Background Meningioma is one of the most common primary tumors of the central nervous system, but there are not many detailed studies on the sex, age, subtypes and locations of large series. This study was a retrospec...Background Meningioma is one of the most common primary tumors of the central nervous system, but there are not many detailed studies on the sex, age, subtypes and locations of large series. This study was a retrospective analysis of the characteristics of meningioma cases consecutively operated on at a single institution in China from 2001 to 2010. Methods This study investigated the demographic background of 7084 meningioma cases, and the subtypes and locations of the tumors. Sex and age distributions were analyzed, and the pathological subtypes were classified according to the World Health Organization （WHO） classification. The location of the meningiomas was also categorized. Results The female：male ratio of the 7084 cases was 2.34：1. The mean age was 51.4 years （range, 11 months-86 years）. The mean age of cases of WHO grade I meningioma was significantly older than that of grade II or III meningiomas （P 〈0.001, Fisher＇s Least Significant Digit test）. There was a significantly higher female：male ratio in WHO grade I meningiomas than in grade II or grade III meningiomas （2.57, 1.03 and 0.76, respectively; P 〈0.001, X^2 test）. Meningothelial （n=2061） and fibrous meningiomas （n=3556） were the most common subtypes, comprising 79.3% of all meningiomas. All meningioma cases were classified into 23 locations in this study, with the cerebral convexity the most common site （38.33%, n=2722）. Cases with uncommon locations such as extra-cranial and sylvian fissure meningiomas were also present in this series. Conclusions Female predominance was found for benign meningiomas, while malignant subtypes showed male predominance. The mean age of patients with WHO grade Ⅰ meningiomas was older than that of patients with higher-grade tumors. Meningothelial and fibrous meningiomas were the most common subtypes. The cerebral convexity was the most common menin.qioma location.展开更多
Background The gender difference on long-term outcome in unselected patients after percutaneous coronary intervention （PCI） has not yet been fully investigated. This study aimed to evaluate the gender difference on ...Background The gender difference on long-term outcome in unselected patients after percutaneous coronary intervention （PCI） has not yet been fully investigated. This study aimed to evaluate the gender difference on five-year outcomes following EXCEL biodegradable polymer-coated sirolimus-eluting stenting in patients with coronary disease. Methods A total of 2077 ＂all comers＂, consisting of 1528 （73.6%） men and 549 （26.4%） women, who were exclusively treated with EXCEL coronary stents were enrolled in the prospective CREATE study at 59 centers from four countries. After propensity score matching, the baseline characteristics of the two groups were well matched. Recommended antiplatelet regimen was clopidogrel and aspirin for six months followed by chronic aspirin therapy. The primary outcome that was the rate of major adverse cardiac events （MACE）, defined as a composite of cardiac mortality, non-fatal myocardial infarction （MI） and target lesion revascularization （TLR）, and stent thrombosis （ST） at five years were compared between the two gender groups. Results In the two groups, women had higher proportions of clinical risk factors, such as being elderly, diabetes mellitus, hypertension and hyperlipidemia, compared to men. Besides, the mean target vessel number per patient was higher and the mean reference vessel diameter smaller for women. Men had higher risks of cardiac death （3.7% vs. 1.6%, P=-0.021） and MACE （8.4% vs. 4.7%, P=-0.004） at five years compared with women. However, the cumulative hazards of non-fatal MI and TLR were similar between men and women. The incidence of Academic Research Consortium （ARC） definite or probable stent thrombosis was similar between the two groups （1.3% vs. 1.0%, P=0.639）. Prolonged clopidogrel therapy （〉6 months） did not reduce the cumulative hazards of ST from six months to five years in both men （X^2=0.098, log rank P=0.754） and women （X2=2.043, log rank P=-0.153） patients. Conclusions Women had a lower MACE and cardiac death rate than men after biodegradable polymer-coated sirolimus-eluting stenting in long term follow-up. Effects of prolonged dual antiplatelet therapy （DAPT） in preventing stent thrombosis was similar with six-month DAPT after EXCEL stent implantation in both men and women groups.展开更多
基金This work was supported by grants from the National Natural Science Foundation of China （No. 30872675 and No. 30901549）, and Science and Technology Commission of Shanghai Municipality （No. 08411965100 and No. 12JC 1401800）. Conflict of interest： none.
文摘Background Meningioma is one of the most common primary tumors of the central nervous system, but there are not many detailed studies on the sex, age, subtypes and locations of large series. This study was a retrospective analysis of the characteristics of meningioma cases consecutively operated on at a single institution in China from 2001 to 2010. Methods This study investigated the demographic background of 7084 meningioma cases, and the subtypes and locations of the tumors. Sex and age distributions were analyzed, and the pathological subtypes were classified according to the World Health Organization （WHO） classification. The location of the meningiomas was also categorized. Results The female：male ratio of the 7084 cases was 2.34：1. The mean age was 51.4 years （range, 11 months-86 years）. The mean age of cases of WHO grade I meningioma was significantly older than that of grade II or III meningiomas （P 〈0.001, Fisher＇s Least Significant Digit test）. There was a significantly higher female：male ratio in WHO grade I meningiomas than in grade II or grade III meningiomas （2.57, 1.03 and 0.76, respectively; P 〈0.001, X^2 test）. Meningothelial （n=2061） and fibrous meningiomas （n=3556） were the most common subtypes, comprising 79.3% of all meningiomas. All meningioma cases were classified into 23 locations in this study, with the cerebral convexity the most common site （38.33%, n=2722）. Cases with uncommon locations such as extra-cranial and sylvian fissure meningiomas were also present in this series. Conclusions Female predominance was found for benign meningiomas, while malignant subtypes showed male predominance. The mean age of patients with WHO grade Ⅰ meningiomas was older than that of patients with higher-grade tumors. Meningothelial and fibrous meningiomas were the most common subtypes. The cerebral convexity was the most common menin.qioma location.
文摘Background The gender difference on long-term outcome in unselected patients after percutaneous coronary intervention （PCI） has not yet been fully investigated. This study aimed to evaluate the gender difference on five-year outcomes following EXCEL biodegradable polymer-coated sirolimus-eluting stenting in patients with coronary disease. Methods A total of 2077 ＂all comers＂, consisting of 1528 （73.6%） men and 549 （26.4%） women, who were exclusively treated with EXCEL coronary stents were enrolled in the prospective CREATE study at 59 centers from four countries. After propensity score matching, the baseline characteristics of the two groups were well matched. Recommended antiplatelet regimen was clopidogrel and aspirin for six months followed by chronic aspirin therapy. The primary outcome that was the rate of major adverse cardiac events （MACE）, defined as a composite of cardiac mortality, non-fatal myocardial infarction （MI） and target lesion revascularization （TLR）, and stent thrombosis （ST） at five years were compared between the two gender groups. Results In the two groups, women had higher proportions of clinical risk factors, such as being elderly, diabetes mellitus, hypertension and hyperlipidemia, compared to men. Besides, the mean target vessel number per patient was higher and the mean reference vessel diameter smaller for women. Men had higher risks of cardiac death （3.7% vs. 1.6%, P=-0.021） and MACE （8.4% vs. 4.7%, P=-0.004） at five years compared with women. However, the cumulative hazards of non-fatal MI and TLR were similar between men and women. The incidence of Academic Research Consortium （ARC） definite or probable stent thrombosis was similar between the two groups （1.3% vs. 1.0%, P=0.639）. Prolonged clopidogrel therapy （〉6 months） did not reduce the cumulative hazards of ST from six months to five years in both men （X^2=0.098, log rank P=0.754） and women （X2=2.043, log rank P=-0.153） patients. Conclusions Women had a lower MACE and cardiac death rate than men after biodegradable polymer-coated sirolimus-eluting stenting in long term follow-up. Effects of prolonged dual antiplatelet therapy （DAPT） in preventing stent thrombosis was similar with six-month DAPT after EXCEL stent implantation in both men and women groups.
