Substantial evidence has suggested that deep brain stimulation of the cuneiform nucleus has become a remarkable treatment option for intractable pain,but the possible mechanism is poorly understood. Using a melanocort...Substantial evidence has suggested that deep brain stimulation of the cuneiform nucleus has become a remarkable treatment option for intractable pain,but the possible mechanism is poorly understood. Using a melanocortin-4 receptor（MC4R）-green fluorescent protein（GFP） reporter knockin mouse,we showed that a large number of MC4R-GFP-positive neurons were expressed in the cuneiform nucleus. Immunofluorescence revealed that approximately 40%–50% of MC4R-GFP-positive neurons expressed mu opioid receptors,indicating that they were opioidergic signaling. Our findings support the hypothesis that MC4 R expression in the cuneiform nucleus is involved in the modulation of opioidergic signaling.展开更多
Preclinical stroke research has introduced a number of potential interventions that can be utilized to enhance recovery after stroke（Lo and Rosenberg,2009）.
Following injury to the peripheral nerve,pain secondary to low threshold innocuous mechanical stimulation（mechanical allodynia）is commonly observed.Its origins are poorly understood and the pain is often refractory ...Following injury to the peripheral nerve,pain secondary to low threshold innocuous mechanical stimulation（mechanical allodynia）is commonly observed.Its origins are poorly understood and the pain is often refractory to common analgesic therapeutics.The past two decades has brought major advances in our understanding of the complexity of systems that underlie processing of neuropathic pain（pain arising from damage or disease of the somatosensory system）.展开更多
基金supported by a grant from Health and Family Planning Commission of Hubei Province(No.WJ2015MB008)
文摘Substantial evidence has suggested that deep brain stimulation of the cuneiform nucleus has become a remarkable treatment option for intractable pain,but the possible mechanism is poorly understood. Using a melanocortin-4 receptor（MC4R）-green fluorescent protein（GFP） reporter knockin mouse,we showed that a large number of MC4R-GFP-positive neurons were expressed in the cuneiform nucleus. Immunofluorescence revealed that approximately 40%–50% of MC4R-GFP-positive neurons expressed mu opioid receptors,indicating that they were opioidergic signaling. Our findings support the hypothesis that MC4 R expression in the cuneiform nucleus is involved in the modulation of opioidergic signaling.
基金supported by RO1-NS063965R21-NS088016+1 种基金VA Merit Review-BX000891Jowdy Professorship to SCF
文摘Preclinical stroke research has introduced a number of potential interventions that can be utilized to enhance recovery after stroke（Lo and Rosenberg,2009）.
基金National Institutes of Health R01DE022757(to VIS,AYS,TLY)supported this work
文摘Following injury to the peripheral nerve,pain secondary to low threshold innocuous mechanical stimulation（mechanical allodynia）is commonly observed.Its origins are poorly understood and the pain is often refractory to common analgesic therapeutics.The past two decades has brought major advances in our understanding of the complexity of systems that underlie processing of neuropathic pain（pain arising from damage or disease of the somatosensory system）.
