BACKGROUND A large number of adults with long-term type 1 diabetes are affected by symmetrical peripheral neuropathy.These complications increase socioeconomic expenses and diminish the individual quality of life.The ...BACKGROUND A large number of adults with long-term type 1 diabetes are affected by symmetrical peripheral neuropathy.These complications increase socioeconomic expenses and diminish the individual quality of life.The 36-Item Short Form Health Survey(SF-36)is a generic patient reported questionnaire,measuring mental and physical health related quality of life.We hypothesized that diabetic neuropathy would decrease physical and mental quality of life measured with SF-36,and that clinical appearance may be associated with the decline.AIM To investigate if diabetic neuropathy would decrease physical and mental quality of life measured with SF-36,and if clinical appearance may be associated with the decline.METHODS Forty-eight adults[age 50±9 years,10 females,disease duration 32(14-51)years]with verified diabetic symmetrical peripheral neuropathy and 21 healthy participants(age 51±6 years,6 females)underwent standardised nerve conduction testing and completed the SF-36 questionnaire.Furthermore,disease duration,number of comorbidities,both diabetes related and nondiabetes related,vibration perception threshold,number of hypoglycaemic events,HbA1c and administration way of insulin was notified.RESULTS In comparison to healthy subjects,patients’mental composite score was not significantly diminished(51.9±8.9 vs 53.1±5.5,P=0.558),while the physical composite score was(46.3±11.7 vs 54.6±3.3,P=0.002).As expected,the overall physical health related symptoms in patients were associated to total number of comorbidities(P<0.0001),comorbidities relation to diabetes(P=0.0002)and HbA1c(P=0.005)as well as comorbidities not related to diabetes(P=0.0006).CONCLUSION The finding of this study emphasises the importance of focusing on quality of life in adults with diabetes and especially in those with multiple comorbidities as well as the possibility of HbA1c as a biomarker for severe complication.展开更多
Objective:Psoriasis is a chronic inflammatory systemic disease that severely impacts patients’ quality of life (QoL) and psychological health.While biologics have been shown to be effective in treating psoriatic lesi...Objective:Psoriasis is a chronic inflammatory systemic disease that severely impacts patients’ quality of life (QoL) and psychological health.While biologics have been shown to be effective in treating psoriatic lesions,thus improving QoL,real-life data regarding such effects remain scant.We administered a repeated cross-sectional survey to assess the effects of 8 weeks of biologics treatment on the QoL and mental health status of patients with moderate-to-severe plaque psoriasis.Methods:From March to May 2022,patients with moderate-to-severe plaque psoriasis were enrolled and treated with biologics in the outpatient clinic at the Dermatology Hospital of Southern Medical University.Assessments were performed before treatment and after 4 and 8 weeks of treatment with biologics.Psoriasis severity,QoL,and mental health status were evaluated using the Psoriasis Area and Severity Index (PASI),Dermatology Life Quality Index (DLQI),36-Item Short-form Health Survey (SF-36),and Hospital Anxiety and Depression Scale (HADS).A multivariate generalized estimating equations (GEE) analysis was used to account for repeated measures and to determine the effects of treatment duration and type of biological agent on relevant indicators.Results:Among the 78 enrolled patients,the ranges of pretreatment scores were 4.6 to 46.8 for the PASI,1 to 30 for the DLQI,31.5 to 100.0 for the physical component score (PCS) of the SF-36,16.6 to 100.0 for the mental component score (MCS) of the SF-36,0 to 15 for the HADS-A,and 0 to 17 for the HADS-D.After 8 weeks of biologics treatment,98.7% (77/78) of patients had obtained PASI 75.All assessed scores changed over time (GEE,P < 0.001).Moreover,there were group-by-time interaction effects for the DLQI score (GEE,P = 0.023) and PCS (GEE,P = 0.029).The HADS-A and HADS-D scores were both decreased at week 8 compared with pretreatment values.Correlation analyses revealed that higher DLQI scores were associated with lower levels of QoL and higher levels of anxiety or depression.Conclusion:Biologics are not only effective in the treatment of skin lesions but also exert beneficial effects upon the QoL and mental health of patients with psoriasis as determined in the short-term assessments conducted in this study.展开更多
目的:研究农村福利院五保老人的生存质量状况,为制定相应的改善措施提供依据。方法:采用多阶段分层整群抽样法,选取湖北省农村6县市≥60岁的福利院五保老人549名(A组)、农村普通老人131名(B组),用简明健康调查量表(Short Form 36 Health...目的:研究农村福利院五保老人的生存质量状况,为制定相应的改善措施提供依据。方法:采用多阶段分层整群抽样法,选取湖北省农村6县市≥60岁的福利院五保老人549名(A组)、农村普通老人131名(B组),用简明健康调查量表(Short Form 36 Health Survey Scale,SF-36)对两组老人进行面对面访谈。结果:A组SF-36量表中躯体健康功能导致的角色受限、总体健康感、生命活力、情感功能所致的角色受限、精神健康因子分均高于B组[如,总体健康感(55.7±23.8)vs(52.3±24.4),P<0.05];平原及丘陵地区的福利院五保老人SF-36量表各因子评分均高于山区[如,躯体功能(77.7±22.0)、(72.4±25.5)vs.(65.5±26.7),P<0.05]。结论:农村福利院五保老人的生存质量较好,不同地理状况五保老人的生存质量不同。展开更多
目的观察疏肝健脾合养心安神方治疗功能性消化不良(functional dyspepsia,FD)伴有焦虑抑郁状态的疗效。方法将90例FD伴焦虑抑郁状态的患者随机分为疏肝组、疏肝养心组和疏肝黛力新组,分别治以中药疏肝健脾方、中药疏肝健脾方+养心安神方...目的观察疏肝健脾合养心安神方治疗功能性消化不良(functional dyspepsia,FD)伴有焦虑抑郁状态的疗效。方法将90例FD伴焦虑抑郁状态的患者随机分为疏肝组、疏肝养心组和疏肝黛力新组,分别治以中药疏肝健脾方、中药疏肝健脾方+养心安神方,及中药疏肝健脾方+黛力新,治疗前后观察3组患者脾胃症状评分,采用36条目生活质量简表(36-item short form health survey questionnaire,SF-36)评价患者治疗前后的生活质量,采用汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)、汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评价患者治疗前后的焦虑抑郁水平。结果疏肝养心组、疏肝黛力新组在改善FD患者脾胃症状,降低HAMA、HAMD评分,改善SF-36各维度评分方面显著优于疏肝组(P<0.05,或P<0.01);疏肝养心组与疏肝黛力新组疗效比较,差异无统计学意义(P>0.05)。结论疏肝健脾方合养心安神方可明显改善FD伴焦虑抑郁状态患者的脾胃症状,并可改善焦虑抑郁症状,提高生活质量。展开更多
[目的]探讨和营止痛颗粒能否缓解腰椎间盘突出症(lumbar intervertebral disc herniation,LIDH)患者的临床症状,改善活动能力和功能,提高生活质量。[方法]根据纳入和排除标准,收集在浙江中医药大学附属第一医院骨伤中心门诊或住院治疗的...[目的]探讨和营止痛颗粒能否缓解腰椎间盘突出症(lumbar intervertebral disc herniation,LIDH)患者的临床症状,改善活动能力和功能,提高生活质量。[方法]根据纳入和排除标准,收集在浙江中医药大学附属第一医院骨伤中心门诊或住院治疗的120例LIDH患者的临床资料。将患者分为3组,观察组、治疗组和对照组,每组40例。观察组口服和营止痛颗粒治疗;治疗组口服塞来昔布胶囊、甲钴胺片和盐酸乙哌立松片,联合和营止痛颗粒治疗;对照组口服塞来昔布胶囊、甲钴胺片和盐酸乙哌立松片治疗。以4周为1个疗程。治疗前、治疗1个疗程后、1个疗程结束后1个月分别进行随访,记录每组患者的疼痛视觉模拟(visual analogue scale,VAS)评分、日本骨科协会(Japanese Orthopaedic Association,JOA)评估治疗评分和SF-36健康调查量表(36-item Short Form Health Survey,SF-36)评分。对3组患者的数据进行对照分析,明确和营止痛颗粒治疗LIDH的临床疗效。[结果]各组患者在性别组成、年龄构成、体质量指数(body mass index,BMI)、病程长短、影像学检查突出节段以及治疗前的VAS评分、JOA评分、SF-36评分等方面差异无统计学意义(P>0.05),提示各组患者基线一致,具有可比性。治疗1个疗程后,与治疗前比较,3组患者的VAS评分均降低(P<0.001),JOA评分均升高(P<0.001),SF-36评分均上升(P<0.001)。对照组VAS评分低于观察组,治疗组低于对照组和观察组(P<0.001);对照组JOA评分高于观察组,治疗组高于对照组和观察组(P<0.001);对照组的SF-36评分高于观察组,治疗组高于对照组和观察组(P<0.001)。1个疗程治疗结束后1个月,与治疗前比较,三组患者的VAS评分均降低(P<0.001),JOA评分均升高(P<0.001),SF-36评分均上升(P<0.001)。对照组VAS评分低于观察组,治疗组低于对照组和观察组(P<0.001);对照组JOA评分高于观察组,治疗组高于对照组和观察组(P<0.001);对照组SF-36评分高于观察组,治疗组高于对照组和观察组(P<0.001)。[结论]和营止痛颗粒能有效缓解LIDH患者的临床症状,改善活动能力和功能,提高生活质量,与西药联用时,能提高西药的临床疗效,是临床治疗LIDH的良好中药制剂。展开更多
目的·探索家庭负担量表(Family Burden Scale,FBS)的自评方式用于神经性厌食症患者照料者负担评定的信度和效度。方法·纳入2017年7月—2019年7月于上海交通大学医学院附属精神卫生中心进食障碍诊治中心诊治的女性厌食症患者10...目的·探索家庭负担量表(Family Burden Scale,FBS)的自评方式用于神经性厌食症患者照料者负担评定的信度和效度。方法·纳入2017年7月—2019年7月于上海交通大学医学院附属精神卫生中心进食障碍诊治中心诊治的女性厌食症患者103例及其照料者(父母)148人。记录患者及照料者的一般人口学资料,患者的病程及体质量指数(body mass index,BMI),以及照料者每日照顾患者的时间。照料者接受FBS、贝克焦虑量表(Beck Anxiety Inventory,BAI)、贝克抑郁量表(Beck Depression Inventory,BDI)、健康调查简表(the MOS item short from health survey,SF-36)的自评。随机数字法抽取1/3照料者进行FBS他评。通过计算Cronbach'sα系数、自评-他评一致性、夫妻间(41对夫妻)一致性来评定量表信度;通过计算FBS自评得分与病程、患者BMI、每日照料时间、BAI评分、BDI评分,以及SF-36的精力、社会功能、情感职能、精神健康因子分的相关性来评定量表的效度。结果·FBS的Cronbach'sα系数为0.921,自评-他评相关系数r=0.705(P=0.000),夫妻间一致性评分的相关系数为r=0.547(P=0.000)。FBS总分与病程、%BMI及每日照料时间无相关性;与BAI得分、BDI得分,以及SF-36的精力、社会功能、情感职能、精神健康因子分呈现一定相关性(均P<0.05)。结论·FBS的自评方式应用于评估厌食症患者的照料者负担时显示出较好的信度,但其效度并不理想,需要进一步修订。展开更多
BACKGROUND Endoscopic submucosal dissection(ESD) is a common surgical strategy for the treatment of early gastrointestinal tumors and precancerous lesions.PDCA nursing can effectively prevent potential risks in the nu...BACKGROUND Endoscopic submucosal dissection(ESD) is a common surgical strategy for the treatment of early gastrointestinal tumors and precancerous lesions.PDCA nursing can effectively prevent potential risks in the nursing process,protect patient privacy,and improve patient satisfaction,nursing integrity,and service quality.AIM To explore the effects of PDCA nursing model on the quality management of gastrointestinal ESD,the 36-item Shot-Form Health Survey(SF-36) score,and negative emotions.METHODS A total of 178 patients who underwent ESD between January 2020 and January 2021 were divided into two groups.The usual care mode was the control group,with 80 cases from January to July 2020;from July 2020 to January 2021,98 patients were enrolled in the PDCA care mode as the research group.The length of hospital stay and the costs of the two groups were statistically analyzed.The visual analog scale(VAS),SF-36 score,Zung self-rating scale for anxiety and depression,and postoperative complications were also assessed.RESULTS The length of hospitalization and cost in the research group were lower than in the control group(P < 0.05),and the VAS scores were lower than those before care(P < 0.05).Moreover,the VAS score of the research group was lower than that of the control group(P < 0.05).The SF-36 scores for physical function,role status,social function,pain,mental health,and physical strength were higher in the research group than in the control group(P < 0.05).Depression and anxiety scores of the research group were lower than those of the control group(P < 0.05).The postoperative complication rate in the research group(6.12%) was lower than in the control group(32.50%)(P < 0.05).CONCLUSION PDCA nursing can improve the quality of management of ESD surgery,shorten the length of hospital stay and cost,reduce the VAS and Zung scale scores to alleviate adverse emotions,improve the SF-36 score,and reduce postoperative complications.展开更多
基金Supported by Aalborg UniversityNovo Nordisk Scandinavia AS+2 种基金Empowering Industry and Research EIR Northern Jutlandduring the conduct of the studyInnovation Fund Denmark,Individuals,Disease and Society,Copenhagen,Denmark
文摘BACKGROUND A large number of adults with long-term type 1 diabetes are affected by symmetrical peripheral neuropathy.These complications increase socioeconomic expenses and diminish the individual quality of life.The 36-Item Short Form Health Survey(SF-36)is a generic patient reported questionnaire,measuring mental and physical health related quality of life.We hypothesized that diabetic neuropathy would decrease physical and mental quality of life measured with SF-36,and that clinical appearance may be associated with the decline.AIM To investigate if diabetic neuropathy would decrease physical and mental quality of life measured with SF-36,and if clinical appearance may be associated with the decline.METHODS Forty-eight adults[age 50±9 years,10 females,disease duration 32(14-51)years]with verified diabetic symmetrical peripheral neuropathy and 21 healthy participants(age 51±6 years,6 females)underwent standardised nerve conduction testing and completed the SF-36 questionnaire.Furthermore,disease duration,number of comorbidities,both diabetes related and nondiabetes related,vibration perception threshold,number of hypoglycaemic events,HbA1c and administration way of insulin was notified.RESULTS In comparison to healthy subjects,patients’mental composite score was not significantly diminished(51.9±8.9 vs 53.1±5.5,P=0.558),while the physical composite score was(46.3±11.7 vs 54.6±3.3,P=0.002).As expected,the overall physical health related symptoms in patients were associated to total number of comorbidities(P<0.0001),comorbidities relation to diabetes(P=0.0002)and HbA1c(P=0.005)as well as comorbidities not related to diabetes(P=0.0006).CONCLUSION The finding of this study emphasises the importance of focusing on quality of life in adults with diabetes and especially in those with multiple comorbidities as well as the possibility of HbA1c as a biomarker for severe complication.
文摘Objective:Psoriasis is a chronic inflammatory systemic disease that severely impacts patients’ quality of life (QoL) and psychological health.While biologics have been shown to be effective in treating psoriatic lesions,thus improving QoL,real-life data regarding such effects remain scant.We administered a repeated cross-sectional survey to assess the effects of 8 weeks of biologics treatment on the QoL and mental health status of patients with moderate-to-severe plaque psoriasis.Methods:From March to May 2022,patients with moderate-to-severe plaque psoriasis were enrolled and treated with biologics in the outpatient clinic at the Dermatology Hospital of Southern Medical University.Assessments were performed before treatment and after 4 and 8 weeks of treatment with biologics.Psoriasis severity,QoL,and mental health status were evaluated using the Psoriasis Area and Severity Index (PASI),Dermatology Life Quality Index (DLQI),36-Item Short-form Health Survey (SF-36),and Hospital Anxiety and Depression Scale (HADS).A multivariate generalized estimating equations (GEE) analysis was used to account for repeated measures and to determine the effects of treatment duration and type of biological agent on relevant indicators.Results:Among the 78 enrolled patients,the ranges of pretreatment scores were 4.6 to 46.8 for the PASI,1 to 30 for the DLQI,31.5 to 100.0 for the physical component score (PCS) of the SF-36,16.6 to 100.0 for the mental component score (MCS) of the SF-36,0 to 15 for the HADS-A,and 0 to 17 for the HADS-D.After 8 weeks of biologics treatment,98.7% (77/78) of patients had obtained PASI 75.All assessed scores changed over time (GEE,P < 0.001).Moreover,there were group-by-time interaction effects for the DLQI score (GEE,P = 0.023) and PCS (GEE,P = 0.029).The HADS-A and HADS-D scores were both decreased at week 8 compared with pretreatment values.Correlation analyses revealed that higher DLQI scores were associated with lower levels of QoL and higher levels of anxiety or depression.Conclusion:Biologics are not only effective in the treatment of skin lesions but also exert beneficial effects upon the QoL and mental health of patients with psoriasis as determined in the short-term assessments conducted in this study.
文摘目的:研究农村福利院五保老人的生存质量状况,为制定相应的改善措施提供依据。方法:采用多阶段分层整群抽样法,选取湖北省农村6县市≥60岁的福利院五保老人549名(A组)、农村普通老人131名(B组),用简明健康调查量表(Short Form 36 Health Survey Scale,SF-36)对两组老人进行面对面访谈。结果:A组SF-36量表中躯体健康功能导致的角色受限、总体健康感、生命活力、情感功能所致的角色受限、精神健康因子分均高于B组[如,总体健康感(55.7±23.8)vs(52.3±24.4),P<0.05];平原及丘陵地区的福利院五保老人SF-36量表各因子评分均高于山区[如,躯体功能(77.7±22.0)、(72.4±25.5)vs.(65.5±26.7),P<0.05]。结论:农村福利院五保老人的生存质量较好,不同地理状况五保老人的生存质量不同。
文摘目的观察疏肝健脾合养心安神方治疗功能性消化不良(functional dyspepsia,FD)伴有焦虑抑郁状态的疗效。方法将90例FD伴焦虑抑郁状态的患者随机分为疏肝组、疏肝养心组和疏肝黛力新组,分别治以中药疏肝健脾方、中药疏肝健脾方+养心安神方,及中药疏肝健脾方+黛力新,治疗前后观察3组患者脾胃症状评分,采用36条目生活质量简表(36-item short form health survey questionnaire,SF-36)评价患者治疗前后的生活质量,采用汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)、汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评价患者治疗前后的焦虑抑郁水平。结果疏肝养心组、疏肝黛力新组在改善FD患者脾胃症状,降低HAMA、HAMD评分,改善SF-36各维度评分方面显著优于疏肝组(P<0.05,或P<0.01);疏肝养心组与疏肝黛力新组疗效比较,差异无统计学意义(P>0.05)。结论疏肝健脾方合养心安神方可明显改善FD伴焦虑抑郁状态患者的脾胃症状,并可改善焦虑抑郁症状,提高生活质量。
文摘[目的]探讨和营止痛颗粒能否缓解腰椎间盘突出症(lumbar intervertebral disc herniation,LIDH)患者的临床症状,改善活动能力和功能,提高生活质量。[方法]根据纳入和排除标准,收集在浙江中医药大学附属第一医院骨伤中心门诊或住院治疗的120例LIDH患者的临床资料。将患者分为3组,观察组、治疗组和对照组,每组40例。观察组口服和营止痛颗粒治疗;治疗组口服塞来昔布胶囊、甲钴胺片和盐酸乙哌立松片,联合和营止痛颗粒治疗;对照组口服塞来昔布胶囊、甲钴胺片和盐酸乙哌立松片治疗。以4周为1个疗程。治疗前、治疗1个疗程后、1个疗程结束后1个月分别进行随访,记录每组患者的疼痛视觉模拟(visual analogue scale,VAS)评分、日本骨科协会(Japanese Orthopaedic Association,JOA)评估治疗评分和SF-36健康调查量表(36-item Short Form Health Survey,SF-36)评分。对3组患者的数据进行对照分析,明确和营止痛颗粒治疗LIDH的临床疗效。[结果]各组患者在性别组成、年龄构成、体质量指数(body mass index,BMI)、病程长短、影像学检查突出节段以及治疗前的VAS评分、JOA评分、SF-36评分等方面差异无统计学意义(P>0.05),提示各组患者基线一致,具有可比性。治疗1个疗程后,与治疗前比较,3组患者的VAS评分均降低(P<0.001),JOA评分均升高(P<0.001),SF-36评分均上升(P<0.001)。对照组VAS评分低于观察组,治疗组低于对照组和观察组(P<0.001);对照组JOA评分高于观察组,治疗组高于对照组和观察组(P<0.001);对照组的SF-36评分高于观察组,治疗组高于对照组和观察组(P<0.001)。1个疗程治疗结束后1个月,与治疗前比较,三组患者的VAS评分均降低(P<0.001),JOA评分均升高(P<0.001),SF-36评分均上升(P<0.001)。对照组VAS评分低于观察组,治疗组低于对照组和观察组(P<0.001);对照组JOA评分高于观察组,治疗组高于对照组和观察组(P<0.001);对照组SF-36评分高于观察组,治疗组高于对照组和观察组(P<0.001)。[结论]和营止痛颗粒能有效缓解LIDH患者的临床症状,改善活动能力和功能,提高生活质量,与西药联用时,能提高西药的临床疗效,是临床治疗LIDH的良好中药制剂。
文摘目的·探索家庭负担量表(Family Burden Scale,FBS)的自评方式用于神经性厌食症患者照料者负担评定的信度和效度。方法·纳入2017年7月—2019年7月于上海交通大学医学院附属精神卫生中心进食障碍诊治中心诊治的女性厌食症患者103例及其照料者(父母)148人。记录患者及照料者的一般人口学资料,患者的病程及体质量指数(body mass index,BMI),以及照料者每日照顾患者的时间。照料者接受FBS、贝克焦虑量表(Beck Anxiety Inventory,BAI)、贝克抑郁量表(Beck Depression Inventory,BDI)、健康调查简表(the MOS item short from health survey,SF-36)的自评。随机数字法抽取1/3照料者进行FBS他评。通过计算Cronbach'sα系数、自评-他评一致性、夫妻间(41对夫妻)一致性来评定量表信度;通过计算FBS自评得分与病程、患者BMI、每日照料时间、BAI评分、BDI评分,以及SF-36的精力、社会功能、情感职能、精神健康因子分的相关性来评定量表的效度。结果·FBS的Cronbach'sα系数为0.921,自评-他评相关系数r=0.705(P=0.000),夫妻间一致性评分的相关系数为r=0.547(P=0.000)。FBS总分与病程、%BMI及每日照料时间无相关性;与BAI得分、BDI得分,以及SF-36的精力、社会功能、情感职能、精神健康因子分呈现一定相关性(均P<0.05)。结论·FBS的自评方式应用于评估厌食症患者的照料者负担时显示出较好的信度,但其效度并不理想,需要进一步修订。
文摘BACKGROUND Endoscopic submucosal dissection(ESD) is a common surgical strategy for the treatment of early gastrointestinal tumors and precancerous lesions.PDCA nursing can effectively prevent potential risks in the nursing process,protect patient privacy,and improve patient satisfaction,nursing integrity,and service quality.AIM To explore the effects of PDCA nursing model on the quality management of gastrointestinal ESD,the 36-item Shot-Form Health Survey(SF-36) score,and negative emotions.METHODS A total of 178 patients who underwent ESD between January 2020 and January 2021 were divided into two groups.The usual care mode was the control group,with 80 cases from January to July 2020;from July 2020 to January 2021,98 patients were enrolled in the PDCA care mode as the research group.The length of hospital stay and the costs of the two groups were statistically analyzed.The visual analog scale(VAS),SF-36 score,Zung self-rating scale for anxiety and depression,and postoperative complications were also assessed.RESULTS The length of hospitalization and cost in the research group were lower than in the control group(P < 0.05),and the VAS scores were lower than those before care(P < 0.05).Moreover,the VAS score of the research group was lower than that of the control group(P < 0.05).The SF-36 scores for physical function,role status,social function,pain,mental health,and physical strength were higher in the research group than in the control group(P < 0.05).Depression and anxiety scores of the research group were lower than those of the control group(P < 0.05).The postoperative complication rate in the research group(6.12%) was lower than in the control group(32.50%)(P < 0.05).CONCLUSION PDCA nursing can improve the quality of management of ESD surgery,shorten the length of hospital stay and cost,reduce the VAS and Zung scale scores to alleviate adverse emotions,improve the SF-36 score,and reduce postoperative complications.
