AIM To compare the results of midazolam-ketaminepropofol sedation performed by an endoscopy nurse and anaesthetist during colonoscopy in terms of patient satisfaction and safety.METHODS American Statistical Associatio...AIM To compare the results of midazolam-ketaminepropofol sedation performed by an endoscopy nurse and anaesthetist during colonoscopy in terms of patient satisfaction and safety.METHODS American Statistical Association(ASA) Ⅰ-Ⅱ 60 patients who underwent colonoscopy under sedation were randomly divided into two groups: sedation under the supervision of an anaesthetist(SSA) and sedation under the supervision of an endoscopy nurse(SSEN). Both groups were initially administered 1 mg midazolam, 50 mg ketamine and 30-50 mg propofol. Continuation of sedation was performed by the anaesthetist in the SSAgroup and the nurse with a patient-controlled analgesia(PCA) pump in the SSEN group. The total propofol consumption, procedure duration, recovery times, pain using the visual analogue scale(VAS) and satisfaction score of the patients, and side effects were recorded. In addition, the patients were asked whether they remembered the procedure and whether they would prefer the same method in the case of re-endoscopy.RESULTS Total propofol consumption in the SSEN group was significantly higher(P < 0.05) than that in the SSA group. When the groups were compared in terms of VAS score, recovery time, patient satisfaction, recall of the procedure, re-preference for the same method in case of re-endoscopy, and side effects, there were no significant differences(P > 0.05) between the two groups. No long-term required intervention side effects were observed in either group.CONCLUSION Colonoscopy sedation in ASA Ⅰ-Ⅱ patients can be safely performed by an endoscopy nurse using PCA pump with the incidence of side effects and patient satisfaction levels similar to sedation under anaesthetist supervision.展开更多
Objective:To compare the effect of ketamine,lidocaine,acetaminophen,and dexmedetomidine combined with morphine patient-controlled analgesia for opium addicts after tibial fracture surgery.Methods:This double-blind cli...Objective:To compare the effect of ketamine,lidocaine,acetaminophen,and dexmedetomidine combined with morphine patient-controlled analgesia for opium addicts after tibial fracture surgery.Methods:This double-blind clinical trial included opium-addicted patients undergoing tibia fracture surgery.Patients were recruited and randomized to four different groups including the ketamine group,the lidocaine group,the acetaminophen group,and the dexmedetomidine group.The hemodynamic parameters such as heart rate(HR),mean arterial pressure,and arterial SaO2,alongside visual analog scale pain scores,sedation assessed by Ramsay score,nausea and vomiting,and opioid use were recorded and compared among the four groups.Results:This study included 140 patients,aged 37(32,41)years,with 92 males and 48 females,and each group had 35 patients.Dexmedetomidine-sedated subjects had the lowest blood pressure from 1 to 24 h after surgery,decreased HR at 12 and 24 h after surgery,and more satisfactory sedation(P<0.05).Notwithstanding no significant difference was noted in the pain scores,or nausea and vomiting among the groups(P>0.05).Conclusions:Dexmedetomidine has a better sedation effect compared to ketamine,lidocaine,and acetaminophen for pain control,but the final choice hinges on the patients’physical condition and the anesthesiologist's preference.Clinical registration:It is registered in Iranian Registry Clinical Trial by code IRCT20141209020258N146.展开更多
目的探讨脉冲泵椎管内分娩镇痛失败中转剖宫产的麻醉方式。方法120例脉冲泵椎管内分娩镇痛失败中转剖宫产产妇为研究对象,按随机数字表法分为A、B、C三组,各40例。A组实施腰硬联合麻醉,B组使用分娩镇痛留置的导管行硬膜外麻醉,C组实施...目的探讨脉冲泵椎管内分娩镇痛失败中转剖宫产的麻醉方式。方法120例脉冲泵椎管内分娩镇痛失败中转剖宫产产妇为研究对象,按随机数字表法分为A、B、C三组,各40例。A组实施腰硬联合麻醉,B组使用分娩镇痛留置的导管行硬膜外麻醉,C组实施气管插管全身麻醉(全麻)。比较三组围麻醉期并发症发生率,入室至切皮时间及麻醉至胎儿取出时间,新生儿出生时、出生1 min和出生5 min Apgar评分。结果C组围麻醉期高血压、低血压、恶心呕吐发生率显著低于A组和B组(P<0.05);三组围麻醉期误吸发生率比较差异无统计学意义(P>0.05)。C组入室至切皮时间和麻醉至胎儿取出时间分别为(8.2±1.6)、(5.3±0.7)min,均短于A组的(15.7±2.6)、(12.2±2.5)min和B组的(15.6±2.7)、(11.5±2.3)min(P<0.05)。C组新生儿出生时、出生1 min和出生5 min Apgar评分分别为(7.8±1.4)、(8.6±0.4)、(9.1±0.7)分,均显著高于A组的(7.0±0.7)、(7.4±0.6)、(8.0±0.5)分和B组的(7.1±0.8)、(7.5±0.6)、(8.1±0.5)分(P<0.05)。结论气管插管全麻用于脉冲泵椎管内分娩镇痛分娩失败中转剖宫产者,具有并发症少,快速娩出胎儿,减少新生儿窒息风险等优势。展开更多
文摘AIM To compare the results of midazolam-ketaminepropofol sedation performed by an endoscopy nurse and anaesthetist during colonoscopy in terms of patient satisfaction and safety.METHODS American Statistical Association(ASA) Ⅰ-Ⅱ 60 patients who underwent colonoscopy under sedation were randomly divided into two groups: sedation under the supervision of an anaesthetist(SSA) and sedation under the supervision of an endoscopy nurse(SSEN). Both groups were initially administered 1 mg midazolam, 50 mg ketamine and 30-50 mg propofol. Continuation of sedation was performed by the anaesthetist in the SSAgroup and the nurse with a patient-controlled analgesia(PCA) pump in the SSEN group. The total propofol consumption, procedure duration, recovery times, pain using the visual analogue scale(VAS) and satisfaction score of the patients, and side effects were recorded. In addition, the patients were asked whether they remembered the procedure and whether they would prefer the same method in the case of re-endoscopy.RESULTS Total propofol consumption in the SSEN group was significantly higher(P < 0.05) than that in the SSA group. When the groups were compared in terms of VAS score, recovery time, patient satisfaction, recall of the procedure, re-preference for the same method in case of re-endoscopy, and side effects, there were no significant differences(P > 0.05) between the two groups. No long-term required intervention side effects were observed in either group.CONCLUSION Colonoscopy sedation in ASA Ⅰ-Ⅱ patients can be safely performed by an endoscopy nurse using PCA pump with the incidence of side effects and patient satisfaction levels similar to sedation under anaesthetist supervision.
文摘Objective:To compare the effect of ketamine,lidocaine,acetaminophen,and dexmedetomidine combined with morphine patient-controlled analgesia for opium addicts after tibial fracture surgery.Methods:This double-blind clinical trial included opium-addicted patients undergoing tibia fracture surgery.Patients were recruited and randomized to four different groups including the ketamine group,the lidocaine group,the acetaminophen group,and the dexmedetomidine group.The hemodynamic parameters such as heart rate(HR),mean arterial pressure,and arterial SaO2,alongside visual analog scale pain scores,sedation assessed by Ramsay score,nausea and vomiting,and opioid use were recorded and compared among the four groups.Results:This study included 140 patients,aged 37(32,41)years,with 92 males and 48 females,and each group had 35 patients.Dexmedetomidine-sedated subjects had the lowest blood pressure from 1 to 24 h after surgery,decreased HR at 12 and 24 h after surgery,and more satisfactory sedation(P<0.05).Notwithstanding no significant difference was noted in the pain scores,or nausea and vomiting among the groups(P>0.05).Conclusions:Dexmedetomidine has a better sedation effect compared to ketamine,lidocaine,and acetaminophen for pain control,but the final choice hinges on the patients’physical condition and the anesthesiologist's preference.Clinical registration:It is registered in Iranian Registry Clinical Trial by code IRCT20141209020258N146.
文摘目的探讨脉冲泵椎管内分娩镇痛失败中转剖宫产的麻醉方式。方法120例脉冲泵椎管内分娩镇痛失败中转剖宫产产妇为研究对象,按随机数字表法分为A、B、C三组,各40例。A组实施腰硬联合麻醉,B组使用分娩镇痛留置的导管行硬膜外麻醉,C组实施气管插管全身麻醉(全麻)。比较三组围麻醉期并发症发生率,入室至切皮时间及麻醉至胎儿取出时间,新生儿出生时、出生1 min和出生5 min Apgar评分。结果C组围麻醉期高血压、低血压、恶心呕吐发生率显著低于A组和B组(P<0.05);三组围麻醉期误吸发生率比较差异无统计学意义(P>0.05)。C组入室至切皮时间和麻醉至胎儿取出时间分别为(8.2±1.6)、(5.3±0.7)min,均短于A组的(15.7±2.6)、(12.2±2.5)min和B组的(15.6±2.7)、(11.5±2.3)min(P<0.05)。C组新生儿出生时、出生1 min和出生5 min Apgar评分分别为(7.8±1.4)、(8.6±0.4)、(9.1±0.7)分,均显著高于A组的(7.0±0.7)、(7.4±0.6)、(8.0±0.5)分和B组的(7.1±0.8)、(7.5±0.6)、(8.1±0.5)分(P<0.05)。结论气管插管全麻用于脉冲泵椎管内分娩镇痛分娩失败中转剖宫产者,具有并发症少,快速娩出胎儿,减少新生儿窒息风险等优势。
