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Semaphorin6D在胃癌中的表达及其意义
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作者 赵向阳 陈凛 +1 位作者 许倩 李玉红 《世界华人消化杂志》 CAS 北大核心 2006年第33期3233-3236,共4页
目的:探讨Semaphorin6D在胃癌中的表达及其意义.方法:应用RT-PCR和Westenblot检测30例胃癌患者的癌组织及胃切缘正常胃黏膜Semaphorin6D的mRNA和蛋白表达.结果:胃癌组织中的Semaphorin6D蛋白及mRNA的表达明显高于胃正常黏膜(0.26±0... 目的:探讨Semaphorin6D在胃癌中的表达及其意义.方法:应用RT-PCR和Westenblot检测30例胃癌患者的癌组织及胃切缘正常胃黏膜Semaphorin6D的mRNA和蛋白表达.结果:胃癌组织中的Semaphorin6D蛋白及mRNA的表达明显高于胃正常黏膜(0.26±0.09vs0.20±0.10,P=0.0194;0.24±0.06vs0.19±0.07,P=0.013).结论:Semaphorin6D在胃癌发生、发展中发挥重要作用. 展开更多
关键词 胃癌 胃正常黏膜 semaphorin6d
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Long noncoding RNA H19 regulates degeneration and regeneration of injured peripheral nerves 被引量:1
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作者 Yu-Mei Feng Jian Shao +6 位作者 Min Cai Yi-Yue Zhou Yi Yao Jia-Xi Qian Zi-Han Ding Mao-Rong Jiang Deng-Bing Yao 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第8期1847-1851,共5页
Our previous studies have shown that long noncoding RNA(lncRNA)H19 is upregulated in injured rat sciatic nerve during the process of Wallerian degeneration,and that it promotes the migration of Schwann cells and slows... Our previous studies have shown that long noncoding RNA(lncRNA)H19 is upregulated in injured rat sciatic nerve during the process of Wallerian degeneration,and that it promotes the migration of Schwann cells and slows down the growth of dorsal root ganglion axons.However,the mechanism by which lncRNA H19 regulates neural repair and regeneration after peripheral nerve injury remains unclear.In this study,we established a Sprague-Dawley rat model of sciatic nerve transection injury.We performed in situ hybridization and found that at 4–7 days after sciatic nerve injury,lncRNA H19 was highly expressed.At 14 days before injury,adeno-associated virus was intrathecally injected into the L4–L5 foramina to disrupt or overexpress lncRNA H19.After overexpression of lncRNA H19,the growth of newly formed axons from the sciatic nerve was inhibited,whereas myelination was enhanced.Then,we performed gait analysis and thermal pain analysis to evaluate rat behavior.We found that lncRNA H19 overexpression delayed the recovery of rat behavior function,whereas interfering with lncRNA H19 expression improved functional recovery.Finally,we examined the expression of lncRNA H19 downstream target SEMA6D,and found that after lncRNA H19 overexpression,the SEMA6D protein level was increased.These findings suggest that lncRNA H19 regulates peripheral nerve degeneration and regeneration through activating SEMA6D in injured nerves.This provides a new clue to understand the role of lncRNA H19 in peripheral nerve degeneration and regeneration. 展开更多
关键词 adeno-associated virus dorsal root ganglion lncRNA H19 nerve degeneration nerve regeneration peripheral nerve rat sciatic nerve injury semaphorin 6D Wallerian degeneration
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Expression of semaphorin 6D in gastric carcinoma and its significance 被引量:1
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作者 Xiang-Yang Zhao Lin Chen +1 位作者 Qian Xu Yu-Hong Li 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第45期7388-7390,共3页
AIM: To investigate the protein and mRNA expression of semaphorin 6D in gastric carcinoma and its significance. METHODS: The protein and mRNA expression of semaphorin 6D was detected by semi-quantitative rever- se tra... AIM: To investigate the protein and mRNA expression of semaphorin 6D in gastric carcinoma and its significance. METHODS: The protein and mRNA expression of semaphorin 6D was detected by semi-quantitative rever- se transcription PCR and Western blotting respectively in 30 cases of gastric carcinoma and normal gastric mucosa. RESULTS: The protein and mRNA expression of semaphorin 6D in gastric carcinoma was significantly higher than that in normal gastric mucosa (0.24 ± 0.06 vs 0.19 ± 0.07, 0.26 ± 0.09 vs 0.20 ± 0.10, P < 0.05). CONCLUSION: Semaphorin 6D may play an important role in the occurrence and development of gastric carcinoma, and is related to tumor angiogenesis. 展开更多
关键词 Semaphorin 6D Gastric carcinoma Norma gastric mucosa ANGIOGENESIS
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