Objective Here, we explored molecular changes that could potentially mediate healing effects of Gua Sha — a method employed by the Chinese traditional medicine with proven track records of safe and efficient applicat...Objective Here, we explored molecular changes that could potentially mediate healing effects of Gua Sha — a method employed by the Chinese traditional medicine with proven track records of safe and efficient applications dating back to ancient times as well as support from randomized controlled trials performed by modern medical studies — yet remaining almost entirely unexplored by the modern-day high-throughput methods of the-omics sciences.Methods We investigated transcriptome changes occurring shortly after Gua Sha treatment in the whole blood of healthy volunteers using bulk RNA-seq analysis. We applied various analytical tools to identify genes with consistent expression changes in multiple individuals in response to Gua Sha and their networks.Results We found that while the changes were very subtle and individual-specific, we could identify consistent upregulation of three histone genes. Further analysis of the potential regulatory networks of these histone genes revealed the enrichment of functions involved in the immune response and inflammation.Conclusion The significance of these results in the context of potential effects of Gua Sha and the next steps in exploring the molecular mechanisms of action of this technique are discussed.展开更多
随着二维码技术广泛应用于电子票务、银行支票、电子保单等多个领域,二维码的信息泄露和信息篡改等安全问题日益突出.为提高二维码内部信息的安全性能,从对二维码内部信息加密和二维码信息防篡改俩个角度来提高.基于Visual Studio 2008...随着二维码技术广泛应用于电子票务、银行支票、电子保单等多个领域,二维码的信息泄露和信息篡改等安全问题日益突出.为提高二维码内部信息的安全性能,从对二维码内部信息加密和二维码信息防篡改俩个角度来提高.基于Visual Studio 2008 C#平台,设计了一种采用SHA512哈希函数和Rijndael加密算法混合加密的方法,该方法利用Rijndael加密和SHA512数字签名等技术,对Rijndael第一次加密密钥系统随机分配,并对系统随机分配密钥采用二次Rijndael加密防护方法,并通过SHA512对二维码内部信息防篡改校验,达到对二维码信息及其加密密钥的安全保护.在生成QR二维码之前实现了信息加密,并从系统构架、算法原理和实现及安全性能等多个方面进行了测试和分析.分析表明此方法提高了二维码信息的安全性能,达到对密钥高效管理和对信息的多重保护,而在加密后密文信息容量较明文信息有所增加.展开更多
基金supported by the National Natural Science Foundation of China [Grant No. 32170619 to PK and Grant No. 32000462 to FQ]the Research Fund for International Senior Scientists from the National Natural Science Foundation of China [Grant No. 32150710525 to PK]+1 种基金the Natural Science Foundation of Fujian Province,China [Grant No. 2020J02006 to PK]the Scientific Research Funds of Huaqiao University [Grant No. 15BS101 to PK and Grant No. 22BS114 to FQ]。
文摘Objective Here, we explored molecular changes that could potentially mediate healing effects of Gua Sha — a method employed by the Chinese traditional medicine with proven track records of safe and efficient applications dating back to ancient times as well as support from randomized controlled trials performed by modern medical studies — yet remaining almost entirely unexplored by the modern-day high-throughput methods of the-omics sciences.Methods We investigated transcriptome changes occurring shortly after Gua Sha treatment in the whole blood of healthy volunteers using bulk RNA-seq analysis. We applied various analytical tools to identify genes with consistent expression changes in multiple individuals in response to Gua Sha and their networks.Results We found that while the changes were very subtle and individual-specific, we could identify consistent upregulation of three histone genes. Further analysis of the potential regulatory networks of these histone genes revealed the enrichment of functions involved in the immune response and inflammation.Conclusion The significance of these results in the context of potential effects of Gua Sha and the next steps in exploring the molecular mechanisms of action of this technique are discussed.
文摘随着二维码技术广泛应用于电子票务、银行支票、电子保单等多个领域,二维码的信息泄露和信息篡改等安全问题日益突出.为提高二维码内部信息的安全性能,从对二维码内部信息加密和二维码信息防篡改俩个角度来提高.基于Visual Studio 2008 C#平台,设计了一种采用SHA512哈希函数和Rijndael加密算法混合加密的方法,该方法利用Rijndael加密和SHA512数字签名等技术,对Rijndael第一次加密密钥系统随机分配,并对系统随机分配密钥采用二次Rijndael加密防护方法,并通过SHA512对二维码内部信息防篡改校验,达到对二维码信息及其加密密钥的安全保护.在生成QR二维码之前实现了信息加密,并从系统构架、算法原理和实现及安全性能等多个方面进行了测试和分析.分析表明此方法提高了二维码信息的安全性能,达到对密钥高效管理和对信息的多重保护,而在加密后密文信息容量较明文信息有所增加.
