Through clinical practice over the last decade, , I have been using Baihui （GV 20） and Sishencong （Ex-HN 1） for treating various diseases or symptoms. It is now reported as follows.
Objective To explore the efficacy of acupuncture at Sish4nc6ng （四神聪 EX- HN 1） and Baihui （百会 GV 20） as well as the possible mechanism. Methods Eighty cases of insomnia patients treated in our hospital were se...Objective To explore the efficacy of acupuncture at Sish4nc6ng （四神聪 EX- HN 1） and Baihui （百会 GV 20） as well as the possible mechanism. Methods Eighty cases of insomnia patients treated in our hospital were selected, and randomly divided into a control group and a treatment group according to the random number table method. Conventional treatment was carried out in the control group by giving cliazepam tablets, and acupuncture at EX-HN 1 and GV 20 was conducted in the treatment group. The sleep time and quality, PSQI score, and the level changes of blood glutamic acid （GLU）, y-aminobutyric acid （GABA）, norepinephrine （NE） and dopamine （DA） were compared in the patients in each group before and after treatment. Results Compared with the results before treatment, the time for falling asleep of the patients in the two groups shortened （both P〈0.05）, the levels of GLU and GABA increased （all P〈0.05）, the sleep time was longer （both P〈0.05）, and the levels of NE and DA, as well as the PSQI score reduced （all P〈0.05）. Compared with the control group, the levels of NE and DA, as well as the PSQI score of patients in the treatment group reduced after treatment （P〈0.05）, the time for falling asleep shortened （P〈0.05）, the levels of GLU and GABA increased （P〈0.05）, and the sleep time was longer （P〈0.05）. Conclusion Acupuncture at EX-HN 1 and GV 20 can prolong the sleep time, improve the sleep quality, and the clinical efficacy is superior to that of western medicine treatment. The mechanism may be related to the synthesis and release of amino acids neurotransmitters.展开更多
目的采用针刺百会、四神聪穴位的方法,干预脑缺血再灌注损伤模型大鼠,通过对各组大鼠脑缺血半暗带组织中NF-κB、IκB蛋白表达水平的检测,探讨针刺百会、四神聪治疗缺血性脑病的部分作用机制。方法SPF级SD大鼠45只,将大鼠随机分为2组:...目的采用针刺百会、四神聪穴位的方法,干预脑缺血再灌注损伤模型大鼠,通过对各组大鼠脑缺血半暗带组织中NF-κB、IκB蛋白表达水平的检测,探讨针刺百会、四神聪治疗缺血性脑病的部分作用机制。方法SPF级SD大鼠45只,将大鼠随机分为2组:假手术组(15只);造模组(30只)。然后采用改良线栓法对造模组30只大鼠进行CIRI模型复制,评价模型成功后,再将成功的动物模型随机分为2组:非穴区对照组和针刺组。最终实验分为3组,即:假手术组、非穴区对照组和针刺组。假手术组大鼠采用相同术式但不予线栓干预。模型复制成功后,针刺组大鼠给予百会、四神聪穴针刺干预,间隔8 h 1次,至再灌注72 h结束;非穴区对照组大鼠分别于百会、四神聪穴区周边5 mm处进行针刺皮肤干预,间隔8 h 1次,至再灌注72 h结束。末次针刺后1 h,过量麻醉法处死大鼠,取脑组织,去除缺血液化区组织后,沿缺血灶走行,剥离缺血灶周边2 mm区域内半暗带组织,用于NF-κB、IκB蛋白表达水平的检测。结果假手术组神经功能缺损评分为0,TTC染色未见梗死灶。非穴区对照组和针刺组神经功能缺损评分和梗死百分比均具有显著的统计学差异。与假手术组比较,非穴区对照组和针刺组大鼠缺血半暗带组织中NF-κB表达水平显著上调(P<0.01),IκB蛋白表达水平显著下降(P<0.01),有统计学差异;针刺干预后,与非穴区对照组比较,针刺组大鼠缺血半暗带组织中NF-κB表达水平显著下调(P<0.01),IκB蛋白表达水平显著上调(P<0.01),有统计学差异。结论针刺百会、四神聪穴可明显降低脑缺血再灌注损伤模型大鼠神经功能缺损评分,减小梗死百分比。其作用机制可能是通过调节NF-κB信号通路实现的。展开更多
Objective： To observe the clinical effect of Acupuncture at Baihui（GV 20）, Sishencong（EX-HN 1） and Anmian [Extra, locates at the midpoint between Yiming（EX-HN 14） and Fengchi（GB 20）] for primary insomnia. Met...Objective： To observe the clinical effect of Acupuncture at Baihui（GV 20）, Sishencong（EX-HN 1） and Anmian [Extra, locates at the midpoint between Yiming（EX-HN 14） and Fengchi（GB 20）] for primary insomnia. Methods： A total of 112 patients with primary insomnia were randomized into an acupuncture group and a medication group according to the visiting sequence, 56 cases in each group. The acupuncture group was intervened by acupuncture at Baihui（GV 20）, Sishencong（EX-HN 1） and Anmian [Extra, locates at the midpoint between Yiming（EX-HN 14） and Fengchi（GB 20）], and points selected based on syndrome differentiation, while the medication group was by oral intake of zopiclone tablet. The Pittsburgh sleep quality index（PSQI） was measured before and after treatment, and the clinical efficacy was compared after 1 month of treatment. Results： After treatment, subscales of PSQI and global score in the acupuncture group were improved, and intra-group comparisons showed statistical differences（all P〈0.05）; subscales of sleep quality, sleep latency, sleep duration and global score of PSQI in the medication group were improved, showing statistical differences（all P〈0.05）. Inter-group comparison of global and subscales scores of PSQI showed statistical differences（all P〈0.05）. The total effective rate in the acupuncture group was 92.9%, higher than 67.9% in the medication group, and between-group comparison showed a statistical difference（P〈0.05）. Conclusion： Acupuncture at Baihui（GV 20）, Sishencong（EX-HN 1） and Anmian [Extra, locates at the midpoint between Yiming（EX-HN 14） and Fengchi（GB 20）] as the main treatment method can produce a better effect than oral intake of zopiclone tablet.展开更多
文摘Through clinical practice over the last decade, , I have been using Baihui （GV 20） and Sishencong （Ex-HN 1） for treating various diseases or symptoms. It is now reported as follows.
文摘Objective To explore the efficacy of acupuncture at Sish4nc6ng （四神聪 EX- HN 1） and Baihui （百会 GV 20） as well as the possible mechanism. Methods Eighty cases of insomnia patients treated in our hospital were selected, and randomly divided into a control group and a treatment group according to the random number table method. Conventional treatment was carried out in the control group by giving cliazepam tablets, and acupuncture at EX-HN 1 and GV 20 was conducted in the treatment group. The sleep time and quality, PSQI score, and the level changes of blood glutamic acid （GLU）, y-aminobutyric acid （GABA）, norepinephrine （NE） and dopamine （DA） were compared in the patients in each group before and after treatment. Results Compared with the results before treatment, the time for falling asleep of the patients in the two groups shortened （both P〈0.05）, the levels of GLU and GABA increased （all P〈0.05）, the sleep time was longer （both P〈0.05）, and the levels of NE and DA, as well as the PSQI score reduced （all P〈0.05）. Compared with the control group, the levels of NE and DA, as well as the PSQI score of patients in the treatment group reduced after treatment （P〈0.05）, the time for falling asleep shortened （P〈0.05）, the levels of GLU and GABA increased （P〈0.05）, and the sleep time was longer （P〈0.05）. Conclusion Acupuncture at EX-HN 1 and GV 20 can prolong the sleep time, improve the sleep quality, and the clinical efficacy is superior to that of western medicine treatment. The mechanism may be related to the synthesis and release of amino acids neurotransmitters.
文摘目的采用针刺百会、四神聪穴位的方法,干预脑缺血再灌注损伤模型大鼠,通过对各组大鼠脑缺血半暗带组织中NF-κB、IκB蛋白表达水平的检测,探讨针刺百会、四神聪治疗缺血性脑病的部分作用机制。方法SPF级SD大鼠45只,将大鼠随机分为2组:假手术组(15只);造模组(30只)。然后采用改良线栓法对造模组30只大鼠进行CIRI模型复制,评价模型成功后,再将成功的动物模型随机分为2组:非穴区对照组和针刺组。最终实验分为3组,即:假手术组、非穴区对照组和针刺组。假手术组大鼠采用相同术式但不予线栓干预。模型复制成功后,针刺组大鼠给予百会、四神聪穴针刺干预,间隔8 h 1次,至再灌注72 h结束;非穴区对照组大鼠分别于百会、四神聪穴区周边5 mm处进行针刺皮肤干预,间隔8 h 1次,至再灌注72 h结束。末次针刺后1 h,过量麻醉法处死大鼠,取脑组织,去除缺血液化区组织后,沿缺血灶走行,剥离缺血灶周边2 mm区域内半暗带组织,用于NF-κB、IκB蛋白表达水平的检测。结果假手术组神经功能缺损评分为0,TTC染色未见梗死灶。非穴区对照组和针刺组神经功能缺损评分和梗死百分比均具有显著的统计学差异。与假手术组比较,非穴区对照组和针刺组大鼠缺血半暗带组织中NF-κB表达水平显著上调(P<0.01),IκB蛋白表达水平显著下降(P<0.01),有统计学差异;针刺干预后,与非穴区对照组比较,针刺组大鼠缺血半暗带组织中NF-κB表达水平显著下调(P<0.01),IκB蛋白表达水平显著上调(P<0.01),有统计学差异。结论针刺百会、四神聪穴可明显降低脑缺血再灌注损伤模型大鼠神经功能缺损评分,减小梗死百分比。其作用机制可能是通过调节NF-κB信号通路实现的。
文摘Objective： To observe the clinical effect of Acupuncture at Baihui（GV 20）, Sishencong（EX-HN 1） and Anmian [Extra, locates at the midpoint between Yiming（EX-HN 14） and Fengchi（GB 20）] for primary insomnia. Methods： A total of 112 patients with primary insomnia were randomized into an acupuncture group and a medication group according to the visiting sequence, 56 cases in each group. The acupuncture group was intervened by acupuncture at Baihui（GV 20）, Sishencong（EX-HN 1） and Anmian [Extra, locates at the midpoint between Yiming（EX-HN 14） and Fengchi（GB 20）], and points selected based on syndrome differentiation, while the medication group was by oral intake of zopiclone tablet. The Pittsburgh sleep quality index（PSQI） was measured before and after treatment, and the clinical efficacy was compared after 1 month of treatment. Results： After treatment, subscales of PSQI and global score in the acupuncture group were improved, and intra-group comparisons showed statistical differences（all P〈0.05）; subscales of sleep quality, sleep latency, sleep duration and global score of PSQI in the medication group were improved, showing statistical differences（all P〈0.05）. Inter-group comparison of global and subscales scores of PSQI showed statistical differences（all P〈0.05）. The total effective rate in the acupuncture group was 92.9%, higher than 67.9% in the medication group, and between-group comparison showed a statistical difference（P〈0.05）. Conclusion： Acupuncture at Baihui（GV 20）, Sishencong（EX-HN 1） and Anmian [Extra, locates at the midpoint between Yiming（EX-HN 14） and Fengchi（GB 20）] as the main treatment method can produce a better effect than oral intake of zopiclone tablet.
