Amphotericin B (Am B), a polyene antibiotic, is one of the gold standards for the treatment of systemic fungal infections and leishmaniasis. Nowadays, only intravenous administration of Am B has been available;because...Amphotericin B (Am B), a polyene antibiotic, is one of the gold standards for the treatment of systemic fungal infections and leishmaniasis. Nowadays, only intravenous administration of Am B has been available;because Am B is poorly absorbed from the gastrointestinal (GI) tract due to its low aqueous solubility. Currently, 2 forms of Am B are available.展开更多
In this paper, nitrogen-doped hierarchical porous carbon(N-HPC) was prepared from polyaniline(PANI)/silica self-aggregates. H-bonding between N\\H groups in aniline/PANI and \\OH groups in nano silica template led to ...In this paper, nitrogen-doped hierarchical porous carbon(N-HPC) was prepared from polyaniline(PANI)/silica self-aggregates. H-bonding between N\\H groups in aniline/PANI and \\OH groups in nano silica template led to a self-assembly type, which enabled the formation of uniform N-HPC nanoparticles. Silica self-aggregates provided macroporous channels resulted in a decreased diffusion distance. After removing the hard template,the N-HPC had a high surface area(899 m^2·g^(-1)). Owing to two co-existed synergetic energy-storage mechanisms and the hierarchical porous structure, the obtained N-HPC exhibited a high specific capacitance of 218.75 F·g^(-1) at 0.5 A·g^(-1), compared with the nonporous nitrogen-doped carbon(N-C) derived from pure PANI. Moreover, the N-HPC electrode demonstrated excellent cycle life, retaining 99% of its initial specific capacitance after 1000 cycles.展开更多
Unconsolidated sandstone reservoirs are most susceptible to sand production that leads to a dramatic oil production decline.In this study,the poly(4-vinyl pyridine)(P_(4)VP)incorporated with self-aggregating behavior ...Unconsolidated sandstone reservoirs are most susceptible to sand production that leads to a dramatic oil production decline.In this study,the poly(4-vinyl pyridine)(P_(4)VP)incorporated with self-aggregating behavior was proposed for sand migration control.The P_(4)VP could aggregate sand grains spontaneously throughπ-πstacking interactions to withstand the drag forces sufficiently.The influential factors on the self-aggregating behavior of the P_(4)VP were evaluated by adhesion force test.The adsorption as well as desorption behavior of P_(4)VP on sand grains was characterized by scanning electron microscopy and adhesion force test at different pH conditions.The result indicated that the pH altered the forms of surface silanol groups on sand grains,which in turn affected the adsorption process of P_(4)VP.The spontaneous dimerization of P_(4)VP molecules resulting from theπ-πstacking interaction was demonstrated by reduced density gradient analysis,which contributed to the self-aggregating behavior and the thermally reversible characteristic of the P_(4)VP.Dynamic sand stabilization test revealed that the P_(4)VP showed wide pH and temperature ranges of application.The production of sands can be mitigated effectively at 20-130℃ within the pH range of 4-8.展开更多
To address proppant flowback issues during post-fracturing treatments and production,self-healing elastomer modified proppants(SMPs)are proposed.Owing to their inherent self-aggregation behavior,the SMPs can aggregate...To address proppant flowback issues during post-fracturing treatments and production,self-healing elastomer modified proppants(SMPs)are proposed.Owing to their inherent self-aggregation behavior,the SMPs can aggregate together spontaneously to prevent proppant flowback and increase the pack porosity.It is noteworthy that the SMPs have a firm and dry self-healing elastomer(SE)coating,making their storage,transport and use as conventional proppants possible.The SE synthesized through polymerization is rich in amidogens and carbonyl groups as characterized by Fourier transform infrared spectroscopy and the proton nuclear magnetic resonance.Thermal and thermomechanical properties of the SE coating are revealed by the thermogravimetric analysis,the differential scanning calorimetry and the rheological tests.The self-aggregation behavior of the SMPs is demonstrated by the adhesion force tests.The reversible hydrogen bonding interactions in SE coating contribute to the self-aggregation behavior of the SMPs,which is revealed by the thixotropy test and the FTIR analysis at different temperatures.With the self-aggregation behavior,the crushed proppants can aggregate in situ to form a stable structure again and therefore reduce the threat of narrowing down the fracture and proppant flowback,which has an important practical significance during oil and gas production.展开更多
On the example of tetraantraquinoporphyrazines—potential photosensitizers for photodynamic therapy, thermodynamic approach to the choice of exogenous transport system was demonstrated. By means of isothermal titratio...On the example of tetraantraquinoporphyrazines—potential photosensitizers for photodynamic therapy, thermodynamic approach to the choice of exogenous transport system was demonstrated. By means of isothermal titration calorimetry and electron absorption spectroscopy, the state of TAP in aqueous solutions was studied. The possibility of aggregation equilibrium displacement due to the pyridine adding was evaluated.展开更多
Water-soluble triplet sensitizer with permethyl-β-cyclodextrin(PMCD)grafting on a Schiff-base Pt(II)complex(Pt-2),in which PMCD unit serves as a host for binding the acceptors and the Schiff-base Pt(II)complex serves...Water-soluble triplet sensitizer with permethyl-β-cyclodextrin(PMCD)grafting on a Schiff-base Pt(II)complex(Pt-2),in which PMCD unit serves as a host for binding the acceptors and the Schiff-base Pt(II)complex serves as a triplet sensitizer,was synthesized to investigate the effect of supramolecular complexation and assembly on the triplet-triplet annihilation upconversion emission in water.9,10-Diphenylanthracence(DPA)carboxylate(A-1)and its dimer(A-2)in which two DPA carboxylate were covalently linked with an alkyl chain were synthesized as triplet acceptors which also play a role of guest molecules for PMCD.A-1 and A-2 showed high affinity with PMCD,and A-2 can readily aggregate in water and form micron sized assemblies due to the hydrophobic effect andπ-πstacking of anthracene core in A-2.The efficiency of TTA-UC was demonstrated to be enhanced by a synergistic effect of host-guest complexation of Pt-2 with A-2 and the self-aggregation of the acceptor A-2,which facilitated the energy transfer and energy fusion among donor and acceptor.展开更多
文摘Amphotericin B (Am B), a polyene antibiotic, is one of the gold standards for the treatment of systemic fungal infections and leishmaniasis. Nowadays, only intravenous administration of Am B has been available;because Am B is poorly absorbed from the gastrointestinal (GI) tract due to its low aqueous solubility. Currently, 2 forms of Am B are available.
基金Supported by the National Natural Science Foundation of China(21401079,21501069)Fundamental Research Funds for Central Universities(JUSRP51626B)+2 种基金the Natural Science Foundation of Jiangsu Province of China(BK20140158,BK20161128,BK20161166)Natural Science Fund for Colleges and Universities in Jiangsu Province(18KJD430008,17KJD430005,17KJB430032)the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions(PPZY2015B181)
文摘In this paper, nitrogen-doped hierarchical porous carbon(N-HPC) was prepared from polyaniline(PANI)/silica self-aggregates. H-bonding between N\\H groups in aniline/PANI and \\OH groups in nano silica template led to a self-assembly type, which enabled the formation of uniform N-HPC nanoparticles. Silica self-aggregates provided macroporous channels resulted in a decreased diffusion distance. After removing the hard template,the N-HPC had a high surface area(899 m^2·g^(-1)). Owing to two co-existed synergetic energy-storage mechanisms and the hierarchical porous structure, the obtained N-HPC exhibited a high specific capacitance of 218.75 F·g^(-1) at 0.5 A·g^(-1), compared with the nonporous nitrogen-doped carbon(N-C) derived from pure PANI. Moreover, the N-HPC electrode demonstrated excellent cycle life, retaining 99% of its initial specific capacitance after 1000 cycles.
基金support from the National Key R&D Program of China(grant number 2018YFA0702400)the Major Scientific and Technological Projects of CNPC(grant number ZD2019-183-007)the China Postdoctoral Science Foundation(grant number 2021M702041)。
文摘Unconsolidated sandstone reservoirs are most susceptible to sand production that leads to a dramatic oil production decline.In this study,the poly(4-vinyl pyridine)(P_(4)VP)incorporated with self-aggregating behavior was proposed for sand migration control.The P_(4)VP could aggregate sand grains spontaneously throughπ-πstacking interactions to withstand the drag forces sufficiently.The influential factors on the self-aggregating behavior of the P_(4)VP were evaluated by adhesion force test.The adsorption as well as desorption behavior of P_(4)VP on sand grains was characterized by scanning electron microscopy and adhesion force test at different pH conditions.The result indicated that the pH altered the forms of surface silanol groups on sand grains,which in turn affected the adsorption process of P_(4)VP.The spontaneous dimerization of P_(4)VP molecules resulting from theπ-πstacking interaction was demonstrated by reduced density gradient analysis,which contributed to the self-aggregating behavior and the thermally reversible characteristic of the P_(4)VP.Dynamic sand stabilization test revealed that the P_(4)VP showed wide pH and temperature ranges of application.The production of sands can be mitigated effectively at 20-130℃ within the pH range of 4-8.
基金the support from the National Key R&D Program of China(grant number 2018YFA0702400)the Major Scientific and Technological Projects of CNPC(grant number ZD2019-183-007)the Fundamental Research Funds for the Central Universities(grant number No.19CX02017A)。
文摘To address proppant flowback issues during post-fracturing treatments and production,self-healing elastomer modified proppants(SMPs)are proposed.Owing to their inherent self-aggregation behavior,the SMPs can aggregate together spontaneously to prevent proppant flowback and increase the pack porosity.It is noteworthy that the SMPs have a firm and dry self-healing elastomer(SE)coating,making their storage,transport and use as conventional proppants possible.The SE synthesized through polymerization is rich in amidogens and carbonyl groups as characterized by Fourier transform infrared spectroscopy and the proton nuclear magnetic resonance.Thermal and thermomechanical properties of the SE coating are revealed by the thermogravimetric analysis,the differential scanning calorimetry and the rheological tests.The self-aggregation behavior of the SMPs is demonstrated by the adhesion force tests.The reversible hydrogen bonding interactions in SE coating contribute to the self-aggregation behavior of the SMPs,which is revealed by the thixotropy test and the FTIR analysis at different temperatures.With the self-aggregation behavior,the crushed proppants can aggregate in situ to form a stable structure again and therefore reduce the threat of narrowing down the fracture and proppant flowback,which has an important practical significance during oil and gas production.
文摘On the example of tetraantraquinoporphyrazines—potential photosensitizers for photodynamic therapy, thermodynamic approach to the choice of exogenous transport system was demonstrated. By means of isothermal titration calorimetry and electron absorption spectroscopy, the state of TAP in aqueous solutions was studied. The possibility of aggregation equilibrium displacement due to the pyridine adding was evaluated.
基金the financial support of the National Natural Science Foundation of China(Nos.21971169,21871194,21572142,21372165 and 21321061)National Key Research and Development Program of China(No.2017YFA0505903)Science & Technology Department of Sichuan Province(Nos.2019YJ0090,2019YJ0160,2017SZ0021)
文摘Water-soluble triplet sensitizer with permethyl-β-cyclodextrin(PMCD)grafting on a Schiff-base Pt(II)complex(Pt-2),in which PMCD unit serves as a host for binding the acceptors and the Schiff-base Pt(II)complex serves as a triplet sensitizer,was synthesized to investigate the effect of supramolecular complexation and assembly on the triplet-triplet annihilation upconversion emission in water.9,10-Diphenylanthracence(DPA)carboxylate(A-1)and its dimer(A-2)in which two DPA carboxylate were covalently linked with an alkyl chain were synthesized as triplet acceptors which also play a role of guest molecules for PMCD.A-1 and A-2 showed high affinity with PMCD,and A-2 can readily aggregate in water and form micron sized assemblies due to the hydrophobic effect andπ-πstacking of anthracene core in A-2.The efficiency of TTA-UC was demonstrated to be enhanced by a synergistic effect of host-guest complexation of Pt-2 with A-2 and the self-aggregation of the acceptor A-2,which facilitated the energy transfer and energy fusion among donor and acceptor.