Effects of Dropsonde Data in Field Campaigns on Forecasts of Tropical Cyclones over the Western North Pacific in 2020 and the Role of CNOP Sensitivity

Valuable dropsonde data were obtained from multiple field campaigns targeting tropical cyclones,namely Higos,Nangka,Saudel,and Atsani,over the western North Pacific by the Hong Kong Observatory and Taiwan Central Weather Bureau in 2020.The conditional nonlinear optimal perturbation(CNOP)method has been utilized in real-time to identify the sensitive regions for targeting observations adhering to the procedure of real-time field campaigns for the first time.The observing system experiments were conducted to evaluate the effect of dropsonde data and CNOP sensitivity on TC forecasts in terms of track and intensity,using the Weather Research and Forecasting model.It is shown that the impact of assimilating all dropsonde data on both track and intensity forecasts is case-dependent.However,assimilation using only the dropsonde data inside the sensitive regions displays unanimously positive effects on both the track and intensity forecast,either of which obtains comparable benefits to or greatly reduces deterioration of the skill when assimilating all dropsonde data.Therefore,these results encourage us to further carry out targeting observations for the forecast of tropical cyclones according to CNOP sensitivity.

Relationship between contrast sensitivity and corneal shape following overnight orthokeratology

AIM: To evaluate the relationship between contrast sensitivity(CS) and corneal shape following overnight orthokeratology(OK). METHODS: We conducted a retrospective clinical study of 80 lens-wearing myopia patients, all of whom had undergone OK and had been evaluated by Orbscan II topography. We measured the surface irregularity index(SIRI) of corneal topography at 3 and 5 mm, the size of the flattened central corneal curvature of OK lens(zone A), the size of the cornea altered by OK lens(zone B), the size of the pupillary area at the corneal level(zone C), the area of crossover between zones A and C(zone AC), the area of crossover between zones B and C(BC), the ratio of BC to B(BC/B), and the ratio of AC to C(AC/C). CS was evaluated using the CSV-1000 with spatial frequencies of 3, 6, 12, and 18 cycles/degree(CPD). RESULTS: Multiple correlation analyses indicated significant negative correlations between CS, zone C, BC/B, and 3-mm SIRI(all P<0.01). There were no significant differences between CS, zone B, AC/A, or 5-mm SIRI(P=0.60, 0.94 and 0.11, respectively). Zone C was negatively correlated with 3, 6, 12, and 18 CPD. 5-mm SIRI were negatively correlated with 6, 12, and 18 CPD. BC/C was negatively correlated with 6 and 18 CPD. AC/C was positively correlated with 3 CPD. CONCLUSION: Zone C, 3-mm SIRI and BC/B affect the CS following overnight OK.

Sensitivity of WRF simulated typhoon track and intensity over the South China Sea to horizontal and vertical resolutions

To determine the grid resolutions of the WRF model in the typhoon simulation,some sensitivity analysis of horizontal and vertical resolutions in different conditions has been carried out.Different horizontal resolutions(5,10,20,30 km),nesting grids(15 and 5 km),different vertical resolutions(35-layers,28-layers,20-layers)and different top maximum pressures(1 000,2 000,3 500,5 000 Pa)had been used in the mesoscale numerical model WRF to simulate the Typhoon Kai-tak.The simulation results of typhoon track,wind speed and sea level pressure at different horizontal and vertical resolutions have been compared and analyzed.The horizontal and vertical resolutions of the model have limited effect on the simulation effect of the typhoon track.Different horizontal and vertical resolutions have obvious effects on typhoon strength(defined by wind speed)and intensity(defined by sea level pressure,SLP),especially for sea level pressure.The typhoon intensity simulated by the high-resolution model is closer to the real situation and the nesting grids can improve computational accuracy and efficiency.The simulation results affected by vertical resolution using 35-layers is better than the simulation results using 20-layers and 28-layers simulations.Through comparison and analysis,the horizontal and vertical resolutions of WRF model are finally determined as follows:the two-way nesting grid of 15 and 5 km is comprehensively determined,and the vertical layers is 35-layers,the top maximum pressure is 2 000 Pa.

A sensitivity study of the WRF model in offshore wind modeling over the Baltic Sea

Accurate wind modeling is important for wind resources assessment and wind power forecasting. To improve the WRF model configuration for the offshore wind modeling over the Baltic Sea, this study performed a sensitivity study of the WRF model to multiple model configurations, including domain setup,grid resolution, sea surface temperature, land surface data, and atmosphere-wave coupling. The simulated offshore wind was evaluated against LiDAR observations under different wind directions, atmospheric stabilities, and sea status. Generally, the simulated wind profiles matched observations, despite systematic underestimations. Strengthening the forcing from the reanalysis data through reducing the number of nested domains played the largest role in improving wind modeling. Atmosphere-wave coupling further improved the simulated wind, especially under the growing and mature sea conditions.Increasing the vertical resolution, and updating the sea surface temperature and the land surface information only had a slight impact, mainly visible during very stable conditions. Increasing the horizontal resolution also only had a slight impact, most visible during unstable conditions. Our study can help to improve the wind resources assessment and wind power forecasting over the Baltic Sea.

An Improvement of the Mass Flux Convection Parameterization Scheme and its Sensitivity Tests for Seasonal Prediction over China

A modified cumulus parameterization scheme, suitable for use in a seasonal forecast model, is presented. This parameterization scheme is an improvement of the mass flux convection scheme developed by Gregory and Rowntree (1989; 1990). This convection scheme uses a 'bulk' cloud model to present an ensemble of convective clouds, and aims to represent shallow, deep, and mid-level convection. At present, this convection scheme is employed in the NCC T63L20 model (National Climate Center, China Meteorological Administration). Simulation results with this scheme have revealed some deficiencies in the scheme, although to some extent, it improves the accuracy of the simulation. In order to alleviate the deficiencies and reflect the effect of cumulus convection in the actual atmosphere, the scheme is modified and improved. The improvements include (i) the full estimation of the effects of the large-scale convergence in the lower layer upon cumulus convection, (ii) the revision of the initial convective mass flux, and (iii) the regulation of convective-scale downdrafts. A comparison of the results obtained by using the original model and the modified one shows that the improvement and modification of the original convection scheme is successful in simulating the precipitation and general circulation field, because the modified scheme provides a good simulation of the main features of seasonal precipitation in China, and an analysis of the anomaly correlation coefficient between the simulation and the observations confirms the improved results.

SENSITIVITY FACTORS FOR TYPHOON GENESIS OVER THE WESTERN NORTH PACIFIC DURING JULY-SEPTEMBER

The paper compares the correlations between individual factors of the cyclogenesis and the number of TCs formed in the western North Pacific in July to September(NTWNP). It also compares the characteristics of zonal anomaly distribution of the factors in the primary TC source areas of the Northern Hemisphere. Results show that the vorticity factor has the closest correlation with NTWNP. In TC genesis conditions, this feature is relatively rich but not enough, which determines that it is the sensitivity factor of NTWNP's annual variation. The paper also analyzes the source of annual variation of the vorticity factor in the key area of the western North Pacific as well as its advantage in showing NTWNP. Results show that the annual variation of the vorticity factor mentioned above is related to the annual variation of Southern Oscillation, Antarctica Oscillation and the geopotential height field of East Australia, which reflects the effect of two large-scale systems in the Southern Hemisphere and ENSO(El Ni?o–Southern Oscillation) on NTWNP. Since the area where the vorticity factor is significantly correlated with NTWNP is consistent with the area of dense TC genesis sources, the vorticity factor has an obvious advantage in showing annual variation of TCs. Those features are very significant for research on the influencing mechanism of NTWNP and simulation of climate models.

Nanoparticle aggregation effects on radiative heat transport of nanoliquid over a vertical cylinder with sensitivity analysis

A sensitivity analysis is performed to analyze the effects of the nanoparticle(NP)aggregation and thermal radiation on heat transport of the nanoliquids(titania based on ethylene glycol)over a vertical cylinder.The optimization of heat transfer rate and friction factor is performed for NP volume fraction(1%≤φ≤3%),radiation parameter(1≤R_(t)≤3),and mixed convection parameter(1.5≤λ≤2.5)via the facecentered central composite design(CCD)and the response surface methodology(RSM).The modified Krieger and Dougherty model(MKDM)for dynamic viscosity and the Bruggeman model(BM)for thermal conductivity are utilized to simulate nanoliquids with the NP aggregation aspect.The complicated nonlinear problem is treated numerically.It is found that the temperature of nanoliquid is enhanced due to the aggregation of NPs.The friction factor is more sensitive to the volume fraction of NPs than the thermal radiation and the mixed convection parameter.Furthermore,the heat transport rate is more sensitive to the effect of radiative heat compared with the NP volume fraction and mixed convection parameter.

Availability of Heat Conduction for Environmental Control Method to Improving Thermal Environment and Preventing Oversensitivity to Cold and Air-Conditioning Disease on Female Office Workers

The purpose of this study is to demonstrate the effect localized heating of the feet has on physiological and psychological reactions of female in an air-conditioned environment in summer. In Japan, female office workers wear less clothing than their male counterparts. In an air-conditioned office space in summer, female conducts thermoregulation by putting on cardigans, etc. but this action does not greatly contribute to improving conditions for the legs and feet, the lower extremities of the body. The improvement of sensational and physiological temperature by localized warming of the body can contribute to a healthy working environment for female office workers, their safety, and a reduction in air conditioning’s energy expenditure. We used the indoor thermal environment evaluation index ETF to investigate the effect localized heating of the feet has on human physiological and psychological response in an air-conditioned environment in summer. The result of heating by means of heat conduction via the sole of the foot was expressed more strongly as a psychological effect than as a whole-body physiological effect. Heating by means of heat conduction via the sole of the foot was a thermal environment factor that compensates for a low temperature in whole-body thermal sensation and whole-body thermal comfort. The effect of heating due to heat conduction via the sole of the foot was expressed in the change in sole-of- the-foot skin temperature. Applying slight heat conduction by means of heating via the sole of the foot demonstrated the result of improved whole-body thermal sensation and whole-body thermal comfort.

Evaluating Sensitivity to Different Options and Parameterizations of a Coupled Air Quality Modelling System over Bogotá, Colombia. Part I: WRF Model Configuration

Meteorological inputs are of great importance when implementing an air quality prediction system. In this contribution, the Weather Research and Forecast (WRF-ARW) model was used to compare the performance of the different cumulus, microphysics and Planet Boundary Layer parameterizations over Bogotá, Colombia. Surface observations were used for comparison and the evaluated meteorological variables include temperature, wind speed and direction and relative humidity. Differences between parameterizations were observed in meteorological variables and Betts-Miller-Janjic, Morrison 2-moment and BouLac schemes proved to be the best parameterizations for cumulus, microphysics and PBL, respectively. As a complement to this study, a WRF-Large Eddy Simulation was conducted in order to evaluate model results with finer horizontal resolution for air quality purposes.

Effect of Employees’ Pay-performance Sensitivity on Future Firm Performance: Evidence from State-owned Listed Enterprises in China over 2007-2015

Taking a balanced panel data consisting of 4365 firm-year observations drawn from the listed state-owned enterprises in Shanghai and Shenzhen Stock Exchange over 2007-2015 as the research sample,the paper examines the effect of the employees’pay-performance sensitivity(PPS)on the future firm performance from the two competing perspectives of“incentive effect”and“risk-aversion effect”,adopting the method of multiple regression analysis based on OLS and applying the SPSS23 as the data processing tool.Theoretical analysis and empirical results demonstrate that there is a positive link between the employees’PPS and the future firm performance.To improve the employees’PPS can stimulate the engagement of the employees,improve their working quality,enrich their workplace innovative behavior,and further lead to higher future firm performance.Meanwhile,the positive effect of the employees’PPS on the future firm performance is,on average,lower than that of the top executives’PPS on the future firm performance.Implications of the findings are provided in the end.

Experimental study about the regulating effect of Par-4 gene overexpression on the nephroblastoma sensitivity to cisplatin

Objective: To study the regulating effect of Par-4 gene overexpression on the nephroblastoma sensitivity to cisplatin. Methods: Nephroblastoma SK-NEP-1 cells were cultured and divided into four groups, control group were treated with RMPI-1640 without serum or drugs, cisplatin group were treated with serum-free RMPI-1640 containing 5 μg/mL cisplatin, Par-4 group were transfected by Par-4 overexpression plasmids with serum-free RMPI-1640, and cisplatin+ Par-4 group were transfected by Par-4 overexpression plasmid with serum-free RMPI-1640 containing 5 μg/mL cisplatin. The cell proliferation activity as well the expression of apoptosis genes, migration genes and invasion genes was measured. Results: 8 h, 16 h and 24 h after different conditions of treatment, the cell proliferation activity of cisplatin group, Par-4 group and cisplatin + Par-4 group were significantly lower than that of control group, and the cell proliferation activity of cisplatin + Par-4 group was significantly lower than that of cisplatin group and Par-4 group;24 h after different conditions of treatment, Bim, PDCD4, WT1, RGS4, Axin, KAI1, E-cadherin, PPARγ and PTEN mRNA expression in cisplatin group, Par-4 group and cisplatin + Par-4 group were greatly higher than those in control group whereas GDNF, GFRα1, TUBB3, NME1 and FGF1 mRNA expression were greatly lower than those in control group;Bim, PDCD4, WT1, RGS4, Axin, KAI1, E-cadherin, PPARγ and PTEN mRNA expression in cisplatin + Par-4 group were greatly higher than those in cisplatin group and Par-4 group whereas GDNF, GFRα1, TUBB3, NME1 and FGF1 mRNA expression were greatly significantly lower than those in cisplatin group and Par-4 group. Conclusion:Par-4 gene overexpression can increase the nephroblastoma sensitivity to cisplatin, reduce cell proliferation activity, promote apoptosis and inhibit cell migration and invasion.

近红外无创血糖浓度的Label Sensitivity算法和支持向量机回归

近红外光谱分析技术在生物医学工程领域具有广阔应用前景。无创且持续性地测量能实时监控人体血糖水平,给糖尿病患者带来极大便利性、提高生存质量、降低糖尿病并发症发生率具有很大的社会效益。无创血糖监测的想法提出较早,但仍然存在预测精度低、预测值与标签值相关性不高等难点,至今没有达到临床要求。近年来,光谱检测技术发展迅猛且机器学习技术在智能信息处理方面具有明显优势,两者结合可以有效提高人体无创血糖医学监测模型的精度和普适性。提出了一种标签敏感度算法(LS),并结合支持向量机方法建立了人体血糖含量预测模型。使用近红外光谱仪采集了4名志愿者食指处动态血液光谱数据(每名志愿者28组数据),并使用多元散射矫正(MSC)方法消除了部分光散射的影响。考虑血糖对不同波长光的吸收有差异,提出了基于血糖浓度标签差的特征波长挑选方法,并构建了标签敏感度支持向量机(LSSVR)预测模型。设计实验,对比该模型与偏最小二乘回归(PLSR)和区分度支持向量机(FSSVR)算法。结果表明,LS算法的最佳特征波长数为32,经特征波长选择后的LSSVR表现最佳,其均方误差降低至0.02 mmol·L^(-1),明显优于全谱段PLSR模型,血糖浓度的预测值与标签值的相关系数提升至99.8%,预测值全部位于可容许误差的克拉克网格A区内。LSSVR模型的优异表现为早日实现血糖的无创监测提供了新思路。

Sensitivity analysis of key input parameters in conditional cell transmission model for oversaturated arterials

A novel conditional cell transmission model (CCTM) is a potential simulation tool because it accommodates all traffic conditions from light condition to oversaturated condition.To test the performance of the CCTM,a series of experiments for sensitivity analysis were designed and performed for a multilane,two-way,three-signal sample network.Experiment 1 shows that the model is performed in a logical and expected manner with variations in traffic demand with time and direction.Experiment 2 shows when the possibility of the occurrence of a useful gap increases to 60% and 100%,the delays in left turns decrease by 5% and 15%,respectively.In Experiment 3,comparing the possibility of a conditional cell of 0 with 100%,delay of left turn and delay of the entire network were underestimated by 58% and 11%,respectively.Hence,sensitivity analysis demonstrates that by reflecting local drivers' behaviors properly,the CCTM provides an accurate representation of traffic flow in simulating oversaturated traffic conditions.

Sensitivity of the Number of Snow Cover Days to Surface Air Temperature over the Qinghai-Tibetan Plateau

基于雪盖子天(NSCD ) 的数字并且一致为时期的表面空气温度数据 19512004，这研究在 Qinghai 西藏的高原(QTP ) 上在 NSCD 的敏感上执行定量分析到表面空气温度。结果证明在当前的气候下面的极端敏感和敏感比在 QTP 的中央区域在边是更高的。在那里存在在车站举起和批评温度，敏感在到达极值之间的强壮的否定关联。在举起和极端敏感之间的否定关联不象以前的一样强壮。当前，在许多车站的 climatological 温度不到达批评阶段。在这些车站的敏感将在温暖的气候的当前的背景下面变得更大，它意味着 NSCD 将对表面空气温度更敏感。引证妈， L. ， D。Qin， L。Bian，等， 2010：到在 Qinghai 西藏的高原上的表面空气温度的雪盖子天的数字的敏感。副词。Clim。变化物件， 1， doi：10.3724/SP .J.1248.2010.00076。

How long does the recovery of corneal sensitivity in different corneal regions take after LASEK?

AIM:To determine the corneal sensitivity recovery period after laser-assisted sub-epithelial keratectomy(LASEK)refractive surgery and investigate the effects of ablation depth on it.METHODS:In this study examinations were performed on 90 right eyes of 90 people(34 males and 56 females)with an age range of 20-35 and an average of 22.26±3.8 years old.A sensation of 5 corneal regions,including the center and 4 mid-peripheral regions,i.e.,nasal,inferior,temporal,and superior,each at a distance of 2 mm from the center of the cornea were measured with a Cochet-Bonnet esthesiometer device in 3-time points including before LASEK,1 and 3mo after the surgery,respectively.LASEK was performed on individuals with stabilized myopia of -1.00 to -7.00 diopters and astigmatism of less than 2.00 diopters.Furthermore,the individuals were divided into three groups regarding ablation depth.RESULTS:The highest level of corneal sensitivity before surgery was related to the center of the cornea(59.1±7.76),and the highest level of corneal sensitivity loss was also related to this region.The sensation of all measured corneal regions significantly reduced 1mo postoperatively and returned to their preoperative levels 3mo after surgery(mean of 5 corneal regions in levels of preoperation:58.2±6.48,1mo postoperation:57.3±5.84,3mo postoperation:58.2±5.49;P<0.05).A significant relationship was found between ablation depth and corneal sensitivity changes in the center and temporal regions(P<0.05).CONCLUSION:Corneal sensitivity in myopia and low astigmatism decreases after LASEK and reaches the preoperative level within 3mo.The depth of ablation during surgery affected the recovery of corneal sensitivity.

Impact of hepatitis C virus heterogeneity on interferon sensitivity:An overview

Hepatitis C virus(HCV)is a major cause of liver disease worldwide.HCV is able to evade host defense mechanisms,including both innate and acquired immune responses,to establish persistent infection,which results in a broad spectrum of pathogenicity,such as lipid and glucose metabolism disorders and hepatocellular carcinoma development.The HCV genome is characterized by a high degree of genetic diversity,which can be associated with viral sensitivity or resistance(reflected by different virological responses)to interferon(IFN)-based therapy.In this regard,it is of importance to note that polymorphisms in certain HCV genomic regions have shown a close correlation with treatment outcome.In particular,among the HCV proteins,the core and nonstructural proteins(NS)5A have been extensively studied for their correlation with responses to IFN-based treatment.This review aims to cover updated information on the impact of major HCV genetic factors,including HCV genotype,mutations in amino acids 70 and91 of the core protein and sequence heterogeneity in the IFN sensitivity-determining region and IFN/ribavirin resistance-determining region of NS5A,on virological responses to IFN-based therapy.

Spatial sensitivity to absorption changes for various near-infrared spectroscopy methods:A compendium review

This compendium review focuses on the spatial distribution of sensitivity to localized absorption changes in optically diffuse media,particularly for measurements relevant to near-infrared spectroscopy.The three temporal domains,continuous wave,frequency domain,and time domain,each obtain different optical data types whose changes may be related to effective homogeneous changes in the absorption coefficient.Sensitivity is the relationship between a localized perturbation and the recovered effective homogeneous absorption change.Therefore,spatial sensitivity maps representing the perturbation location can be generated for the numerous optical data types in the three temporal domains.The review first presents a history of the past 30 years of work investigating this sensitivity in optically diffuse media.These works are experimental and theoretical,presenting one-,two-,and three-dimensional sensitivity maps for different Near-Infrared Spectroscopy methods,domains,and data types.Following this history,we present a compendium of sensitivity maps organized by temporal domain and then data type.This compendium provides a valuable tool to compare the spatial sensitivity of various measurement methods and parameters in one document.Methods for one to generate these maps are provided in Appendix A,including the code.This historical review and comprehensive sensitivity map compendium provides a single source researchers may use to visualize,investigate,compare,and generate sensitivity to localized absorption change maps.

MAX-DOAS and in-situ measurements of aerosols and trace gases over Dongying,China:Insight into ozone formation sensitivity based on secondary HCHO

This study presents a comprehensive overview of the atmospheric pollutants including Sulfur dioxide(SO_(2)),Nitrogen dioxide(NO_(2)),Formaldehyde(HCHO),Particulate Matter PM;PM_(10):diameter≤10μm,and PM_(2.5):diameter≤2.5μm,and Ozone(O_(3)),over Dongying(Shandong Province)from March-April 2018 and September-October 2019 by employing ground-based Multiple Axis Differential Optical Absorption Spectroscopy(MAX-DOAS)observations along with the in-situ measurements attained by the national air quality monitoring platform.The concentrations of SO_(2)and NO_(2)were under the acceptable level,while both PM_(2.5),and PM_(10)were higher than the safe levels as prescribed by national and international air quality standards.The results depict that 21%of the total observation days were found to be complex polluted days(PM_(2.5)>35μg/m^(3) and O_(3)>160μg/m^(3)).The secondary HCHO was used for accurate analysis of O_(3)sensitivity.A difference of 11.40%and 10%during March-April 2018 and September-October 2019 respectively in O_(3)sensitivity was found between HCHO_(total)/NO_(2)and HCHO_(sec)/NO_(2).The results indicate that primary HCHO have significant contribution in HCHO.O_(3)formation predominantly remained to be in VOC-limited and transitional regime during March-April 2018 and September-October 2019 in Dongying.These results imply that concurrent control of both NO_(x) and VOCs would benefit in ozone reductions.Additionally,the criteria pollutants(PM,SO_(2),and NO_(2))depicted strong correlations with each other except for O_(3)for which weak correlation coefficient was obtained with all the species.This study will prove to be baseline for designing of air pollution control strategies.

Identification, pathogenicity, and fungicide sensitivity of Eutiarosporella dactylidis associated with leaf blight on maize in China

Maize(Zea mays L.) is an economically vital grain crop that is cultivated worldwide. In 2011, a maize foliar disease was detected in Lingtai and Lintao counties in Gansu Province, China. The characteristic signs and symptoms of this disease include irregular chlorotic lesions on the tips and edges of infected leaves and black punctate fruiting bodies in dead leaf tissues. Given favourable environmental conditions, this disease spread to areas surrounding Gansu. In this study, infected leaves were collected from Gansu and Ningxia Hui Autonomous Region between 2018and 2020 to identify the disease-causing pathogen. Based on morphological features, pathogenicity tests, and multilocus phylogenetic analysis involving internal transcribed spacer(ITS), 18S small subunit rDNA(SSU), 28S large subunit rDNA(LSU), translation elongation factor 1-alpha(TEF), and β-tubulin(TUB) sequences, Eutiarosporella dactylidis was identified as the causative pathogen of this newly discovered leaf blight. Furthermore, an in vitro bioassay was conducted on representative strains using six fungicides, and both fludioxonil and carbendazim were found to significantly inhibit the mycelial growth of E. dactylidis. The results of this study provide a reference for the detection and management of Eutiarosporella leaf blight.

Uncertainty and sensitivity analysis of in-vessel phenomena under severe accident mitigation strategy based on ISAA-SAUP program

The phenomenology involved in severe accidents in nuclear reactors is highly complex.Currently,integrated analysis programs used for severe accident analysis heavily rely on custom empirical parameters,which introduce considerable uncertainty.Therefore,in recent years,the field of severe accidents has shifted its focus toward applying uncertainty analysis methods to quantify uncertainty in safety assessment programs,known as“best estimate plus uncertainty(BEPU).”This approach aids in enhancing our comprehension of these programs and their further development and improvement.This study concentrates on a third-generation pressurized water reactor equipped with advanced active and passive mitigation strategies.Through an Integrated Severe Accident Analysis Program(ISAA),numerical modeling and uncertainty analysis were conducted on severe accidents resulting from large break loss of coolant accidents.Seventeen uncertainty parameters of the ISAA program were meticulously screened.Using Wilks'formula,the developed uncertainty program code,SAUP,was employed to carry out Latin hypercube sampling,while ISAA was employed to execute batch calculations.Statistical analysis was then conducted on two figures of merit,namely hydrogen generation and the release of fission products within the pressure vessel.Uncertainty calculations revealed that hydrogen production and the fraction of fission product released exhibited a normal distribution,ranging from 182.784 to 330.664 kg and from 15.6 to 84.3%,respectively.The ratio of hydrogen production to reactor thermal power fell within the range of 0.0578–0.105.A sensitivity analysis was performed for uncertain input parameters,revealing significant correlations between the failure temperature of the cladding oxide layer,maximum melt flow rate,size of the particulate debris,and porosity of the debris with both hydrogen generation and the release of fission products.