The concept of the binary sequence pair is generalized from a single binary sequence. Binary sequence pairs are applied in many fields of radar, sonar or communication systems, in which signals with optimal periodic c...The concept of the binary sequence pair is generalized from a single binary sequence. Binary sequence pairs are applied in many fields of radar, sonar or communication systems, in which signals with optimal periodic correlation are required. Several types of almost perfect binary sequence pairs of length T = 2q are constructed, where q is an odd number. These almost perfect binary sequence pairs are based on binary ideal sequence or binary ideal two-level correlation sequence pairs by using Chinese remainder theorem. For these almost perfect binary sequence pairs with good balanced property, their corresponding divisible difference set pairs(DDSPs) are also derived.展开更多
On the basis of the relationship between the Hamiltonian of spin 1/2 quantum system under control and the energy level structure and transitions, a radio frequency pulse sequence is designed using intuitive and half c...On the basis of the relationship between the Hamiltonian of spin 1/2 quantum system under control and the energy level structure and transitions, a radio frequency pulse sequence is designed using intuitive and half counter-intuitive sequences of pulse to transfer the population of the 3-qubit system coherently. The effectiveness of the designed control sequence is verified through the system simulation experiment of the evolution of state. In principle, the design method of the control pulse sequence proposed can be generalized to use in the quantum systems of higher dimension.展开更多
Although the Cramer-Rao Bound(CRB) can be used as the benchmark of estimation algorithm performance,it's too complicated for joint training sequence(TS) design for multiple input multiple output(MIMO) orthogonal f...Although the Cramer-Rao Bound(CRB) can be used as the benchmark of estimation algorithm performance,it's too complicated for joint training sequence(TS) design for multiple input multiple output(MIMO) orthogonal frequency division multiplexing(OFDM) coordination on multiple point(CoMP) systems.So a minimum mean square error(MSE) based sub-optimal sequence design criterion was proposed,including ideal sequence correlation property and sequence length constraint.The simulation results verify the theory analysis.展开更多
Efficient translation mediated by the 5'untranslated region(5'UTR)is essential for the robust efficacy of mRNA vaccines.However,the N1-methyl-pseudouridine(m1)modification of mRNA can impact the translation ef...Efficient translation mediated by the 5'untranslated region(5'UTR)is essential for the robust efficacy of mRNA vaccines.However,the N1-methyl-pseudouridine(m1)modification of mRNA can impact the translation efficiency of the 5'UTR.We discovered that the optimal 5'UTR for m1y-modified mRNA(m1y-5'UTR)differs significantly from its unmodified counterpart,high-lighting the need for a specialized tool for designing mly-5'UTRs rather than directly utilizing high-expression endogenous gene 5'UTRs.In response,we developed a novel machine learning-based tool,Smart5UTR,which employs a deep generative model to identify superior m1y-5'UTRs in silico.The tailored loss function and network architecture enable Smart5UTR to overcome limitations inherent in existing models.As a result,Smart5UTR can successfully design superior 5'UTRs,greatly benefiting mRNA vaccine development.Notably,Smart5UTR-designed superior 5'UTRs significantly enhanced antibody titers induced by COVID-19 mRNA vaccines against the Delta and Omicron variants of SARS-CoV-2,surpassing the performance of vaccines using high-expression endogenous gene 5'UTRs.展开更多
基金supported by the National Natural Science Foundation of China(6160140161501395+6 种基金6160139961671402)Natural Science Foundation of Hebei Province(F2015203150F2016203293F2016203312)Natural Science Research Programs of Hebei Educational Committee(QN2016120)the Independent Research Programs for Young Teachers of Yanshan University(15LGB013)
文摘The concept of the binary sequence pair is generalized from a single binary sequence. Binary sequence pairs are applied in many fields of radar, sonar or communication systems, in which signals with optimal periodic correlation are required. Several types of almost perfect binary sequence pairs of length T = 2q are constructed, where q is an odd number. These almost perfect binary sequence pairs are based on binary ideal sequence or binary ideal two-level correlation sequence pairs by using Chinese remainder theorem. For these almost perfect binary sequence pairs with good balanced property, their corresponding divisible difference set pairs(DDSPs) are also derived.
基金supported by the National Natural Science Foundation of China (60774098)the National Key Basic Research Program (2006922004)
文摘On the basis of the relationship between the Hamiltonian of spin 1/2 quantum system under control and the energy level structure and transitions, a radio frequency pulse sequence is designed using intuitive and half counter-intuitive sequences of pulse to transfer the population of the 3-qubit system coherently. The effectiveness of the designed control sequence is verified through the system simulation experiment of the evolution of state. In principle, the design method of the control pulse sequence proposed can be generalized to use in the quantum systems of higher dimension.
基金International Science&Technology Cooperation Projects of Qinghai,China(Nos.2013-H-811,2014-HZ-821)Chunhui Plan Projects,China(Nos.Z2014013,Z2014014)
文摘Although the Cramer-Rao Bound(CRB) can be used as the benchmark of estimation algorithm performance,it's too complicated for joint training sequence(TS) design for multiple input multiple output(MIMO) orthogonal frequency division multiplexing(OFDM) coordination on multiple point(CoMP) systems.So a minimum mean square error(MSE) based sub-optimal sequence design criterion was proposed,including ideal sequence correlation property and sequence length constraint.The simulation results verify the theory analysis.
基金This work was financially supported by the Postdoctoral Research Foundation of National Key S&T Special Projects(2018ZX09201018-024,China)Sichuan Province Science and Technology Support Program(2022YFH0001 and 2021YFH0003,China).
文摘Efficient translation mediated by the 5'untranslated region(5'UTR)is essential for the robust efficacy of mRNA vaccines.However,the N1-methyl-pseudouridine(m1)modification of mRNA can impact the translation efficiency of the 5'UTR.We discovered that the optimal 5'UTR for m1y-modified mRNA(m1y-5'UTR)differs significantly from its unmodified counterpart,high-lighting the need for a specialized tool for designing mly-5'UTRs rather than directly utilizing high-expression endogenous gene 5'UTRs.In response,we developed a novel machine learning-based tool,Smart5UTR,which employs a deep generative model to identify superior m1y-5'UTRs in silico.The tailored loss function and network architecture enable Smart5UTR to overcome limitations inherent in existing models.As a result,Smart5UTR can successfully design superior 5'UTRs,greatly benefiting mRNA vaccine development.Notably,Smart5UTR-designed superior 5'UTRs significantly enhanced antibody titers induced by COVID-19 mRNA vaccines against the Delta and Omicron variants of SARS-CoV-2,surpassing the performance of vaccines using high-expression endogenous gene 5'UTRs.
基金the Scientific Research Fund of Southwestern University of FinanceEconomics and the National Natural Science Foundation of China (Grant No. 60572142)