Randomized urinary and blood samples were obtained from three hundred and ninety-two cases of late pregnancies simultaneously for comparison of the validity in perinatal fetal monitoring. The results of randomized uri...Randomized urinary and blood samples were obtained from three hundred and ninety-two cases of late pregnancies simultaneously for comparison of the validity in perinatal fetal monitoring. The results of randomized urinary estriol/creatinine （RUE<sub>3</sub>/C） and serum free estriol （SFE<sub>3</sub>） tests revealed that Ⅰ. The coefficient of correlation between RUE<sub>3</sub>/C and SFE<sub>3</sub> level were close in either normal or high-risk pregnancies （y=0.1477X+14.2368, r=0.4586, n=170; y=0.1724X+8.6698, r=0.5868, n=222, respectively, P【0.001）; 2.92%cases of the false positive rate of RUE<sub>3</sub>/C were corrected by SFE<sub>3</sub> test. In cases of pregnancy-induced hypertension （PIH） the false positive rate of RUE<sub>3</sub>/C were highest in comparison with those in cuses of other high-risk pregnancies （53.6%）; 3. The correct rate of SFE<sub>3</sub> test in prenatal predication of fetal well-being was significantly higher （95.6%） than that of RUE<sub>3</sub>/C （87.3%） （X<sup>2</sup>=17.77, P【0.001）. This paper suggests that RUE<sub>3</sub>/C can be used as a first line test for perinatal monitoring. When RUE<sub>3</sub>/C value is lower than normal, SFE<sub>3</sub> test should be added to ensure the reliability of perinatal diagnosis, especially in PIH cases. Obviously, to use these two tests for perinatal fetal monitoring simultaneously is better than to use any one test alone.展开更多
目的探讨肝功能与雌三醇预测肝内胆汁淤积症孕妇妊娠结局的价值。方法选取2017年1月至2018年12月在本院妇产科收治,23例妊娠期肝内胆汁淤积症孕妇作为研究组,另选择23例随机抽取的妊娠期正常孕妇作为对照组。对两组孕妇的肝功能[血清甘...目的探讨肝功能与雌三醇预测肝内胆汁淤积症孕妇妊娠结局的价值。方法选取2017年1月至2018年12月在本院妇产科收治,23例妊娠期肝内胆汁淤积症孕妇作为研究组,另选择23例随机抽取的妊娠期正常孕妇作为对照组。对两组孕妇的肝功能[血清甘胆酸(cholyglycine,CG)与总胆汁酸(total bile acid,TBA)]及游离雌三醇(unconjugated E3,uE3)水平进行检测,并比较两组孕妇检测结果数据和不良妊娠结局(胎儿窘迫、早产、新生儿窒息和新生儿死亡)发生情况。结果研究组孕妇血清的CG、TBA以及uE3的平均水平明显高于对照组,两组比较差异有统计学意义(P<0.05)。研究组孕妇的胎儿窘迫和新生儿窒息发生率明显高于对照组,两组比较差异有统计学意义(P<0.05)。两组孕妇早产、新生儿死亡率比较差异无统计学意义。结论肝功能和雌三醇水平升高会导致孕妇患上妊娠期肝内胆汁淤积症,及早检测肝功能和雌三醇有利于降低不良妊娠结局的发生率,具有良好的临床实用价值。展开更多
文摘Randomized urinary and blood samples were obtained from three hundred and ninety-two cases of late pregnancies simultaneously for comparison of the validity in perinatal fetal monitoring. The results of randomized urinary estriol/creatinine （RUE<sub>3</sub>/C） and serum free estriol （SFE<sub>3</sub>） tests revealed that Ⅰ. The coefficient of correlation between RUE<sub>3</sub>/C and SFE<sub>3</sub> level were close in either normal or high-risk pregnancies （y=0.1477X+14.2368, r=0.4586, n=170; y=0.1724X+8.6698, r=0.5868, n=222, respectively, P【0.001）; 2.92%cases of the false positive rate of RUE<sub>3</sub>/C were corrected by SFE<sub>3</sub> test. In cases of pregnancy-induced hypertension （PIH） the false positive rate of RUE<sub>3</sub>/C were highest in comparison with those in cuses of other high-risk pregnancies （53.6%）; 3. The correct rate of SFE<sub>3</sub> test in prenatal predication of fetal well-being was significantly higher （95.6%） than that of RUE<sub>3</sub>/C （87.3%） （X<sup>2</sup>=17.77, P【0.001）. This paper suggests that RUE<sub>3</sub>/C can be used as a first line test for perinatal monitoring. When RUE<sub>3</sub>/C value is lower than normal, SFE<sub>3</sub> test should be added to ensure the reliability of perinatal diagnosis, especially in PIH cases. Obviously, to use these two tests for perinatal fetal monitoring simultaneously is better than to use any one test alone.
文摘目的探讨肝功能与雌三醇预测肝内胆汁淤积症孕妇妊娠结局的价值。方法选取2017年1月至2018年12月在本院妇产科收治,23例妊娠期肝内胆汁淤积症孕妇作为研究组,另选择23例随机抽取的妊娠期正常孕妇作为对照组。对两组孕妇的肝功能[血清甘胆酸(cholyglycine,CG)与总胆汁酸(total bile acid,TBA)]及游离雌三醇(unconjugated E3,uE3)水平进行检测,并比较两组孕妇检测结果数据和不良妊娠结局(胎儿窘迫、早产、新生儿窒息和新生儿死亡)发生情况。结果研究组孕妇血清的CG、TBA以及uE3的平均水平明显高于对照组,两组比较差异有统计学意义(P<0.05)。研究组孕妇的胎儿窘迫和新生儿窒息发生率明显高于对照组,两组比较差异有统计学意义(P<0.05)。两组孕妇早产、新生儿死亡率比较差异无统计学意义。结论肝功能和雌三醇水平升高会导致孕妇患上妊娠期肝内胆汁淤积症,及早检测肝功能和雌三醇有利于降低不良妊娠结局的发生率,具有良好的临床实用价值。
