The effects of toughener and coupling agent on special epoxy silicone adhesive were discussed by researching the surface morphology characters, thermal properties and shear strength of the adhesive. The results indica...The effects of toughener and coupling agent on special epoxy silicone adhesive were discussed by researching the surface morphology characters, thermal properties and shear strength of the adhesive. The results indicate that silicone coupling agent (KH-550) can improve the shear strength of the epoxy silicone adhesive effectively. The mass fraction of the toughener in the epoxy silicone adhesive plays an important role in its properties. When the mass fraction of the toughener is less than 14%, the shear strength of the adhesive is low. When the mass fraction of the toughener is over 33%, thermal properties and shear strength of the adhesive decrease with the increasing of the toughener. The mass fraction of toughener of 25% results in good integral properties of the epoxy silicone adhesive. The morphologic analysis indicates that the micro-phase separation exists in the epoxy molecular chain and the silicone molecular chain of the epoxy silicone adhesive.展开更多
Induction of tumor vasculature occlusion by targeting a thrombogen to newly formed blood vessels in tumor tissues represents an intriguing approach to the eradication of primary solid tumors. In the current study, we ...Induction of tumor vasculature occlusion by targeting a thrombogen to newly formed blood vessels in tumor tissues represents an intriguing approach to the eradication of primary solid tumors. In the current study, we construct and express a fusion protein containing vascular endothelial growth factor (VEGF) and tissue factor (TF) to explore whether this fusion protein has the capability of inhibiting tumor growth in a colon carcinoma model. The murine cDNA of VEGF A and TF were amplified by reverse transcriptase polymerase chain reaction (RT-PCR), and then cloned into prokaryotic expression plasmid pQE30 with a linker. The expression product recombinant VEGF-TF (rVEGF-TF) was purified and proved to have comparable enzyme activity to a commercial TF and the capability of specific binding to tumor vessels. Significant decrease of tumor growth was found in the mice administered with rVEGF-TF on Day 6 after initiated rVEGF-TF treatment (P<0.05), and the tumor masses in 2 of 10 mice were almost disappeared on Day 14 after the first treatment. In addition, valid thrombogenesis and tumor necrosis were observed in the tumor tissues injected with rVEGF-TF. Our results demonstrate that occlusion of tumor vasculature with rVEGF-TF is potentially an effective approach for cancer therapy.展开更多
This paper introduces the ceramic materials fusion method to use porcelain crucible instead of platinum crucible. By this method, not only the funds can be saved, but also the operation becomes simple and the analysed...This paper introduces the ceramic materials fusion method to use porcelain crucible instead of platinum crucible. By this method, not only the funds can be saved, but also the operation becomes simple and the analysed results are accurate and reliable. On the other hand, the high fusion point materials, such as high aluminum ceramic raw ma- terials, can also be melted and their aluminum contents can be determined by this method. Thus, it can be widely used in the students laboratory and routine analysis of small and middle industrial enterprises.展开更多
针对由于血管类间具有强相似性造成的动静脉错误分类问题,提出了一种新的融合上下文信息的多尺度视网膜动静脉分类网络(multi-scale retinal artery and vein classification network,MCFNet),该网络使用多尺度特征(multi-scale feature...针对由于血管类间具有强相似性造成的动静脉错误分类问题,提出了一种新的融合上下文信息的多尺度视网膜动静脉分类网络(multi-scale retinal artery and vein classification network,MCFNet),该网络使用多尺度特征(multi-scale feature,MSF)提取模块及高效的全局上下文信息融合(efficient global contextual information aggregation,EGCA)模块结合U型分割网络进行动静脉分类,抑制了倾向于背景的特征并增强了血管的边缘、交点和末端特征,解决了段内动静脉错误分类问题。此外,在U型网络的解码器部分加入3层深度监督,使浅层信息得到充分训练,避免梯度消失,优化训练过程。在2个公开的眼底图像数据集(DRIVE-AV,LES-AV)上,与3种现有网络进行方法对比,该模型的F1评分分别提高了2.86、1.92、0.81个百分点,灵敏度分别提高了4.27、2.43、1.21个百分点,结果表明所提出的模型能够很好地解决动静脉分类错误的问题。展开更多
基金Project supported by the National High-Tech Research and Development Program of China
文摘The effects of toughener and coupling agent on special epoxy silicone adhesive were discussed by researching the surface morphology characters, thermal properties and shear strength of the adhesive. The results indicate that silicone coupling agent (KH-550) can improve the shear strength of the epoxy silicone adhesive effectively. The mass fraction of the toughener in the epoxy silicone adhesive plays an important role in its properties. When the mass fraction of the toughener is less than 14%, the shear strength of the adhesive is low. When the mass fraction of the toughener is over 33%, thermal properties and shear strength of the adhesive decrease with the increasing of the toughener. The mass fraction of toughener of 25% results in good integral properties of the epoxy silicone adhesive. The morphologic analysis indicates that the micro-phase separation exists in the epoxy molecular chain and the silicone molecular chain of the epoxy silicone adhesive.
基金the National Natural Science Foundation of China (Nos. 30560160 and 30560048)the New Century Excellent Talents in University of China (No. NCET-05-0757)the Education Department of Hainan Province, China (No. Hjkj200422)
文摘Induction of tumor vasculature occlusion by targeting a thrombogen to newly formed blood vessels in tumor tissues represents an intriguing approach to the eradication of primary solid tumors. In the current study, we construct and express a fusion protein containing vascular endothelial growth factor (VEGF) and tissue factor (TF) to explore whether this fusion protein has the capability of inhibiting tumor growth in a colon carcinoma model. The murine cDNA of VEGF A and TF were amplified by reverse transcriptase polymerase chain reaction (RT-PCR), and then cloned into prokaryotic expression plasmid pQE30 with a linker. The expression product recombinant VEGF-TF (rVEGF-TF) was purified and proved to have comparable enzyme activity to a commercial TF and the capability of specific binding to tumor vessels. Significant decrease of tumor growth was found in the mice administered with rVEGF-TF on Day 6 after initiated rVEGF-TF treatment (P<0.05), and the tumor masses in 2 of 10 mice were almost disappeared on Day 14 after the first treatment. In addition, valid thrombogenesis and tumor necrosis were observed in the tumor tissues injected with rVEGF-TF. Our results demonstrate that occlusion of tumor vasculature with rVEGF-TF is potentially an effective approach for cancer therapy.
文摘This paper introduces the ceramic materials fusion method to use porcelain crucible instead of platinum crucible. By this method, not only the funds can be saved, but also the operation becomes simple and the analysed results are accurate and reliable. On the other hand, the high fusion point materials, such as high aluminum ceramic raw ma- terials, can also be melted and their aluminum contents can be determined by this method. Thus, it can be widely used in the students laboratory and routine analysis of small and middle industrial enterprises.
文摘针对由于血管类间具有强相似性造成的动静脉错误分类问题,提出了一种新的融合上下文信息的多尺度视网膜动静脉分类网络(multi-scale retinal artery and vein classification network,MCFNet),该网络使用多尺度特征(multi-scale feature,MSF)提取模块及高效的全局上下文信息融合(efficient global contextual information aggregation,EGCA)模块结合U型分割网络进行动静脉分类,抑制了倾向于背景的特征并增强了血管的边缘、交点和末端特征,解决了段内动静脉错误分类问题。此外,在U型网络的解码器部分加入3层深度监督,使浅层信息得到充分训练,避免梯度消失,优化训练过程。在2个公开的眼底图像数据集(DRIVE-AV,LES-AV)上,与3种现有网络进行方法对比,该模型的F1评分分别提高了2.86、1.92、0.81个百分点,灵敏度分别提高了4.27、2.43、1.21个百分点,结果表明所提出的模型能够很好地解决动静脉分类错误的问题。
