Misdiagnosis of Sexually Transmitted Diseases in Hong Kong Outpatient Private Healthcare

Background and objective: Early and accurate diagnosis is one of the critical requirements for successful management of all diseases. Yet, delayed diagnosis and misdiagnosis remain as vital problems, consequently impose adverse effects on patient treatment. Sexually transmitted disease (STD) is one of the most common infectious diseases, and more than one million of STD cases are acquired every day globally. Misdiagnosis of STD inevitably exists, therefore should not be overlooked. Being a medical diagnostic laboratory providing various STDs diagnosing service in Hong Kong, we aimed to determine the misdiagnosis rate of STDs and investigate the possible underlying cause. Methods: Specimens were collected for STD diagnosis from multiple clinics during 1 June 2021 to 20 October 2021 from different clinics and hospitals were included in the study. DNA extraction was performed using magnetic bead based method;then the extracted DNA was tested using the DiagCor GenoFlowTM STD Array kit to detect the existence of any targeted pathogens. Results: 1459 specimens were collected and included during the designated time period, with 643 specimens found to be positive with at least one targeted STD pathogen. 494 of these were found to be aligned with test ordered by physicians, and the remaining 149 positive cases had at least one pathogen detected but not requested to be tested by the physicians resulting in misdiagnosis. The overall misdiagnosis rate was determined to be 23.2% (149/643), with high frequency of misdiagnosis occurred to tests ordered for one to three pathogens detection. Also, Ureaplasma urealyticum and/or Ureaplasma parvum (UU/UP) was the commonest pathogen detected in this study. Conclusion: The findings suggested incorrect test selection made by physicians was one of the major reasons of STDs misdiagnosis in outpatient settings. To reduce diagnostic errors in STD diagnosis, physicians are encouraged to select and request test that allow detection of multiple pathogens, as co-infection of multiple pathogens in STD patients is commonly observed. The correct selection of test would not only benefit the patient, but also the public health.

Epidemiological Investigation of Human Papillomavirus Infection in Men Attending a Sexually Transmitted Disease Clinic in Hangzhou Area

Objective To investigate the epidemiological characteristics of human papillomavirus （HPV） infection in men attending a sexually transmitted diseases （STD） clinic in Hangzhou area. Methods Male subjects （n=375） aged 18-70 years, attending the STD clinic were recruited. Urethral swabs were assessed for HPV DNA using polymerase chain reaction （PCR） with the consensus primers MY09/11. HPV genotypes of positive PCR products were determined by restriction fragment length polymorphisms and direct sequence analysis. Results Of the 375 swabs collected, 305 （81.3%） yielded sufficient DNA for the subsequent HPV analysis. Among the 305 subjects, the prevalence of HPV was 13.8%. Nononcogenic HPV types were found in 8.5% （26/305） of subjects, oncogenic types in 4.3% （13/305）, and multiple types in 1.0% （3/305）. The prevalence of HPV infection was higher in subjects from urban area than in those from rural area （P〈0.05）. The prevalence was also higher in those who received fewer years of education （P〈0.05） and those who had more sex partners （P〈0.05）. Conclusions HPV infection among men at high risk is not uncommon. The detection rate of HPV DNA is significantly related to some sociodemographic factors, such as residence, educational level and the number of sex partners.

Global epidemiology of sexually transmitted diseases

Sexually transmitted diseases （STDs） are among the first ten causes of unpleasant diseases in young adult males in developing countries and the second major cause of unpleasant diseases in young adult women. Adolescents and young adults （15-24 years old） make up only 25% of the sexually active population, but represent almost 50% of all new acquired STDs. In general, STDs are epidemics and present an enormous health and economic consequences. An adequate screening for STDs should be done on a routine basis in every part of the world. Many STDs are asymptomatic and therefore can difficult to control. The purpose of reporting of STDs is to ensure that persons who are infected will be quickly diagnosed and appropriately treated to control the spread of infection and also so that partners are notified, tested and appropriately treated. It is estimated that reported cases of STDs represent only 50%-80% of reportable STD infections in the United States, reflecting limited screening and low disease reporting. High-risk sexual behavior is a highly contributive factor of this process as it often leads to teenage pregnancies and HIV/AIDS. One possible explanation for this behavior is that people do not have enough information about the transmission of STDs or ignore the precautions required for safe sex. Approximately 60% of new HIV infections worldwide occur in young people. The frequency of high-risk behaviors among youths may also be influenced by opportunity to engage in them, particularly the amount of time that they are unsupervised by adults. However, in diagnosing and treating these patients, we can effectively prevent the spread of HIV/AIDS. Individuals infected with STDs are 5-10 times more likely than uninfected individuals to acquire or transmit HIV through sexual contact. The breaking of the genital tract lining or skin creates a portal of entry for HIV and, hence, HIV-infected individuals with other STDs are more likely to shed HIV in their genital secretions. To date, the condom is the most effective method available for males for protection against STDs. It is important to control STDs, and prevention can be the key of this process. Prevention can be achieved through education of the population, identification of symptomatic and asymptomatic people, and effective diagnosis and treatment of these patients and their partners.

Dynamic analysis of a sexually transmitted disease model on complex networks

In this paper,a sexually transmitted disease model is proposed on complex networks,where contacts between humans are treated as a scale-free social network.There are three groups in our model,which are dangerous male,non-dangerous male,and female.By mathematical analysis,we obtain the basic reproduction number for the existence of endemic equilibrium and study the effects of various immunization schemes about different groups.Furthermore,numerical simulations are undertaken to verify more conclusions.

SEXUALLY TRANSMITTED DISEASE CONTROL IN CHINA(1949—1994)

ＳＥＸＵＡＬＬＹＴＲＡＮＳＭＩＴＴＥＤＤＩＳＥＡＳＥＣＯＮＴＲＯＬＩＮＣＨＩＮＡ（１９４９─１９９４）ＳｈａｏＣｈａｎｇｇｅｎｇ（邵长庚）；ＸｕＷｅｎｙａｎ（徐文严）ａｎｄＹｅＧａｎｙｕｎ（叶干运）（ＩｎｓｔｉｔｕｔｅｏｆＤｅｒｍａｔｏｌｏｇｙ，ＣＡ...

Case of Fitz-Hugh-Curtis syndrome in male without presentation of sexually transmitted disease

Fitz-Hugh-Curtis syndrome is a type of perihepatitis that causes liver capsular infection without infecting the hepatic parenchyma or pelvis. Fitz-Hugh-Curtis syndrome is known to occur commonly in women of childbearing age who do not use oral contraceptives and have sexual partners older than 25 years of age. However, the syndrome has been reported to occur rarely in males. The clinical symptoms are right upper quadrant pain and tenderness, and pleuritic right sided chest pain. The clinical presentation is similar in male and female. We experienced a case of Fitz-HughCurtis syndrome in a 60-year-old man with the chief complaint of right upper quadrant abdominal pain. Despite a previous history of gonorrhea, we have also described our experiences of improved symptoms and recovery with allopathic medicines and have thereby reported the present case with a literature review.

Advances on Syndromic Management of Sexually Transmitted Diseases

Research data showed that syndromic approach could successfully manage gonococcal and chlamydial infections in males and syphilis and chancroid in males and females. However, low sensitivity, specificity and positive predictive value were found in the syndromic management of vaginal discharge. It is recommended that the syndromic algorithm for management of vaginal discharge used when serving high-risk and symptomatic women.

Sexually transmitted infections of the anus and rectum

Sexually transmitted infections(STIs) represent a significant public health concern.Several STIs,once thought to be on the verge of extinction,have recently reemerged.This change is thought to be partially related to an increase in STIs of the anus and rectum.Importantly,the global human immunodeficiency virus and acquired immunodeficiency syndrome(HIV/AIDS) epidemic has contributed to the emergence of particular anorectal lesions that require specialized approaches.In this report,we review common anorectal STIs that are frequently referred to colorectal surgeons in the United States.Epidemiology,clinical presentation,and management are summarized,including the latest treatment recommendations.The particularity of anorectal diseases in HIV/AIDS is addressed,along with recent trends in anal cytology and human papillomavirus vaccination.

Perception of Sexually Transmitted Infection-Preventive Measures among Senior Secondary School Students in Nnewi-North Local Government Area, Anambra State, Nigeria

Background: Sexually transmitted infections-preventive measures are effective methods employed in the prevention of sexually transmitted infections [STIs]. Sexually transmitted infections are among the most common infections in the world and therefore a major public health problem as they cause devastating long term consequences if untreated, especially in adolescents. Sexually transmitted infection-preventive measures, if correctly and consistently used, have been proven to be efficacious. Methodology: This was a cross-sectional descriptive study carried out among SS2 and SS3 students in Nnewi North Local Government Area of Anambra state, Nigeria. A structured, self administered questionnaire was administered to consenting senior secondary students to gather relevant information about socio-demogaraphic characteristics, knowledge about STIs, sexual behaviours. Three hundred and thirty four students participated in the study. Multi stage sampling technique was used. SPSS version 20 was used to analyze the data. Results were represented in tables and graphs. Results: Three hundred and thirty four students participated in the study, of which females and males are 167 each. 89% understood the meaning of STI. The majority of the respondents got the knowledge from TV/radio (34.4%), teachers (28.1%) and mother (27.0%). The majority of respondents knew that HIV/AIDS (89.8%), syphilis (58.1%) and Gonorrhoea (56.9%) were STIs. Good numbers of respondents knew the symptoms of STIs and risk factors of STI with unprotected sex and multiple sexual partners (57.5%) and (42.2%) respectively, as the highest risk factors. About 75.7% of respondents knew that HIV/AIDS cannot be cured. The Majority knew that avoiding sexual intercourse, being faithful to one partner and use of condom are preventive measures respectively. The majority of respondents (71%) felt they cannot be infected with an STI. 92.8% believed that STIs can be prevented. Age range for first sexual intercourse was 13 - 18 years for females and 8 - 19 years for males. Of the 86 that have had sexual intercourse, 48.8% had experienced one or more of the symptoms of STIs and the majority (80.9%) went to a hospital for treatment. Males (31.4%) are more likely to have multiple sexual partners than females (4.7%). Conclusion: The majority of the students had an objective knowledge on STIs transmission and prevention. Their overall attitude was positive but their practices were not satisfactory, especially for the males. Females were more careful and health conscious than their male counterpart.

Impact of sexually transmitted infections on women health

Sexually transmitted infections (STIs) are the infections that can be transmitted from one sex partner, who already has such infection, to another. The causes of STIs in human are very well elucidated and their causative agents are identified as bacteria, parasites and viruses. The worldwide epidemiology of more than 20 types of STIs has been established, which includes diseases like Chlamydia, Gonorrhea, Genital herpes, HIV/ AIDS, HPV, Syphilis and Trichomoniasis. Though STIs affect both men and women indiscriminately, however, the pathophysiology of disease is more obvious among women. Other than abstinence, the most effective way to prevent the transmission or acquisition of STIs is to use a condom during sexual intercourse. Condoms are effective in decreasing the transmission of HIV. However, once contacted, STIs caused by bacteria or parasites can be treated with antibiotics. STIs caused by a virus may not virtually have any cure though the medicines may keep the disease under control. Correct usage of preventive measures greatly reduces but does not completely eliminate the risk of catching or spreading STIs.

Sexually Transmitted Infections (STIs) Knowledge Assessment of Adults in a US South Eastern Texas Region

The purpose of this cross-sectional descriptive study was to assess knowledge level regarding signs and symptoms, prevention, treatment of STIs among a sample of residents from Southeastern Texas. One hundred and fifty-seven participants age 18 and over responded to the 23 questionnaire items. Questionnaires were distributed to mostly public places such as hair salons, fitness centers, health centers, gas stations, apartments, and stores. Results indicated that 50.3% of participants reported syphilis was not curable;while over 61% reported gonorrhea was incurable. Over 64% of respondents reported they did know the symptoms for syphilis and over 70% believed that syphilis was vaccine preventable. The data collected from this study indicated that some residents from Southeast Texas lack basic information concerning Syphilis, Gonorrhea, and Chlamydia with regard to prevention, signs and symptoms, and treatment. The cost and effort to increase educational programs and educational messages appear to be justified. Implications for practice include increasing funding and efforts to provide more educational programs focusing on sexually transmitted disease prevention, health literary education to dispel the myths and stigma related to STIs and community wide collaboration efforts to increase awareness.

Women and Sexually Transmitted Infections in Africa

Despite efforts to control the spread of sexually transmitted infections (STIs), these infections are still highly prevalent in the developing world, especially in Africa where the prevalence and incidence of Human immunodeficiency virus (HIV) is also very high. Unfortunately, women bear the disproportionate burden of both STIs and HIV in this region. Early diagnosis, treatment and prevention of STIs is therefore crucial in this population given the strong evidence that some STIs have been shown to facilitate the transmission of HIV. This review summarizes the epidemiology, and management of the common STIs affecting African women, and the health complications associated with these infections in the era of emerging antimicrobial resistance.

Sexually Transmitted Infections among African-American Population of the Midwest United States

Background: Sexually transmitted infections (STIs) such as chlamydia and gonorrhea are commonly reported infections in the United States. Greater Omaha has had continually higher reported rates of chlamydia and gonorrhea for more than a decade compared to the rest of the state rates. Minority and young adults have been disproportionately affected. Purpose: The objectives of our study were to estimate the prevalence and to identify risk factors for chlamydia and gonorrhea among young adults. Methods: We conducted a cross-sectional survey with 310 young adults aged 19 -25 years between June 2011 and June 2012. The study collected socio-demographic, behavioral and other risk factors for STIs utilizing a pre-design standardized questionnaire. Gonorrhea and chlamydia status of the participants were established by testing urine samples using PCR-based diagnostic technique. Descriptive and multivariable regression analyses were used to examine risk factors for STIs. Results: About 12.6% survey participants had at least one STI test positive. Lower education was associated with STIs but was not statistically significant (Odd Ratio for no schooling was 8.24, 95% CI 0.93 -72.86, Odd Ratio for high school education was 2.05, 95% CI 0.25 -16.63 compared to associate or college level education). No other predictors were associated with STIs. The average age of the first sexual intercourse was lower, and the number of sexual partners was higher compared to their national counterparts. Conclusion: We found a higher percentage of STI-positive individuals compared to previously reported county-level estimates. Education was the single and most important predictor of positive STI status.

Knowledge of sexually transmitted infections among senior high school adolescents in the Wa Municipality of Ghana

Background:Sexually transmitted infections(STIs)are responsible for a high burden of morbidity and mortality in many developing countries especially among adolescents.Adolescents are predisposed to STIs because they are more likely to engage in unhealthy lifestyles.However,these adolescents have limited knowledge of the use and barriers to sexual and reproductive health information and care services.This study explored the knowledge of STIs among Senior High School Adolescents in the Wa Municipality of Ghana.Method:The study designed as a descriptive cross-sectional research.A multistage sampling technique was used to recruit these adolescents for the study.Totally 355 adolescents were selected from senior high schools in the Wa Municipality.Descriptive statistics and Chi-square test were used to analyze the data,at a significance level ofP<0.05.Results:The majority of respondents had good knowledge of STIs,with the most common examples of STIs identified as HIV/AIDS(80.8%,287/355)and gonorrhea(73.8%,262/355).The main known signs and symptoms identified were discharges from the penis/vagina(72.4%,257/355),painful urination(71.5%,254/355),and itching,and sores around the genital area(72.7%,258/355).The main sources of information/education of STIs for these adolescents were the school,hospital,internet and mother.Whom respondent lived with was found to be significantly associated with knowledge of STI(P<0.001).Conclusion:Many of the respondents had good knowledge of STI,and the school was the most common source of information on STL It is,therefore,important for the Ghana Education Service and the Ghana Health Service to strengthen the School Health Education Programme in second cycle institutions in the Wa Municipality.Parents,especially mothers,should be actively involved in the sexual health education of adolescents.

Sexually Transmitted Diseases at Monkey Bay Community Hospital in Mangochi, Malawi;an Analysis of Characteristics of Common Sexually Transmitted Diseases

We present the characteristics of the commonly diagnosed sexually transmitted infections (STI) at a clinic of Monkey Bay community hospital by a retrospective study. We conducted an audit of patients’ hospital records from a STIs clinic at Monkey Bay community hospital in Mangochi District (Malawi) covering a period from January 2019 to June 2019 (18 months). Data was tabulated in excel and analyses were made based on sex, age, male circumcision status, pregnancy and the pattern of STIs diagnosed within the chosen study period. A total number of 659 clients presented at STI clinic of Monkey Bay community hospital between January 2018 and June 2019. Out these clients, 409 (62%) were females and 250 (38%) were males. Most of the patients were in the age range of 25 years or above (447, 68%). Majority of the patients were HIV negative (523, 79%). Out of the 250 males, 113 (45%) were circumcised. Among female patients 56 of the 409 (14%) were pregnant. The most common presentations for all cases put together were lower abdominal pain (253, 38%), then urethral discharge (189, 29%), abnormal vaginal discharge (141, 21%), genital ulcer disease (64, 10%), in that order. Syphilis, genital warts, inguinal bubo and scrotal swelling were less common. The most common presentation in males was urethral discharge (178, 71%), while in females it was lower abdominal pain (214, 52%). Our audit showed that in Mangochi (Malawi) sexually transmitted diseases of various types are more common among young adults, females and uncircumcised men. There was no much difference in the percentage of STI’s between HIV positive and HIV negative people. These results point to an alarmingly high level of risky sexual behaviors among sexually active age groups in this part of Malawi, a country which still has one of the highest HIV prevalence in sub-Saharan Africa. This calls for continued and better research and control for transmission of STIs in the district.

The Social Determinants of Health in Relation to Sexually Transmitted Infections in Maricopa County Arizona

Based on the information that was collected on the County Health Rankings website [1], one of the top health concerns for Maricopa County was sexually transmitted infections or STIs. A big concern with STIs is this is not a common subject explored in educational settings or addressed socially. There are many organizations, including the CDC, that have access to materials, there is limited distribution of the educational content. Therefore, the public is not well informed and lacks the information to make educated decisions. The areas with insufficiencies are knowledge of the disease processes, prevention, and treatment.

Socio-Demographic, Clinical, and Hygiene Profile of Syndromically Managed Sexually Transmitted Diseases: A Cross Sectional Study in a Tertiary Care Center in India

Background: Sexually transmitted diseases are one of the several major public health concerns, the burden of which is borne by low- and middle-income countries like India. Purpose: The purpose is to evaluate the relationship between menstrual and sanitary hygiene and sexually transmitted diseases (STD) based on syndromic diagnosis Methods: An out-patient department (OPD) based cross sectional survey to determine these associations, if any exist, which would help critically analyze syndromic management. STD was reported by the presence of vaginal/cervical/urethral discharge with or without irritation and itching, lower abdominal pain and ulcer. Results: The prevalence of STD was 66.84% with the most commonly reported symptoms being discharged (31.18%), followed by abdominal pain (17.92%) and itching/irritation (12.90%), with ulcer (4.83%) being the least reported symptom. Perimenopausal age ((AOR: 0.420 [CI: 0.189 - 0.915];p = 0.030), higher grades of education ((AOR: 0.228 [CI: 0.119 - 0.424];p < 0.001) for secondary), urban residency (AOR: 0.435 [CI: 0.686 - 2.733];p < 0.001), and contraception use (AOR: 0.531 [CI: 0.308 - 0.887];p = 0.018) were associated with lesser odds of presenting with an STD symptom. Belonging to a minority religious community (AOR: 7.20 [CI: 1.866 - 48.251];p < 0.012) or backward castes (AOR: 3.753 [CI: 1.587 - 10.144];p < 0.001), having similar illness (AOR: 4.205 [CI: 2.795 - 6.439];p < 0.001) or having an invasive gynecological procedure done in the past one year (AOR: 1.953 [CI: 1.184 - 3.295];p = 0.010) and washing the reusable sanitary material only with water (AOR: 4.900 [CI: 2.701 - 9.116];p < 0.001) as compared to washing it with water and soap, had a higher association with presenting with STD symptoms. Stratified analysis also showed that women presenting discharge (AOR: 2.049 [CI: 1.343 - 3.146] for vaginal and cervical;AOR: 1.426 [CI: 0.826 - 2.482] for urethral) were more likely to not have a toilet facility in an accessible condition. Women with sanitary napkin use had lesser odds (AOR: 0.780 [CI: 0.516 - 1.180];p = 0.293) of presentation for STD in OPD than women who used other material. Conclusion: To better manage the group of diseases that may present with symptoms of STD under syndromic approach, we propose interventions such as menstrual hygiene education and promotion of the use of sanitary napkins among women especially those belonging to lower socio-economic sections of the society.

SEXUALLY TRANSMITTED DISEASES:INCIDENCE AND DISTRIBUTION

ＳＥＸＵＡＬＬＹＴＲＡＮＳＭＩＴＴＥＤＤＩＳＥＡＳＥＳ：ＩＮＣＩＤＥＮＣＥＡＮＤＤＩＳＴＲＩＢＵＴＩＯＮＷａｎｇＱｉａｎｑｉｕ王千秋（ＮａｔｉｏｎａｌＣｅｎｔｅｒｆｏｒＳＴＤａｎｄＬｅｐｒｏｓｙＣｏｎｔｒｏｌ，ＩｎｓｔｉｔｕｔｅｏｆＤｅｒｍａｔｏｌｏ...

Rapid Determination of Sexually Transmitted Infections by Real-time Polymerase Chain Reaction Using Microchip Analyzer

Development of non expensive and time-saving techniques based on the polymerase chain reaction (PCR) is of great importance for modern diagnostics. We considered a new approach for PCR determination of a variety of sexually transmitted infections using microchip analyzer “AriaDNA”, which had been tested using clinical samples in several medical institutions of St. Petersburg (Russia). The use of microchips containing lyophilized PCR reagents allows reducing significantly time of analysis and the number of manipulations thus preventing possible sample contamination.

Arboviruses and Sexually Transmitted Infections in the Bioceanic Route: Health Indicators in a Municipality

Background: the physical integration of South America through a Bioceanic Corridor has been idealized for a long time by the countries that make up Mercosur. This integration will have impacts on the population residing in the cities where the route will be built. Among them, Porto Murtinho, southern Mato Grosso on the border with Paraguay, stands out, where a bridge will be built over the Paraguay River that will link these two countries. Methods: a retrospective, quantitative and cross-sectional study of a descriptive type of documentary approach that sought to analyze the prevalence of arboviruses, Sexually Transmitted Infections (STIs) and Diseases Related to Inadequate Environmental Sanitation (DRIES) notified and stored in the National System of Notifiable Diseases (SINAN). The sample consisted of new cases of these pathologies in the municipality of Porto Murtinho registered between January 2017 and December 2020. Results: there was an increase of 10% in the total number of diseases within this period. The number of dengue cases increased 36 times;the incidence of Syphilis, HIV and HPV decreased;and, finally, maintenance of cases of Gonorrhea, Leptospirosis, Yellow Fever, Zika, Chikungunya, Hepatitis A and B. Conclusions: actions are needed to prevent the increase of these pathologies together with the construction of the Bioceanic Route, thus avoiding damage population health and increased consumption of government resources.