目的探究拉贝洛尔联合低分子肝素对早发型重度子痫前期孕妇凝血功能及血压影响。方法选取2021年1月至2022年7月济南市第一人民医院收治的80例早发型重度子痫前期患者作为研究对象,随机分为A组与B组,每组40例。A组给予拉贝洛尔治疗,B组...目的探究拉贝洛尔联合低分子肝素对早发型重度子痫前期孕妇凝血功能及血压影响。方法选取2021年1月至2022年7月济南市第一人民医院收治的80例早发型重度子痫前期患者作为研究对象,随机分为A组与B组,每组40例。A组给予拉贝洛尔治疗,B组给予拉贝洛尔联合低分子肝素治疗。比较两组治疗前后凝血功能指标、血压、血脂水平、母婴结局、新生儿Apgar评分及不良反应发生情况。结果治疗后,B组凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)均长于A组,新生儿5、10 min Apgar评分均高于A组,纤维蛋白原(FIB)、收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平及不良新生儿结局、不良妊娠结局发生率均低于A组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论拉贝洛尔联合低分子肝素治疗早发型重度子痫前期,可改善患者凝血功能、血脂及血压水平,改善母婴结局,且安全性较高。展开更多
目的 探讨胰岛素样生长因子-1与早发型重度子痫前期的关系.方法 采用放免法测定研究组（早发型重度子痫前期）和对照组母血、脐血胰岛素样生长因子-1水平,免疫组化法测定胎盘中胰岛素样生长因子-1表达水平.结果 研究组母血胰岛素样生长...目的 探讨胰岛素样生长因子-1与早发型重度子痫前期的关系.方法 采用放免法测定研究组（早发型重度子痫前期）和对照组母血、脐血胰岛素样生长因子-1水平,免疫组化法测定胎盘中胰岛素样生长因子-1表达水平.结果 研究组母血胰岛素样生长因子-1（160.32±21.03 vs 230.21±31.09μg/L）、脐血胰岛素样生长因子-1水平（41.21±20.51 vs 80.57±19.39μg/L）、胎盘中胰岛素样生长因子-1表达水平（平均灰度71.13±30.59 vs 110.54±28.91）水平明显低于对照组（P〈0.01）,且母血胰岛素样生长因子-1水平与脐血、胎盘及新生儿出生体重成正相关（相关系数r值分别为0.36,0.44,0.61,P〈0.05）.结论 早发型重度子痫前期的发生与胰岛素样生长因子-1的水平降低有关.展开更多
Background Early onset severe preeclampsia is a specific type of severe preeclampsia, which causes high morbidity and mortality of both mothers and fetus. This study aimed to investigate the clinical definition, featu...Background Early onset severe preeclampsia is a specific type of severe preeclampsia, which causes high morbidity and mortality of both mothers and fetus. This study aimed to investigate the clinical definition, features, treatment, outcome and risk factors of early onset severe preeclampsia in Chinese women. Methods Four hundred and thirteen women with severe preeclampsia from June 2006 to June 2009 were divided into three groups according to the gestational age at the onset of preeclampsia as follows： group A （less than 32 weeks, 73 cases）, group B ,（between 32 and 34 weeks, 71 cases）, and group C （greater than 34 weeks, 269 cases）. The demographic characteristics of the subjects, complications, delivery modes and outcome of pregnancy were analyzed retrospectively. Results The systolic blood pressure at admission and the incidence of severe complications were significantly lower in group C than those in groups A and B, prolonged gestational weeks and days of hospitalization were significantly shorter in group C than those in groups A and B. Liver and kidney dysfunction, pleural and peritoneal effusion, placental abruption and postpartum hemorrhage were more likely to occur in group A compared with the other two groups. Twenty-four-hour urine protein levels at admission, intrauterine fetal death and days of hospitalization were risk factors that affected complications of severe preeclampsia. Gestational week at admission and delivery week were also risk factors that affected perinatal outcome. Conclusions Early onset severe preeclampsia should be defined as occurring before 34 weeks, and it is featured by more maternal complications and a worse perinatal prognosis compared with that defined as occurring after 34 weeks. Independent risk factors should be used to tailor the optimized individual treatment plan, to balance both maternal and neonatal safety.展开更多
目的探究血清TSP-1、VEGF及TSP-1/VEGF与早发型重度子痫前期(early onset severe preeclampsia,EOSP)发病的相关性,进一步探究这些指标在妊娠中期预测EOSP的临床价值。方法选取2019年8月~2020年8月在笔者医院收治的妊娠28~33^(+6)周EOS...目的探究血清TSP-1、VEGF及TSP-1/VEGF与早发型重度子痫前期(early onset severe preeclampsia,EOSP)发病的相关性,进一步探究这些指标在妊娠中期预测EOSP的临床价值。方法选取2019年8月~2020年8月在笔者医院收治的妊娠28~33^(+6)周EOSP孕妇38例为病例组,同期门诊正常产检的妊娠28~33^(+6)周健康孕妇40例为对照组,用ELISA法检测两组血清TSP-1、VEGF水平,并进行对比分析,探究血清TSP-1、VEGF及TSP-1/VEGF与EOSP的相关性及诊断价值。回顾性选取2018年9月~2020年8月在笔者医院行中期唐氏筛查(15~20^(+6)周,一般为15~17周)并分娩的孕妇90例为验证组(其中妊娠结局为EOSP孕妇30例,为EOSP组;正常分娩孕妇60例,为非EOSP组),探究TSP-1、VEGF、TSP-1/VEGF对EOSP的预测价值。结果病例组TSP-1值、TSP-1/VEGF值高于对照组(P<0.001),VEGF值低于对照组(P<0.001)。ROC分析TSP-1、VEGF及TSP-1/VEGF的最佳诊断截断值分别为2.44ng/ml、271.21pg/ml、9.13。使用TSP-1、VEGF及TSP-1/VEGF的最佳诊断截断值预测验证组,敏感度分别为70.00%、66.67%、90.00%,特异性为41.67%、90.00%、70.00%,符合率为51.11%、82.22%、76.67%。结论使用TSP-1/VEGF诊断截断值检测EOSP比单独使用VEGF或TSP-1更具有诊断价值。妊娠中期血清TSP-1/VEGF取值9.13对预测EOSP具有一定的价值。展开更多
文摘目的探究拉贝洛尔联合低分子肝素对早发型重度子痫前期孕妇凝血功能及血压影响。方法选取2021年1月至2022年7月济南市第一人民医院收治的80例早发型重度子痫前期患者作为研究对象,随机分为A组与B组,每组40例。A组给予拉贝洛尔治疗,B组给予拉贝洛尔联合低分子肝素治疗。比较两组治疗前后凝血功能指标、血压、血脂水平、母婴结局、新生儿Apgar评分及不良反应发生情况。结果治疗后,B组凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)均长于A组,新生儿5、10 min Apgar评分均高于A组,纤维蛋白原(FIB)、收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平及不良新生儿结局、不良妊娠结局发生率均低于A组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论拉贝洛尔联合低分子肝素治疗早发型重度子痫前期,可改善患者凝血功能、血脂及血压水平,改善母婴结局,且安全性较高。
文摘目的 探讨胰岛素样生长因子-1与早发型重度子痫前期的关系.方法 采用放免法测定研究组（早发型重度子痫前期）和对照组母血、脐血胰岛素样生长因子-1水平,免疫组化法测定胎盘中胰岛素样生长因子-1表达水平.结果 研究组母血胰岛素样生长因子-1（160.32±21.03 vs 230.21±31.09μg/L）、脐血胰岛素样生长因子-1水平（41.21±20.51 vs 80.57±19.39μg/L）、胎盘中胰岛素样生长因子-1表达水平（平均灰度71.13±30.59 vs 110.54±28.91）水平明显低于对照组（P〈0.01）,且母血胰岛素样生长因子-1水平与脐血、胎盘及新生儿出生体重成正相关（相关系数r值分别为0.36,0.44,0.61,P〈0.05）.结论 早发型重度子痫前期的发生与胰岛素样生长因子-1的水平降低有关.
文摘Background Early onset severe preeclampsia is a specific type of severe preeclampsia, which causes high morbidity and mortality of both mothers and fetus. This study aimed to investigate the clinical definition, features, treatment, outcome and risk factors of early onset severe preeclampsia in Chinese women. Methods Four hundred and thirteen women with severe preeclampsia from June 2006 to June 2009 were divided into three groups according to the gestational age at the onset of preeclampsia as follows： group A （less than 32 weeks, 73 cases）, group B ,（between 32 and 34 weeks, 71 cases）, and group C （greater than 34 weeks, 269 cases）. The demographic characteristics of the subjects, complications, delivery modes and outcome of pregnancy were analyzed retrospectively. Results The systolic blood pressure at admission and the incidence of severe complications were significantly lower in group C than those in groups A and B, prolonged gestational weeks and days of hospitalization were significantly shorter in group C than those in groups A and B. Liver and kidney dysfunction, pleural and peritoneal effusion, placental abruption and postpartum hemorrhage were more likely to occur in group A compared with the other two groups. Twenty-four-hour urine protein levels at admission, intrauterine fetal death and days of hospitalization were risk factors that affected complications of severe preeclampsia. Gestational week at admission and delivery week were also risk factors that affected perinatal outcome. Conclusions Early onset severe preeclampsia should be defined as occurring before 34 weeks, and it is featured by more maternal complications and a worse perinatal prognosis compared with that defined as occurring after 34 weeks. Independent risk factors should be used to tailor the optimized individual treatment plan, to balance both maternal and neonatal safety.
文摘目的探究血清TSP-1、VEGF及TSP-1/VEGF与早发型重度子痫前期(early onset severe preeclampsia,EOSP)发病的相关性,进一步探究这些指标在妊娠中期预测EOSP的临床价值。方法选取2019年8月~2020年8月在笔者医院收治的妊娠28~33^(+6)周EOSP孕妇38例为病例组,同期门诊正常产检的妊娠28~33^(+6)周健康孕妇40例为对照组,用ELISA法检测两组血清TSP-1、VEGF水平,并进行对比分析,探究血清TSP-1、VEGF及TSP-1/VEGF与EOSP的相关性及诊断价值。回顾性选取2018年9月~2020年8月在笔者医院行中期唐氏筛查(15~20^(+6)周,一般为15~17周)并分娩的孕妇90例为验证组(其中妊娠结局为EOSP孕妇30例,为EOSP组;正常分娩孕妇60例,为非EOSP组),探究TSP-1、VEGF、TSP-1/VEGF对EOSP的预测价值。结果病例组TSP-1值、TSP-1/VEGF值高于对照组(P<0.001),VEGF值低于对照组(P<0.001)。ROC分析TSP-1、VEGF及TSP-1/VEGF的最佳诊断截断值分别为2.44ng/ml、271.21pg/ml、9.13。使用TSP-1、VEGF及TSP-1/VEGF的最佳诊断截断值预测验证组,敏感度分别为70.00%、66.67%、90.00%,特异性为41.67%、90.00%、70.00%,符合率为51.11%、82.22%、76.67%。结论使用TSP-1/VEGF诊断截断值检测EOSP比单独使用VEGF或TSP-1更具有诊断价值。妊娠中期血清TSP-1/VEGF取值9.13对预测EOSP具有一定的价值。
