Objective： To observe the efficacy and safety of Jingui Shengqi Pill （金匮肾气丸, JSP） in treating partial androgen deficiency in aging males （PADAM）, and to explore the new approach in improving the quality of l...Objective： To observe the efficacy and safety of Jingui Shengqi Pill （金匮肾气丸, JSP） in treating partial androgen deficiency in aging males （PADAM）, and to explore the new approach in improving the quality of life in PADAM patients. Methods： Forty patients with PADAM were treated with JSP, the efficacy was evaluated with international index of erectile function （IIEF） scoring, PADAM questionnaire scoring, hormone, prostatic specific antigen （PSA）, etc., and the data before treatment were compared with those after treatment in the same group. Results： After 3 months of treatment, PADAM scoring and IIEF scoring were all significantly improved. Symptoms regarding physical ability, vasomotion, and psychical and mental condition all got improved more markedly than symptoms regarding sexual hypofunction. The serum level of testosterone was 3.85±0.36 before treatment and 5.02±0.83 after treatmnet （P〈0.05）; luteinizing hormone of 7.33±2.14 and 4.84±1.43 （P〈0.01）, follicule-stimulating hormone of 10.22±4.48 and 6.47±3.28 （P〈0.01）, respectively. The level of PSA failed to change significantly （1.94±0.55 and 2.06±0.47, P〉0.05）. Conclusion： JSP is effective and safe in treating PADAM, the mechanism of it is different from supplementing extrinsic androgen. It may have produced the effect by means of favorably regulating the condition of sex hormone to improve the balance of pituitary-sex gland axis, so it has more extensive clinical application.展开更多
Objective:To provide ideas for more scientific and rational application of Jingui Shenqi pill in the treatment of diseases.Methods:We searched and analyzed the literatures about the composition principle,pharmacology ...Objective:To provide ideas for more scientific and rational application of Jingui Shenqi pill in the treatment of diseases.Methods:We searched and analyzed the literatures about the composition principle,pharmacology and clinical researches of Jingui Shenqi pill.Conclusion:The pharmacology mechanism researches about Jingui Shenqi pill were extensive and in-depth.Combining the pharmacology with the clinical research should become a new direction of Jingui Shenqi pill,and can also provide reference for clinical use of this prescription.展开更多
Background:Guillain-Barré syndrome (GBS) is an acute demyelinating polyneuritis in which the immune system attacks part of the peripheral nervous system.About two-thirds of GBS patients have a history of acute in...Background:Guillain-Barré syndrome (GBS) is an acute demyelinating polyneuritis in which the immune system attacks part of the peripheral nervous system.About two-thirds of GBS patients have a history of acute infection before developing GBS.Immunotherapy and supportive therapies are widely used to treat GBS;however,one in three patients experiences neurologic sequelae.In China,acupuncture-moxibustion has shown unique benefits for the treatment of neurological diseases and has a wide range of applications in neurology.Case presentation:We treated an elderly Russian female patient diagnosed with GBS.The chief complaints were upper limb weakness,lower limb paralysis,and inability to self-care.The traditional Chinese medicine diagnosis was flaccidity syndrome (Wei Zheng).After 5 weeks of acupuncture and moxibustion combined with Chinese patent medicine treatment,the patient's limb muscle strength was significantly improved and her ability to self-care was largely restored.Conclusion:The present findings demonstrated that acupuncture and moxibustion combined with Chinese patent medicine can alleviate muscle weakness caused by GBS.However,clinical randomized controlled trials are warranted to verify the precise clinical efficacy.展开更多
文摘Objective： To observe the efficacy and safety of Jingui Shengqi Pill （金匮肾气丸, JSP） in treating partial androgen deficiency in aging males （PADAM）, and to explore the new approach in improving the quality of life in PADAM patients. Methods： Forty patients with PADAM were treated with JSP, the efficacy was evaluated with international index of erectile function （IIEF） scoring, PADAM questionnaire scoring, hormone, prostatic specific antigen （PSA）, etc., and the data before treatment were compared with those after treatment in the same group. Results： After 3 months of treatment, PADAM scoring and IIEF scoring were all significantly improved. Symptoms regarding physical ability, vasomotion, and psychical and mental condition all got improved more markedly than symptoms regarding sexual hypofunction. The serum level of testosterone was 3.85±0.36 before treatment and 5.02±0.83 after treatmnet （P〈0.05）; luteinizing hormone of 7.33±2.14 and 4.84±1.43 （P〈0.01）, follicule-stimulating hormone of 10.22±4.48 and 6.47±3.28 （P〈0.01）, respectively. The level of PSA failed to change significantly （1.94±0.55 and 2.06±0.47, P〉0.05）. Conclusion： JSP is effective and safe in treating PADAM, the mechanism of it is different from supplementing extrinsic androgen. It may have produced the effect by means of favorably regulating the condition of sex hormone to improve the balance of pituitary-sex gland axis, so it has more extensive clinical application.
基金National Natural Science Foundation of China(Nos.81803979,81741130,81673979 and 81473688)Natural Science Foundation of Guangdong Province(Nos.2018A030313393,2016A030313114)+3 种基金Science and Technology Program of Guangzhou(Nos.201803010051,201707010245,201704020117)Science and Technology Program of Guangdong(No.2014A020212672)the Fourth Batch of TCM Clinical Outstanding Talent Program of China(No.444258)Scientific Research and Innovation Fund of Jinan University/the Fundamental Research Funds for the Central Universities,China(Nos.21617467,21615412).
文摘Objective:To provide ideas for more scientific and rational application of Jingui Shenqi pill in the treatment of diseases.Methods:We searched and analyzed the literatures about the composition principle,pharmacology and clinical researches of Jingui Shenqi pill.Conclusion:The pharmacology mechanism researches about Jingui Shenqi pill were extensive and in-depth.Combining the pharmacology with the clinical research should become a new direction of Jingui Shenqi pill,and can also provide reference for clinical use of this prescription.
文摘Background:Guillain-Barré syndrome (GBS) is an acute demyelinating polyneuritis in which the immune system attacks part of the peripheral nervous system.About two-thirds of GBS patients have a history of acute infection before developing GBS.Immunotherapy and supportive therapies are widely used to treat GBS;however,one in three patients experiences neurologic sequelae.In China,acupuncture-moxibustion has shown unique benefits for the treatment of neurological diseases and has a wide range of applications in neurology.Case presentation:We treated an elderly Russian female patient diagnosed with GBS.The chief complaints were upper limb weakness,lower limb paralysis,and inability to self-care.The traditional Chinese medicine diagnosis was flaccidity syndrome (Wei Zheng).After 5 weeks of acupuncture and moxibustion combined with Chinese patent medicine treatment,the patient's limb muscle strength was significantly improved and her ability to self-care was largely restored.Conclusion:The present findings demonstrated that acupuncture and moxibustion combined with Chinese patent medicine can alleviate muscle weakness caused by GBS.However,clinical randomized controlled trials are warranted to verify the precise clinical efficacy.
