Antibodies to the ubiquitous group of stress proteins known as heat shock proteins (Hsps) have been found to be associated with a number of diseases in humans. Hsps are known to be induced by certain xenobiotics, some...Antibodies to the ubiquitous group of stress proteins known as heat shock proteins (Hsps) have been found to be associated with a number of diseases in humans. Hsps are known to be induced by certain xenobiotics, some of which are common in the working environment. The biological significance of the presence of such autoantibodies is presently unclear. In the present study, we used immunoblotting to investigate the presence of antibodies against the different stress proteins, Hsp27, Hsp60, Hsp71, Hse (heat shock cognate ) 73 and Hsp89a and D in groups of workers exposed to high temperature or carbon monoxide. These data were related to a detailed clinical evaluation and to various laboratory measurements including electrocardiogram (ECG), B echogram, white blood cell counts and typing, the activity of alanine aminotransferase (ALT), acid phosphatase (ACP) and alkaline phosphatase (ALP) and lymphocyte DNA damage. Antibodies to Hsp27 and Hsp71 were found more frequently in the high temperature and carbon monoxide-exposed groups than in controls (P (0.05 ). The carbon monoxide-exposed group showed the highest incidence of anti-Hsp antibodies. Anti-Hsp60 antibodies were only detected in workers exposed to high temperature or carbon monoxide. The percentage of workers with abnormal ECG, B echogram changes and displaying hepatitis B antigen (HBsAg ) was higher in the carbon monoxide group than in the control group (P＜0.05 ).There was a significant inerease in the activity of ALT in the high temperature and carbon monoxide groups and in the activities of ACP and ALP in the carbon monoxide group (P＜0.05 ). The extent of DNA damage measured in lymphoeytes was higher in workers from the high temperature and carbon monoxide-cxposed groups. We suggest that the increased frequeney of antibodies to Hsps is the result of these damages, of the release of denatured Hsps and of a decrease in the phagocytic ability of macrophages in these workers. The data gathered in the present study show a statistical relation between the occurrence of antibodies against Hsps and the frequency of health problems in workers and suggest a potential role for the antibodies as useful biomarkers to assess whether workers are experieneing environmental stress展开更多
Asthemaintectoniccomponentofthe Himalayan–Tibetan orogen,the Lhasa terrane has received much attention as it records the entire history of the orogeny.The occurrence of high pressure eclogite in the Sumdo complex in ...Asthemaintectoniccomponentofthe Himalayan–Tibetan orogen,the Lhasa terrane has received much attention as it records the entire history of the orogeny.The occurrence of high pressure eclogite in the Sumdo complex in central Lhasa terrane has a significant importance on the understanding of the Paleo-Tethys subduction and plate itineration processes in this area.The petrological,geochemical and geochronological data of eclogite and associated blueschist and garnet-bearing mica schist from Sumdo,Jilang and Bailang area have been briefly reviewed to explore the origin and metamorphic evolution of this suture.Eclogites from the Sumdo complex have experienced low temperature,high pressure to ultrahigh pressure metamorphism,revealing a fastsubduction and exhumation process in a typical oceanic subduction zone.The large P-T range between different eclogites in the literature may be affected by the big error of unappropriated using geothermobarometry and may also because of slices of subducted blocks derived from different depths juxtapose together during exhumation.By summarizing the U-Pb,Lu-Hf and Sm-Nd ages of eclogites,the eclogite facies metamorphism is likely to occur in early Triassic during 245-225 Ma,but not the previously accepted late Permian at ca.260 Ma by the reinterpretation of the former geochronological data from literature.The opening of Paleo-Tethys Ocean between the Lhasa terrane initiate prior to ca.280 Ma and ultimate closure to integrate the Lhasa terrane was no earlier than225 Ma and may triggered by the initial subduction of Bangong-Nujiang Tethys Ocean in the north.展开更多
文摘Antibodies to the ubiquitous group of stress proteins known as heat shock proteins (Hsps) have been found to be associated with a number of diseases in humans. Hsps are known to be induced by certain xenobiotics, some of which are common in the working environment. The biological significance of the presence of such autoantibodies is presently unclear. In the present study, we used immunoblotting to investigate the presence of antibodies against the different stress proteins, Hsp27, Hsp60, Hsp71, Hse (heat shock cognate ) 73 and Hsp89a and D in groups of workers exposed to high temperature or carbon monoxide. These data were related to a detailed clinical evaluation and to various laboratory measurements including electrocardiogram (ECG), B echogram, white blood cell counts and typing, the activity of alanine aminotransferase (ALT), acid phosphatase (ACP) and alkaline phosphatase (ALP) and lymphocyte DNA damage. Antibodies to Hsp27 and Hsp71 were found more frequently in the high temperature and carbon monoxide-exposed groups than in controls (P (0.05 ). The carbon monoxide-exposed group showed the highest incidence of anti-Hsp antibodies. Anti-Hsp60 antibodies were only detected in workers exposed to high temperature or carbon monoxide. The percentage of workers with abnormal ECG, B echogram changes and displaying hepatitis B antigen (HBsAg ) was higher in the carbon monoxide group than in the control group (P＜0.05 ).There was a significant inerease in the activity of ALT in the high temperature and carbon monoxide groups and in the activities of ACP and ALP in the carbon monoxide group (P＜0.05 ). The extent of DNA damage measured in lymphoeytes was higher in workers from the high temperature and carbon monoxide-cxposed groups. We suggest that the increased frequeney of antibodies to Hsps is the result of these damages, of the release of denatured Hsps and of a decrease in the phagocytic ability of macrophages in these workers. The data gathered in the present study show a statistical relation between the occurrence of antibodies against Hsps and the frequency of health problems in workers and suggest a potential role for the antibodies as useful biomarkers to assess whether workers are experieneing environmental stress
文摘Asthemaintectoniccomponentofthe Himalayan–Tibetan orogen,the Lhasa terrane has received much attention as it records the entire history of the orogeny.The occurrence of high pressure eclogite in the Sumdo complex in central Lhasa terrane has a significant importance on the understanding of the Paleo-Tethys subduction and plate itineration processes in this area.The petrological,geochemical and geochronological data of eclogite and associated blueschist and garnet-bearing mica schist from Sumdo,Jilang and Bailang area have been briefly reviewed to explore the origin and metamorphic evolution of this suture.Eclogites from the Sumdo complex have experienced low temperature,high pressure to ultrahigh pressure metamorphism,revealing a fastsubduction and exhumation process in a typical oceanic subduction zone.The large P-T range between different eclogites in the literature may be affected by the big error of unappropriated using geothermobarometry and may also because of slices of subducted blocks derived from different depths juxtapose together during exhumation.By summarizing the U-Pb,Lu-Hf and Sm-Nd ages of eclogites,the eclogite facies metamorphism is likely to occur in early Triassic during 245-225 Ma,but not the previously accepted late Permian at ca.260 Ma by the reinterpretation of the former geochronological data from literature.The opening of Paleo-Tethys Ocean between the Lhasa terrane initiate prior to ca.280 Ma and ultimate closure to integrate the Lhasa terrane was no earlier than225 Ma and may triggered by the initial subduction of Bangong-Nujiang Tethys Ocean in the north.
