Antiretroviral therapy has achieved great success in suppressing human immunodeficiency virus(HIV)replication and transforming HIV infection from a fatal disease to a manageable chronic disease.However,the latent HIV ...Antiretroviral therapy has achieved great success in suppressing human immunodeficiency virus(HIV)replication and transforming HIV infection from a fatal disease to a manageable chronic disease.However,the latent HIV reservoir persists in the body of HIVinfected individuals and is prone to reactivation.Therefore,the development of new treatment methods aimed at a complete cure for HIV is needed.The leading strategy for HIV eradication is based on eliminating and preventing the reactivation of latent reservoirs through an approach known as“shock and kill.”This strategy involves the use of latency-reversing agents(LRAs)to activate the HIV provirus in latent viral reservoir cells.Many LRAs can be obtained from natural resources,including plants and marine organisms.In this review,we provide an overview of natural products used to eliminate HIV latency.展开更多
Human immunodeficiency virus(HIV)-1 infection creates a persistent latent reservoir even after antiretroviral therapy,which is the main barrier to HIV cure.One of the most explored strategies is the use of latent reve...Human immunodeficiency virus(HIV)-1 infection creates a persistent latent reservoir even after antiretroviral therapy,which is the main barrier to HIV cure.One of the most explored strategies is the use of latent reversal agents(LRAs)to activate HIV latent reservoirs,followed by immunotherapy to remove infected cells.Immunomodulatory LRAs have the dual advantage of activating viral latency and promoting immune cell elimination of HIV-infected cells.The emergence of novel immunotherapies has also enhanced the possibility ofHIV clearance.Here we review the activity and potential mechanisms of immunomodulatory agonists and immunotherapies.The possible combinational strategies to achieve HIV functional cure and the problems encountered using this approach are discussed.展开更多
人类免疫缺陷病毒(human immunodeficiency virus,HIV)潜伏是艾滋病无法治愈的主要障碍。针对HIV潜伏的治疗策略之一"shock and kill",是通过潜伏感染激活剂激活潜伏的HIV使之发生转录,然后与高效抗逆转录病毒疗法(highly act...人类免疫缺陷病毒(human immunodeficiency virus,HIV)潜伏是艾滋病无法治愈的主要障碍。针对HIV潜伏的治疗策略之一"shock and kill",是通过潜伏感染激活剂激活潜伏的HIV使之发生转录,然后与高效抗逆转录病毒疗法(highly active antiretroviral therapy,HAART)联合使用,并结合细胞的自身免疫监视系统,从而实现清除HIV-1病毒潜伏库的目的。这种策略的核心是安全高效、作用机制新颖HIV潜伏激活剂的发现。从结构分类、来源和作用机制对天然产物HIV-1潜伏激活剂的研究进展进行综述。展开更多
基金supported by the Japan Society for the Promotion of Science KAKENHI 17K08348 and 21K06619(Wei Li).
文摘Antiretroviral therapy has achieved great success in suppressing human immunodeficiency virus(HIV)replication and transforming HIV infection from a fatal disease to a manageable chronic disease.However,the latent HIV reservoir persists in the body of HIVinfected individuals and is prone to reactivation.Therefore,the development of new treatment methods aimed at a complete cure for HIV is needed.The leading strategy for HIV eradication is based on eliminating and preventing the reactivation of latent reservoirs through an approach known as“shock and kill.”This strategy involves the use of latency-reversing agents(LRAs)to activate the HIV provirus in latent viral reservoir cells.Many LRAs can be obtained from natural resources,including plants and marine organisms.In this review,we provide an overview of natural products used to eliminate HIV latency.
基金funded by the Beijing Municipal Science and Technology Commission(No.D17110700050000).
文摘Human immunodeficiency virus(HIV)-1 infection creates a persistent latent reservoir even after antiretroviral therapy,which is the main barrier to HIV cure.One of the most explored strategies is the use of latent reversal agents(LRAs)to activate HIV latent reservoirs,followed by immunotherapy to remove infected cells.Immunomodulatory LRAs have the dual advantage of activating viral latency and promoting immune cell elimination of HIV-infected cells.The emergence of novel immunotherapies has also enhanced the possibility ofHIV clearance.Here we review the activity and potential mechanisms of immunomodulatory agonists and immunotherapies.The possible combinational strategies to achieve HIV functional cure and the problems encountered using this approach are discussed.
文摘人类免疫缺陷病毒(human immunodeficiency virus,HIV)潜伏是艾滋病无法治愈的主要障碍。针对HIV潜伏的治疗策略之一"shock and kill",是通过潜伏感染激活剂激活潜伏的HIV使之发生转录,然后与高效抗逆转录病毒疗法(highly active antiretroviral therapy,HAART)联合使用,并结合细胞的自身免疫监视系统,从而实现清除HIV-1病毒潜伏库的目的。这种策略的核心是安全高效、作用机制新颖HIV潜伏激活剂的发现。从结构分类、来源和作用机制对天然产物HIV-1潜伏激活剂的研究进展进行综述。
