Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous socia...Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous social and economic burden to the affected in- dividuals and their families, but is also a great scientific challenge. Currently 25-35 million people worldwide suffer from AD, the single largest cause of dementia in middle- to old-aged individuals. These numbers are projected to triple by 2050 if no treatment to prevent or reverse AD is developed.展开更多
The increasing overlap of core and colony populations during the anaphase of evolution may limit the performance of shifting balance genetic algorithms. To decrease such overlapping,so as to increase the local search ...The increasing overlap of core and colony populations during the anaphase of evolution may limit the performance of shifting balance genetic algorithms. To decrease such overlapping,so as to increase the local search capability of the core population,the sub-space method was used to generate uniformly distributed initial colony populations over the decision variable space. The core population was also dynamically divided,making simultaneous searching in several local spaces possible. The algorithm proposed in this paper was compared to the original one by searching for the optimum of a complicated multi-modal function. The results indicate that the solutions obtained by the modified algorithm are better than those of the original algorithm.展开更多
基金supported in part by the New York State Office of People with Developmental Disabilities(OPWDD)Zenith Award ZEN-12-241233 from Alzheimer’s Associationa research grant#20121203 from Alzheimer’s Drug Discovery Foundation,New York
文摘Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous social and economic burden to the affected in- dividuals and their families, but is also a great scientific challenge. Currently 25-35 million people worldwide suffer from AD, the single largest cause of dementia in middle- to old-aged individuals. These numbers are projected to triple by 2050 if no treatment to prevent or reverse AD is developed.
基金Project 60575046 supported by the National Natural Science Foundation of China
文摘The increasing overlap of core and colony populations during the anaphase of evolution may limit the performance of shifting balance genetic algorithms. To decrease such overlapping,so as to increase the local search capability of the core population,the sub-space method was used to generate uniformly distributed initial colony populations over the decision variable space. The core population was also dynamically divided,making simultaneous searching in several local spaces possible. The algorithm proposed in this paper was compared to the original one by searching for the optimum of a complicated multi-modal function. The results indicate that the solutions obtained by the modified algorithm are better than those of the original algorithm.
