BACKGROUND Diabetes and thyroiditis are closely related.They occur in combination and cause significant damage to the body.There is no clear treatment for type-2 diabetes mellitus(T2DM)with Hashimoto's thyroiditis...BACKGROUND Diabetes and thyroiditis are closely related.They occur in combination and cause significant damage to the body.There is no clear treatment for type-2 diabetes mellitus(T2DM)with Hashimoto's thyroiditis(HT).While single symptomatic drug treatment of the two diseases is less effective,combined drug treatment may improve efficacy.AIM To investigate the effect of a combination of vitamin D,selenium,and hypoglycemic agents in T2DM with HT.METHODS This retrospective study included 150 patients with T2DM and HT treated at The Central Hospital of Shaoyang from March 2020 to February 2023.Fifty patients were assigned to the control group,test group A,and test group B according to different treatment methods.The control group received low-iodine diet guidance and hypoglycemic drug treatment.Test group A received the control treatment plus vitamin D treatment.Test group B received the group A treatment plus selenium.Blood levels of markers of thyroid function[free T3(FT3),thyroid stimulating hormone(TSH),free T4(FT4)],autoantibodies[thyroid peroxidase antibody(TPOAB)and thyroid globulin antibody(TGAB)],blood lipid index[low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triacylglycerol(TG)],blood glucose index[fasting blood glucose(FBG),and hemoglobin A1c(HbA1c)]were measured pre-treatment and 3 and 6 months after treatment.The relationships between serum 25-hydroxyvitamin D3[25(OH)D3]level and each of these indices were analyzed.RESULTS The levels of 25(OH)D3,FT3,FT4,and LDL-C increased in the order of the control group,test group A,and test group B(all P<0.05).The TPOAB,TGAB,TC,TG,FBG,HbA1c,and TSH levels increased in the order of test groups B,A,and the control group(all P<0.05).All the above indices were compared after 3 and 6 months of treatment.Pre-treatment,there was no divergence in serum 25(OH)D3 level,thyroid function-related indexes,autoantibodies level,blood glucose,and blood lipid index between the control group,test groups A and B(all P>0.05).The 25(OH)D3 levels in test groups A and B were negatively correlated with FT4 and TGAB(all P<0.05).CONCLUSION The combination drug treatment for T2DM with HT significantly improved thyroid function,autoantibody,and blood glucose and lipid levels.展开更多
为提高冰雹探测算法(Hail Detection Algorithm, HDA)产品的可用性,针对2015—2020年普洱地区监测到的22次冰雹个例,利用新一代雷达业务应用软件ROSE2.0对相关雷达基数据进行回放及产品分析,以命中率、虚警率、临界成功指数为指标对HDA...为提高冰雹探测算法(Hail Detection Algorithm, HDA)产品的可用性,针对2015—2020年普洱地区监测到的22次冰雹个例,利用新一代雷达业务应用软件ROSE2.0对相关雷达基数据进行回放及产品分析,以命中率、虚警率、临界成功指数为指标对HDA算法在普洱地区的识别效果进行评估并给出本地化参数配置方案。结果表明:HDA算法在普洱地区命中率接近100%,但虚警现象非常普遍,使用强冰雹概率(Probability of Severe Hail, POSH)的预警效果优于任意大小冰雹概率(Probability of Hail, POH),且冰雹尺寸越大POSH虚警的概率越低。进一步使用模拟测评法对POSH算法的适配参数进行分析,发现正确输入降雹日当天的0℃层和-20℃层高度能有效减少POSH的虚警率及提高临界成功指数;同时使算法预测的最大冰雹直径普遍偏大的情况得到控制,其中,中小冰雹直径偏离百分比减小76.07%,改善效果显著高于大冰雹。此外,增大反射率因子及POSH阈值能有效控制虚警,但也导致漏报次数快速增加,当阈值太大时命中率明显降低,为了保证较高的命中率和临界成功指数,选择Z=50 dBz或POSH=70%为阈值能明显改善HDA算法的识别效果。展开更多
基金Supported by Science and Technology Plan Project of Shaoyang City,No.2022GX4139.
文摘BACKGROUND Diabetes and thyroiditis are closely related.They occur in combination and cause significant damage to the body.There is no clear treatment for type-2 diabetes mellitus(T2DM)with Hashimoto's thyroiditis(HT).While single symptomatic drug treatment of the two diseases is less effective,combined drug treatment may improve efficacy.AIM To investigate the effect of a combination of vitamin D,selenium,and hypoglycemic agents in T2DM with HT.METHODS This retrospective study included 150 patients with T2DM and HT treated at The Central Hospital of Shaoyang from March 2020 to February 2023.Fifty patients were assigned to the control group,test group A,and test group B according to different treatment methods.The control group received low-iodine diet guidance and hypoglycemic drug treatment.Test group A received the control treatment plus vitamin D treatment.Test group B received the group A treatment plus selenium.Blood levels of markers of thyroid function[free T3(FT3),thyroid stimulating hormone(TSH),free T4(FT4)],autoantibodies[thyroid peroxidase antibody(TPOAB)and thyroid globulin antibody(TGAB)],blood lipid index[low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triacylglycerol(TG)],blood glucose index[fasting blood glucose(FBG),and hemoglobin A1c(HbA1c)]were measured pre-treatment and 3 and 6 months after treatment.The relationships between serum 25-hydroxyvitamin D3[25(OH)D3]level and each of these indices were analyzed.RESULTS The levels of 25(OH)D3,FT3,FT4,and LDL-C increased in the order of the control group,test group A,and test group B(all P<0.05).The TPOAB,TGAB,TC,TG,FBG,HbA1c,and TSH levels increased in the order of test groups B,A,and the control group(all P<0.05).All the above indices were compared after 3 and 6 months of treatment.Pre-treatment,there was no divergence in serum 25(OH)D3 level,thyroid function-related indexes,autoantibodies level,blood glucose,and blood lipid index between the control group,test groups A and B(all P>0.05).The 25(OH)D3 levels in test groups A and B were negatively correlated with FT4 and TGAB(all P<0.05).CONCLUSION The combination drug treatment for T2DM with HT significantly improved thyroid function,autoantibody,and blood glucose and lipid levels.
文摘为提高冰雹探测算法(Hail Detection Algorithm, HDA)产品的可用性,针对2015—2020年普洱地区监测到的22次冰雹个例,利用新一代雷达业务应用软件ROSE2.0对相关雷达基数据进行回放及产品分析,以命中率、虚警率、临界成功指数为指标对HDA算法在普洱地区的识别效果进行评估并给出本地化参数配置方案。结果表明:HDA算法在普洱地区命中率接近100%,但虚警现象非常普遍,使用强冰雹概率(Probability of Severe Hail, POSH)的预警效果优于任意大小冰雹概率(Probability of Hail, POH),且冰雹尺寸越大POSH虚警的概率越低。进一步使用模拟测评法对POSH算法的适配参数进行分析,发现正确输入降雹日当天的0℃层和-20℃层高度能有效减少POSH的虚警率及提高临界成功指数;同时使算法预测的最大冰雹直径普遍偏大的情况得到控制,其中,中小冰雹直径偏离百分比减小76.07%,改善效果显著高于大冰雹。此外,增大反射率因子及POSH阈值能有效控制虚警,但也导致漏报次数快速增加,当阈值太大时命中率明显降低,为了保证较高的命中率和临界成功指数,选择Z=50 dBz或POSH=70%为阈值能明显改善HDA算法的识别效果。