is comprised in 13 exons that are alternatively spliced to produce two major transcripts: the full length SR-BI and the splice variant SR-BII, in which exon 12 is skipped. Considering that type 2 diabetes status is characterized by changes in the concentration of plasma lipids, modifications in lipoprotein size and composition, which may be important modulators of the SR-BI expression;the aims of the study were to examine the influence of SR-BI polymorphism (rs838895) on lipid profile and SR-BI mRNA expression in a population of diabetic patients living in Juana Koslay City. Blood samples were drawn from controls (n = 40) and Type 2 diabetic patients (n = 66) and DNA and total RNA were obtained. SR-BI mRNA expression was measured by RT-PCR and SR-BI polymorphism was detected by Tetra Primer ARMSPCR. Compared to controls, diabetic patients had higher fasting serum glucose, glycated hemoglobin, triglycerides, total cholesterol, lowdensity lipoprotein cholesterol, and lower highdensity lipoprotein cholesterol. SR-BI mRNA expression was lower in T2DM when compared to controls, suggesting that the hyperglycemia presents in T2DM patients down-regulates SR-BI mRNA expression. Interestingly, we found that decreased SR-BI expression resulted in markedly increased plasma LDL concentrations in T2DM subjects, and the overexpression of SRBII isoform is responsible for the markedly increased plasma LDL-c concentrations. The polymorphism (rs838895) did not modify the mRNA level of SR-BI in leucocytes from control and diabetic patients. This study provides novel evidence suggesting that hyperglycemia may affect reverse cholesterol transport by controlling SRBI expression in diabetic patients. LDL cholesterol levels are associated with low SR-BI mRNA expression in T2DM. 展开更多
关键词 TYPE 2 Diabetes Mellitus HYPERGLYCEMIA scavenger Receptor Class B TYPE I and Polymorphism
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Comparative Efficacy of Polyamine-Based Scavenger Resins
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作者 Krishnarao Sandhya Bhagavathula Ravindranath 《International Journal of Organic Chemistry》 2012年第1期71-74,共4页
Polyamine-based scavenger resins containing 2, 3 and 4 nitrogen atoms have been prepared and their comparative efficacy to scavenge appropriate electrophilic chemicals (acids, acid chlorides, isocyanates and aldehydes... Polyamine-based scavenger resins containing 2, 3 and 4 nitrogen atoms have been prepared and their comparative efficacy to scavenge appropriate electrophilic chemicals (acids, acid chlorides, isocyanates and aldehydes) from solutions has been studied. As expected, the scavenging efficiency is directly proportional to the number of nucleophic nitrogens present on the resin. The results have been compared with the performance of the popular scavenger resin, namely, tris(2-aminoethyl)amine resin, to conclude that the low-cost polyamine resins now prepared can be conveniently used as effectively as the expensive commercial product. 展开更多
关键词 Acids Acid Chlorides Aldehydes ISOCYANATES ETHYLENEDIAMINE DIETHYLENETRIAMINE TRIETHYLENETETRAMINE Tris(2-aminoethyl)amine scavenger RESINS Combinatorial Synthesis
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The effective transfection of a low dose of negatively charged drug-loaded DNA-nanocarriers into cancer cells via scavenger receptors
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作者 Mirza Muhammad Faran Ashraf Baig Chengfei Zhang +2 位作者 Muhammad Furqan Akhtar Ammara Saleem Jahanzeb Mudassir 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2021年第2期174-182,共9页
DNA-nanotechnology-based nano-architecture scaffolds based on circular strands were designed in the form of DNA-nanowires(DNA-NWs) as a polymer of DNA-triangles. Circularizing a scaffold strand(84-NT) was the critical... DNA-nanotechnology-based nano-architecture scaffolds based on circular strands were designed in the form of DNA-nanowires(DNA-NWs) as a polymer of DNA-triangles. Circularizing a scaffold strand(84-NT) was the critical step followed by annealing with various staple strands to make stiff DNAtriangles. Atomic force microcopy(AFM), native polyacrylamide gel electrophoresis(PAGE), UVanalysis, MTT-assay, flow cytometry, and confocal imaging were performed to assess the formulated DNA-NWs and cisplatin(CPT) loading. The AFM and confocal microscopy images revealed a uniform shape and size distribution of the DNA-NWs, with lengths ranging from 2 to 4 mm and diameters ranging from 150 to 300 nm. One sharp band at the top of the lane(500 bp level) with the loss of electrophoretic mobility during the PAGE(native) gel analysis revealed the successful fabrication of DNA-NWs. The loading efficiency of CPT ranged from 66.85% to 97.35%. MTT and flow cytometry results showed biocompatibility of the blank DNA-NWs even at 95% concentration compared with the CPT-loaded DNANWs. The CPT-loaded DNA-NWs exhibited enhanced apoptosis(22%) compared to the apoptosis(7%)induced by the blank DNA-NWs. The release of CPT from the DNA-NWs was sustained at < 75% for 6 h in the presence of serum, demonstrating suitability for systemic applications. The IC_(50) of CPT@DNA-NWs was reduced to 12.8 nM CPT, as compared with the free CPT solution exhibiting an IC_(50) of 51.2 n M.Confocal imaging revealed the targetability, surface binding, and slow internalization of the DNA-NWs in the scavenger-receptor-rich cancer cell line(HepG2) compared with the control cell line. 展开更多
关键词 Cisplatin(CPT) DNA-nanowires(DNA-NWs) HepG2 resistant cancer cells scavenger receptors
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Possible Synergistic Toxicity of Oxygen Scavenger and Defoamer on the Niger Delta Freshwater <i>Tilapia guineensis</i>
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作者 Ikechukwu Kingsley Anyanwu Ogbonna Friday Joel Owunari Abraham Georgewill 《Journal of Environmental Protection》 2021年第11期903-912,共10页
Globally, the generation of produced water keeps increasing due to depleting wells and about 40% of this wastewater is disposed of into the environment. Produced water is made up of several components that are toxic i... Globally, the generation of produced water keeps increasing due to depleting wells and about 40% of this wastewater is disposed of into the environment. Produced water is made up of several components that are toxic in nature, like production chemicals that are used for oil and gas production activities. Oxygen scavenger and defoamer are commonly used for corrosion prevention as both are applied at different stages of corrosion prevention. Evaluation of the possible synergistic toxicity contribution of oxygen scavenger and defoamer formed the basis of this research and was conducted using the <i>Tilapia guineensis</i> as bio-indicator. The toxicity test was carried out using the ELIMINOX (oxygen scavenger) and EC9017A (defoamer) individually and both chemicals were combined together. The choice of these chemicals was premised on previous researches that have confirmed that they are toxic individually, without further research on how they interact when they are combined. These chemicals and freshwater were used to generate produced water samples in the laboratory. The experiment was set up by adding ten fishes into each of the glass containers, containing the produced water samples at different concentrations and a control sample without the chemicals. The rate of mortality of the fish for the individual chemicals ranged from 100% to 10% for the different percentage concentrations. While on the other hand, a combination of the two chemicals had more survival than mortality, the percentage survival rate ranged from 100% to 90% across all the percentage concentrations. The lethal concentration also showed that the oxygen scavenger was more toxic than the defoamer, however, when they were combined;they showed an antagonistic relationship as the toxicity of the oxygen scavenger drastically reduced. The research findings intend to create awareness of the possible interaction of production chemicals when they are used for oil and gas activities and their combined toxicity contribution to produced water. This will in turn aid government regulators in their decision-making for disposal of produced water. 展开更多
关键词 Produced Water Oxygen scavenger DEFOAMER Tilapia guineensis TOXICITY Lethal Concentration Synergetic Effects
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Indirect photocatalytic reduction of arsenate to arsenite in aqueous solution with TiO_2 in the presence of hole scavengers
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作者 Abdus Samad Shamim Ahsan +4 位作者 Ikki Tateishi Mai Furukawa Hideyuki Katsumata Tohru Suzuki Satoshi Kaneco 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2018年第3期529-533,共5页
The indirect photocatalytic reduction of arsenate to arsenite in aqueous solution with titanium dioxide(TiO_2)was investigated with various hole scavengers such as methanol, ethanol, 2-propanol, formaldehyde, acetone,... The indirect photocatalytic reduction of arsenate to arsenite in aqueous solution with titanium dioxide(TiO_2)was investigated with various hole scavengers such as methanol, ethanol, 2-propanol, formaldehyde, acetone,formic acid and acetic acid. Although the direct photocatalytic reduction of arsenate to arsenite with TiO_2 was impossible, an indirect reduction of As(V) was possible in the presence of sacrificial electron donors to form strongly reductive radicals. The addition of ethanol was very effective for indirect photocatalytic reduction of As(V) in aqueous solution with TiO_2 photocatalyst. The indirect photocatalytic reduction rate of As(V) may be related with both the reaction rate constants of reaction of hydroxyl radicals with hole scavenger and the reactivities for the radicals M· which are produced by the reaction of ·OH with hole scavenger. 展开更多
关键词 亚砷酸盐 TiO2 间接 反应率 二氧化物 光催化剂 分子
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A Novel Dominant Allele from 93-11, ES(4), Represses Reactive Oxygen Species Scavenging and Leads to Early-Senescence in Rice
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作者 Zhishu Jiang Cong Gan +5 位作者 Yulian Liu Xiaoli Lin Limei Peng Yongping Song Xiaowei Luo Jie Xu 《Phyton-International Journal of Experimental Botany》 SCIE 2023年第3期665-677,共13页
Senescence is the last developmental process in plant,which has an important impact on crop yield and quality.In this study,a stable hereditary early-senescence line BC64 was isolated from the high-generation recombin... Senescence is the last developmental process in plant,which has an important impact on crop yield and quality.In this study,a stable hereditary early-senescence line BC64 was isolated from the high-generation recombinant inbred lines of 93-11 and Wuyunjing7(W7).Genetic analysis showed that the premature aging phenotype was controlled by a dominant gene derived from 93-11.By linkage analysis,the gene was primarily mapped in the region between marker B4 and B5 near the centromere of chromosome 4,described as ES(4).Through multiple backcrossing with W7,the near-isogenic line of ES(4)(NIL-ES(4))was obtained.Compared with wild-type W7,NIL-ES(4)plants showed more sever senescence phenotype in both nature and dark conditions.In NIL plants,leaves turned yellow at the fully tillering stage;photosynthetic rate,pollen fertility and seed setting rate were decreased.Moreover,the malondialdehyde,proline content and relative conductivity in NIL-ES(4)were significantly higher than those in W7;both transcript level and activities of reactive oxygen species scavenging enzymes were repressed;H2O2 and O^(2−)were significantly accumulated.This study provides a basis for further cloning and function identification of ES(4). 展开更多
关键词 RICE early-senescence gene mapping chlorophyll degradation reactive oxygen species scavenging
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A Review of Thermo- and Diffusio-Phoresis in the Atmospheric Aerosol Scavenging Process. Part 2: Ice Crystal and Snow Scavenging
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作者 Gianni Santachiara Franco Prodi +1 位作者 Franco Belosi Alessia Nicosia 《Atmospheric and Climate Sciences》 2023年第4期466-477,共12页
The role of phoretic forces in the identification of particles acting as ice nuclei in mixed phase cloud is discussed. A method used to identify the effective ice nucleating particles is to sample ice crystals, which ... The role of phoretic forces in the identification of particles acting as ice nuclei in mixed phase cloud is discussed. A method used to identify the effective ice nucleating particles is to sample ice crystals, which are afterwards sublimated, and to examine the particles remaining after evaporation. The procedure takes into account only crystal with a maximum diameter of 20 μm, by assuming that small crystals do not scavenge aerosol during growth, and therefore that crystals contain only the effective nucleating particles. This assumption is questionable, however, as experiments have shown that even small ice crystals can scavenge aerosol. Another approach has been to compare the number and elemental composition of residual particles in small ice crystals and of aerosol near the cloud. By considering as example soot and black carbon aerosol, contradictory conclusions on their importance in the processes of ice nucleation have been reported in the literature. We suggest that, in addition to physico-chemical properties of soot/carbon aerosol particles, even the microphysical and environmental parameters involved in the transition of aerosol from gas phase to ice crystals in cloud should be considered. The contribution of phoretic forces should also be considered. After initial growth ice crystals can continue to grow by water vapour diffusion. Laboratory experiments confirm the contribution of diffusiophoresis with Stefan flow in the scavenging by snow crystals up to 3 mm in diameter. The particle scavenging efficiency of snow crystals is related to crystalline shape and depends on air relative humidity and temperature. 展开更多
关键词 Ice Crystals Snow Crystals Ice Nucleating Particles Aerosol scavenging Phoretic Forces
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OP2S双燃料发动机气口匹配特性研究
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作者 杨伟 马富康 +3 位作者 许俊峰 邹润 徐洋 李峰 《重庆理工大学学报(自然科学)》 CAS 北大核心 2024年第4期275-282,共8页
对置活塞二冲程(OP2S)发动机是一种结构可调性较高的动力系统,采用等效二冲程方法建立并校验了OP2S柴油机的一维仿真模型,研究了不同甲醇含量下进排气口高度冲程比对OP2S柴油机动力性能、燃油经济性、换气性能和排放性能的影响。结果表... 对置活塞二冲程(OP2S)发动机是一种结构可调性较高的动力系统,采用等效二冲程方法建立并校验了OP2S柴油机的一维仿真模型,研究了不同甲醇含量下进排气口高度冲程比对OP2S柴油机动力性能、燃油经济性、换气性能和排放性能的影响。结果表明:OP2S柴油机具有换气性能和排放性能的双“trade-off”关系。甲醇含量增加会促进经济性能的提高和动力性能的降低,也会促进扫气效率的增加和捕获率的降低。进排气口的匹配设计是提升OP2S柴油机性能的关键之一。进气口通过增加新鲜空气主动促进燃烧,而排气口通过减少能量和新鲜充量损失被动改善换气性能。随着气口高度的增加,OP2S柴油机的性能曲线具有双转捩点。将性能曲线分为3个区域,其中第2区域为最佳性能区,该区域对应的进/排气口高冲程比分别为0.056~0.122和0.078~0.100。 展开更多
关键词 对置活塞二冲程 甲醇柴油 气口高度 换气性能
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