In this note,we prove a logarithmic Sobolev inequality which holds for compact submanifolds without a boundary in manifolds with asymptotically nonnegative sectional curvature.Like the Michale-Simon Sobolev inequality...In this note,we prove a logarithmic Sobolev inequality which holds for compact submanifolds without a boundary in manifolds with asymptotically nonnegative sectional curvature.Like the Michale-Simon Sobolev inequality,this inequality contains a term involving the mean curvature.展开更多
Many solutions of variational inequalities have been proposed,among which the subgradient extragradient method has obvious advantages.Two different algorithms are given for solving variational inequality problem in th...Many solutions of variational inequalities have been proposed,among which the subgradient extragradient method has obvious advantages.Two different algorithms are given for solving variational inequality problem in this paper.The problem we study is defined in a real Hilbert space and has L-Lipschitz and pseudomonotone condition.Two new algorithms adopt inertial technology and non-monotonic step size rule,and their convergence can still be proved when the value of L is not given in advance.Finally,some numerical results are designed to demonstrate the computational efficiency of our two new algorithms.展开更多
Clustering a social network is a process of grouping social actors into clusters where intra-cluster similarities among actors are higher than inter-cluster similarities. Clustering approaches, i.e. , k-medoids or hie...Clustering a social network is a process of grouping social actors into clusters where intra-cluster similarities among actors are higher than inter-cluster similarities. Clustering approaches, i.e. , k-medoids or hierarchical, use the distance function to measure the dissimilarities among actors. These distance functions need to fulfill various properties, including the triangle inequality (TI). However, in some cases, the triangle inequality might be violated, impacting the quality of the resulting clusters. With experiments, this paper explains how TI violates while performing traditional clustering techniques: k-medoids, hierarchical, DENGRAPH, and spectral clustering on social networks and how the violation of TI affects the quality of the resulting clusters.展开更多
In this paper,we define a new class of control functions through aggregate special functions.These class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better...In this paper,we define a new class of control functions through aggregate special functions.These class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better estimation for permuting tri-homomorphisms and permuting tri-derivations in unital C*-algebras and Banach algebras by the vector-valued alternative fixed point theorem.展开更多
Let f be a twice continuously differentiable self-mapping of a unit disk satisfying Poisson differential inequality |△f(z)| ≤ B · |Df(z)|^(2) for some B > 0 and f(0) = 0. In this note, we show that f does no...Let f be a twice continuously differentiable self-mapping of a unit disk satisfying Poisson differential inequality |△f(z)| ≤ B · |Df(z)|^(2) for some B > 0 and f(0) = 0. In this note, we show that f does not always satisfy the Schwarz-Pick type inequality (1-|z|^(2))/(1-|f(z)|^(2))≤ C(B),where C(B) is a constant depending only on B. Moreover, a more general Schwarz-Pick type inequality for mapping that satisfies general Poisson differential inequality is established under certain conditions.展开更多
Let C be the familiar class of normalized close-to-convex functions in the unit disk.In[17],Koepf demonstrated that,as to a function■in the class C,■By applying this inequality,it can be proven that‖a3|-|a2‖≤1 fo...Let C be the familiar class of normalized close-to-convex functions in the unit disk.In[17],Koepf demonstrated that,as to a function■in the class C,■By applying this inequality,it can be proven that‖a3|-|a2‖≤1 for close-to-convex functions.Now we generalized the above conclusions to a subclass of close-to-starlike mappings defined on the unit ball of a complex Banach space.展开更多
We prove the L estimate for the isotropic version of the homogeneous landau problem, which was explored by M. Gualdani and N. Guillen. As shown in a region of the smooth potentials range under values of the interactio...We prove the L estimate for the isotropic version of the homogeneous landau problem, which was explored by M. Gualdani and N. Guillen. As shown in a region of the smooth potentials range under values of the interaction exponent (2), a weighted Poincaré inequality is a natural consequence of the traditional weighted Hardy inequality, which in turn implies that the norms of solutions propagate in the L1 space. Now, the L estimate is based on the work of De Giorgi, Nash, and Moser, as well as a few weighted Sobolev inequalities.展开更多
Böröczky-Lutwak-Yang-Zhang proved the log-Brunn-Minkowski inequality for two origin-symmetric convex bodies in the plane in a way that is stronger than for the classical Brunn-Minkowski inequality.In this pa...Böröczky-Lutwak-Yang-Zhang proved the log-Brunn-Minkowski inequality for two origin-symmetric convex bodies in the plane in a way that is stronger than for the classical Brunn-Minkowski inequality.In this paper,we investigate the relative positive center set of planar convex bodies.As an application of the relative positive center,we prove the log-Minkowski inequality and the log-Brunn-Minkowski inequality.展开更多
It is not generally known that the inequality that Bell derived using three random variables must be identically satisfied by any three corresponding data sets of ±1’s that are writable on paper. This surprising...It is not generally known that the inequality that Bell derived using three random variables must be identically satisfied by any three corresponding data sets of ±1’s that are writable on paper. This surprising fact is not immediately obvious from Bell’s inequality derivation based on causal random variables, but follows immediately if the same mathematical operations are applied to finite data sets. For laboratory data, the inequality is identically satisfied as a fact of pure algebra, and its satisfaction is independent of whether the processes generating the data are local, non-local, deterministic, random, or nonsensical. It follows that if predicted correlations violate the inequality, they represent no three cross-correlated data sets that can exist, or can be generated from valid probability models. Reported data that violate the inequality consist of probabilistically independent data-pairs and are thus inconsistent with inequality derivation. In the case of random variables as Bell assumed, the correlations in the inequality may be expressed in terms of the probabilities that give rise to them. A new inequality is then produced: The Wigner inequality, that must be satisfied by quantum mechanical probabilities in the case of Bell experiments. If that were not the case, predicted quantum probabilities and correlations would be inconsistent with basic algebra.展开更多
Holder’s inequality, its refinement, and reverse have received considerable attention in the theory of mathematical analysis and differential equations. In this paper, we give some refinements of Holder’s inequality...Holder’s inequality, its refinement, and reverse have received considerable attention in the theory of mathematical analysis and differential equations. In this paper, we give some refinements of Holder’s inequality and its reverse using a simple analytical technique of algebra and calculus. Our results show many results related to holder’s inequality as special cases of the inequalities presented.展开更多
In this paper,we prove Talagrand’s T2 transportation cost-information inequality for the law of stochastic heat equation driven by Gaussian noise,which is fractional for a time variable with the Hurst index H∈(1/2,1...In this paper,we prove Talagrand’s T2 transportation cost-information inequality for the law of stochastic heat equation driven by Gaussian noise,which is fractional for a time variable with the Hurst index H∈(1/2,1),and is correlated for the spatial variable.The Girsanov theorem for fractional-colored Gaussian noise plays an important role in the proof.展开更多
In order to solve variational inequality problems of pseudomonotonicity and Lipschitz continuity in Hilbert spaces, an inertial subgradient extragradient algorithm is proposed by virtue of non-monotone stepsizes. More...In order to solve variational inequality problems of pseudomonotonicity and Lipschitz continuity in Hilbert spaces, an inertial subgradient extragradient algorithm is proposed by virtue of non-monotone stepsizes. Moreover, weak convergence and R-linear convergence analyses of the algorithm are constructed under appropriate assumptions. Finally, the efficiency of the proposed algorithm is demonstrated through numerical implementations.展开更多
Little is known about the association between structural gender inequality and health in patriarchal China.This study employed a sample from the Chinese Women’s Social Status,consisting of 26,139 participants aged 18...Little is known about the association between structural gender inequality and health in patriarchal China.This study employed a sample from the Chinese Women’s Social Status,consisting of 26,139 participants aged 18 and 70 years(13,494 women and 12,645 men).Structural gender inequality was assessed at the macro-,meso-,and micro-levels.Mental health was measured by the summed scores of eight questions on depressive symptoms.Multilevel linear regression was applied for analysis.Results showed that total sex ratio at birth was associated with poorer mental health among women and men but sex ratio at birth of the second-born child predicted better mental health.Gender inequality at meso-level resulted in poorer mental health and gender inequality at micro-level was associated with poorer mental health both for men and women.Eliminating structural gender inequality promotes populations’mental health in China.展开更多
We recently read the opinion piece titled“Why people should run after positive affective experiences instead of health benefits”,which was carried out by Maltagliati et al.^(1)and published in the Journal of Sport a...We recently read the opinion piece titled“Why people should run after positive affective experiences instead of health benefits”,which was carried out by Maltagliati et al.^(1)and published in the Journal of Sport and Health Science.The article started an important discussion about a physical activity(PA)promotion approach that encourages the use of affective experience to PA activity.Although we agree with the authors’point of view and believe that its message can generate an important insight for PA promotion,the authors presented a scenario where behavior change seems to be exclusively dependent on the individual.Recognizing the existence of other barriers to an active lifestyle(e.g.,social inequalities)could enhance the authors’suggested approach because many people live in conditions that reduce their opportunities to engage in affective experiences related to PA;furthermore,affective experiences can vary depending on individual context.展开更多
Background Educational inequalities in suicide have become increasingly prominent over the past decade.Elucidating modifiable risk factors that serve as intermediaries in the impact of low educational attainment on su...Background Educational inequalities in suicide have become increasingly prominent over the past decade.Elucidating modifiable risk factors that serve as intermediaries in the impact of low educational attainment on suicide has the potential to reduce health disparities.Aims To examine the risk factors that mediate the relationship between educational attainment and suicide attempts and quantify their contributions to the mediation effect.Methods We conducted a two-sample Mendelian randomisation(MR)analysis to estimate the causal effect of educational attainment on suicide attempts,utilising genome-wide association study summary statistics from the Integrative Psychiatric Research(iPSYCH;6024 cases and 44240 controls)and FinnGen(8978 cases and 368299 controls).We systematically evaluated 42 putative mediators within the causal pathway connecting reduced educational attainment to suicide attempts and employed two-step and multivariable MR to quantify the proportion of the mediated effect.Results In the combined analysis of iPSYCH and FinnGen,each standard deviation(SD)decrease in genetically predicted educational attainment(equating to 3.4 years of education)was associated with a 105%higher risk of suicide attempts(odds ratio(OR):2.05;95%confidence interval(Cl):1.81 to 2.31).0f the 42 risk factors analysed,the two-step MR identified five factors that mediated the association between educational attainment and suicide attempts.The respective proportions of mediation were 47%(95%Cl:29%to 66%)for smoking behaviour,36%(95%Cl:0%to 84%)for chronic pain,49%(95%Cl:36%to 61%)for depression,35%(95%Cl:12%to 59%)for anxiety and 26%(95%Cl:18%to 34%)for insomnia.Multivariable MR implicated these five mediators collectively,accounting for 68%(95%Cl:40%to 96%)of the total effect.Conclusions This study identified smoking,chronic pain and mental disorders as primary intervention targets for attenuating suicide risk attributable to lower educational levels in the European population.展开更多
A new concept generalized(h,m)−preinvex function on Yang’s fractal sets is proposed.Some Ostrowski’s type inequalities with two parameters for generalized(h,m)−preinvex function are established,where three local fra...A new concept generalized(h,m)−preinvex function on Yang’s fractal sets is proposed.Some Ostrowski’s type inequalities with two parameters for generalized(h,m)−preinvex function are established,where three local fractional inequalities involving generalized midpoint type,trapezoid type and Simpson type are derived as consequences.Furthermore,as some applications,special means inequalities and numerical quadratures for local fractional integrals are discussed.展开更多
This paper studies a strongly convergent inertial forward-backward-forward algorithm for the variational inequality problem in Hilbert spaces.In our convergence analysis,we do not assume the on-line rule of the inerti...This paper studies a strongly convergent inertial forward-backward-forward algorithm for the variational inequality problem in Hilbert spaces.In our convergence analysis,we do not assume the on-line rule of the inertial parameters and the iterates,which have been assumed by several authors whenever a strongly convergent algorithm with an inertial extrapolation step is proposed for a variational inequality problem.Consequently,our proof arguments are different from what is obtainable in the relevant literature.Finally,we give numerical tests to confirm the theoretical analysis and show that our proposed algorithm is superior to related ones in the literature.展开更多
Equal access to social infrastructures is a fundamental prerequisite for sustainable development,but has long been a great challenge worldwide.Previous studies have primarily focused on the accessibility to social inf...Equal access to social infrastructures is a fundamental prerequisite for sustainable development,but has long been a great challenge worldwide.Previous studies have primarily focused on the accessibility to social infras-tructures in urban areas across various scales,with less attention to rural areas,where inequality can be more severe.Particularly,few have investigated the disparities of accessibility to social infrastructures between urban and rural areas.Here,using the Changsha-Zhuzhou-Xiangtan urban agglomeration,China,as an example,we investigated the inequality of accessibility in both urban and rural areas,and further compared the urban-rural difference.Accessibility was measured by travel time of residents to infrastructures.We selected four types of social infrastructures including supermarkets,bus stops,primary schools,and health care,which were funda-mentally important to both urban and rural residents.We found large disparities in accessibility between urban and rural areas,ranging from 20 min to 2 h.Rural residents had to spend one to two more hours to bus stops than urban residents,and 20 min more to the other three types of infrastructures.Furthermore,accessibility to multiple infrastructures showed greater urban-rural differences.Rural residents in more than half of the towns had no access to any infrastructure within 15 min,while more than 60%of the urban residents could access to all infrastructures within 15 min.Our results revealed quantitative accessibility gap between urban and rural areas and underscored the necessity of social infrastructures planning to address such disparities.展开更多
In this article,we first establish an asymptotically sharp result on the higher order Fréchet derivatives for bounded holomorphic mappings f(x)=f(0)+∞∑s=1Dskf(0)(x^(sk))/(sk)!:B_(X)→B_(Y),where B_X is the unit...In this article,we first establish an asymptotically sharp result on the higher order Fréchet derivatives for bounded holomorphic mappings f(x)=f(0)+∞∑s=1Dskf(0)(x^(sk))/(sk)!:B_(X)→B_(Y),where B_X is the unit ball of X.We next give a sharp result on the first order Fréchet derivative for bounded holomorphic mappings F(X)=F(0+)∞∑s=KD^(s)f(0)(x^(8)/s!):B_(X)→B_(Y),where B_(X)is the unit ball of X.The results that we derive include some results in several complex variables,and extend the classical result in one complex variable to several complex variables.展开更多
Background:Guidelines recommend that adolescents should accumulate an average of 60 min per day of moderate-to-vigorous physical activity(MVPA).However,using only this cut-off could hide important information.For inst...Background:Guidelines recommend that adolescents should accumulate an average of 60 min per day of moderate-to-vigorous physical activity(MVPA).However,using only this cut-off could hide important information.For instance,from a population-level point of view,increasing physical activity for those with no or low physical activity could provide more health benefits than increasing physical activity for those with intermediate levels.Also,including a more sensitive cut-point of≥1 days per week could be an additional strategy for identifying those with low access/opportunities for physical activity practice.Thus,the current study aims to estimate the prevalence of≥60 min of MVPA≥1 days per week among adolescents globally,and to describe any relevant gender inequalities.Methods:We used representative datasets from 146 countries/territories collected between 2003 and 2019.MVPA was self-reported.Participants were grouped into younger(≤14 years old)and older(>14 years old)adolescents.Crude Poisson regression models were used to identify the relative differences in≥60 min of MVPA≥1 days per week between boys and girls,and random-effects meta-analysis models were used to identify the pooled estimates.Analyses were stratified by country and region.Results:Approximately 80%of both younger and older adolescents reported≥60 min of MVPA≥1 days per week.This prevalence was≥94%in Europe and Central Asia and North America,while the estimates for the other regions were<77%.The prevalence of≥60 min of MVPA≥1 days per week was higher among boys than girls,with the largest differences occurring among the oldest adolescents(Prevalence ratio_(≤14y)=1.04(95%confidence interval(95%CI)):1.03-1.04)vs.Prevalence ratio_(>14y)=1.09(95%CI:1.08-1.10)).Conclusion:Approximately 8 out of 10 adolescents reported accumulating≥60 min of MVPA≥1 days per week,with notable differences between regions.Gender differences were observed in several countries,especially among the oldest adolescents.Priorities for physical activity promotion among adolescents should include increasing access/opportunities for physical activity among those who do not achieve≥60 min of MVPA≥1 days per week and reducing gender inequalities.展开更多
基金Supported by the NSFC(11771087,12171091 and 11831005)。
文摘In this note,we prove a logarithmic Sobolev inequality which holds for compact submanifolds without a boundary in manifolds with asymptotically nonnegative sectional curvature.Like the Michale-Simon Sobolev inequality,this inequality contains a term involving the mean curvature.
文摘Many solutions of variational inequalities have been proposed,among which the subgradient extragradient method has obvious advantages.Two different algorithms are given for solving variational inequality problem in this paper.The problem we study is defined in a real Hilbert space and has L-Lipschitz and pseudomonotone condition.Two new algorithms adopt inertial technology and non-monotonic step size rule,and their convergence can still be proved when the value of L is not given in advance.Finally,some numerical results are designed to demonstrate the computational efficiency of our two new algorithms.
文摘Clustering a social network is a process of grouping social actors into clusters where intra-cluster similarities among actors are higher than inter-cluster similarities. Clustering approaches, i.e. , k-medoids or hierarchical, use the distance function to measure the dissimilarities among actors. These distance functions need to fulfill various properties, including the triangle inequality (TI). However, in some cases, the triangle inequality might be violated, impacting the quality of the resulting clusters. With experiments, this paper explains how TI violates while performing traditional clustering techniques: k-medoids, hierarchical, DENGRAPH, and spectral clustering on social networks and how the violation of TI affects the quality of the resulting clusters.
基金partially supported by the Natural Sciences and Engineering Research Council of Canada(2019-03907)。
文摘In this paper,we define a new class of control functions through aggregate special functions.These class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better estimation for permuting tri-homomorphisms and permuting tri-derivations in unital C*-algebras and Banach algebras by the vector-valued alternative fixed point theorem.
基金supported by NNSF of China(11701111)NNSFs of Guangdong Province (2016A030310257 and 2015A030313346)the Visiting Scholar Program of Chern Institute of Mathematics at Nankai University when the authors worked as visiting scholars。
文摘Let f be a twice continuously differentiable self-mapping of a unit disk satisfying Poisson differential inequality |△f(z)| ≤ B · |Df(z)|^(2) for some B > 0 and f(0) = 0. In this note, we show that f does not always satisfy the Schwarz-Pick type inequality (1-|z|^(2))/(1-|f(z)|^(2))≤ C(B),where C(B) is a constant depending only on B. Moreover, a more general Schwarz-Pick type inequality for mapping that satisfies general Poisson differential inequality is established under certain conditions.
基金Supported by the NNSF of China(11971165)the Natural Science Foundation of Zhejiang Province(LY21A010003)。
文摘Let C be the familiar class of normalized close-to-convex functions in the unit disk.In[17],Koepf demonstrated that,as to a function■in the class C,■By applying this inequality,it can be proven that‖a3|-|a2‖≤1 for close-to-convex functions.Now we generalized the above conclusions to a subclass of close-to-starlike mappings defined on the unit ball of a complex Banach space.
文摘We prove the L estimate for the isotropic version of the homogeneous landau problem, which was explored by M. Gualdani and N. Guillen. As shown in a region of the smooth potentials range under values of the interaction exponent (2), a weighted Poincaré inequality is a natural consequence of the traditional weighted Hardy inequality, which in turn implies that the norms of solutions propagate in the L1 space. Now, the L estimate is based on the work of De Giorgi, Nash, and Moser, as well as a few weighted Sobolev inequalities.
基金Supported by the Excellent Young Talents Fund Program of Higher Education Institutions of Anhui Province (gxyqZD2020022)the University Natural Science Research Project of Anhui Province (2022AH040067)+1 种基金the Fundamental Research Funds for the Central Universities (3132023202)National Natural Science Foundation of China (12001080).
文摘Böröczky-Lutwak-Yang-Zhang proved the log-Brunn-Minkowski inequality for two origin-symmetric convex bodies in the plane in a way that is stronger than for the classical Brunn-Minkowski inequality.In this paper,we investigate the relative positive center set of planar convex bodies.As an application of the relative positive center,we prove the log-Minkowski inequality and the log-Brunn-Minkowski inequality.
文摘It is not generally known that the inequality that Bell derived using three random variables must be identically satisfied by any three corresponding data sets of ±1’s that are writable on paper. This surprising fact is not immediately obvious from Bell’s inequality derivation based on causal random variables, but follows immediately if the same mathematical operations are applied to finite data sets. For laboratory data, the inequality is identically satisfied as a fact of pure algebra, and its satisfaction is independent of whether the processes generating the data are local, non-local, deterministic, random, or nonsensical. It follows that if predicted correlations violate the inequality, they represent no three cross-correlated data sets that can exist, or can be generated from valid probability models. Reported data that violate the inequality consist of probabilistically independent data-pairs and are thus inconsistent with inequality derivation. In the case of random variables as Bell assumed, the correlations in the inequality may be expressed in terms of the probabilities that give rise to them. A new inequality is then produced: The Wigner inequality, that must be satisfied by quantum mechanical probabilities in the case of Bell experiments. If that were not the case, predicted quantum probabilities and correlations would be inconsistent with basic algebra.
文摘Holder’s inequality, its refinement, and reverse have received considerable attention in the theory of mathematical analysis and differential equations. In this paper, we give some refinements of Holder’s inequality and its reverse using a simple analytical technique of algebra and calculus. Our results show many results related to holder’s inequality as special cases of the inequalities presented.
基金supported by the Shanghai Sailing Program (21YF1415300)the Natural Science Foundation of China (12101392)supported by the Natural Science Foundation of China (11871382,11771161).
文摘In this paper,we prove Talagrand’s T2 transportation cost-information inequality for the law of stochastic heat equation driven by Gaussian noise,which is fractional for a time variable with the Hurst index H∈(1/2,1),and is correlated for the spatial variable.The Girsanov theorem for fractional-colored Gaussian noise plays an important role in the proof.
文摘In order to solve variational inequality problems of pseudomonotonicity and Lipschitz continuity in Hilbert spaces, an inertial subgradient extragradient algorithm is proposed by virtue of non-monotone stepsizes. Moreover, weak convergence and R-linear convergence analyses of the algorithm are constructed under appropriate assumptions. Finally, the efficiency of the proposed algorithm is demonstrated through numerical implementations.
文摘Little is known about the association between structural gender inequality and health in patriarchal China.This study employed a sample from the Chinese Women’s Social Status,consisting of 26,139 participants aged 18 and 70 years(13,494 women and 12,645 men).Structural gender inequality was assessed at the macro-,meso-,and micro-levels.Mental health was measured by the summed scores of eight questions on depressive symptoms.Multilevel linear regression was applied for analysis.Results showed that total sex ratio at birth was associated with poorer mental health among women and men but sex ratio at birth of the second-born child predicted better mental health.Gender inequality at meso-level resulted in poorer mental health and gender inequality at micro-level was associated with poorer mental health both for men and women.Eliminating structural gender inequality promotes populations’mental health in China.
基金supported by the Coordination for the Improvement of Higher Education Personnel (CAPES) with a PhD scholarship (CAPES process:88887.605034/2021-00)a Research Internship Abroad scholarship (CAPES process:88881.846428/2023-01)+1 种基金supported by the Sao Paulo Research Foundation (FAPESP) with a PhD scholarship (process:2019/24124-7)a Research Internship Abroad scholarship (process:2023/00790-3)
文摘We recently read the opinion piece titled“Why people should run after positive affective experiences instead of health benefits”,which was carried out by Maltagliati et al.^(1)and published in the Journal of Sport and Health Science.The article started an important discussion about a physical activity(PA)promotion approach that encourages the use of affective experience to PA activity.Although we agree with the authors’point of view and believe that its message can generate an important insight for PA promotion,the authors presented a scenario where behavior change seems to be exclusively dependent on the individual.Recognizing the existence of other barriers to an active lifestyle(e.g.,social inequalities)could enhance the authors’suggested approach because many people live in conditions that reduce their opportunities to engage in affective experiences related to PA;furthermore,affective experiences can vary depending on individual context.
基金the Key Discipline of Zhejang Province in Public Health and Preventative Medicine(First Class,Category A)at the Hangzhou Medical College,China.
文摘Background Educational inequalities in suicide have become increasingly prominent over the past decade.Elucidating modifiable risk factors that serve as intermediaries in the impact of low educational attainment on suicide has the potential to reduce health disparities.Aims To examine the risk factors that mediate the relationship between educational attainment and suicide attempts and quantify their contributions to the mediation effect.Methods We conducted a two-sample Mendelian randomisation(MR)analysis to estimate the causal effect of educational attainment on suicide attempts,utilising genome-wide association study summary statistics from the Integrative Psychiatric Research(iPSYCH;6024 cases and 44240 controls)and FinnGen(8978 cases and 368299 controls).We systematically evaluated 42 putative mediators within the causal pathway connecting reduced educational attainment to suicide attempts and employed two-step and multivariable MR to quantify the proportion of the mediated effect.Results In the combined analysis of iPSYCH and FinnGen,each standard deviation(SD)decrease in genetically predicted educational attainment(equating to 3.4 years of education)was associated with a 105%higher risk of suicide attempts(odds ratio(OR):2.05;95%confidence interval(Cl):1.81 to 2.31).0f the 42 risk factors analysed,the two-step MR identified five factors that mediated the association between educational attainment and suicide attempts.The respective proportions of mediation were 47%(95%Cl:29%to 66%)for smoking behaviour,36%(95%Cl:0%to 84%)for chronic pain,49%(95%Cl:36%to 61%)for depression,35%(95%Cl:12%to 59%)for anxiety and 26%(95%Cl:18%to 34%)for insomnia.Multivariable MR implicated these five mediators collectively,accounting for 68%(95%Cl:40%to 96%)of the total effect.Conclusions This study identified smoking,chronic pain and mental disorders as primary intervention targets for attenuating suicide risk attributable to lower educational levels in the European population.
基金Supported by the National Natural Science Foundation of China(Grant No.11801342)the Natural Science Foundation of Shaanxi Province(Grant No.2023-JC-YB-043).
文摘A new concept generalized(h,m)−preinvex function on Yang’s fractal sets is proposed.Some Ostrowski’s type inequalities with two parameters for generalized(h,m)−preinvex function are established,where three local fractional inequalities involving generalized midpoint type,trapezoid type and Simpson type are derived as consequences.Furthermore,as some applications,special means inequalities and numerical quadratures for local fractional integrals are discussed.
文摘This paper studies a strongly convergent inertial forward-backward-forward algorithm for the variational inequality problem in Hilbert spaces.In our convergence analysis,we do not assume the on-line rule of the inertial parameters and the iterates,which have been assumed by several authors whenever a strongly convergent algorithm with an inertial extrapolation step is proposed for a variational inequality problem.Consequently,our proof arguments are different from what is obtainable in the relevant literature.Finally,we give numerical tests to confirm the theoretical analysis and show that our proposed algorithm is superior to related ones in the literature.
基金supported by funding from the National Natural Science Foundation of China(Grant No.U21A2010)the National Science Fund for Distinguished Young Scholars(Grant No.42225104)the National Key Research and Development Program(Grant No.2022YFF130110O).
文摘Equal access to social infrastructures is a fundamental prerequisite for sustainable development,but has long been a great challenge worldwide.Previous studies have primarily focused on the accessibility to social infras-tructures in urban areas across various scales,with less attention to rural areas,where inequality can be more severe.Particularly,few have investigated the disparities of accessibility to social infrastructures between urban and rural areas.Here,using the Changsha-Zhuzhou-Xiangtan urban agglomeration,China,as an example,we investigated the inequality of accessibility in both urban and rural areas,and further compared the urban-rural difference.Accessibility was measured by travel time of residents to infrastructures.We selected four types of social infrastructures including supermarkets,bus stops,primary schools,and health care,which were funda-mentally important to both urban and rural residents.We found large disparities in accessibility between urban and rural areas,ranging from 20 min to 2 h.Rural residents had to spend one to two more hours to bus stops than urban residents,and 20 min more to the other three types of infrastructures.Furthermore,accessibility to multiple infrastructures showed greater urban-rural differences.Rural residents in more than half of the towns had no access to any infrastructure within 15 min,while more than 60%of the urban residents could access to all infrastructures within 15 min.Our results revealed quantitative accessibility gap between urban and rural areas and underscored the necessity of social infrastructures planning to address such disparities.
基金supported by the NSFC(11871257,12071130)supported by the NSFC(11971165)。
文摘In this article,we first establish an asymptotically sharp result on the higher order Fréchet derivatives for bounded holomorphic mappings f(x)=f(0)+∞∑s=1Dskf(0)(x^(sk))/(sk)!:B_(X)→B_(Y),where B_X is the unit ball of X.We next give a sharp result on the first order Fréchet derivative for bounded holomorphic mappings F(X)=F(0+)∞∑s=KD^(s)f(0)(x^(8)/s!):B_(X)→B_(Y),where B_(X)is the unit ball of X.The results that we derive include some results in several complex variables,and extend the classical result in one complex variable to several complex variables.
基金supported by the Brazilian Coordination for the Improvement of Higher Education Personnel(CAPES)with a PhD scholarship(CAPES process:88887.605034/2021-00,88887.605029/2021-00,and 88887.694146/2022-00,respectively)supported by the S?o Paulo Research Foundation(FAPESP)with a PhD scholarship(FAPESP process:2019/24124-7)。
文摘Background:Guidelines recommend that adolescents should accumulate an average of 60 min per day of moderate-to-vigorous physical activity(MVPA).However,using only this cut-off could hide important information.For instance,from a population-level point of view,increasing physical activity for those with no or low physical activity could provide more health benefits than increasing physical activity for those with intermediate levels.Also,including a more sensitive cut-point of≥1 days per week could be an additional strategy for identifying those with low access/opportunities for physical activity practice.Thus,the current study aims to estimate the prevalence of≥60 min of MVPA≥1 days per week among adolescents globally,and to describe any relevant gender inequalities.Methods:We used representative datasets from 146 countries/territories collected between 2003 and 2019.MVPA was self-reported.Participants were grouped into younger(≤14 years old)and older(>14 years old)adolescents.Crude Poisson regression models were used to identify the relative differences in≥60 min of MVPA≥1 days per week between boys and girls,and random-effects meta-analysis models were used to identify the pooled estimates.Analyses were stratified by country and region.Results:Approximately 80%of both younger and older adolescents reported≥60 min of MVPA≥1 days per week.This prevalence was≥94%in Europe and Central Asia and North America,while the estimates for the other regions were<77%.The prevalence of≥60 min of MVPA≥1 days per week was higher among boys than girls,with the largest differences occurring among the oldest adolescents(Prevalence ratio_(≤14y)=1.04(95%confidence interval(95%CI)):1.03-1.04)vs.Prevalence ratio_(>14y)=1.09(95%CI:1.08-1.10)).Conclusion:Approximately 8 out of 10 adolescents reported accumulating≥60 min of MVPA≥1 days per week,with notable differences between regions.Gender differences were observed in several countries,especially among the oldest adolescents.Priorities for physical activity promotion among adolescents should include increasing access/opportunities for physical activity among those who do not achieve≥60 min of MVPA≥1 days per week and reducing gender inequalities.