含葡萄糖基团缩氨基硫脲Schiff Base的合成

本论文以 2 ,3 ,4,6-四 -O-乙酰基 -β-D-吡喃葡萄糖基异硫氰酸酯为原料 ,制得了 8个未见报道的含葡萄糖基硫脲基 Schiff base(希夫碱类化合物 ) :芳香醛缩 N-氨基 -N′-2′,3′,4′,6′-四 -O-乙酰基 -β-D-吡喃葡萄糖基硫脲 ,所有目标化合物均经 IR,1 HNMR进行了表征。

L-苯丙氨酸Schiff Base金属铜配合物的合成、表征及理论研究

氨基酸Schiff Base金属配合物由于在磁学、非线性光学材料、荧光探针、生物活性等诸多领域有着潜在的应用价值,受到了极大的关注。本文采用L-苯丙氨酸与2-乙酰吡啶反应,合成了一种新型Schiff Base。随后用溶剂热合成法制得蓝色的L-苯丙氨酸Schiff Base金属铜的配合物单晶,并通过X射线单晶衍射、红外光谱、热重分析等对实验产物进行了结构解析和性质表征。为进一步了解其内在结构和性质,采用密度泛函理论,在分子水平进行了理论计算,对配合物进行了全优化,并在优化构型的基础上探讨了其平衡结构、NBO电荷分布和转移以及红外光谱等。结果表明,2个金属Cu(Ⅱ)离子分别与配体中的2个N、1个O原子配位,形成中心对称的六配位的弱氯桥双核化合物。该晶体属单斜晶系,晶胞参数a=1.246nm,b=0.886nm,c=1.451nm,α=90°,β=101.982(2)°,γ=90°。通过对单晶结构、NBO电荷、红外光谱的探讨,进一步说明了配位键的形成和配体在配位前后结构的变化,可为氨基酸金属配合物的合成、性质及应用研究提供理论参考。

Adsorption isotherm and inhibition effect of a synthesized di-(m-Formylphenol)-1,2-cyclohexandiimine on corrosion of steel X52 in HCl solution

The potential of di-(m-Formylphenol)-1,2-cyclohexandiimine as an environmentally friendly corrosion inhibitor for steel was investigated in 1 mol/L HCl using potentiodynamic polarization, electrochemical impedance spectroscopy and chronoamperometry measurements. All electrochemical measurements suggest that this compound is an excellent corrosion inhibitor for mild steel and the inhibition efficiency increases with the increase in inhibitor concentration. The effect of temperature on the corrosion behavior of mild steel with the addition of the Schiff base was studied in the temperature range from 25 °C to 65 °C. It is found that the adsorption of this inhibitor follows the Langmuir adsorption isotherms. The value of activation energy and the thermodynamic parameters such as ΔHads, ΔSads, Kads and ΔGads were calculated by the corrosion currents at different temperatures using the adsorption isotherm. The morphology of mild steel surface in the absence and presence of inhibitor was examined by scanning electron microscopy(SEM) images.

In vivo anticancer activity of vanillin semicarbazone

Objective:To evaluate the anticancer activity of vanillin semicarbazone(VSC) against Ehrlich ascites carcinoma(EAC) cells in Swiss albino mice.Methods:The compound VSC at three doses(5, 7.5 and 10 mg/kg i.p.) was administered into the intraperitoneal cavity of the EAC inoculated mice to observe its efficiency by studying the cell growth inhibition, reduction of tumour weight,enhancement of survival time as well as the changes in depleted hematological parameters. Allsuch parameters were also studied with a known standard drug bleomycin at the dose of 0.3 mg/kg(i.p.).Results:Among the doses studied, 10 mg/kg(i.p.) was found to be quite comparable in potency to that of bleomycin at the dose of 0.3 mg/kg(i.p.). The host toxic effects of VSC was found to be negligible.Conclusions:It can be concluded that VSC can therefore be considered as potent anticancer agent.

Dioxygen Affinities and Biomimetic Catalytic Performance of Transition-metal Complexes with Benzoin Schiff Bases

The oxygenation constants of transition-metal complexes with benzoin Schiff bases were measured and these complexes were first employed as models for mimicking monooxygenase in catalytic epoxidation of styrene. The highest conversion and selectivity were up to 39.6% and 100% respectively at ambient temperature and pressure. The effects of structures of the bridge group R in the ligands on the dioxygen affinities and catalytic activities to epoxidize styrene were also investigated.

Syntheses,Crystal Structures and Complexing Properties of 1,3-Distal Calix[4]arene Schiff Bases

Novel 1,3-distal p-tert-butylcalix[4]arene Schiff bases were efficiently synthesized in three steps. At first p-tert-hutylcalix[4]arene was reacted with N-2-hydroxyethylphthalimide catalyzed by TPP/DEAD or alkylated with ω-hatoalkylphthalimide in the system of K2CO3/KI/CH3COCH3 to give 1,3-distal diphthalimidoalkyl calixarenes, which were in turn hydrazinolyzed to give diaminoalkyl calixarenes. Then with the aid of the condensation of active calixarene amines with salicylaldehyde, 2-hydroxy-l-naphthaldehyde or pyridine-2-carboxaldehyde, a series of 1,3-distal calixarene Schiff bases was prepared in satisfied yields. The single crystal structures and complexing properties of these Schiff bases for transition metal ions were studied.

Inhibition effect of a synthesized N,N′-bis(2-hydroxybenzaldehyde)-1,3-propandiimine on corrosion of mild steel in HCl

The corrosion inhibition of mild steel in 1 mol/L HC1 by N, N＇-bis （2-hydroxybenzaldehyde）- 1, 3-propandiimine （2-HBP） has been investigated by using potentiodynamic polarization, electrochemical impedance spectroscopy （EIS） and chronoamperometry measurements. The experimental results suggest that this compound is an excellent corrosion inhibitor for mild steel and the inhibition efficiency increases with the increase in inhibitor concentration. Polarization curves reveal that this organic compound is a mixed type inhibitor. The effect of temperature on the corrosion behavior of mild steel with the addition of the Schiff base was studied in the temperature range from 25 ℃ to 65℃. The experimentally obtained adsorption isotherms follow the Langmuir equation. Activation and thermodynamic adsorption parameters such as Ea, △H, △S,Kads and AG,ds were calculated by the corrosion currents at different temperatures and using the adsorption isotherm. The morphology of mild steel surface in the absence and presence of 2-HBP was examined by atomic force microscope （AFM） images.

Crystal Structures of Two Potential Tumor Imaging Agents and Therapeutic Agents-Copper(Ⅱ) Ternary Complexes with Salicylidene-tyrosinato Schiff Base and Nitrogen-donor Chelating Lewis Base

The crystal structures of two potential tumor imaging agents and therapeutic agents -copper(Ⅱ) complexes with salicylidene-tyrosinato Schiff base and nitrogen-donor chelating Lewis base, [Cu(sal-tyr)(bipy)] 1 and [Cu(sal-tyr)(phen)]2CH3OH 2 are presented. Our work is helpful to get deep understanding of novel 64Cu tumor imaging agents and therapeutic agents.

Synthesis and Identification of Some New Tetrazole Derivatives from 4,5-dichloro Imidazole and Study of Their Biological Activity

A number of tetrazoles derivatives were prepared by series of steps, the first step includes react （4,5-dichloroimidazole） with （4-aminoacetophenone） to form 1-（4-（（4,5-dichloro-lH-imidazol-2yl）diazenyl）ethanone （1）. The second step was （1） reaction with （Amines derivatives） to get Schiff bases （2-7）. The third step was reaction of Shciff base with sodiumazide to form tetrazoles derivatives （8-13）. then study the biological activity for all compounds to word two type of bacteria.

Observation of Reciprocal Induced CD between Colloidal Gold Nanoparticles and Chiral Schiff Base Zn （11） Complexes with Parallel Dipole Moments

The authors have prepared suprameolecular systems of chiral Schiffbase ZnAZSB （Zn（II） complexes with azo-groups） or without ZnSB （azo-groups） and colloidal AuNP （gold nanoparticles） of 10, 40 and 80 nm diameters. They exhibited gradual shifts of surface plasmon bands as well as fluorescence bands. The authors observed and discussed induced CD bands on gold nanoparticles from chiral ZnAZSB or ZnSB. Absence of cis-trans photoisomerization of ZnAZSB with AuNP also supported direct contact near the surface of AuNP. Quenching and splitting of fluorescence bands of ZnSB （λex = 550 nm and λem = 400 nm） depending on concentration of ZnSB and size of AuNP also suggested intermolecular （electric） interaction on the surface of AuNE Decrease of the intensity of the CD band around 380 nm resulted from reciprocal induced CD effect due to parallel arrangement of electric transition moments of ZnAZSB or ZnSB and surface of AuNP.

Anthraquinone Derivative Chiral Schiff Base Copper（Ⅱ） Complexes for Enzyme Type Bio-Fuel Cell Mediators

Electrochemically, laccase, a family of multi-copper oxidase, has specificity for performing not only one-electron oxidation of phenolic-related compounds but also four-electron reduction of oxygen, which is expected to be a cathode of biofuel ceils. We have prepared three amino-acid derivatives （for enhancing affinity to laccase） and one control （just for determining redox behavior of ligands and Cu（II/I）） copper（lI） complexes 0-3 having phenolic-related ligands involving anthraquinone moiety. Enhancing current density of electron transfer between the cathode （composed of electron conducting materials such as Nation and carbon nanotube） and laccase could be observed for all 1-3 acting as good mediators according to （spectro）electrochemical results.

Synthesis, Characterization and Thermodecomposition Kinetics of Dy-Complex with Furfural and DL-α-Alanine

A new schiff base complex derived from furfural-DL-α-alanine and Dy(NO_3)·6H_2O was synthesized. It was characterized by elemental analysis, infrared spectra, ultraviolet spectra, molar conductivity measurements and thermogravimetric analysis. The stoichiometry was deduced to be [Dy(C_8H_8NO_3)(H_2O)(NO_3)](H_2O)(NO_3). Its thermal decomposition reaction kinetics was studied by thermogravimetry.

Synthesis of Calix[4]resorcinarene Core Dendrimers with Peripheral Salicylideneimine Functional Groups

First to third-generation calix[4] resorcinarene core dendrimers, compounds 4a, 4b, 7a, 7b, 10a and 10b, were prepared via the divergent method in seven steps with the corresponding tetraphenyl- and tetra （hydroxyphenyl） calix[4] resorcinarenes （compounds 1a, 1b） as the starting material. The repeat units of the polyamidoamines of these dendrimers were obtained by the ammonolysis of ethyl calixarylacetates 2a and 2b with 1,3-diaminopropane, that is, amide derivatives with terminal amino groups, which in turn reacted with ethyl acrylate to give a higher generation of ester derivatives. The structures of these dendrimers were characterized by IR, ^1H and ^13C NMR spoctrometries. The crystal structure of compound 2b with 12 ethoxycarbonylmethoxy groups was determined by X-ray analysis.

Synthesis and Color-tunable Fluorescence Properties of Schiff Base Zinc (II) Complexes Used as Electroluminescent Materials

Four kinds of bis(N-alkylsalicylaldiminato) zinc(II) complexes were synthesized, and their molecular structures were determined by FT-IR and elemental analysis. Their photoluminescence properties were determined, which indicated that they could emit strong fluorescence varying from blue to yellow to reddish orange depending on their different molecular structures. They had good thermostability, solubility and film forming capability, and can be used as organic lectroluminescent materials. These new complexes may afford the feasibility to realize full-color display with materials based on similar molecular structures.

Synthesis of ethoxycarbonyl isothiocyanate by orthogonal design

Using Schiff base as a phase transfer catalyst, ethoxycarbonyl isothiocyanate was synthesized by reacting ethyl chloroformate with sodium thiocyanate. In order to get the best synthetic technology, an orthogonal test （L9（34）） was applied. The results show that reaction temperature, reaction time, content of catalyst and molar ratio of sodium thiocyanate to ethyl chloroformate are the main factors influencing the yield. The four factors chosen for the present investigation are based on the results of a single-factor test. The optimum synthetic technology is determined as follows： reaction temperature 35 ℃, reaction time 3 h, the content of catalyst （molar fraction based on ethyl chloroformate） 1.5% and molar ratio of sodium thiocyanate to ethyl chloroformate 1.1. Under the optimized synthetic technology, the experimental yield reaches 96.8%.

Syntheses, Crystal Structures and Antibacterial Activities of Copper(Ⅱ) and Zinc(Ⅱ) Complexes Based on (E)-4-fluoro-2-((3-morpholinopropylimino)methyl)phenol

Two Schiff base complexes [Cu（L）2] （1） and [Zn（L）2]·3H2O（2） of （E）-4-fluoro-2-（（3-morpholino propylimino）methyl）phenol （HL） have been synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. Crystal data for 1： triclinic, space group Pī with a=4.8000（10）, b=11.109（2）, c=13.921（3）,α=66.55（3）,β=80.35（3）,γ=81.09（3）°, V=668.2（2）3 , Z=1, Dc=1.477g/cm 3 , F（000）=311, and the final R=0.0744 and wR=0.1601 for 2301 observed reflections with I 〉 2σ（I）. And those for 2： monoclinic, space group P21 /c with a=14.789（3）, b=11.713（2）, c=18.846（4）,β=107.85（3）°, V=3107.4（11）3 , Z=4, D c=1.389 g/cm 3 , F（000）=1368, and the final R=0.0749 and wR=0.1348 for 5423 observed reflections with I 〉 2σ（I）. Both 1 and 2 are four-coordinated complexes, with a square-planar geometry of copper（Ⅱ） in 1 and a slightly distorted tetrahedral geometry of zinc（Ⅱ） in 2. An asymmetric unit consists of only one half of a Cu ion and one L ligand in 1, while an asymmetric unit is composed of one Zn ion, two L ligands and three water molecules in 2. Non-classical C-H···O and C-H F hydrogen bonds play important roles in the formation of a 1D chain of 1, but O-H O and O-H N hydrogen bonds play dominant roles in the self-assembly of a 3D network of 2. The antibacterial activities of 1 and 2 against B. subtilis, S. aureus, S. faecalis, P. aeruginosa, E. coli and E. cloacae have been evaluated by MTT method.

Organocatalyzed Highly Efficient Michael Addition of Malonate Derivatives to α,β-Unsaturated Ketones Using Chiral Schiff Bases

An efficient enantioselective Michael addition of ethyl-2-cyanoacetate and diethyl malonate to α,β-unsaturated ketones catalyzed by a simple chiral Schiff base, and products were obtained in good yields at room temperature.

Viscosity Dependence of Solid-State CD Peaks of Chiral Schiff Base Ni（ll） and Cu（ll） Complexes in PMMA Soft Mater Matrices

Two new chiral Schiff base acacen-derivative nickel（II） and copper（II） complexes have been prepared and characterized with IR, electronic, and CD spectra and X-ray crystallography. So-called artifact peaks of solid-state CD spectra due to restricted to rotate freely of molecules appeared at about 334 and 460 nm for nickel（II） and copper（II） complexes. Changes of intensity of the peaks have been investigated in different matrices such as solid-state （microcrystals or KBr pellets）, PMMA cast films and acetone solutions of various concentrations and pure acetone solutions. Although restricted orientation of molecules in rigid matrices leads to increase the peak intensity toward negative and positive optical rotation for nickel（II） and copper（II） complexes, respectively, the degree of increasing intensity depends on not concentration but viscosity of polymer solutions. Therefore, the artifact CD peaks of solid-state can act as an indicator of environmental viscosity of soft mater matrices.

Synthesis and Structure of Chromium Complexes with New Tetradentate Schiff Base N202-Type Ligand

In this research two chromium（II][） and （VI） complexes of tetradentate Schiff bases have been prepared by condensing of salicylaldehyde with 4-methyl 1,2-phenylenediamine. Schiff base complexes of chromium（Ill） have been employed to design and synthesize polynuclear complexes. So they have played an important role in molecular magnetism. Synthesized complexes were characterized by elemental analysis, IR, molar conductivity and NMR. The free ligands were alsc characterized by 1H, 13C NMR spectra. The 13C NMR and IR spectra of free ligand and the complexes are compared and discussed.

Synthesis and Biological Evaluation of Some Schiff Bases Compounds Derivative of 2,5-di（p-aminophenyl） -3,6-diphenyl Pyrazine

In this present, a new series of Schiffbases from 2,5-di（p-aminophenyl）-3,6-diphenyl pyrazine in the presence of the benzil, 4-bromo benzaldehyde, 4-chlor benzaldehyde, 4-hydroxy benzaldehyde, 4-nitro benzaldehyde and 4-methyl benzaldehyde were studied. The structures of the synthesized compounds were determined on the basis of their Infra-red spectra, H-nuclear magnetic resonase and analysis elemental analysis spectral data. The purity of the synthesized compounds was checked by performing thin layer chromatography. The antibacterial activity was evaluated by paper disc diffusion method.