目的探究精神分裂症患者脑部代谢激素同型半胱氨酸(homocysteine,HCY)、催乳素(prolactin,PRL)与认知功能的相关性,挖掘重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)联合奥氮平治疗该病的效果,以期解读脑部代谢...目的探究精神分裂症患者脑部代谢激素同型半胱氨酸(homocysteine,HCY)、催乳素(prolactin,PRL)与认知功能的相关性,挖掘重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)联合奥氮平治疗该病的效果,以期解读脑部代谢激素与认知功能的影响机制,同时,挖掘rTMS联合奥氮平这种内外结合治疗方式来丰富该领域研究,为相关研究提供借鉴。方法选取2021年6月至2023年8月笔者医院治疗的128例精神分裂症患者资料进行回顾性分析,根据治疗方式的不同划分为观察组72例(rTMS联合奥氮平治疗)和对照组56例(奥氮平单药治疗)。分析两组患者血清HCY、PRL、阳性和阴性综合征量表(positive and negative syndrome scale,PANSS)、白细胞介素(interleukin,IL)-12,肿瘤坏死因子(tumor necrosis factor,TNF)-α及其相关性。比较两组患者不良反应发生率情况。结果治疗后,观察组PRL、HCY、IL-12、TNF-α水平低于对照组,差异有统计学意义(P<0.05)。交互作用、时点作用、组间作用下,两组患者的PANSS评分会因为不同治疗方式的时间推移而发生变化,但观察组均低于对照组,差异有统计学意义(P<0.05)。治疗方法与HCY、PRL、IL-12、TNF-α、PANSS均呈负相关,且HCY、PRL、IL–12、TNF–α、PANSS两两间为正相关(P<0.05)。观察组头痛、记忆受损、嗜睡、不良反应事件等发生率低于对照组,差异有统计学意义(P<0.05)。结论经rTMS联合奥氮平治疗后,可以降低精神分裂症患者HCY、PRL激素水平,减轻炎症,减少不良反应,改善患者认知功能。展开更多
Objective： The aim of the study was to explore the bone morphogenetic protein 4 （BMP-4） how to regulate pro- lactin （PRL） secreting, cell proliferation and invasiveness in human prolactinorna. Methods： Ten patie...Objective： The aim of the study was to explore the bone morphogenetic protein 4 （BMP-4） how to regulate pro- lactin （PRL） secreting, cell proliferation and invasiveness in human prolactinorna. Methods： Ten patients who diagnosed as prolactinoma by clinical characteristics and pathology were divided into two groups, one was sensitive to Brornocriptine, the other was insensitive to Brornocriptine. Every case was conducted by primal cell culture then treated by different concentrations of BMP-4. The cell configuration was observed and PRL hormone was measured in different times. The expressions of BMP-4 rnRNA and BMP-4 in 37 cases of prolactinorna and 8 cases of normal pituitary tissues samples were detected by immunohistochemical and in situ hybridization technique, and the results were analyzed by statistic methods. Results： BMP-4 （5 ng/rnL） could accelerate the secreting of PRL in prolactinorna cell, and it could reach the greatest effect in the concentration of 20 ng/mL. BMP-4 could increase prolactinoma cell proliferation, but when the concentration was 50 ng/rnL, the BMP-4 effect of increasing secreting decreased. When 100 ng/mL, the cell began to die. The effects of the BMP-4 in sensitive group and insensitive group had no difference. The BMP-4 was highly expressed in the prolactinornas and was positively related with the invasiveness grades. Conclusion： BMP-4 have positive regulation in prolactinoma secreting, proliferation, invasiveness effects, BMP-4 probably has the important role in prolactinoma pathogenesis.展开更多
BACKGROUND： Researchers discovered that serum prolactin could rise following an epileptic seizure. The prolactin level might reach three times more than basic level within 30 minutes and decrease to the normal value ...BACKGROUND： Researchers discovered that serum prolactin could rise following an epileptic seizure. The prolactin level might reach three times more than basic level within 30 minutes and decrease to the normal value 2 hours after the seizure occurred. The mechanism might result in an increase of serum prolactin concentrations with the activation of the hypothalamic-pituitary axis. OBJECTIVE：To probe into the correlation between changes of serum prolactin and incidence of epileptic discharges of electroencephalogram （EEG） at 24-36 hours after epileptic onset of patients with secondary epilepsy. DESIGN ： Clinical observational study SEI-FING： Department of Neurology, First Hospital affiliated to Soochow University PARTICIPANTS： A total of 21 patients with secondary epilepsy were selected from the Department of Neurological Emergency or Hospital Room of the First Hospital affiliated to Soochow University from November 2005 to April 2006. There were 14 males and 7 females aged from 25 to 72 years. All patients met International League Anti-epileptic （ILAE） criteria in 1981 for secondary generalized tonic clonic seizure through CT or MRI and previous EEG. All patients were consent. Primary diseases included cerebral trauma （3 cases）, tumor （2 cases）, stroke （7 cases） and intracranial infeion （9 cases）. METHODS ： Venous blood of all patients was collected at 24-36 hours after epileptic onset. Serum prolactin kit （Beckman Coulter, Inc in USA） was used to measure value of serum prolactin according to kit instruction. Then, value of serum prolactin was compared with the normal value （male： 2.64-13.13 mg/L; female： 3.34- 26.72 mg/L）; meanwhile, EEG equipment （American Nicolet Incorporation） was used in this study. MAIN OUTCOME MEASURES ： ① Abnormal rate of serum prolactin of patients with secondary epilepsy; ②Comparison between normal and abnormal level of serum prolactin and incidence of EEG epileptic discharge of patients with secondary epilepsy. RESULTS：All 21 patients with secondary epilepsy were involved in the final analysis. ① Results of serum prolactin level： Among 21 patients with of secondary epilepsy, 10 of them had normal serum prolactin and 11 had abnormal one, and the abnormal rate was 52% （11/21）. ② Detecting results of EEG： EEG results showed that 6 cases were normal and 15 were abnormal, and the abnormal rate was 71% （15/21）. The symptoms were sharp wave, spike wave or sharp slow wave, spike slow wave of epileptic discharges in 8 cases, which was accounted for 38%. ③ Correlation between abnormality of serum prolactin and EEG epileptic wave： Eleven cases had abnormal serum prolactin, and the incidence was 64% （7/11）, which was higher of epileptic wave than that of non-epileptic wave [36% （4/11）, P 〈 0.05]; however, 10 cases had normal serum prolactin, and the incidence was 10% （1/10）. Epileptic wave was lower than non-epileptic wave [90% （9/10）, P 〈 0.01]. CONCLUSION ： The level of serum prolactin of patients with secondary epilepsy is abnormally increased at 24- 36 hours after epileptic onset; in addition, incidence of epileptic discharge is also increased remarkably.展开更多
文摘目的探究精神分裂症患者脑部代谢激素同型半胱氨酸(homocysteine,HCY)、催乳素(prolactin,PRL)与认知功能的相关性,挖掘重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)联合奥氮平治疗该病的效果,以期解读脑部代谢激素与认知功能的影响机制,同时,挖掘rTMS联合奥氮平这种内外结合治疗方式来丰富该领域研究,为相关研究提供借鉴。方法选取2021年6月至2023年8月笔者医院治疗的128例精神分裂症患者资料进行回顾性分析,根据治疗方式的不同划分为观察组72例(rTMS联合奥氮平治疗)和对照组56例(奥氮平单药治疗)。分析两组患者血清HCY、PRL、阳性和阴性综合征量表(positive and negative syndrome scale,PANSS)、白细胞介素(interleukin,IL)-12,肿瘤坏死因子(tumor necrosis factor,TNF)-α及其相关性。比较两组患者不良反应发生率情况。结果治疗后,观察组PRL、HCY、IL-12、TNF-α水平低于对照组,差异有统计学意义(P<0.05)。交互作用、时点作用、组间作用下,两组患者的PANSS评分会因为不同治疗方式的时间推移而发生变化,但观察组均低于对照组,差异有统计学意义(P<0.05)。治疗方法与HCY、PRL、IL-12、TNF-α、PANSS均呈负相关,且HCY、PRL、IL–12、TNF–α、PANSS两两间为正相关(P<0.05)。观察组头痛、记忆受损、嗜睡、不良反应事件等发生率低于对照组,差异有统计学意义(P<0.05)。结论经rTMS联合奥氮平治疗后,可以降低精神分裂症患者HCY、PRL激素水平,减轻炎症,减少不良反应,改善患者认知功能。
文摘Objective： The aim of the study was to explore the bone morphogenetic protein 4 （BMP-4） how to regulate pro- lactin （PRL） secreting, cell proliferation and invasiveness in human prolactinorna. Methods： Ten patients who diagnosed as prolactinoma by clinical characteristics and pathology were divided into two groups, one was sensitive to Brornocriptine, the other was insensitive to Brornocriptine. Every case was conducted by primal cell culture then treated by different concentrations of BMP-4. The cell configuration was observed and PRL hormone was measured in different times. The expressions of BMP-4 rnRNA and BMP-4 in 37 cases of prolactinorna and 8 cases of normal pituitary tissues samples were detected by immunohistochemical and in situ hybridization technique, and the results were analyzed by statistic methods. Results： BMP-4 （5 ng/rnL） could accelerate the secreting of PRL in prolactinorna cell, and it could reach the greatest effect in the concentration of 20 ng/mL. BMP-4 could increase prolactinoma cell proliferation, but when the concentration was 50 ng/rnL, the BMP-4 effect of increasing secreting decreased. When 100 ng/mL, the cell began to die. The effects of the BMP-4 in sensitive group and insensitive group had no difference. The BMP-4 was highly expressed in the prolactinornas and was positively related with the invasiveness grades. Conclusion： BMP-4 have positive regulation in prolactinoma secreting, proliferation, invasiveness effects, BMP-4 probably has the important role in prolactinoma pathogenesis.
文摘BACKGROUND： Researchers discovered that serum prolactin could rise following an epileptic seizure. The prolactin level might reach three times more than basic level within 30 minutes and decrease to the normal value 2 hours after the seizure occurred. The mechanism might result in an increase of serum prolactin concentrations with the activation of the hypothalamic-pituitary axis. OBJECTIVE：To probe into the correlation between changes of serum prolactin and incidence of epileptic discharges of electroencephalogram （EEG） at 24-36 hours after epileptic onset of patients with secondary epilepsy. DESIGN ： Clinical observational study SEI-FING： Department of Neurology, First Hospital affiliated to Soochow University PARTICIPANTS： A total of 21 patients with secondary epilepsy were selected from the Department of Neurological Emergency or Hospital Room of the First Hospital affiliated to Soochow University from November 2005 to April 2006. There were 14 males and 7 females aged from 25 to 72 years. All patients met International League Anti-epileptic （ILAE） criteria in 1981 for secondary generalized tonic clonic seizure through CT or MRI and previous EEG. All patients were consent. Primary diseases included cerebral trauma （3 cases）, tumor （2 cases）, stroke （7 cases） and intracranial infeion （9 cases）. METHODS ： Venous blood of all patients was collected at 24-36 hours after epileptic onset. Serum prolactin kit （Beckman Coulter, Inc in USA） was used to measure value of serum prolactin according to kit instruction. Then, value of serum prolactin was compared with the normal value （male： 2.64-13.13 mg/L; female： 3.34- 26.72 mg/L）; meanwhile, EEG equipment （American Nicolet Incorporation） was used in this study. MAIN OUTCOME MEASURES ： ① Abnormal rate of serum prolactin of patients with secondary epilepsy; ②Comparison between normal and abnormal level of serum prolactin and incidence of EEG epileptic discharge of patients with secondary epilepsy. RESULTS：All 21 patients with secondary epilepsy were involved in the final analysis. ① Results of serum prolactin level： Among 21 patients with of secondary epilepsy, 10 of them had normal serum prolactin and 11 had abnormal one, and the abnormal rate was 52% （11/21）. ② Detecting results of EEG： EEG results showed that 6 cases were normal and 15 were abnormal, and the abnormal rate was 71% （15/21）. The symptoms were sharp wave, spike wave or sharp slow wave, spike slow wave of epileptic discharges in 8 cases, which was accounted for 38%. ③ Correlation between abnormality of serum prolactin and EEG epileptic wave： Eleven cases had abnormal serum prolactin, and the incidence was 64% （7/11）, which was higher of epileptic wave than that of non-epileptic wave [36% （4/11）, P 〈 0.05]; however, 10 cases had normal serum prolactin, and the incidence was 10% （1/10）. Epileptic wave was lower than non-epileptic wave [90% （9/10）, P 〈 0.01]. CONCLUSION ： The level of serum prolactin of patients with secondary epilepsy is abnormally increased at 24- 36 hours after epileptic onset; in addition, incidence of epileptic discharge is also increased remarkably.
