Optimization of Compound Coptis Ointment Extraction through the Integration of Pharmacodynamic Indices and Orthogonal Test

[Objectives]To determine the optimal reflux extraction process conditions for Compound Coptis Ointment.[Methods]The study employed the orthogonal experimental design method and drug-sensitive disc agar diffusion method to evaluate the extraction rate,berberine hydrochloride content,and bacteriostatic ring diameter of the extract as comprehensive indices,and optimized the extraction process conditions of Compound Coptis Ointment using ethanol reflux.[Results]Based on the results of comprehensive indices,the optimal reflux extraction conditions for Compound Coptis Ointment were determined to be soaking in 1.5 times the amount of 70%ethanol for 2 h,followed by two extractions with 6 times the amount of 70%ethanol for 1 h each time.Three verification tests were conducted under the optimal process conditions.The yield of the extract was 28.32%±0.53%,the content of berberine hydrochloride was 4.68%±0.45%,and the diameter of the bacteriostatic ring was(2.5±0.2)cm.[Conclusions]The extract had higher drug content and exhibited better antibacterial effects.The optimized extraction process is simple,stable,and reliable,and can be effectively used to optimize the extraction process of Compound Coptis Ointment.

Optimization of short-circuit transition parameters of Q235B steel GMAW based on orthogonal gray relational analysis

In gas metal arc welding(GMAW)process,the short-circuit transition was the most typical transition observed in molten metal droplets.This paper used orthogonal tests to explore the coupling effect law of welding process parameters on the quality of weld forming under short-circuit transition,the design of 3 factors and 3 levels of a total of 9 groups of orthogonal tests,welding current,welding voltage,welding speed as input parameters:effective area ratio,humps,actual linear power density,aspect ratio,Vickers hardness as output paramet-ers(response targets).Using range analysis and trend charts,we can visually depict the relationship between input parameters and a single output parameter,ultimately determining the optimal process parameters that impact the single output index.Then combined with gray the-ory to transform the three response targets into a single gray relational grade(GRG)for analysis,the optimal combination of the weld mor-phology parameters as follows:welding current 100 A,welding voltage 25 V,welding speed 30 cm/min.Finally,validation experiments were conducted,and the results showed that the error between the gray relational grade and the predicted value was 2.74%.It was observed that the effective area ratio of the response target significantly improved,validating the reliability of the orthogonal gray relational method.

Influence of multiple structural parameters on interior ballistics based on orthogonal test methods

Influence of multiple structural parameters on the performance of a gun launch system driven by highpressure reactive gases is important for structural design and performance adjustment.A coupled lumped parameter model was utilized to predict the propellant combustion,and a dynamic finite element method was applied to approximate the mechanical interactions between the projectile and the barrel.The combustion and the mechanical interactions were coupled through a user subroutine interface in ABAQUS.The correctness and the capability of the finite element approximations in capturing small structural changes were validated by comparing predicted resistance with experiments.Based on the coupled model,the influence of structural parameters of a medium-caliber gun on the system performance was investigated.In order to reduce the research costs,orthogonal tests were designed to investigate the comprehensive effects of the parameters.According to statistical analysis,the important order of the structural parameters on the launching process was obtained.The results indicate that the influence of the width of the rotating band stands out among the studied parameters in the gun.The work provides a method to investigate the influence of multiple parameters on system performance and gives guidance for controlling the system performance.

Optimization of a Centrifugal Pump Used as a Turbine Impeller By Means of an Orthogonal Test Approach

A prototype centrifugal pump with a specific speed of 110 is used to investigate and optimize the performances of a turbine for power generation.Particular attention is given to the design of the internal impeller.The internal flow field is simulated in the framework of a commercial computational fluid dynamics software(ANSYS).Four geometrical parameters of the impeller are considered,i.e.,the inlet diameter,the inlet width,the blade number,and the blade angle.The optimization is carried out on the basis of a three-level approach relying on an orthogonal test method.The results of the numerical simulations show good agreement with the experimental tests under different flow conditions.In accordance with the L9(34)design table,the head and efficiency under the rated flow rate of the nine designed schemes are calculated and processed with the method of range analysis to obtain an optimized model.

Orthogonal tests of copper-clad aluminum bimetal continuous casting by nitrogen pressure core-illing

To provide theoretical basis and practical guidance for preparing composite rods by direct continuous casting, copper-clad aluminum composite rods of external copper layer diameter 12 mm and inner aluminum core diameter 8 mm were manufactured. Orthogonal tests consisted of three factors and three levels were carried out to research the effects of melting copper temperature, continuous casting speed and nitrogen pressure on the performance of composite rods. Results showed that nitrogen pressure is the most important factor in influencing the surface quality; continuous casting speed is the most important factor in influencing copper & aluminum inter diffusion amount. Nitrogen pressure can noticeably improve the surface quality and make the rods easily be drawn out, but the surface quality does not show visible improvement when the nitrogen pressure is above 0.05 MPa. Measured by tests, the compound layer can be divided into three types according to its cladding layer degree: deficient cladding, normal cladding and excess cladding. The diameter of normal copper-clad aluminum composite rods can be successfully drawn less than 0.6 mm without annealing.

Mathematical model for abrasive suspension jet cutting based on orthogonal test design

This paper describes the application of orthogonal test design coupled with non-linear regression analysis to optimize abrasive suspension jet （AS J） cutting process and construct its cutting model. Orthogonal test design is applied to cutting stainless steel. Through range analysis on experiment results, the optimal process conditions for the cutting depth and the kerr ratio of the bottom width to the top width can be determined. In addition, the analysis of ranges and variances are all employed to identify various factors： traverse rate, working pressure, nozzle diameter, standoff distance which denote the importance order of the cutting parameters affecting cutting depth and the kerf ratio of the bottom width to the top width. ~rthermore, non-linear regression analysis is used to establish the mathematical models of the cutting parameters based on the cutting depth and the kerr ratio. Finally, the verification experiments of cutting parameters＇ effect on cutting performance, which show that optimized cutting parameters and cutting model can significantly improve the prediction of the cutting ability and quality of ASJ.

Orthogonal Test About Biogas Upgrading by Pressured Water Scrubbing

Biogas is a kind of regenerable energy which is inexpensive and friendly to the environment, but the potential ofbiogas is difficult to develop fully in China, for most biogas have badly qualities and the utilization of it is monotonous. The suitable operation term about biogas upgrading by pressurized water scrubbing was researched through the orthogonal test in this study. Two sorts of scrubber packing included the random multidimensional hollow sphere packing and the structured screen packing were also used, and the effects of experiment factors included packing, water temperature, gas flow speed, water flow speed and washing pressure were studied. The results showed that better effect was got when the screen structured packing was used; all the five test factors affected the processing significantly in the arrange as before and had better and better significant effects.

Optimization of Extraction Process of Prunellae Spica Compound by Orthogonal Test

[Objectives] The study aimed to optimize the extraction process of Prunellae Spica compound to provide an experimental basis for the development and utilization of the compound. [Methods]Through orthogonal test,the optimal extraction process of Prunellae Spica compound was chosen by using the yield of dry paste and ursolic acid content as evaluation indicators. [Results]The optimal extraction process of Prunellae Spica compound is as follows: solvent dosage was 16 times,and extraction frequency was 3 times,while extraction time was 1 h.[Conclusions]The extraction process of Prunellae Spica compound was stable and feasible,and this study can provide a theoretical basis for further preparation of the compound.

Optimization of Ultrasonic Extraction Process of Oenanthe benghalensis Polysaccharide by Orthogonal Test

[Objectives] The research aimed to explore extraction method of Oenanthe benghalensis polysaccharide,and determine the optimal process of its ultrasonic extraction by orthogonal test. [Methods] Phenol-sulfuric acid method was used to determine polysaccharide's content. Based on single-factor experiment and orthogonal test,the influences of solid-liquid ratio( A),ultrasonic extraction temperature( B),ultrasonic power( C) and ultrasonic time( D) on extraction rate of O. benghalensis polysaccharide were studied,and the optimal process of ultrasonic extraction was selected. [Results] The influence order of solid-liquid ratio( A),ultrasonic extraction temperature( B),ultrasonic power( C) and ultrasonic time( D) on extraction rate of O. benghalensis polysaccharide was A > D > B > C. Via the orthogonal test,it was determined that the optimal extraction condition of O. benghalensis polysaccharide was as below: solid-liquid ratio 1∶ 25( g/mL),extraction temperature 60℃,extraction power 80 W,extraction time 40 min. Under the condition,extraction rate of O. benghalensis polysaccharide was9. 80%. [Conclusions] The process could provide the reference basis for extracting and producing O. benghalensis polysaccharides.

Optimization of Extraction Process of Zihua Qinghuo Capsule by Orthogonal Test

With quercetin content and yield of dry extract as investigation indices, three factors, amount of water added, decoction time and decoction times were investigated by an orthogonal test, so as to select the optimal water extraction process for Zihua Qinghuo Capsule. The determined extraction process was adding 8 times of water in five herbs including Viola philippica and decocting for 2 times, 1.5 h each time. Pilot scale test demonstrated that the selected process is stable and feasible, and could provide reliable reference for practical production.

Study on the insecticidal activities of the extracts from four plants under orthogonal test

Aim To prepare dry powder insecticide by mixing the plant samples of Aconitum ochranthum Mey.,Aconitum hemsleyanum Pritz.and Dictamnus dasycarpus Turcz.Method The dosage ratios of the break stocks from the plants mentioned above are installed as four factors,and three levels are selected for every factor.The test is actualized according to L 9(3 4) orthogonal array.Results An optimized recipe A 3 B 3 C 3 D 1 has been obtained after considering multifarious factors such as the resources of these plants and the water-solubility of samples.Conclusion The dry powder insecticide prepared by mixing the plant samples mentioned above as 1∶1∶1mass ratio revealed that insecticidal activities for cickets,grasshopper,aphid,and 3rd instar Mythimna separata walker are significant,respectively.

Orthogonal tests of lead-clad tin bimetal continuous casting by air pressure core-filling

To provide theoretical basis and practical guidance for preparing composite rods of external diameter no larger than 12 mm by directly continuous casting,low melting point materials of lead and tin were selected to prepare composite rods of external diameter 12 mm and inner diameter 8 mm with air pressing core filled continuous casting process.The orthogonal tests consisting of three factors and three levels were designed to investigate the parameters of melting lead temperature,continuous casting speed and air pressure that affect the performance of the composite rods.The results show that melting lead temperature is the most important factor that influences the solid/liquid interface location;continuous casting speed is the most important factor that influences the surface quality and lead and tin inter-diffusion amount;air pressure can improve the surface quality obviously and make the rods easily drawn out,but the surface quality cannot get obvious improvement when the air pressure is above 0.03 MPa.The composite rods have excellent surface quality,obvious intermediate layer,even thick clad,and metallurgical bonding interface under the condition of melting lead temperature of 375 °C,continuous casting speed of 10 mm/min,and air pressure of 0.03 MPa.

Decompositions of Symmetry Using Generalized Linear Diagonals-Parameter Symmetry Model and Orthogonality of Test Statistic for Square Contingency Tables

For square contingency tables with ordered categories, the present paper gives several theorems that the symmetry model holds if and only if the generalized linear diagonals-parameter symmetry model for cell probabilities and for cumulative probabilities and the mean nonequality model of row and column variables hold. It also shows the orthogonality of statistic for testing goodness-of-fit of the symmetry model. An example is given.

Optimization of the Ethanol Extraction Method of Monoester Alkaloids from Radix Aconiti Preparata Based on HPLC-MS and Orthogonal Test

[Objectives] This study was conducted to optimize the ethanol extraction technology of monoester alkaloids from Radix Aconiti Preparata. [Methods]On the basis of defined extraction times,ethanol concentration,ethanol times and extraction time were investigated by HPLC-MS combined with orthogonal test to optimize extraction process using the content of monoester alkaloids( the sum of benzoyl neoaconitine,benzoyl hypoaconitine and benzoyl aconitine) as an index.[Results]The optimum ethanol extraction technology was as follows: 75% ethanol,ethanol amount 25 times of the medicinal material,and each extraction for 1. 5 h.[Conclusions] The optimal extraction technology is simple,feasible,stable and reliable. It can provide reference for the industrial production and quality control of monoester alkaloids from Radix Aconiti Preparata.

Research on Treatment of Landfill Leachate Polluting Groundwater by Orthogonal Test

Through PRB simulated device and orthogonal test,we discussed the treatment effect of groundwater polluted by landfill leachate with three reaction mediums of zero-valent iron powder,activated carbon and zeolite. We considered four factors of iron powder mass,activated carbon mass,particle size of iron powder and zeolite mass,and designed a two-level orthogonal test. It concluded that effluent pH appeared to fall or rise as the reaction proceeded,which changed during 7- 8. The removal rates of CODCrin eight reactors were during 60. 7%- 78. 3%,and the removal rates of NH3-N were during 34. 0%- 58. 8%. Activated carbon mass and the interaction of iron powder mass and activated carbon mass had significant influences on the removal of CODCr,while iron powder mass,particle size of iron powder and zeolite mass had insignificant influences on the removal of CODCr. Zeolite mass and activated carbon mass had significant influences on the removal of NH3,while iron powder mass,particle size of iron powder and the interaction with activated carbon mass had insignificant influences on the removal of NH3-N.

Test case generation based on orthogonal table for software black-box testing

Software testing is an important means to assure the software quality. This paper presents a practicable method to generate test cases of software testing, which is operational and high efficient. We discuss the identification of software specification categories and choices and make a classification tree. Based on the orthogonal array, it is easy to generate test cases. The number of this method is less than that of all combination of the choices.

Warm Compaction Process of P/M Steels by Orthogonal Testing Method

为了用 die 完成 P/M 钢的更高的密度，围在温暖的压缩过程压缩方法或粉末润滑剂的润滑油，温暖的压缩样品的绿密度上的不同过程参数的影响被学习。根据直角的测试方法，作者系统地学习不同压缩压力的影响，润滑油的状况；在温暖的压缩过程的样品的绿密度上的压缩温度，；提出温暖的压缩实验的最佳的进程参数。它被发现那，一个高压缩压力(≥ 7 00 MPa ) ，死墙润滑油与内部润滑剂的小数量结合了，；由润滑油的不同状况的恰当的压缩温度，是在温暖的压缩的最佳的参数过程。

Mechanical Test and Meso-Model Numerical Study of Composite Rubber Concrete under Salt-Freezing Cycle

A composite rubber concrete(CRC)was designed by combining waste tire rubber particles with particle sizes of 3~5 mm,1~3 mm and 20 mesh.Taking the rubber content of different particle sizes as the influencing factors,the range and variance analysis of the mechanical and impermeability properties of CRC was carried out by orthogonal test.Through analysis,it is concluded that the optimal proportion of 3~5 mm,1~3 mm,and 20 mesh particle size composite rubber is 1:2.5:5.5 kinds of CRC and 3 kinds of ordinary single-mixed rubber concrete(RC)with a total content of 10%~20%were designed under this ratio,and the salt-freezing cycle test was carried out with a concentration of 5%Na 2 SO4 solution.The physical and mechanical damage laws during 120 salt-freezing cycles are obtained,and the corresponding damage prediction model is established according to the experimental data.The results show that:on the one hand,the composite rubber in CRC produces a more uniform“graded”structure,forms a retractable particle group,and reduces the loss of mechanical properties of CRC.On the other hand,colloidal particles with different particle sizes are used as air entraining agent to improve the pore structure of concrete and introduce evenly dispersed bubbles,which fundamentally improves the durability of concrete.Under the experimental conditions,the CRC performance is the best when the overall content of composite rubber is 15%.

Optimal Design of High-Speed Partial Flow Pumps using Orthogonal Tests and Numerical Simulations

To investigate the influence of structural parameters on the performances and internal flow characteristics of partial flow pumps at a low specific speed of 10000 rpm,special attention was paid to the first and second stage impeller guide vanes.Moreover,the impeller blade outlet width,impeller inlet diameter,blade inclination angle,and number of blades were considered for orthogonal tests.Accordingly,nine groups of design solutions were formed,and then used as a basis for the execution of numerical simulations(CFD)aimed at obtaining the efficiency values and heads for each design solution group.The influence of impeller geometric parameters on the efficiency and head was explored,and the“weight”of each factor was obtained via a range analysis.Optimal structural parameters were finally chosen on the basis of the numerical simulation results,and the performances of the optimized model were verified accordingly(yet by means of CFD).Evidence is provided that the increase in the efficiency and head of the optimized model was 12.11%and 23.5 m,respectively,compared with those of the original model.