By considering electromechanical coupling, a unified dynamic model of the cylindrical shell with the piezoelectric shunt damping patch(PSDP) is created. The model is universal and can simulate the vibration characteri...By considering electromechanical coupling, a unified dynamic model of the cylindrical shell with the piezoelectric shunt damping patch(PSDP) is created. The model is universal and can simulate the vibration characteristic of the shell under different states including the states in which PSDP cannot be connected, partially connected, and completely connected to the shunt circuit. The equivalent loss factor and elastic modulus with frequency dependence are proposed to consider the electrical damping effect of resistance shunt circuits. Moreover, the semi-analytical dynamic equation of the cylindrical shell with PSDP is derived by the Lagrange equation. An experimental test is carried out on the cylindrical shell with PSDP to verify the vibration suppression ability of PSDP on the cylindrical shell and the correctness of the proposed model. Furthermore, the parameter analysis shows that determining the appropriate resistance value in the shunt circuit can achieve a good vibration suppression effect.展开更多
Secchi depth(SD,m)is a direct and intuitive measure of water's transparency,which is also an indicator of water quality.In 2015,a semi-analytical model was developed to derive SD from remote sensing reflectance,th...Secchi depth(SD,m)is a direct and intuitive measure of water's transparency,which is also an indicator of water quality.In 2015,a semi-analytical model was developed to derive SD from remote sensing reflectance,thus able to provide maps of water's transparency in satellite images.Here an in-situ dataset(338 stations)is used to evaluate its potential ability to monitor water quality in the coastal and estuarine waters,with measurements covering the Zhujiang(Pearl)River Estuary,the Yellow Sea and the East China Sea where measured SD values span a range of 0.2–21.0 m.As a preliminary validation result,according to the whole dataset,the unbiased percent difference(UPD)between estimated and measured SD is 23.3%(N=338,R^2=0.89),with about 60%of stations in the dataset having relative difference(RD)≤20%,over 80%of stations having RD≤40%.Furthermore,by excluding the field data which with relatively larger uncertainties,the semi-analytical model yielded the UPD of 17.7%(N=132,R^2=0.92)with SD range of 0.2–11.0 m.In addition,the semi-analytical model was applied to Landsat-8 images in the Zhujiang River Estuary,and retrieved high-quality mapping and reliable spatial-temporal patterns of water clarity.Taking into account the uncertainties associated with both field measurements and satellite data processing,and that there were no tuning of the semi-analytical model for these regions,these findings indicate highly robust retrieval of SD from spectral techniques for such turbid coastal and estuarine waters.The results suggest it is now possible to routinely monitor coastal water transparency or visibility at high-spatial resolutions from measurements,like Landsat-8 and Sentinel-2 and newly launched Gaofen-5.展开更多
Fatigue damage monitoring is critical metallic structure health monitoring of aircraft.The sensor should be high sensitive,easy to be integrated into structure and well adaptable for poor working conditions.Therefore,...Fatigue damage monitoring is critical metallic structure health monitoring of aircraft.The sensor should be high sensitive,easy to be integrated into structure and well adaptable for poor working conditions.Therefore,an attached eddy current sensor with flexible plane is put forward and its characteristics are analyzed.By extracting material′s conductivity as the crack features,forward semi-analytical model is established and parameter optimizations are carried out.Crack perturbation model of attached eddy current sensor is constructed,and perturbation voltages of sensing channels under three-dimension structural crack are obtained.To verify the sensor′s performance,monitoring experiment on crack extension is conducted under condition of 3 MHz frequency.The validation experimental results show that perturbation model of 2A12-T4 aluminum alloy agrees well with experiment results,and perturbation model errors of four sensing channels are within 25%.The attached eddy current sensor is capable of testing the crack nondestructively and measuring the crack extension quantitatively with the accuracy of 1mm.展开更多
Tokamak plasma density evolution is generally modeled by a diffusion-convection equation in cylindrical geometry. By using a semi-analytical approach, we solve such an equation for a given diffusion coefficient and in...Tokamak plasma density evolution is generally modeled by a diffusion-convection equation in cylindrical geometry. By using a semi-analytical approach, we solve such an equation for a given diffusion coefficient and inward convection velocity as an arbitrary function of the radial position. Through variable separation, a Sturm-Liouville-type eigenvalue problem is solved, thereby constructing a complete set of orthogonal eigenfunctions. Based on the decomposition of the solution, the initial function, and the source function in these eigenfunctions, several problems of practical interest about the density evolution are analyzed. They include the density evolution, with boundary density not being zero; the density profile with internal transport barrier; the damping profile during particle source being shut-down. Results are found to be qualitatively consistent with the tokamak experiments.展开更多
The tunnel subjected to strike-slip fault dislocation exhibits severe and catastrophic damage.The existing analysis models frequently assume uniform fault displacement and fixed fault plane position.In contrast,post-e...The tunnel subjected to strike-slip fault dislocation exhibits severe and catastrophic damage.The existing analysis models frequently assume uniform fault displacement and fixed fault plane position.In contrast,post-earthquake observations indicate that the displacement near the fault zone is typically nonuniform,and the fault plane position is uncertain.In this study,we first established a series of improved governing equations to analyze the mechanical response of tunnels under strike-slip fault dislocation.The proposed methodology incorporated key factors such as nonuniform fault displacement and uncertain fault plane position into the governing equations,thereby significantly enhancing the applicability range and accuracy of the model.In contrast to previous analytical models,the maximum computational error has decreased from 57.1%to 1.1%.Subsequently,we conducted a rigorous validation of the proposed methodology by undertaking a comparative analysis with a 3D finite element numerical model,and the results from both approaches exhibited a high degree of qualitative and quantitative agreement with a maximum error of 9.9%.Finally,the proposed methodology was utilized to perform a parametric analysis to explore the effects of various parameters,such as fault displacement,fault zone width,fault zone strength,the ratio of maximum fault displacement of the hanging wall to the footwall,and fault plane position,on the response of tunnels subjected to strike-slip fault dislocation.The findings indicate a progressive increase in the peak internal forces of the tunnel with the rise in fault displacement and fault zone strength.Conversely,an augmentation in fault zone width is found to contribute to a decrease in the peak internal forces.For example,for a fault zone width of 10 m,the peak values of bending moment,shear force,and axial force are approximately 46.9%,102.4%,and 28.7% higher,respectively,compared to those observed for a fault zone width of 50 m.Furthermore,the position of the peak internal forces is influenced by variations in the ratio of maximum fault displacement of the hanging wall to footwall and the fault plane location,while the peak values of shear force and axial force always align with the fault plane.The maximum peak internal forces are observed when the footwall exclusively bears the entirety of the fault displacement,corresponding to a ratio of 0:1.The peak values of bending moment,shear force,and axial force for the ratio of 0:1 amount to approximately 123.8%,148.6%,and 111.1% of those for the ratio of 0.5:0.5,respectively.展开更多
The increasing use of small material components in a wide range of industrial fields necessitates the development of an accurate and robust indentation testing method.To this end,this paper proposes an Energy-density-...The increasing use of small material components in a wide range of industrial fields necessitates the development of an accurate and robust indentation testing method.To this end,this paper proposes an Energy-density-equivalence for a Flat Indentation(E-FI)model based on the energy density equivalent principle.The proposed model describes the relationships among the material parameters of Hollomon's power law(H-law),flat indenter diameter,energy,and indentation displacement.An E-FI Method(E-FIM)that determines the H-law parameters of materials through the indentation test is also developed.The energy-displacement curves forward-predicted by the E-FI model(based on known H-law parameters of materials)and the H-law parameters of materials given by the E-FIM(based on known energy-displacement curves)are consistent with the results of Finite Element Analysis(FEA)and the H-law parameters of materials used as the input for FEA,respectively.Using E-FIM,the goodness of fit for both stress–strain curves with H-law,predicted based on the displacement with 2%signal interference,and that for stress–strain curves without interference is more than 0.98.The stress–strain relations predicted by E-FIM were consistent with the results obtained via uniaxial tensile tests of ten ductile materials.展开更多
Behaviour of scalar and vector characteristics of steady-state acoustical field is modeled based on analytical-numerical approach. This field is radiated by low-frequency monochromatic point-like source in the determi...Behaviour of scalar and vector characteristics of steady-state acoustical field is modeled based on analytical-numerical approach. This field is radiated by low-frequency monochromatic point-like source in the deterministic layered shallow sea, which has various hydrologic and bottom conditions. Approach being developed is free of any mathematical approximations and without the difficulties it enables to calculate sound field vector characteristics for various展开更多
安全生产事故往往由多组织交互、多因素耦合造成,事故原因涉及多个组织。为预防和遏制多组织生产安全事故的发生,基于系统理论事故建模与过程模型(Systems-Theory Accident Modeling and Process,STAMP)、24Model,构建一种用于多组织事...安全生产事故往往由多组织交互、多因素耦合造成,事故原因涉及多个组织。为预防和遏制多组织生产安全事故的发生,基于系统理论事故建模与过程模型(Systems-Theory Accident Modeling and Process,STAMP)、24Model,构建一种用于多组织事故分析的方法,并以青岛石油爆炸事故为例进行事故原因分析。结果显示:STAMP-24Model可以分组织,分层次且有效、全面、详细地分析涉及多个组织的事故原因,探究多组织之间的交互关系;对事故进行动态演化分析,可得到各组织不安全动作耦合关系与形成的事故失效链及管控失效路径,进而为预防多组织事故提供思路和参考。展开更多
Longitudinal cracks on the tunnel lining significantly influence the performance of tunnels in operation.In this study,we propose a semi-analytical method that provides a simple and effective way to calculate the inte...Longitudinal cracks on the tunnel lining significantly influence the performance of tunnels in operation.In this study,we propose a semi-analytical method that provides a simple and effective way to calculate the internal forces of tunnel linings with multiple cracks.The semi-analytical solution is obtained using structural analysis considering the flexural rigidity for the cracked longitudinal section of the tunnel lining.Then the proposed solution is verified numerically.Using the proposed method,the influences of the crack depth and the number of cracks on the bending moment and modified crack tip stress are investigated.With the increase in crack depth,the bending moment of lining scetion adjacent to the crack decreases,while the bending moment of lining scetion far away from the crack increases slightly.The more the number of cracks in a tunnel lining,the easier the new cracks initiated.展开更多
The calculation of frost heaving with ice lens formation is still not standard for construction projects using artificial ground freezing(AGF).In fine-grained material,ice lenses may initiate and lead to significant h...The calculation of frost heaving with ice lens formation is still not standard for construction projects using artificial ground freezing(AGF).In fine-grained material,ice lenses may initiate and lead to significant heaving at the ground surface,which should be considered in advance.However,the complex processes during ice lens formation are still not fully understood and difficult to capture in a simple approach.In the past,the semi-analytical approach of Konrad and Morgenstern used one soil constant,the“segregation potential(SP)”.It has been mainly and most successfully applied to the heave calculation of natural-induced soil freezing in cold regions.Its application to AGF has been so far unsuccessful.To solve this,a new semi-analytical approach is presented in this paper.It includes AGF conditions such as bottom-up freezing,temperature gradients to reach great freezing velocities,and a distinction between two freezing states.One is the freezing-up state until a certain frost body thickness is reached(thermal transient state),and the other is a holding phase where the frost body thickness is kept constant(thermal quasi-steady state).To test its ability,the results are applied to another freezing direction,the top-down freezing.The new approach is validated using two different frost-susceptible soils and,in total,50 frost heave tests.In the thermal transient region,where the SP is applicable,the two semi-analytical approaches are compared,showing improved performance of the current method by about 15%.展开更多
Understanding the anisotropic creep behaviors of shale under direct shearing is a challenging issue.In this context,we conducted shear-creep and steady-creep tests on shale with five bedding orientations (i.e.0°,...Understanding the anisotropic creep behaviors of shale under direct shearing is a challenging issue.In this context,we conducted shear-creep and steady-creep tests on shale with five bedding orientations (i.e.0°,30°,45°,60°,and 90°),under multiple levels of direct shearing for the first time.The results show that the anisotropic creep of shale exhibits a significant stress-dependent behavior.Under a low shear stress,the creep compliance of shale increases linearly with the logarithm of time at all bedding orientations,and the increase depends on the bedding orientation and creep time.Under high shear stress conditions,the creep compliance of shale is minimal when the bedding orientation is 0°,and the steady-creep rate of shale increases significantly with increasing bedding orientations of 30°,45°,60°,and 90°.The stress-strain values corresponding to the inception of the accelerated creep stage show an increasing and then decreasing trend with the bedding orientation.A semilogarithmic model that could reflect the stress dependence of the steady-creep rate while considering the hardening and damage process is proposed.The model minimizes the deviation of the calculated steady-state creep rate from the observed value and reveals the behavior of the bedding orientation's influence on the steady-creep rate.The applicability of the five classical empirical creep models is quantitatively evaluated.It shows that the logarithmic model can well explain the experimental creep strain and creep rate,and it can accurately predict long-term shear creep deformation.Based on an improved logarithmic model,the variations in creep parameters with shear stress and bedding orientations are discussed.With abovementioned findings,a mathematical method for constructing an anisotropic shear creep model of shale is proposed,which can characterize the nonlinear dependence of the anisotropic shear creep behavior of shale on the bedding orientation.展开更多
Lunar Environment heliospheric X-ray Imager(LEXI)and Solar wind−Magnetosphere−Ionosphere Link Explorer(SMILE)will observe magnetosheath and its boundary motion in soft X-rays for understanding magnetopause reconnectio...Lunar Environment heliospheric X-ray Imager(LEXI)and Solar wind−Magnetosphere−Ionosphere Link Explorer(SMILE)will observe magnetosheath and its boundary motion in soft X-rays for understanding magnetopause reconnection modes under various solar wind conditions after their respective launches in 2024 and 2025.Magnetosheath conditions,namely,plasma density,velocity,and temperature,are key parameters for predicting and analyzing soft X-ray images from the LEXI and SMILE missions.We developed a userfriendly model of magnetosheath that parameterizes number density,velocity,temperature,and magnetic field by utilizing the global Magnetohydrodynamics(MHD)model as well as the pre-existing gas-dynamic and analytic models.Using this parameterized magnetosheath model,scientists can easily reconstruct expected soft X-ray images and utilize them for analysis of observed images of LEXI and SMILE without simulating the complicated global magnetosphere models.First,we created an MHD-based magnetosheath model by running a total of 14 OpenGGCM global MHD simulations under 7 solar wind densities(1,5,10,15,20,25,and 30 cm)and 2 interplanetary magnetic field Bz components(±4 nT),and then parameterizing the results in new magnetosheath conditions.We compared the magnetosheath model result with THEMIS statistical data and it showed good agreement with a weighted Pearson correlation coefficient greater than 0.77,especially for plasma density and plasma velocity.Second,we compiled a suite of magnetosheath models incorporating previous magnetosheath models(gas-dynamic,analytic),and did two case studies to test the performance.The MHD-based model was comparable to or better than the previous models while providing self-consistency among the magnetosheath parameters.Third,we constructed a tool to calculate a soft X-ray image from any given vantage point,which can support the planning and data analysis of the aforementioned LEXI and SMILE missions.A release of the code has been uploaded to a Github repository.展开更多
BACKGROUND Colorectal cancer(CRC)is a serious threat worldwide.Although early screening is suggested to be the most effective method to prevent and control CRC,the current situation of early screening for CRC is still...BACKGROUND Colorectal cancer(CRC)is a serious threat worldwide.Although early screening is suggested to be the most effective method to prevent and control CRC,the current situation of early screening for CRC is still not optimistic.In China,the incidence of CRC in the Yangtze River Delta region is increasing dramatically,but few studies have been conducted.Therefore,it is necessary to develop a simple and efficient early screening model for CRC.AIM To develop and validate an early-screening nomogram model to identify individuals at high risk of CRC.METHODS Data of 64448 participants obtained from Ningbo Hospital,China between 2014 and 2017 were retrospectively analyzed.The cohort comprised 64448 individuals,of which,530 were excluded due to missing or incorrect data.Of 63918,7607(11.9%)individuals were considered to be high risk for CRC,and 56311(88.1%)were not.The participants were randomly allocated to a training set(44743)or validation set(19175).The discriminatory ability,predictive accuracy,and clinical utility of the model were evaluated by constructing and analyzing receiver operating characteristic(ROC)curves and calibration curves and by decision curve analysis.Finally,the model was validated internally using a bootstrap resampling technique.RESULTS Seven variables,including demographic,lifestyle,and family history information,were examined.Multifactorial logistic regression analysis revealed that age[odds ratio(OR):1.03,95%confidence interval(CI):1.02-1.03,P<0.001],body mass index(BMI)(OR:1.07,95%CI:1.06-1.08,P<0.001),waist circumference(WC)(OR:1.03,95%CI:1.02-1.03 P<0.001),lifestyle(OR:0.45,95%CI:0.42-0.48,P<0.001),and family history(OR:4.28,95%CI:4.04-4.54,P<0.001)were the most significant predictors of high-risk CRC.Healthy lifestyle was a protective factor,whereas family history was the most significant risk factor.The area under the curve was 0.734(95%CI:0.723-0.745)for the final validation set ROC curve and 0.735(95%CI:0.728-0.742)for the training set ROC curve.The calibration curve demonstrated a high correlation between the CRC high-risk population predicted by the nomogram model and the actual CRC high-risk population.CONCLUSION The early-screening nomogram model for CRC prediction in high-risk populations developed in this study based on age,BMI,WC,lifestyle,and family history exhibited high accuracy.展开更多
Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell behavior and tumor progression.However,the lack of tumor models able to precisely emulate natural brain tumor ...Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell behavior and tumor progression.However,the lack of tumor models able to precisely emulate natural brain tumor tissue has impeded the study of the effects of hypoxia on the progression and growth of tumor cells.This study reports a three-dimensional(3D)brain tumor model obtained by encapsulating U87MG(U87)cells in a hydrogel containing type I collagen.It also documents the effect of various oxygen concentrations(1%,7%,and 21%)in the culture environment on U87 cell morphology,proliferation,viability,cell cycle,apoptosis rate,and migration.Finally,it compares two-dimensional(2D)and 3D cultures.For comparison purposes,cells cultured in flat culture dishes were used as the control(2D model).Cells cultured in the 3D model proliferated more slowly but had a higher apoptosis rate and proportion of cells in the resting phase(G0 phase)/gap I phase(G1 phase)than those cultured in the 2D model.Besides,the two models yielded significantly different cell morphologies.Finally,hypoxia(e.g.,1%O2)affected cell morphology,slowed cell growth,reduced cell viability,and increased the apoptosis rate in the 3D model.These results indicate that the constructed 3D model is effective for investigating the effects of biological and chemical factors on cell morphology and function,and can be more representative of the tumor microenvironment than 2D culture systems.The developed 3D glioblastoma tumor model is equally applicable to other studies in pharmacology and pathology.展开更多
Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse ...Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease itself.Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s disease.Mesenchymal stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of teratogenicity.We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal model.We searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,2023.The study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control groups.We use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the meta-analysis.Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test.Among the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a protective effect on dopaminergic neurons.Subgroup analysis of the amphetamine-induced rotation test showed a significant reduction only in the intracranial-striatum route(SMD[95%CI]=-2.59[-3.25 to-1.94],P=0.0001,I^(2)=74.4%).The memory test showed significant improvement only in the intravenous route(SMD[95%CI]=4.80[1.84 to 7.76],P=0.027,I^(2)=79.6%).Mesenchymal stem cells have been shown to positively impact motor function and memory function and protect dopaminergic neurons in preclinical models of Parkinson’s disease.Further research is required to determine the optimal stem cell types,modifications,transplanted cell numbe rs,and delivery methods for these protocols.展开更多
Both the attribution of historical change and future projections of droughts rely heavily on climate modeling. However,reasonable drought simulations have remained a challenge, and the related performances of the curr...Both the attribution of historical change and future projections of droughts rely heavily on climate modeling. However,reasonable drought simulations have remained a challenge, and the related performances of the current state-of-the-art Coupled Model Intercomparison Project phase 6(CMIP6) models remain unknown. Here, both the strengths and weaknesses of CMIP6 models in simulating droughts and corresponding hydrothermal conditions in drylands are assessed.While the general patterns of simulated meteorological elements in drylands resemble the observations, the annual precipitation is overestimated by ~33%(with a model spread of 2.3%–77.2%), along with an underestimation of potential evapotranspiration(PET) by ~32%(17.5%–47.2%). The water deficit condition, measured by the difference between precipitation and PET, is 50%(29.1%–71.7%) weaker than observations. The CMIP6 models show weaknesses in capturing the climate mean drought characteristics in drylands, particularly with the occurrence and duration largely underestimated in the hyperarid Afro-Asian areas. Nonetheless, the drought-associated meteorological anomalies, including reduced precipitation, warmer temperatures, higher evaporative demand, and increased water deficit conditions, are reasonably reproduced. The simulated magnitude of precipitation(water deficit) associated with dryland droughts is overestimated by 28%(24%) compared to observations. The observed increasing trends in drought fractional area,occurrence, and corresponding meteorological anomalies during 1980–2014 are reasonably reproduced. Still, the increase in drought characteristics, associated precipitation and water deficit are obviously underestimated after the late 1990s,especially for mild and moderate droughts, indicative of a weaker response of dryland drought changes to global warming in CMIP6 models. Our results suggest that it is imperative to employ bias correction approaches in drought-related studies over drylands by using CMIP6 outputs.展开更多
基金Project supported by the National Natural Science Foundation of China (No. 12272087)。
文摘By considering electromechanical coupling, a unified dynamic model of the cylindrical shell with the piezoelectric shunt damping patch(PSDP) is created. The model is universal and can simulate the vibration characteristic of the shell under different states including the states in which PSDP cannot be connected, partially connected, and completely connected to the shunt circuit. The equivalent loss factor and elastic modulus with frequency dependence are proposed to consider the electrical damping effect of resistance shunt circuits. Moreover, the semi-analytical dynamic equation of the cylindrical shell with PSDP is derived by the Lagrange equation. An experimental test is carried out on the cylindrical shell with PSDP to verify the vibration suppression ability of PSDP on the cylindrical shell and the correctness of the proposed model. Furthermore, the parameter analysis shows that determining the appropriate resistance value in the shunt circuit can achieve a good vibration suppression effect.
基金The National Natural Science Foundation of China under contract No.61527810the Marine Science and Technology Fund from Director of South China Sea Branch+1 种基金State Oceanic Administration of China under contract No.180101the Key Laboratory Open Project Fund of Technology and Application for Safeguarding of Marine Rights and Interests,State Oceanic Administration of China under contract No.1720。
文摘Secchi depth(SD,m)is a direct and intuitive measure of water's transparency,which is also an indicator of water quality.In 2015,a semi-analytical model was developed to derive SD from remote sensing reflectance,thus able to provide maps of water's transparency in satellite images.Here an in-situ dataset(338 stations)is used to evaluate its potential ability to monitor water quality in the coastal and estuarine waters,with measurements covering the Zhujiang(Pearl)River Estuary,the Yellow Sea and the East China Sea where measured SD values span a range of 0.2–21.0 m.As a preliminary validation result,according to the whole dataset,the unbiased percent difference(UPD)between estimated and measured SD is 23.3%(N=338,R^2=0.89),with about 60%of stations in the dataset having relative difference(RD)≤20%,over 80%of stations having RD≤40%.Furthermore,by excluding the field data which with relatively larger uncertainties,the semi-analytical model yielded the UPD of 17.7%(N=132,R^2=0.92)with SD range of 0.2–11.0 m.In addition,the semi-analytical model was applied to Landsat-8 images in the Zhujiang River Estuary,and retrieved high-quality mapping and reliable spatial-temporal patterns of water clarity.Taking into account the uncertainties associated with both field measurements and satellite data processing,and that there were no tuning of the semi-analytical model for these regions,these findings indicate highly robust retrieval of SD from spectral techniques for such turbid coastal and estuarine waters.The results suggest it is now possible to routinely monitor coastal water transparency or visibility at high-spatial resolutions from measurements,like Landsat-8 and Sentinel-2 and newly launched Gaofen-5.
基金supported by the National Natural Science Foundation of China(No.51175509)
文摘Fatigue damage monitoring is critical metallic structure health monitoring of aircraft.The sensor should be high sensitive,easy to be integrated into structure and well adaptable for poor working conditions.Therefore,an attached eddy current sensor with flexible plane is put forward and its characteristics are analyzed.By extracting material′s conductivity as the crack features,forward semi-analytical model is established and parameter optimizations are carried out.Crack perturbation model of attached eddy current sensor is constructed,and perturbation voltages of sensing channels under three-dimension structural crack are obtained.To verify the sensor′s performance,monitoring experiment on crack extension is conducted under condition of 3 MHz frequency.The validation experimental results show that perturbation model of 2A12-T4 aluminum alloy agrees well with experiment results,and perturbation model errors of four sensing channels are within 25%.The attached eddy current sensor is capable of testing the crack nondestructively and measuring the crack extension quantitatively with the accuracy of 1mm.
文摘Tokamak plasma density evolution is generally modeled by a diffusion-convection equation in cylindrical geometry. By using a semi-analytical approach, we solve such an equation for a given diffusion coefficient and inward convection velocity as an arbitrary function of the radial position. Through variable separation, a Sturm-Liouville-type eigenvalue problem is solved, thereby constructing a complete set of orthogonal eigenfunctions. Based on the decomposition of the solution, the initial function, and the source function in these eigenfunctions, several problems of practical interest about the density evolution are analyzed. They include the density evolution, with boundary density not being zero; the density profile with internal transport barrier; the damping profile during particle source being shut-down. Results are found to be qualitatively consistent with the tokamak experiments.
基金Projects(52378411,52208404)supported by the National Natural Science Foundation of China。
文摘The tunnel subjected to strike-slip fault dislocation exhibits severe and catastrophic damage.The existing analysis models frequently assume uniform fault displacement and fixed fault plane position.In contrast,post-earthquake observations indicate that the displacement near the fault zone is typically nonuniform,and the fault plane position is uncertain.In this study,we first established a series of improved governing equations to analyze the mechanical response of tunnels under strike-slip fault dislocation.The proposed methodology incorporated key factors such as nonuniform fault displacement and uncertain fault plane position into the governing equations,thereby significantly enhancing the applicability range and accuracy of the model.In contrast to previous analytical models,the maximum computational error has decreased from 57.1%to 1.1%.Subsequently,we conducted a rigorous validation of the proposed methodology by undertaking a comparative analysis with a 3D finite element numerical model,and the results from both approaches exhibited a high degree of qualitative and quantitative agreement with a maximum error of 9.9%.Finally,the proposed methodology was utilized to perform a parametric analysis to explore the effects of various parameters,such as fault displacement,fault zone width,fault zone strength,the ratio of maximum fault displacement of the hanging wall to the footwall,and fault plane position,on the response of tunnels subjected to strike-slip fault dislocation.The findings indicate a progressive increase in the peak internal forces of the tunnel with the rise in fault displacement and fault zone strength.Conversely,an augmentation in fault zone width is found to contribute to a decrease in the peak internal forces.For example,for a fault zone width of 10 m,the peak values of bending moment,shear force,and axial force are approximately 46.9%,102.4%,and 28.7% higher,respectively,compared to those observed for a fault zone width of 50 m.Furthermore,the position of the peak internal forces is influenced by variations in the ratio of maximum fault displacement of the hanging wall to footwall and the fault plane location,while the peak values of shear force and axial force always align with the fault plane.The maximum peak internal forces are observed when the footwall exclusively bears the entirety of the fault displacement,corresponding to a ratio of 0:1.The peak values of bending moment,shear force,and axial force for the ratio of 0:1 amount to approximately 123.8%,148.6%,and 111.1% of those for the ratio of 0.5:0.5,respectively.
基金co-supported by the National Natural Science Foundation of China(No.11872320)。
文摘The increasing use of small material components in a wide range of industrial fields necessitates the development of an accurate and robust indentation testing method.To this end,this paper proposes an Energy-density-equivalence for a Flat Indentation(E-FI)model based on the energy density equivalent principle.The proposed model describes the relationships among the material parameters of Hollomon's power law(H-law),flat indenter diameter,energy,and indentation displacement.An E-FI Method(E-FIM)that determines the H-law parameters of materials through the indentation test is also developed.The energy-displacement curves forward-predicted by the E-FI model(based on known H-law parameters of materials)and the H-law parameters of materials given by the E-FIM(based on known energy-displacement curves)are consistent with the results of Finite Element Analysis(FEA)and the H-law parameters of materials used as the input for FEA,respectively.Using E-FIM,the goodness of fit for both stress–strain curves with H-law,predicted based on the displacement with 2%signal interference,and that for stress–strain curves without interference is more than 0.98.The stress–strain relations predicted by E-FIM were consistent with the results obtained via uniaxial tensile tests of ten ductile materials.
基金This work was supported by the Foundation for University Key Teacher by the Ministry of Education of China.
文摘Behaviour of scalar and vector characteristics of steady-state acoustical field is modeled based on analytical-numerical approach. This field is radiated by low-frequency monochromatic point-like source in the deterministic layered shallow sea, which has various hydrologic and bottom conditions. Approach being developed is free of any mathematical approximations and without the difficulties it enables to calculate sound field vector characteristics for various
文摘安全生产事故往往由多组织交互、多因素耦合造成,事故原因涉及多个组织。为预防和遏制多组织生产安全事故的发生,基于系统理论事故建模与过程模型(Systems-Theory Accident Modeling and Process,STAMP)、24Model,构建一种用于多组织事故分析的方法,并以青岛石油爆炸事故为例进行事故原因分析。结果显示:STAMP-24Model可以分组织,分层次且有效、全面、详细地分析涉及多个组织的事故原因,探究多组织之间的交互关系;对事故进行动态演化分析,可得到各组织不安全动作耦合关系与形成的事故失效链及管控失效路径,进而为预防多组织事故提供思路和参考。
基金The authors gratefully acknowledge the financial support by the Key Project of High-speed Rail Joint Fund of National Natural Science Foundation of China(Grant No.U1934210)the Natural Science Foundation of Beijing,China(Grant No.8202037).
文摘Longitudinal cracks on the tunnel lining significantly influence the performance of tunnels in operation.In this study,we propose a semi-analytical method that provides a simple and effective way to calculate the internal forces of tunnel linings with multiple cracks.The semi-analytical solution is obtained using structural analysis considering the flexural rigidity for the cracked longitudinal section of the tunnel lining.Then the proposed solution is verified numerically.Using the proposed method,the influences of the crack depth and the number of cracks on the bending moment and modified crack tip stress are investigated.With the increase in crack depth,the bending moment of lining scetion adjacent to the crack decreases,while the bending moment of lining scetion far away from the crack increases slightly.The more the number of cracks in a tunnel lining,the easier the new cracks initiated.
基金supported by the German Research Foundation(DFG)under the project“Investigation and calculation of frost heave considering specific boundary conditions of ground freezing”(Grant No.409760547).
文摘The calculation of frost heaving with ice lens formation is still not standard for construction projects using artificial ground freezing(AGF).In fine-grained material,ice lenses may initiate and lead to significant heaving at the ground surface,which should be considered in advance.However,the complex processes during ice lens formation are still not fully understood and difficult to capture in a simple approach.In the past,the semi-analytical approach of Konrad and Morgenstern used one soil constant,the“segregation potential(SP)”.It has been mainly and most successfully applied to the heave calculation of natural-induced soil freezing in cold regions.Its application to AGF has been so far unsuccessful.To solve this,a new semi-analytical approach is presented in this paper.It includes AGF conditions such as bottom-up freezing,temperature gradients to reach great freezing velocities,and a distinction between two freezing states.One is the freezing-up state until a certain frost body thickness is reached(thermal transient state),and the other is a holding phase where the frost body thickness is kept constant(thermal quasi-steady state).To test its ability,the results are applied to another freezing direction,the top-down freezing.The new approach is validated using two different frost-susceptible soils and,in total,50 frost heave tests.In the thermal transient region,where the SP is applicable,the two semi-analytical approaches are compared,showing improved performance of the current method by about 15%.
基金funded by the National Natural Science Foundation of China(Grant Nos.U22A20166 and 12172230)the Guangdong Basic and Applied Basic Research Foundation(Grant No.2023A1515012654)+1 种基金funded by the National Natural Science Foundation of China(Grant Nos.U22A20166 and 12172230)the Guangdong Basic and Applied Basic Research Foundation(Grant No.2023A1515012654)。
文摘Understanding the anisotropic creep behaviors of shale under direct shearing is a challenging issue.In this context,we conducted shear-creep and steady-creep tests on shale with five bedding orientations (i.e.0°,30°,45°,60°,and 90°),under multiple levels of direct shearing for the first time.The results show that the anisotropic creep of shale exhibits a significant stress-dependent behavior.Under a low shear stress,the creep compliance of shale increases linearly with the logarithm of time at all bedding orientations,and the increase depends on the bedding orientation and creep time.Under high shear stress conditions,the creep compliance of shale is minimal when the bedding orientation is 0°,and the steady-creep rate of shale increases significantly with increasing bedding orientations of 30°,45°,60°,and 90°.The stress-strain values corresponding to the inception of the accelerated creep stage show an increasing and then decreasing trend with the bedding orientation.A semilogarithmic model that could reflect the stress dependence of the steady-creep rate while considering the hardening and damage process is proposed.The model minimizes the deviation of the calculated steady-state creep rate from the observed value and reveals the behavior of the bedding orientation's influence on the steady-creep rate.The applicability of the five classical empirical creep models is quantitatively evaluated.It shows that the logarithmic model can well explain the experimental creep strain and creep rate,and it can accurately predict long-term shear creep deformation.Based on an improved logarithmic model,the variations in creep parameters with shear stress and bedding orientations are discussed.With abovementioned findings,a mathematical method for constructing an anisotropic shear creep model of shale is proposed,which can characterize the nonlinear dependence of the anisotropic shear creep behavior of shale on the bedding orientation.
基金supported by the NSF grant AGS-1928883the NASA grants,80NSSC20K1670 and 80MSFC20C0019+2 种基金support from NASA GSFC IRADHIFISFM funds。
文摘Lunar Environment heliospheric X-ray Imager(LEXI)and Solar wind−Magnetosphere−Ionosphere Link Explorer(SMILE)will observe magnetosheath and its boundary motion in soft X-rays for understanding magnetopause reconnection modes under various solar wind conditions after their respective launches in 2024 and 2025.Magnetosheath conditions,namely,plasma density,velocity,and temperature,are key parameters for predicting and analyzing soft X-ray images from the LEXI and SMILE missions.We developed a userfriendly model of magnetosheath that parameterizes number density,velocity,temperature,and magnetic field by utilizing the global Magnetohydrodynamics(MHD)model as well as the pre-existing gas-dynamic and analytic models.Using this parameterized magnetosheath model,scientists can easily reconstruct expected soft X-ray images and utilize them for analysis of observed images of LEXI and SMILE without simulating the complicated global magnetosphere models.First,we created an MHD-based magnetosheath model by running a total of 14 OpenGGCM global MHD simulations under 7 solar wind densities(1,5,10,15,20,25,and 30 cm)and 2 interplanetary magnetic field Bz components(±4 nT),and then parameterizing the results in new magnetosheath conditions.We compared the magnetosheath model result with THEMIS statistical data and it showed good agreement with a weighted Pearson correlation coefficient greater than 0.77,especially for plasma density and plasma velocity.Second,we compiled a suite of magnetosheath models incorporating previous magnetosheath models(gas-dynamic,analytic),and did two case studies to test the performance.The MHD-based model was comparable to or better than the previous models while providing self-consistency among the magnetosheath parameters.Third,we constructed a tool to calculate a soft X-ray image from any given vantage point,which can support the planning and data analysis of the aforementioned LEXI and SMILE missions.A release of the code has been uploaded to a Github repository.
基金Supported by the Project of NINGBO Leading Medical Health Discipline,No.2022-B11Ningbo Natural Science Foundation,No.202003N4206Public Welfare Foundation of Ningbo,No.2021S108.
文摘BACKGROUND Colorectal cancer(CRC)is a serious threat worldwide.Although early screening is suggested to be the most effective method to prevent and control CRC,the current situation of early screening for CRC is still not optimistic.In China,the incidence of CRC in the Yangtze River Delta region is increasing dramatically,but few studies have been conducted.Therefore,it is necessary to develop a simple and efficient early screening model for CRC.AIM To develop and validate an early-screening nomogram model to identify individuals at high risk of CRC.METHODS Data of 64448 participants obtained from Ningbo Hospital,China between 2014 and 2017 were retrospectively analyzed.The cohort comprised 64448 individuals,of which,530 were excluded due to missing or incorrect data.Of 63918,7607(11.9%)individuals were considered to be high risk for CRC,and 56311(88.1%)were not.The participants were randomly allocated to a training set(44743)or validation set(19175).The discriminatory ability,predictive accuracy,and clinical utility of the model were evaluated by constructing and analyzing receiver operating characteristic(ROC)curves and calibration curves and by decision curve analysis.Finally,the model was validated internally using a bootstrap resampling technique.RESULTS Seven variables,including demographic,lifestyle,and family history information,were examined.Multifactorial logistic regression analysis revealed that age[odds ratio(OR):1.03,95%confidence interval(CI):1.02-1.03,P<0.001],body mass index(BMI)(OR:1.07,95%CI:1.06-1.08,P<0.001),waist circumference(WC)(OR:1.03,95%CI:1.02-1.03 P<0.001),lifestyle(OR:0.45,95%CI:0.42-0.48,P<0.001),and family history(OR:4.28,95%CI:4.04-4.54,P<0.001)were the most significant predictors of high-risk CRC.Healthy lifestyle was a protective factor,whereas family history was the most significant risk factor.The area under the curve was 0.734(95%CI:0.723-0.745)for the final validation set ROC curve and 0.735(95%CI:0.728-0.742)for the training set ROC curve.The calibration curve demonstrated a high correlation between the CRC high-risk population predicted by the nomogram model and the actual CRC high-risk population.CONCLUSION The early-screening nomogram model for CRC prediction in high-risk populations developed in this study based on age,BMI,WC,lifestyle,and family history exhibited high accuracy.
基金supported by the National Natural Science Foundation of China (No. 52275291)the Fundamental Research Funds for the Central Universitiesthe Program for Innovation Team of Shaanxi Province,China (No. 2023-CX-TD-17)
文摘Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell behavior and tumor progression.However,the lack of tumor models able to precisely emulate natural brain tumor tissue has impeded the study of the effects of hypoxia on the progression and growth of tumor cells.This study reports a three-dimensional(3D)brain tumor model obtained by encapsulating U87MG(U87)cells in a hydrogel containing type I collagen.It also documents the effect of various oxygen concentrations(1%,7%,and 21%)in the culture environment on U87 cell morphology,proliferation,viability,cell cycle,apoptosis rate,and migration.Finally,it compares two-dimensional(2D)and 3D cultures.For comparison purposes,cells cultured in flat culture dishes were used as the control(2D model).Cells cultured in the 3D model proliferated more slowly but had a higher apoptosis rate and proportion of cells in the resting phase(G0 phase)/gap I phase(G1 phase)than those cultured in the 2D model.Besides,the two models yielded significantly different cell morphologies.Finally,hypoxia(e.g.,1%O2)affected cell morphology,slowed cell growth,reduced cell viability,and increased the apoptosis rate in the 3D model.These results indicate that the constructed 3D model is effective for investigating the effects of biological and chemical factors on cell morphology and function,and can be more representative of the tumor microenvironment than 2D culture systems.The developed 3D glioblastoma tumor model is equally applicable to other studies in pharmacology and pathology.
文摘Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease itself.Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s disease.Mesenchymal stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of teratogenicity.We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal model.We searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,2023.The study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control groups.We use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the meta-analysis.Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test.Among the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a protective effect on dopaminergic neurons.Subgroup analysis of the amphetamine-induced rotation test showed a significant reduction only in the intracranial-striatum route(SMD[95%CI]=-2.59[-3.25 to-1.94],P=0.0001,I^(2)=74.4%).The memory test showed significant improvement only in the intravenous route(SMD[95%CI]=4.80[1.84 to 7.76],P=0.027,I^(2)=79.6%).Mesenchymal stem cells have been shown to positively impact motor function and memory function and protect dopaminergic neurons in preclinical models of Parkinson’s disease.Further research is required to determine the optimal stem cell types,modifications,transplanted cell numbe rs,and delivery methods for these protocols.
基金supported by Ministry of Science and Technology of China (Grant No. 2018YFA0606501)National Natural Science Foundation of China (Grant No. 42075037)+1 种基金Key Laboratory Open Research Program of Xinjiang Science and Technology Department (Grant No. 2022D04009)the National Key Scientific and Technological Infrastructure project “Earth System Numerical Simulation Facility” (EarthLab)。
文摘Both the attribution of historical change and future projections of droughts rely heavily on climate modeling. However,reasonable drought simulations have remained a challenge, and the related performances of the current state-of-the-art Coupled Model Intercomparison Project phase 6(CMIP6) models remain unknown. Here, both the strengths and weaknesses of CMIP6 models in simulating droughts and corresponding hydrothermal conditions in drylands are assessed.While the general patterns of simulated meteorological elements in drylands resemble the observations, the annual precipitation is overestimated by ~33%(with a model spread of 2.3%–77.2%), along with an underestimation of potential evapotranspiration(PET) by ~32%(17.5%–47.2%). The water deficit condition, measured by the difference between precipitation and PET, is 50%(29.1%–71.7%) weaker than observations. The CMIP6 models show weaknesses in capturing the climate mean drought characteristics in drylands, particularly with the occurrence and duration largely underestimated in the hyperarid Afro-Asian areas. Nonetheless, the drought-associated meteorological anomalies, including reduced precipitation, warmer temperatures, higher evaporative demand, and increased water deficit conditions, are reasonably reproduced. The simulated magnitude of precipitation(water deficit) associated with dryland droughts is overestimated by 28%(24%) compared to observations. The observed increasing trends in drought fractional area,occurrence, and corresponding meteorological anomalies during 1980–2014 are reasonably reproduced. Still, the increase in drought characteristics, associated precipitation and water deficit are obviously underestimated after the late 1990s,especially for mild and moderate droughts, indicative of a weaker response of dryland drought changes to global warming in CMIP6 models. Our results suggest that it is imperative to employ bias correction approaches in drought-related studies over drylands by using CMIP6 outputs.