Acupoints combination correlates with activation of cerebral areas A functional MRI study

Acupoint combination is a method used for acupoint treatment of patients. Traditionally, acupoints are matched along the meridian distribution, which is a common rule in clinical practice, but the underlying mechanism remains unclear. Cerebral scans with functional magnetic resonance imaging （fMRI） have been used in the study of acupuncture and acupoint specifically. In this study, fMRI was used to detect the activation of the brain areas under different acupoints, matched along different meridians, to elucidate the acupoint combination via a modern medical approach. Forty healthy volunteers were randomly divided into the following groups： Waiguan point （SJ 5）, Waiguan （SJ 5） ＋ Zhigou （SJ 6） （2 acupoints come from the same meridian）, Waiguan （SJ 5） ＋ Neiguan （PC 6） （2 acupoints come from 2 meridians with the relationship of interior-exterior）, Waiguan （SJ 5） ＋ Yanglingquan （GB 34） （2 acupoints come from 2 meridians with the same name-Shaoyang Meridian）, and sham point groups （needling in different points on the right hand）. A real-time cerebral fMRI scan was simultaneously performed. The cerebral activation rate, and the number and strength of different regions of interest were compared among the groups. The fMRI cerebral imaging confirmed that there were some differences in the activation of cerebral areas by the needlings in SJ 5, and in combination with other acupoints. Needling at SJ 5 alone greatly activated the right cerebellum, while needling at both SJ 5 and different co-needling points activated different cerebral functional areas.

Positioning performance analysis on combined GPS/BDS precise point positioning

Combining the observation data from five Multi-GNSS Experiment(MGEX)stations with the precise orbit and clock products from Global Positioning System(GPS)and BeiDou Navigation Satellite System(BDS),we studied the model of combined GPS/BDS precise point positioning,and then analyzed the convergence speed and short-time(6 h)positioning accuracy.The calculation results show that in static positioning,the average convergence time of GPS is about 50 min,and its horizontal accuracy is better than 2 cm while the vertical accuracy is better than 4 cm.The convergence speed of combined GPS/BDS is about 40 min,and its positioning accuracy is close to that of GPS.In kinematic positioning,the average convergence time of GPS is about 72 min,and its horizontal accuracy is better than 5 cm while the vertical accuracy is better than 12 cm.The average convergence time of GPS/BDS is about 57 min,and its horizontal accuracy is better than 3 cm while the vertical accuracy is better than 9 cm.Combined GPS/BDS has significantly improved the convergence speed,and its positioning accuracy is slightly than that of GPS.

Thirty Cases of Acute Lumbar Sprain Treated by Acupuncture Combined with Point-Injection at Tianzhu

In recent years, the authors have treated 30 cases of acute lumbar sprain by acupuncture combined with point medicinal injection at Tianzhu (BL 10), and obtained quite good therapeutic results, as is reported in the following.

Treatment of 482 Cases of Cervical Spondylopathy by Combining Point-injection and Needle-warming via Moxibustion

From January 1993 to December 1996, we treated 482 cases of cervical spondylopathy with a combined method of point-injection and needle-warming via moxibustion. Except for the cases of sympathetic nerve type and spinal cord type, the combined method was superior to traction therapy in the control group and reported as follows.Clinical DataThe Criteria of Diagnosis and Curative Effect in TCM issued by the State Administrative Bureau of TCM and Pharmacy in 1994 was adopted for the enrollment of patients of cervical spondylopathy and the pathological typing. Only the patients who had completed the treatment and with complete records were collected for analysis.

Combined Use of the Points Shenmai and Zhaohai for Treatment of Craniofacial Diseases

Shenmai (BL 62) and Zhaohai (KI 6), first recorded in A Classic of Acupuncture and Moxibustion (针灸甲乙经), are respectively the starting point of the YangqiaoChannel and the Yinqiao Channel, and they are two of the eight confluence points. Although records about the right-left compatible use of these two points can be found in documents, the same-side compatible use of them has never been heardabout. Inspired by the good therapeutic effects in the treatment of paralytic strabismus by means of the same-side compatible use of these two points1, the author has applied this compatible use of them in the treatment of craniofacial diseases and obtained obvious therapeutic effects. Some of the sample cases are reported in the following. ……

Electroacupuncture at He-Mu points reduces P2X_4 receptor expression in visceral hypersensitivity

Electroacupuncture at Shangjuxu （ST37） and Tianshu （ST25） was reported to improve visceral hypersensitivity in rats, Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome, Results showed that abdominal withdrawal reflex scores noticeably increased after model establishment. Simultaneously, P2X4 receptor immunore- activity significantly increased in the colon and spinal cord. Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity, and significantly decreased P2X4 receptor immunoreactivity in the colon and spinal cord. These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X4 receptor immunoreactivity in the colon and spinal cord,

Value of elastography point quantification in improving the diagnostic accuracy of early diabetic kidney disease

BACKGROUND Diabetic kidney disease(DKD)is a common complication of diabetes.The patient’s prognosis is poor once DKD progresses to advanced stage.Accurate diagnosis and timely treatment of early DKD are important for improving patient’s prognosis and reducing mortality.AIM To explore the value of elastography point quantification(ElastPQ)in improving the accuracy of early DKD diagnosis.METHODS A total of 69 patients with type 2 diabetes were recruited from Naval Military Medical University Affiliated Gongli Hospital.Patients were divided into early DKD group and medium DKD group according to pathological results and urinary albumin excretion rate(UAER).Another 40 patients with simple diabetes were included as the diabetes group.The baseline data,laboratory diagnostic indicators,and ultrasound indicators for each patient were recorded.The differences of the indicators in the three groups were compared.Multivariate logistic regression was used to analyze the influencing factors of the development from simple diabetes into early DKD and from early DKD into medium DKD.Receiver operating characteristic analyses of potential indicators in identifying early DKD and medium DKD,and early DKD and simple diabetes were established.RESULTS Multivariate logistic regression analysis showed that UAER(P<0.001),renocortical Young's Modulus(YM)(P<0.001),and renal parenchymal thickness(P=0.013)were the independent influencing factors of the development from early DKD into medium DKD.Diabetes duration(P=0.041),UAER(P=0.034),and renocortical YM(P=0.017)were the independent influencing factors of the development from simple diabetes into early DKD.Receiver operating characteristic analysis indicated that UAER,renocortical YM,and renal parenchymal thickness were accurate in identifying early DKD and medium DKD[all area under curve(AUC)>0.9].The accuracy of UAER(AUC=0.744),diabetes duration(AUC=0.757),and renocortical YM(AUC=0.782)for the diagnosis of early DKD and simple diabetes were limited.However,the combined diagnosis of UAER,diabetes duration,and renocortical YM was accurate in identifying early DKD and simple diabetes(AUC=0.906),which was significantly higher than any of the three indicators(all P<0.05).CONCLUSION ElastPQ is of great value in the diagnosis of early DKD.When combined with the diabetes duration and UAER,it is expected to diagnose accurately early DKD.

Point injection of Injectio Radici Astragali for Treatment of Post-chemotherapy Adverse Reactions

With injection of Injectio Radici Astragli into the point Zusanli (ST 36), we have obtained quite satisfactory therapeutic results for treating leukopenia and the impairment in immune functions occurred in cancer chemotherapy. A report follows.

A CLINICAL STUDY ON THE SUBTOTAL GASTRECTOMY UNDER ACUPUNCTURE COMBINED WITH EPIDURAL ANESTHESIA OF SMALL DOSAGE

We have performed operations on the patients with perforation of gastric ulcer forsubtotal gastrectomy under acupuncture combined with epidural anesthesia of smaIl dosage （studygroup） or epidural anesthesia only（control gr0up） at rand0m, 2O cases in each group. There is no ob-vious difference of successful rates between tw0 groups （P】O. O5）. But the fluctuation of the bloodpressure of the study group is smaller than that of the control group（PwtO- O1 ）; the comparison of thefluctuations of capacity of vessel and the changes 0f TMwave of ECG before and during operationshows that the study group is better than control gr0up （PrO. O1, P【O. O5, respectively）; in thestudy group, WBC is decreased significantly after operation, while in the control guoup, CRP（C-re-active pr0tein） is markedIy increased, there are significant differences of these indices between twogroups（P【0. 05, respectively）; complement C3, IgA, IgG and IgM are decreased to a different ex- tent after operation in both groups, but the

16 CASES OF SCALENUS SYNDROME TREATED BY MASSAGE AND ACUPOINT-INJECTION

Scalenus syndrome is a kind of thoracicoutlet syndrome. I treated 16 such cases withmassage in combination with acupointinjection from 1989-1996. The results weresatisfactory and introduced as follows.

Protrusion of Lumbar Intervertebral Disc Treated by Ultra Short Wave and the Point Injection in 40 Cases

Since 1996,the author has treated 40 cases of protrusion of lumbar intervertebral disc with ultra short wave and the point injection,and obtained good therapeutic effects.This is reported as follows.

Clinical Application of the Point Yongquan

Yongquan (KI 1) is a jing (well) point of the Kidney Meridian of Foot-Shaoyin. As this point is widely used for treatment of acute or chronic diseases, it has drawn attentions from physicians both in the ancient and in the present times. If this point is taken accurately and the differentiation of disease is made properly, both the needling and the external drug application can achieve satisfactory therapeutic results.

Twenty-eight Cases of Neuritis of Lateral Cutaneous Nerve of Thigh Treated by Acupuncture and Point-Injection

Neuritis of lateral cutaneous nerve of thigh, also called meralgia paresthetica, is a commonly encountered disease in clinical practice. The author has treated 28 cases of meralgia paresthetica since 1996 by acupuncture plus point-injection with satisfactory results. A report follows.Clinical Data Among the 28 cases, 13 were male and 15 female. Their age ranged from 24 to 72 years, most of the patients being 35 to 50 years; the duration of illness varied from one month to ten years and 6 cases were affected on left side, 8 cases on right side and 14 cases on both sides.

A study of acupoint selection rules of moxibustion and auricular point therapy in the treatment of urinary retention after anorectal surgery based on data mining

Based on the Traditional Chinese Medicine Inheritance Support System(V2.5),we explored the compatibility rules of moxibustion and auricular point prescriptions in the treatment of urinary retention after anorectal surgery,and further to obtain new prescriptions.Methods:We searched CNKI,Wanfang,VIP and CBM databases for the literature of moxibustion and auricular point therapy for urinary retention after anorectal surgery,collecting complete prescriptions and entering them into the Traditional Chinese Medicine Inheritance Support System(V2.5).The acupoint frequency,association rules,and combination rules were analyzed by data mining method of software integration.Results:126 moxibustion prescriptions were selected,and the acupoints for urinary retention after anorectal surgery in the literature were analyzed,including 10 acupoints with frequency≥6,9 acupoint combinations with frequency≥26,5 acupoints with association rules,6 core acupoint combinations and 3 new prescription.124 auricular point prescriptions were selected,and the relevant acupoints in the literature were analyzed,including 10 acupoints with frequency of use≥18,15 acupoint combinations with frequency≥40,12 acupoint combinations with association rules,6 core acupoint combinations,and 3 new prescriptions.The core points include Qihai(RN6),Sanyinjiao(SP6),Zhongji(RN3),Guanyuan(RN4).The auricular point therapy is more to select the tenderness points and acupoints that have an impact on the urinary system,mainly including“Pangguang”(CO9),“Shenmen”(TF4),“Shen”(CO10),“Sanjiao”(CO17),“Pizhixia”(AT4),“Niaodao”(HX3),“Fei”(CO14),“Jiaogan”(AH6a).Conclusion:Moxibustion for the treatment of urinary retention is mainly based on invigorating“Primordial Qi”and regulating the functions of“Middle Jiao”(refers to the area of the body just below the diaphragm and above the navel that helps produce delicate nutrients).The entropic clustering of complex systems excavated new prescriptions for the treatment of urinary retention after anorectal surgery,providing new ideas for future research and treatment.

三部配穴法针刺治疗慢性中心性浆液性脉络膜视网膜病变的临床效果

目的 观察三部配穴法针刺治疗慢性中心性浆液性脉络膜视网膜病变(CSC)的临床效果。方法 将2022年1月至12月于上海市第一人民医院就诊的84例慢性CSC患者按随机数字表法分为对照组(42例)与治疗组(42例),对照组予维生素B1片、肌苷片、三磷酸腺苷二钠片的基础治疗(40 d),治疗组在对照组的基础上联合三部配穴法针刺,隔天针刺1次,共20次(40 d)。比较两组临床疗效,比较两组治疗前后美国国立眼科研究院视功能问卷-25(NEI-VFQ-25)、中医症状证候量表、最佳矫正视力(BCVA)变化。结果 对照组脱落3例,治疗组脱落4例。治疗组临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,两组NEI-VFQ-25评分、BCVA均高于治疗前,且治疗组高于对照组,差异有统计学意义(P<0.05)。治疗后,治疗组中医症状证候量表评分低于本组治疗前及对照组,差异有统计学意义(P<0.05)。结论 三部配穴法针刺联合基础治疗慢性CSC效果显著,具有较高的临床推广及应用价值。

基于极点对称模态分解的中长期径流预报组合模型

为提高径流预报精度,解决径流序列分解后高频分量波动范围大、预报精度差的问题,基于极点对称模态分解法(ESMD)平稳化处理技术将径流序列分解,通过分析不同频率分量特征,择优选取预报方法,结合粒子群优化最小二乘支持向量机(PSO-LSSVM)全局优化和非线性建模能力及适应性强的特点,对高频分量进行预测,利用BP神经网络非线性映射能力和逼近任意非线性函数的优势对中低频分量和趋势分量进行预报,构建了ESMD-PSO-LSSVM-BP组合预报模型,对西江干流上中下游三座水文站的年、月尺度径流开展中长期径流预报。结果表明,对不同频率分量采用不同预报方法的组合模型可以有效提高径流预报精度。

俞募配穴联合脐针疗法治疗脑卒中后昼夜节律失调性睡眠-觉醒障碍的临床研究

目的探讨俞募配穴联合脐针疗法治疗脑卒中后昼夜节律失调性睡眠-觉醒障碍(circadian rhythm sleep-wake disorder,CRSWD)的临床疗效。方法选取2020年5月至2022年8月就诊于杭州市中医院的脑卒中后CRSWD患者87例为研究对象,根据随机数字表法将其分为治疗组(n=44)和对照组(n=43)。对照组患者予艾司唑仑片治疗,治疗组患者予俞募配穴联合脐针疗法治疗,观察两组患者治疗前、治疗5d、治疗2周的匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)和清晨型-夜晚型量表(morningness-eveningness questionnaire,MEQ)评分。结果两组患者的PSQI总分、PSQI-D、PSQI-G评分、MEQ评分以时点因素、时点与组别交互、组别为源的主体间效应比较,差异均有统计学意义(P<0.05);治疗2周后,治疗组患者的PSQI总分、PSQI-C、PSQI-D、PSQI-G评分均显著低于对照组,MEQ评分显著高于对照组(P<0.05)。结论俞募配穴联合脐针疗法治疗脑卒中后CRSWD可显著改善患者的睡眠质量,延长睡眠时间,改善日间功能状态,调整昼夜节律,有良好的临床疗效。

基于商用密码的水利重要数据点面结合安全保护方法

为保障数字孪生流域建设过程中的重要数据安全,针对破解海量高精度数据汇集面临的数据窃取、泄露、损毁等问题隐患开展研究,提出网络安全基础—数据分类分级—数据安全防护的数字孪生流域数据安全总体防护方案。针对数据安全传输、存储、使用中的安全薄弱点,提出全面通用防护和应用内加密相结合的点面结合加密保护方法,利用商用密码技术对数据进行机密性、完整性、可用性保护。本研究方法已在全国水利一张图等重要系统中得到应用,可实现数据安全保护和便捷高效应用平衡,广泛适用于数字孪生流域建设中的水利重要数据全生命周期保护。

耳穴压豆联合枯草杆菌二联活菌颗粒在心脏瓣膜置换术后腹胀患者中的应用效果

目的探析耳穴压豆联合枯草杆菌二联活菌颗粒在心脏瓣膜置换术后腹胀患者中的应用效果。方法选取2022年1月至6月于南昌大学第二附属医院心脏大血管外科100例行瓣膜置换术后腹胀患者作为研究对象,根据随机数字表法分为对照组和观察组,每组50例。对照组接受多潘立酮常规干预,观察组加用耳穴压豆联合枯草杆菌二联活菌颗粒干预,两组均干预1周。比较两组的护理效果、胃肠道症状消失时间(排气时间、排便时间以及肠胀气消失时间)以及安全性。结果观察组患者的总有效率高于对照组,差异有统计学意义(P<0.05)。观察组患者术后首次排气、排便时间以及肠胀气消失时间均短于对照组,差异有统计学意义(P<0.05)。两组患者术后并发症总发生率比较,差异无统计学意义(P>0.05)。结论耳穴压豆联合枯草杆菌二联活菌颗粒在心脏瓣膜置换术后腹胀患者中应用价值良好,可有效缩短患者术后排气时间、排便时间以及肠胀气消失时间,安全性尚可。

基于数据挖掘探析针药结合治疗哮喘的临床优势与针灸选穴规律

目的系统梳理针药结合治疗哮喘的临床研究文献,利用数据挖掘探讨其潜在的临床优势与针灸选穴规律。方法检索收录在中国知网、维普资讯中文期刊服务平台、万方数据知识服务平台、中国生物医学文献数据库及PubMed、Web of Science、Embase、Scoups等数据库中的近20年临床研究文献,建立“针药结合治疗哮喘数据库”,运用频数统计及SPSS Modeler 18.0、Gephi0.10.1软件进行文献挖掘分析。结果①针刺优势以靶器官功能与多项血生化指标(免疫功能指标、血清炎症因子)的调节为主;中药优势为能进一步增强肺通气功能;针刺与中药联合应用可显著提高哮喘患者临床疗效。②针刺治疗哮喘重要程度排名前5位的腧穴依次为肺俞、定喘、足三里、肾俞、膻中,关联规则分析显示定喘-肺俞支持度最高,其次为脾俞-肺俞;足太阳膀胱经与手太阴肺经为常用经脉。③体现针刺优势的腧穴处方重视局部选穴,循经选穴,上下配穴。结论针药结合治疗哮喘是提高疗效的主要原因,其临床优势在于局部与整体兼顾,“标本同治,从肺论治,局部选穴,远近配穴”的临床取穴规律是针刺优势的体现之一,这为针药结合的科学应用提供了新思路。