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Introducing the nth-Order Features Adjoint Sensitivity Analysis Methodology for Nonlinear Systems (nth-FASAM-N): I. Mathematical Framework
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作者 Dan Gabriel Cacuci 《American Journal of Computational Mathematics》 2024年第1期11-42,共32页
This work presents the “n<sup>th</sup>-Order Feature Adjoint Sensitivity Analysis Methodology for Nonlinear Systems” (abbreviated as “n<sup>th</sup>-FASAM-N”), which will be shown to be the... This work presents the “n<sup>th</sup>-Order Feature Adjoint Sensitivity Analysis Methodology for Nonlinear Systems” (abbreviated as “n<sup>th</sup>-FASAM-N”), which will be shown to be the most efficient methodology for computing exact expressions of sensitivities, of any order, of model responses with respect to features of model parameters and, subsequently, with respect to the model’s uncertain parameters, boundaries, and internal interfaces. The unparalleled efficiency and accuracy of the n<sup>th</sup>-FASAM-N methodology stems from the maximal reduction of the number of adjoint computations (which are considered to be “large-scale” computations) for computing high-order sensitivities. When applying the n<sup>th</sup>-FASAM-N methodology to compute the second- and higher-order sensitivities, the number of large-scale computations is proportional to the number of “model features” as opposed to being proportional to the number of model parameters (which are considerably more than the number of features).When a model has no “feature” functions of parameters, but only comprises primary parameters, the n<sup>th</sup>-FASAM-N methodology becomes identical to the extant n<sup>th</sup> CASAM-N (“n<sup>th</sup>-Order Comprehensive Adjoint Sensitivity Analysis Methodology for Nonlinear Systems”) methodology. Both the n<sup>th</sup>-FASAM-N and the n<sup>th</sup>-CASAM-N methodologies are formulated in linearly increasing higher-dimensional Hilbert spaces as opposed to exponentially increasing parameter-dimensional spaces thus overcoming the curse of dimensionality in sensitivity analysis of nonlinear systems. Both the n<sup>th</sup>-FASAM-N and the n<sup>th</sup>-CASAM-N are incomparably more efficient and more accurate than any other methods (statistical, finite differences, etc.) for computing exact expressions of response sensitivities of any order with respect to the model’s features and/or primary uncertain parameters, boundaries, and internal interfaces. 展开更多
关键词 Computation of High-Order sensitivities sensitivities to Features of Model Parameters sensitivities to Domain Boundaries Adjoint sensitivity Systems
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Introducing the nth-Order Features Adjoint Sensitivity Analysis Methodology for Nonlinear Systems (nth-FASAM-N): II. Illustrative Example
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作者 Dan Gabriel Cacuci 《American Journal of Computational Mathematics》 2024年第1期43-95,共54页
This work highlights the unparalleled efficiency of the “n<sup>th</sup>-Order Function/ Feature Adjoint Sensitivity Analysis Methodology for Nonlinear Systems” (n<sup>th</sup>-FASAM-N) by con... This work highlights the unparalleled efficiency of the “n<sup>th</sup>-Order Function/ Feature Adjoint Sensitivity Analysis Methodology for Nonlinear Systems” (n<sup>th</sup>-FASAM-N) by considering the well-known Nordheim-Fuchs reactor dynamics/safety model. This model describes a short-time self-limiting power excursion in a nuclear reactor system having a negative temperature coefficient in which a large amount of reactivity is suddenly inserted, either intentionally or by accident. This nonlinear paradigm model is sufficiently complex to model realistically self-limiting power excursions for short times yet admits closed-form exact expressions for the time-dependent neutron flux, temperature distribution and energy released during the transient power burst. The n<sup>th</sup>-FASAM-N methodology is compared to the extant “n<sup>th</sup>-Order Comprehensive Adjoint Sensitivity Analysis Methodology for Nonlinear Systems” (n<sup>th</sup>-CASAM-N) showing that: (i) the 1<sup>st</sup>-FASAM-N and the 1<sup>st</sup>-CASAM-N methodologies are equally efficient for computing the first-order sensitivities;each methodology requires a single large-scale computation for solving the “First-Level Adjoint Sensitivity System” (1<sup>st</sup>-LASS);(ii) the 2<sup>nd</sup>-FASAM-N methodology is considerably more efficient than the 2<sup>nd</sup>-CASAM-N methodology for computing the second-order sensitivities since the number of feature-functions is much smaller than the number of primary parameters;specifically for the Nordheim-Fuchs model, the 2<sup>nd</sup>-FASAM-N methodology requires 2 large-scale computations to obtain all of the exact expressions of the 28 distinct second-order response sensitivities with respect to the model parameters while the 2<sup>nd</sup>-CASAM-N methodology requires 7 large-scale computations for obtaining these 28 second-order sensitivities;(iii) the 3<sup>rd</sup>-FASAM-N methodology is even more efficient than the 3<sup>rd</sup>-CASAM-N methodology: only 2 large-scale computations are needed to obtain the exact expressions of the 84 distinct third-order response sensitivities with respect to the Nordheim-Fuchs model’s parameters when applying the 3<sup>rd</sup>-FASAM-N methodology, while the application of the 3<sup>rd</sup>-CASAM-N methodology requires at least 22 large-scale computations for computing the same 84 distinct third-order sensitivities. Together, the n<sup>th</sup>-FASAM-N and the n<sup>th</sup>-CASAM-N methodologies are the most practical methodologies for computing response sensitivities of any order comprehensively and accurately, overcoming the curse of dimensionality in sensitivity analysis. 展开更多
关键词 Nordheim-Fuchs Reactor Safety Model Feature Functions of Model Parameters High-Order Response sensitivities to Parameters Adjoint sensitivity Systems
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Promoting Ethical Sensitivity in Nursing Education:A Systematic Review of Case Study-Based Health Education
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作者 Jinyi Tang Santhna Letchmi Panduragan +1 位作者 Fatimah Yahya Nisha Nambiar 《Journal of Clinical and Nursing Research》 2024年第4期22-29,共8页
Introduction: Nursing ethical sensitivity refers to a nurse’s capacity for thoughtful consideration of ethical issues when faced with dilemmas. In the nursing domain, ethical dilemmas arise when nurses face challenge... Introduction: Nursing ethical sensitivity refers to a nurse’s capacity for thoughtful consideration of ethical issues when faced with dilemmas. In the nursing domain, ethical dilemmas arise when nurses face challenges in making sound ethical decisions during clinical practice. These challenges may stem from conflicts between personal values and professional responsibilities. Methodology: Articles downloaded from Pub Med, CNKI, and Google Scholar were reviewed. Results: After rigorous screening, a meticulous analysis was conducted, encompassing 10 articles and involving a substantial cohort of 2863 participants. Existing literature revealed variations in the ethical dilemmas faced by nurses across different departments. The ethical sensitivity of nurses also varies, with higher ethical sensitivity correlating with stronger empathetic abilities. Zhen et al. classified the causes of ethical dilemmas into four main categories: (1) Ethical dilemmas arising from personal reasons of nursing students;(2) Ethical dilemmas stemming from the actions of teachers;(3) Ethical dilemmas triggered by patients;(4) Ethical dilemmas resulting from miscellaneous reasons. Conclusion: According to literature findings, nursing ethical sensitivity was positively linked to the nurse’s ethical decision-making ability. A case study-oriented teaching program has proven effective in enhancing ethical sensitivity among nursing students. 展开更多
关键词 Ethical sensitivity Ethical dilemma Case study education Nursing ethical sensitivity scale Influencing factors Nursing student
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近红外无创血糖浓度的Label Sensitivity算法和支持向量机回归
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作者 孟琪 赵鹏 +4 位作者 宦克为 李野 姜志侠 张瀚文 周林华 《光谱学与光谱分析》 SCIE EI CAS CSCD 北大核心 2024年第3期617-624,共8页
近红外光谱分析技术在生物医学工程领域具有广阔应用前景。无创且持续性地测量能实时监控人体血糖水平,给糖尿病患者带来极大便利性、提高生存质量、降低糖尿病并发症发生率具有很大的社会效益。无创血糖监测的想法提出较早,但仍然存在... 近红外光谱分析技术在生物医学工程领域具有广阔应用前景。无创且持续性地测量能实时监控人体血糖水平,给糖尿病患者带来极大便利性、提高生存质量、降低糖尿病并发症发生率具有很大的社会效益。无创血糖监测的想法提出较早,但仍然存在预测精度低、预测值与标签值相关性不高等难点,至今没有达到临床要求。近年来,光谱检测技术发展迅猛且机器学习技术在智能信息处理方面具有明显优势,两者结合可以有效提高人体无创血糖医学监测模型的精度和普适性。提出了一种标签敏感度算法(LS),并结合支持向量机方法建立了人体血糖含量预测模型。使用近红外光谱仪采集了4名志愿者食指处动态血液光谱数据(每名志愿者28组数据),并使用多元散射矫正(MSC)方法消除了部分光散射的影响。考虑血糖对不同波长光的吸收有差异,提出了基于血糖浓度标签差的特征波长挑选方法,并构建了标签敏感度支持向量机(LSSVR)预测模型。设计实验,对比该模型与偏最小二乘回归(PLSR)和区分度支持向量机(FSSVR)算法。结果表明,LS算法的最佳特征波长数为32,经特征波长选择后的LSSVR表现最佳,其均方误差降低至0.02 mmol·L^(-1),明显优于全谱段PLSR模型,血糖浓度的预测值与标签值的相关系数提升至99.8%,预测值全部位于可容许误差的克拉克网格A区内。LSSVR模型的优异表现为早日实现血糖的无创监测提供了新思路。 展开更多
关键词 无创血糖 近红外光谱 特征波长 Label sensitivity算法 支持向量机
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Synthesis and Characterization of Novel Schiff Base for Enhanced Dye-Sensitized Solar Cell Photo-Response Mechanism
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作者 Raphael Shadai Oguike Hanatu Akanagn Omolara Oni 《Crystal Structure Theory and Applications》 2024年第2期11-20,共10页
The efficient photo-response mechanism is one of the key factors in the commercialization of dye-sensitized solar cells in a bid to satisfy renewable energy demands. Progress in green technology has put solar energy o... The efficient photo-response mechanism is one of the key factors in the commercialization of dye-sensitized solar cells in a bid to satisfy renewable energy demands. Progress in green technology has put solar energy on the front burner as a provider of clean and affordable energy for a sustainable society. We report the synthesis of a novel Schiff base with optical transparency in the visible and near IR region of the solar spectrum that can find application in the DSSCs photo-response mechanism. The synthesized crystal exhibited features that could handle some of the shortcomings of dye-sensitized solar cells which include wide band solar spectrum absorption and capability for swift charge transfer within the photoelectrodes. The synthesized Schiff base was characterized using x-ray diffractometer, UV/Visible spectrometer, Frontier transmission infrared spectrometer and conductometer. XRD data revealed the grown crystal to have an average crystallite size of 2.08 nm with average microstrain value of about 269.43. The FT-IR recorded transmission wave ѵ (CO) at 1207.7 cm<sup>−1</sup> while dominant wave occurred at ѵ1654.9 and ѵ1592.3 cm<sup>−1</sup> relating to ѵ (CN) stretching and ѵ (NH) bending respectively were observed. The IR spectrum revealed the bonding species and a probable molecular structure of 2,6-bis(benzyloxy)pyridine. The UV/Visible spectra convoluted to maximum peak within the near IR region suggesting that 2,6-bis(benzyloxy)pyridine can absorb both the visible and near IR region while its electrical conductivity was determined to be 4.58 µS/cm. The obtained result of the present study revealed promising characteristics of a photosensitizer that can find application in the photo-response mechanism of DSSCs. 展开更多
关键词 Dye-sensitized Solar Cell Schiff Base PHOTOsensitIZER Optical Transparency BENZIL PYRIDINE
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Identification, pathogenicity, and fungicide sensitivity of Eutiarosporella dactylidis associated with leaf blight on maize in China
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作者 Cheng Guo Xiaojie Zhang +9 位作者 Baobao Wang Zhihuan Yang Jiping Li Shengjun Xu Chunming Wang Zhijie Guo Tianwang Zhou Liu Hong Xiaoming Wang Canxing Duan 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第3期888-900,共13页
Maize(Zea mays L.) is an economically vital grain crop that is cultivated worldwide. In 2011, a maize foliar disease was detected in Lingtai and Lintao counties in Gansu Province, China. The characteristic signs and s... Maize(Zea mays L.) is an economically vital grain crop that is cultivated worldwide. In 2011, a maize foliar disease was detected in Lingtai and Lintao counties in Gansu Province, China. The characteristic signs and symptoms of this disease include irregular chlorotic lesions on the tips and edges of infected leaves and black punctate fruiting bodies in dead leaf tissues. Given favourable environmental conditions, this disease spread to areas surrounding Gansu. In this study, infected leaves were collected from Gansu and Ningxia Hui Autonomous Region between 2018and 2020 to identify the disease-causing pathogen. Based on morphological features, pathogenicity tests, and multilocus phylogenetic analysis involving internal transcribed spacer(ITS), 18S small subunit rDNA(SSU), 28S large subunit rDNA(LSU), translation elongation factor 1-alpha(TEF), and β-tubulin(TUB) sequences, Eutiarosporella dactylidis was identified as the causative pathogen of this newly discovered leaf blight. Furthermore, an in vitro bioassay was conducted on representative strains using six fungicides, and both fludioxonil and carbendazim were found to significantly inhibit the mycelial growth of E. dactylidis. The results of this study provide a reference for the detection and management of Eutiarosporella leaf blight. 展开更多
关键词 maize leaf blight MORPHOLOGY molecular phylogeny Eutiarosporella dactylidis fungicide sensitivity
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A semi-analytical model for coupled flow in stress-sensitive multi-scale shale reservoirs with fractal characteristics
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作者 Qian Zhang Wen-Dong Wang +4 位作者 Yu-Liang Su Wei Chen Zheng-Dong Lei Lei Li Yong-Mao Hao 《Petroleum Science》 SCIE EI CAS CSCD 2024年第1期327-342,共16页
A large number of nanopores and complex fracture structures in shale reservoirs results in multi-scale flow of oil. With the development of shale oil reservoirs, the permeability of multi-scale media undergoes changes... A large number of nanopores and complex fracture structures in shale reservoirs results in multi-scale flow of oil. With the development of shale oil reservoirs, the permeability of multi-scale media undergoes changes due to stress sensitivity, which plays a crucial role in controlling pressure propagation and oil flow. This paper proposes a multi-scale coupled flow mathematical model of matrix nanopores, induced fractures, and hydraulic fractures. In this model, the micro-scale effects of shale oil flow in fractal nanopores, fractal induced fracture network, and stress sensitivity of multi-scale media are considered. We solved the model iteratively using Pedrosa transform, semi-analytic Segmented Bessel function, Laplace transform. The results of this model exhibit good agreement with the numerical solution and field production data, confirming the high accuracy of the model. As well, the influence of stress sensitivity on permeability, pressure and production is analyzed. It is shown that the permeability and production decrease significantly when induced fractures are weakly supported. Closed induced fractures can inhibit interporosity flow in the stimulated reservoir volume (SRV). It has been shown in sensitivity analysis that hydraulic fractures are beneficial to early production, and induced fractures in SRV are beneficial to middle production. The model can characterize multi-scale flow characteristics of shale oil, providing theoretical guidance for rapid productivity evaluation. 展开更多
关键词 Multi-scale coupled flow Stress sensitivity Shale oil Micro-scale effect Fractal theory
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A polarization sensitive interferometer:Delta interferometer
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作者 卫超奇 刘建彬 +7 位作者 董翼飞 孙雨农 周宇 郑淮斌 刘严严 闫秀生 李福利 徐卓 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第3期369-377,共9页
A new type of polarization sensitive interferometer is proposed,named the Delta interferometer,inspired by its geometry resembling the Greek letter Delta.The main difference between the Delta interferometer and other ... A new type of polarization sensitive interferometer is proposed,named the Delta interferometer,inspired by its geometry resembling the Greek letter Delta.The main difference between the Delta interferometer and other existing interferometers,such as Michelson,Mach-Zehnder and Young's double-slit interferometers,is that the two interfering paths are asymmetrical in the Delta interferometer.The visibility of the first-order interference pattern observed in the Delta interferometer is dependent on the polarization of the incidental light.Optical coherence theory is employed to interpret this phenomenon and single-mode continuous-wave laser light is employed to verify the theoretical predictions.The theoretical and experimental results are consistent.The Delta interferometer is a perfect tool to study the reflection of electromagnetic fields in different polarizations and may find applications in polarization-sensitive scenarios. 展开更多
关键词 phase sensitive interferometer Fresnel formula first-order interference
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Uncertainty and sensitivity analysis of in-vessel phenomena under severe accident mitigation strategy based on ISAA-SAUP program
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作者 Hao Yang Ji-Shen Li +2 位作者 Zhi-Ran Zhang Bin Zhang Jian-Qiang Shan 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第1期108-123,共16页
The phenomenology involved in severe accidents in nuclear reactors is highly complex.Currently,integrated analysis programs used for severe accident analysis heavily rely on custom empirical parameters,which introduce... The phenomenology involved in severe accidents in nuclear reactors is highly complex.Currently,integrated analysis programs used for severe accident analysis heavily rely on custom empirical parameters,which introduce considerable uncertainty.Therefore,in recent years,the field of severe accidents has shifted its focus toward applying uncertainty analysis methods to quantify uncertainty in safety assessment programs,known as“best estimate plus uncertainty(BEPU).”This approach aids in enhancing our comprehension of these programs and their further development and improvement.This study concentrates on a third-generation pressurized water reactor equipped with advanced active and passive mitigation strategies.Through an Integrated Severe Accident Analysis Program(ISAA),numerical modeling and uncertainty analysis were conducted on severe accidents resulting from large break loss of coolant accidents.Seventeen uncertainty parameters of the ISAA program were meticulously screened.Using Wilks'formula,the developed uncertainty program code,SAUP,was employed to carry out Latin hypercube sampling,while ISAA was employed to execute batch calculations.Statistical analysis was then conducted on two figures of merit,namely hydrogen generation and the release of fission products within the pressure vessel.Uncertainty calculations revealed that hydrogen production and the fraction of fission product released exhibited a normal distribution,ranging from 182.784 to 330.664 kg and from 15.6 to 84.3%,respectively.The ratio of hydrogen production to reactor thermal power fell within the range of 0.0578–0.105.A sensitivity analysis was performed for uncertain input parameters,revealing significant correlations between the failure temperature of the cladding oxide layer,maximum melt flow rate,size of the particulate debris,and porosity of the debris with both hydrogen generation and the release of fission products. 展开更多
关键词 Gen-III PWR Severe accident mitigation Wilks’formula HYDROGEN Fission products Uncertainty and sensitivity analysis
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Comparison of immune responses and intestinal flora in epicutaneously sensitized BALB/c or C57BL/6 mouse models of food allergy
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作者 Gang Yu Yuhao Jiang +6 位作者 Shuifeng Zhang Pengpeng Liu Shunyu Wang Huadong Sheng Yanbo Wang Qiaozhi Zhang Linglin Fu 《Food Science and Human Wellness》 SCIE CSCD 2024年第2期668-680,共13页
Cutaneous exposure to food allergens through a disrupted skin barrier is recognized as an important cause of food allergy,and the cutaneous sensitized mouse model has been established to investigate relevant allergic ... Cutaneous exposure to food allergens through a disrupted skin barrier is recognized as an important cause of food allergy,and the cutaneous sensitized mouse model has been established to investigate relevant allergic disorders.However,the role of different genetic backgrounds of mice on immune responses to food allergens upon epicutaneous sensitization is largely unknown.In this study,two strains of mice,i.e.,the BALB/c and C57BL/6 mice,were epicutaneously sensitized with ovalbumin on atopic dermatitis(AD)-like skin lesions,followed by intragastric challenge to induce IgE-mediated food allergy.Allergic outcomes were measured as clinical signs,specific antibodies and cytokines,and immune cell subpopulations,as well as changes in intestinal barrier function and gut microbiota.Results showed that both strains of mice exhibited typical food-allergic symptoms with a Th2-skewed response.The C57BL/6 mice,rather than the BALB/c mice,were fitter for establishing an epicutaneously sensitized model of food allergy since a stronger Th2-biased response and severer disruptions in the intestinal barrier and gut homeostasis were observed.This study provides knowledge for selecting an appropriate mouse model to study food-allergic responses associated with AD-like skin lesions and highlights the role of genetic variations in the immune mechanism underlying pathogenesis of food allergy. 展开更多
关键词 Food allergy Mouse models Epicutaneous sensitization Th2 response Gut microbiota
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Phase sensitivity with a coherent beam and twin beams via intensity difference detection
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作者 刘俊 邵涛 +4 位作者 李晨露 张敏洋 胡友友 陈东旭 卫栋 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第1期400-406,共7页
We focus on the Mach–Zehnder interferometer(MZI) with the input of a coherent beam and one of the bright entangled twin beams with an external power reference beam employed for measurement. The results show that the ... We focus on the Mach–Zehnder interferometer(MZI) with the input of a coherent beam and one of the bright entangled twin beams with an external power reference beam employed for measurement. The results show that the phase sensitivity can reach sub-Heisenberg limit and approach quantum Cramer–Rao bound by changing the squeezing parameters and the photon number of the coherent beam, under the phase-matching condition. The absence of the external power reference beam will degrade the performance of the phase sensitivity. Meanwhile, this scheme shows good robustness against the losses of the photon detectors. We present a detailed discussion about the phase sensitivities when the inputs are two coherent beams, or a coherent beam plus a single-mode squeezed vacuum beam based on the MZI. This scenario can be applied in the field of phase precision measurements and other optical sensors. 展开更多
关键词 Mach–Zehnder interferometer phase sensitivity quantum squeezing
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An impact sensitivity assessment method of spacecraft based on virtual exterior wall
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作者 Runqiang Chi Yuyan Liu +1 位作者 Diqi Hu Baojun Pang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第1期142-157,共16页
The impact sensitivity assessment of spacecraft is to obtain the probability of spacecraft encountering the OD/M(orbital debris or meteoroid),which is a prerequisite for survivability assessment of on-orbit spacecraft... The impact sensitivity assessment of spacecraft is to obtain the probability of spacecraft encountering the OD/M(orbital debris or meteoroid),which is a prerequisite for survivability assessment of on-orbit spacecraft.An impact sensitivity assessment method of spacecraft based on virtual exterior wall was proposed to improve the computational efficiency.This method eliminates determination of the outermost surface elements of the spacecraft before generating the debris rays,which are assumed to originate from a non-concave virtual wall that completely wraps the spacecraft.The Dist Mesh method was adopted for the generating of the virtual wall to ensure its mesh quality.The influences of the sizes,mesh densities,shapes of the virtual wall on the efficiency and accuracy were considered to obtain the best combination of the size and mesh density of the wall and spacecraft.The results of this method were compared with those of S3DE(Survivability of Spacecraft in Space Debris Environment),BUMPER,MDPANTO,ESABASE2/Debris to verify the feasibility of the method.The PCHIP(Piecewise Cubic Hermite Interpolating Polynomial)was used to fit the size vs.flux relationship of the space debris to acquire the impact probability of OD/M with arbitrary size on the spacecraft. 展开更多
关键词 sensitivity OD/M SPACECRAFT Virtual exterior wall
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Distribution of pathogenic bacteria and antimicrobial sensitivity of eye infections in Suzhou
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作者 Li Zhang Hai-Zhang You +4 位作者 Guo-Hui Wang Wei Xu Jian-Shan Li Qing-Liang Zhao Shu Du 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第4期700-706,共7页
AIM:To investigate the types of bacteria in patients with eye infections in Suzhou and their drug resistance to commonly used antibacterial drugs.METHODS:The clinical data of 155 patients were retrospectively collecte... AIM:To investigate the types of bacteria in patients with eye infections in Suzhou and their drug resistance to commonly used antibacterial drugs.METHODS:The clinical data of 155 patients were retrospectively collected in this study,and the pathogenic bacteria species and drug resistance of each pathogenic bacteria were analyzed.RESULTS:Among the 155 patients(age from 12 to 87 years old,with an average age of 57,99 males and 56 females)with eye infections(160 eyes:74 in the left eye,76 in the right eye and 5 in both eyes,all of which were exogenous),71(45.81%)strains were gram-positive bacteria,23(14.84%)strains were gram-negative bacteria and 61(39.35%)strains were fungi.Gram-positive bacteria were highly resistant to penicillin and erythromycin(78.87%and 46.48%respectively),but least resistant to vancomycin at 0.Gram-negative bacteria were highly resistant to cefoxitin and compound sulfamethoxazole(100%and 95.65%respectively),but least resistant to meropenem at 0.Comparison of the resistance of gram-positive and gram-negative bacteria to some drugs revealed statistically significant differences(P<0.05)in the resistance of both to cefoxitin,cotrimoxazole,levofloxacin,cefuroxime,ceftriaxone and ceftazidime,and both had higher rates of resistance to gram-negative bacteria than to gram-positive bacteria.The distribution of bacterial infection strains showed that Staphylococcus epidermidis was the most common strain in the conjunctiva,cornea,aqueous humor or vitreous body and other eye parts.Besides,Fusarium and Pseudomonas aeruginosa were also among the most common strains of conjunctival and corneal infections.CONCLUSION:Gram-positive bacteria are the dominant bacteria in eye infections,followed by gram-negative bacteria and fungi.Considering the resistance of gramnegative bacteria to multiple drugs,monitoring of bacteria should be strengthened in eye bacterial infections for effective prevention and control to reduce complications caused by eye infections. 展开更多
关键词 eye infection pathogenic bacteria drug resistance antimicrobial sensitivity test
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A Bayesian multi-model inference methodology for imprecise momentindependent global sensitivity analysis of rock structures
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作者 Akshay Kumar Gaurav Tiwari 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第3期840-859,共20页
Traditional global sensitivity analysis(GSA)neglects the epistemic uncertainties associated with the probabilistic characteristics(i.e.type of distribution type and its parameters)of input rock properties emanating du... Traditional global sensitivity analysis(GSA)neglects the epistemic uncertainties associated with the probabilistic characteristics(i.e.type of distribution type and its parameters)of input rock properties emanating due to the small size of datasets while mapping the relative importance of properties to the model response.This paper proposes an augmented Bayesian multi-model inference(BMMI)coupled with GSA methodology(BMMI-GSA)to address this issue by estimating the imprecision in the momentindependent sensitivity indices of rock structures arising from the small size of input data.The methodology employs BMMI to quantify the epistemic uncertainties associated with model type and parameters of input properties.The estimated uncertainties are propagated in estimating imprecision in moment-independent Borgonovo’s indices by employing a reweighting approach on candidate probabilistic models.The proposed methodology is showcased for a rock slope prone to stress-controlled failure in the Himalayan region of India.The proposed methodology was superior to the conventional GSA(neglects all epistemic uncertainties)and Bayesian coupled GSA(B-GSA)(neglects model uncertainty)due to its capability to incorporate the uncertainties in both model type and parameters of properties.Imprecise Borgonovo’s indices estimated via proposed methodology provide the confidence intervals of the sensitivity indices instead of their fixed-point estimates,which makes the user more informed in the data collection efforts.Analyses performed with the varying sample sizes suggested that the uncertainties in sensitivity indices reduce significantly with the increasing sample sizes.The accurate importance ranking of properties was only possible via samples of large sizes.Further,the impact of the prior knowledge in terms of prior ranges and distributions was significant;hence,any related assumption should be made carefully. 展开更多
关键词 Bayesian inference Multi-model inference Statistical uncertainty Global sensitivity analysis(GSA) Borgonovo’s indices Limited data
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Synthesis and Charcterization of Silane Crosslinked Hydrogel to pH Sensitive Study
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作者 Muhammad Awais Shahid Abdul Haseeb Tahir +1 位作者 Zeeshan Ahmad Muhammad Arslan 《American Journal of Analytical Chemistry》 CAS 2024年第5期165-176,共12页
Eco-friendly and biodegradable novel hydrogel were prepared by blending and solution casting method. The designed hydrogel is based on chitosan/ PEG600/Gurgam with carbon nanofiller along silane crosslinked (TEOS) wit... Eco-friendly and biodegradable novel hydrogel were prepared by blending and solution casting method. The designed hydrogel is based on chitosan/ PEG600/Gurgam with carbon nanofiller along silane crosslinked (TEOS) with pH sensitive response to controlled release of drug in biomedical materials and agriculture industry. The various concentration of carbon nanofiller is used to analyze its effect on the fabricated hydrogel characteristics by using FTIR, SEM, TGA, swelling studies (water, buffer and ionic solution). Spectra of FTIR reflected both established and newly developed groups (like hydrogel). COOH group presence is clearly observed in this range in the carbon filler reinforced hydrogel. The SEM micrographs show that CPG0.003 had a collection of polysaccharide chains as thin helices, which is attributed to the increase in the size of porosity. TGA shows to increase concentration of nanofiller enhanced the thermal stability of the designed hydrogels at temperature 25˚C to 550˚C mass loss percentage decrease upto 20% and increase thermal stability. This pH response made these resultant hydrogels as fruitful competitor against the many reported controlled release application. 展开更多
关键词 CHITOSAN Guargum HYDROGEL Carbon Nano Filler Silane Cross Linker pH sensitive
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Antarctic red algae in dye-sensitized photoelectrochemical cells for water splitting
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作者 Florentina ARISPE María Fernanda CERDÁ 《Advances in Polar Science》 CSCD 2024年第2期219-227,共9页
Phycoerythrin extracted from Antarctic red seaweeds shows promising characteristics to be applied as an anode sensitizer in water-splitting photoelectrochemical cells.Under light irradiation and using an LED lamp,the ... Phycoerythrin extracted from Antarctic red seaweeds shows promising characteristics to be applied as an anode sensitizer in water-splitting photoelectrochemical cells.Under light irradiation and using an LED lamp,the red-colored protein shows an interesting ability to profit the incident light,as confirmed by the presence of oxygen bubbles next to the electrode surface without applying any external potential.Our results showed that the addition of iodide is helpful to allow the regeneration of the dye;nevertheless,oxygen evolution is not favored.Thermodynamics analysis of the involved semi-reactions is also helpful to understand the observed results.The exploration of Antarctic resources offers then an alternative for the development of green energies,with a particular focus on their use as sensitizers to profit from the sunlight in water-splitting as well as in photovoltaic devices. 展开更多
关键词 sensitIZERS WATER-SPLITTING red algae ELECTROCHEMICAL
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Sensitivity of Commercial Enzyme Inhibition Colorimetric Pesticide Residue Rapid Test Kit to a Variety of Pesticides
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作者 Junxia LUO Qianqian ZHAO +4 位作者 Lumei DUAN Yanzhen LI Huifang QIAO Zhipei DOU Jianbo ZHAO 《Asian Agricultural Research》 2024年第5期29-32,共4页
[Objectives]To fully understand the quality of commercial enzyme inhibition-colorimetric pesticide residue rapid detection kits,so that they can play a greater role in the detection and supervision of agricultural pro... [Objectives]To fully understand the quality of commercial enzyme inhibition-colorimetric pesticide residue rapid detection kits,so that they can play a greater role in the detection and supervision of agricultural products.[Methods]The sensitivity of 28 kinds of pesticides was determined by using the commercially available enzyme inhibition colorimetric rapid detection kit with Hendu brand.[Results]There was a significant difference in the sensitivity of the kit to each pesticide,and the kit was more sensitive to dichlorvos among the 28 pesticides tested.The sensitivity to methyl isosalifos,dimethoate,isocarbophos,fenthion and phorate was poor,and the sensitivity to quinalphos was different between 3.0 and 2.5 mL.[Conclusions]The large difference of the sensitivity of the enzyme inhibition-colorimetric rapid detection kit for pesticide residues to different kits is a reason for the false positive and false negative test results of the kit,which needs to be considered by relevant personnel. 展开更多
关键词 Enzyme inhibition-colorimetry Reagent kit PESTICIDE Inhibition rate sensitivity
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Evidence-Based Nursing Practice of Reducing Immune-Related Skin Toxicity of Tumor Patients Guided by Sensitive Indicators
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作者 Lingling Tang Qiong Wen 《Journal of Biosciences and Medicines》 2024年第4期210-215,共6页
Purpose research on nursing sensitive indicators in tumor Patients application effect in immune-related skin toxicity management. Method select our hospital April to June, 202360 cases patients with immune therapy set... Purpose research on nursing sensitive indicators in tumor Patients application effect in immune-related skin toxicity management. Method select our hospital April to June, 202360 cases patients with immune therapy settings as the control group. August-October, 2023 60 cases the patients treated with immune therapy were the experimental group. The control group adopted regular nursing methods, while the experimental group sensitive Indicators, evidence-based give preventive care. The social situation, psychological state, physical function, quality of life score, incidence of skin toxicity caused by immune checkpoint inhibitors, moderate and above of the two groups of patients were compared. Incidence of skin toxicity. Result: experience group SAS score, SDS score higher than the control group, the difference was statistically significant (P < 0.05);The incidence of skin toxic reactions caused by immune checkpoint inhibitors and the incidence of moderate and above skin toxic reactions in the experimental group are lower than those in the control group, and the difference is statistically significant (P < 0.05). Conclusion: sensitive indicator guidance evidence-based preventive care can reduce the degree of immune-related skin toxicity, improve the psychological state and quality of life of tumor patients treated with immune therapy and reduce the incidence of adverse reactions, improve nursing quality and patient satisfaction. 展开更多
关键词 sensitive Indicators Immune-Related Skin Toxicity Evidence-Based Practice Tumor
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Sensitive Information Security Based on Elliptic Curves
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作者 Nadine Nibigira Vincent Havyarimana Zhu Xiao 《World Journal of Engineering and Technology》 2024年第2期274-285,共12页
The elliptic curve cryptography algorithm represents a major advancement in the field of computer security. This innovative algorithm uses elliptic curves to encrypt and secure data, providing an exceptional level of ... The elliptic curve cryptography algorithm represents a major advancement in the field of computer security. This innovative algorithm uses elliptic curves to encrypt and secure data, providing an exceptional level of security while optimizing the efficiency of computer resources. This study focuses on how elliptic curves cryptography helps to protect sensitive data. Text is encrypted using the elliptic curve technique because it provides great security with a smaller key on devices with limited resources, such as mobile phones. The elliptic curves cryptography of this study is better than using a 256-bit RSA key. To achieve equivalent protection by using the elliptic curves cryptography, several Python libraries such as cryptography, pycryptodome, pyQt5, secp256k1, etc. were used. These technologies are used to develop a software based on elliptic curves. If built, the software helps to encrypt and decrypt data such as a text messages and it offers the authentication for the communication. 展开更多
关键词 CRYPTOGRAPHY Elliptic Curves Digital Security Data sensitive Data IMPLEMENTATION
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Environmental Sensitivity Index Mapping for Environmental Sustainable Cleanup along NAOC Pipeline, Asemoku, Delta State, Nigeria
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作者 Chineme Christabel Ifuwe Christopher Onosemuode 《Journal of Geographic Information System》 2024年第2期148-165,共18页
During emergency response to oil spills incident accurate information is required in order to reduce the risk associated with oil spill disasters. This study focuses on Environmental Sensitivity mapping for sustainabl... During emergency response to oil spills incident accurate information is required in order to reduce the risk associated with oil spill disasters. This study focuses on Environmental Sensitivity mapping for sustainable environmental clean-up and contingency planning along the 3.0 km of AGIP pipeline at Asemoku in Delta State, Nigeria. Geographic information systems (GIS) techniques were used to create an Environmental Sensitivity Index (ESI) map in the study area. A 2018 Google Earth Satellite imagery of the study area was downloaded, and landuse/cover classification scheme comprising of Vegetation, Farmland, Water Body, Wetland, built up area and Bare Surface was adopted. Existing categorization, ranking and classification of the inland habitat were adopted and used to create a Landuse/cover Environmental Sensitivity Index (ESI) map, while the buffer zones of 100 m, 200 m, 300 m and 400 m were adopted. In the ArcGIS 10.8 environment, the landuse/cover map was generated and buffer distances of 100 m, 200 m, 300 m and 400 m were created on the landuse/cover map to ascertain the features that are vulnerable and could be at risk in the event of oil spill. This study established that the Natural Vegetation areas are the most vulnerable and sensitive feature as a result of their size along the created buffer zones. Findings from this study thus provide insight into the most sensitive land-use/land-cover, in the event of a spill or emergency oil spill clean-up response. 展开更多
关键词 sensitivity-Index-Mapping Environmental-Sustainability Land-Use/Land-Cover Asemoku
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