Objective: To investigate the dissolution behavior similarity between Self-made praeparatum and reference praeparatum in different pH menstruum,using the Olanzapine Orally Disintegrating Tablets listed in abroad as th...Objective: To investigate the dissolution behavior similarity between Self-made praeparatum and reference praeparatum in different pH menstruum,using the Olanzapine Orally Disintegrating Tablets listed in abroad as the reference praeparatum. Methods: The dissolution curve of olanzapine in Self-made praeparatum and reference praeparatum was measured,the similarity of the dissolution curve was evalued by F2 similar factor. Results: The single-point dissolution of both Self-made praeparatum and reference praeparatum within 15 min was more than 85%. Conclusion: Self-made praeparatum and reference praeparatum were similar in dissolution behavior.展开更多
The purpose of this experimental study is to evaluate the feasibility and oil recovery efficiency of continuous N_(2) injection in a multi-well fractured-cavity reservoir.In this study,the similar criterion of physica...The purpose of this experimental study is to evaluate the feasibility and oil recovery efficiency of continuous N_(2) injection in a multi-well fractured-cavity reservoir.In this study,the similar criterion of physical simulation was firstly discussed.In order to reveal the mechanism of remaining oil startup and production performance characteristic by continuous N_(2) injection,a visualized twodimensional fractured-cavity model and a three-dimensional pressure resistant model were designed and fabricated respectively based on the similar theory.And the 2D visualized physical experiments and 3D physical experiments were performed with the simulated oil and brine reservoir samples in Tahe oilfield.Four groups of experiments in 2D and 3D model were performed,each of which included bottom water depletion driving,water injection and N_(2) injection.The 2D visualized experiments indicated the main mechanism of N_(2) developing remaining oil was to occupy the high position and replace the attic oil due to gravitational differentiation.Furthermore,both the 2D and 3D experiments demonstrated that higher oil recovery factor could be achieved if N_(2) was injected through high positional wells.The 3D physical model is closer to the real reservoir condition,so the production performance can reflect the real field production process.This paper confirmed the efficiency of continuous N2 flooding in the light oil saturated fractured-cavity reservoir.展开更多
文摘Objective: To investigate the dissolution behavior similarity between Self-made praeparatum and reference praeparatum in different pH menstruum,using the Olanzapine Orally Disintegrating Tablets listed in abroad as the reference praeparatum. Methods: The dissolution curve of olanzapine in Self-made praeparatum and reference praeparatum was measured,the similarity of the dissolution curve was evalued by F2 similar factor. Results: The single-point dissolution of both Self-made praeparatum and reference praeparatum within 15 min was more than 85%. Conclusion: Self-made praeparatum and reference praeparatum were similar in dissolution behavior.
基金The authors wish to thank the National Natural Science Foundation of China(NO.51174216)State Key Science&Technology Project of China(NO.2011ZX05009-004 and NO.2011ZX05052)for their financial support to carry out this research.The insightful and constructive comments of the anonymous reviewers are also gratefully acknowledged.
文摘The purpose of this experimental study is to evaluate the feasibility and oil recovery efficiency of continuous N_(2) injection in a multi-well fractured-cavity reservoir.In this study,the similar criterion of physical simulation was firstly discussed.In order to reveal the mechanism of remaining oil startup and production performance characteristic by continuous N_(2) injection,a visualized twodimensional fractured-cavity model and a three-dimensional pressure resistant model were designed and fabricated respectively based on the similar theory.And the 2D visualized physical experiments and 3D physical experiments were performed with the simulated oil and brine reservoir samples in Tahe oilfield.Four groups of experiments in 2D and 3D model were performed,each of which included bottom water depletion driving,water injection and N_(2) injection.The 2D visualized experiments indicated the main mechanism of N_(2) developing remaining oil was to occupy the high position and replace the attic oil due to gravitational differentiation.Furthermore,both the 2D and 3D experiments demonstrated that higher oil recovery factor could be achieved if N_(2) was injected through high positional wells.The 3D physical model is closer to the real reservoir condition,so the production performance can reflect the real field production process.This paper confirmed the efficiency of continuous N2 flooding in the light oil saturated fractured-cavity reservoir.
