Polychlorinated biphenyls (PCBs) are ubiquitous, persistent and lipophilic environmental endocrine disrupters that can be biomagnified in human and animals including birds and thus to affect reproductive functions. Po...Polychlorinated biphenyls (PCBs) are ubiquitous, persistent and lipophilic environmental endocrine disrupters that can be biomagnified in human and animals including birds and thus to affect reproductive functions. Poultry meat and eggs contain a great deal of fat and possibly concentrate higher PCBs and other environmental contaminants such as dichlorodiphenyl-trichloroethane (DDT). In order to identify the adverse effects of PCBs and possible sexual difference on chicken gonadal development, Aroclor 1254 was injected into fertilized Hyline chicken eggs before incubation. Four groups of eggs received yolk injection of either peanut oil as control, 1, 10 or 100 μg/egg of Aroclor 1254 as treatment group, respectively. After hatching the gonads were removed for histological examination. Testicular structure was apparently changed and exhibited dramatic decrease in area of the transverse sections (1μg/egg, P【 0.01; 10 and 100 μg/egg, P【0.001), diameter (10 and 100 μg/egg, P 【0.05) and relative area of展开更多
Genital tract infections with ureaplasma urealyticum（UU） and chlamydia trachomatis（CT） are the most frequent sexually-transmitted disease worldwide. UU and CT infections are considered to be the leading cause for ...Genital tract infections with ureaplasma urealyticum（UU） and chlamydia trachomatis（CT） are the most frequent sexually-transmitted disease worldwide. UU and CT infections are considered to be the leading cause for infertility and adverse pregnancy outcomes. However, little is known about the specific effect of cervical UU and CT infections on the etiology of female infertility, as well as the pregnancy outcomes of the patients undergoing in vitro fertilization/intracytoplasmic sperm injection-embryo transfer（IVF/ICSI-ET）. In order to find the association between cervical UU and/or CT infection and pregnancy outcomes, we conducted a retrospective case-control study on the patients undergoing IVF/ICSI-ET with cervical UU and/or CT infection. A total of 2208 patients who received IVF/ICSI-ET were enrolled in this study. Data on the general conditions, pregnancy history and clinical pregnant outcomes were analyzed in terms of the cervical UU and CT detection. Our results revealed that cervical UU and CT infections were the risk factors for ectopic pregnancy and tubal factor-induced infertility. Moreover, the pregnancy rate, abortion rate, ectopic pregnancy rate and premature birth rate in patients with UU and/or CT infections showed no significant difference when compared with the control group. We recommend that cervical UU and CT detection should be an optional item for infertility patients and clinical UU detection should differentiate the subtypes of cervical UU. Positive cervical UU and CT infections should not be taken as strict contraindications for IVF/ICSI-ET.展开更多
基金This work was supported by the Beijing Natural Science Foundation (Grant No. 6992019) the National Natural Sci- ence Foundation of China (Grant No. 39970535).
文摘Polychlorinated biphenyls (PCBs) are ubiquitous, persistent and lipophilic environmental endocrine disrupters that can be biomagnified in human and animals including birds and thus to affect reproductive functions. Poultry meat and eggs contain a great deal of fat and possibly concentrate higher PCBs and other environmental contaminants such as dichlorodiphenyl-trichloroethane (DDT). In order to identify the adverse effects of PCBs and possible sexual difference on chicken gonadal development, Aroclor 1254 was injected into fertilized Hyline chicken eggs before incubation. Four groups of eggs received yolk injection of either peanut oil as control, 1, 10 or 100 μg/egg of Aroclor 1254 as treatment group, respectively. After hatching the gonads were removed for histological examination. Testicular structure was apparently changed and exhibited dramatic decrease in area of the transverse sections (1μg/egg, P【 0.01; 10 and 100 μg/egg, P【0.001), diameter (10 and 100 μg/egg, P 【0.05) and relative area of
基金supported by a research program on the Hubei provincial population and family planning(No.JS-2012011)
文摘Genital tract infections with ureaplasma urealyticum（UU） and chlamydia trachomatis（CT） are the most frequent sexually-transmitted disease worldwide. UU and CT infections are considered to be the leading cause for infertility and adverse pregnancy outcomes. However, little is known about the specific effect of cervical UU and CT infections on the etiology of female infertility, as well as the pregnancy outcomes of the patients undergoing in vitro fertilization/intracytoplasmic sperm injection-embryo transfer（IVF/ICSI-ET）. In order to find the association between cervical UU and/or CT infection and pregnancy outcomes, we conducted a retrospective case-control study on the patients undergoing IVF/ICSI-ET with cervical UU and/or CT infection. A total of 2208 patients who received IVF/ICSI-ET were enrolled in this study. Data on the general conditions, pregnancy history and clinical pregnant outcomes were analyzed in terms of the cervical UU and CT detection. Our results revealed that cervical UU and CT infections were the risk factors for ectopic pregnancy and tubal factor-induced infertility. Moreover, the pregnancy rate, abortion rate, ectopic pregnancy rate and premature birth rate in patients with UU and/or CT infections showed no significant difference when compared with the control group. We recommend that cervical UU and CT detection should be an optional item for infertility patients and clinical UU detection should differentiate the subtypes of cervical UU. Positive cervical UU and CT infections should not be taken as strict contraindications for IVF/ICSI-ET.
