Clinical Study on the Effectiveness of Xian Fang Huo Ming Yin for Treating Cutaneous Infections and Promoting Wound Healing in Patients with Perianal Abscess

Objective:To explore the effect of the Xian Fang Huo Ming Yin(XFHM)for treating cutaneous infections and promoting wound healing in patients with perianal abscesses.Methods:Sixty-one patients with perianal abscesses who were admitted to our hospital(Xinghua City People’s Hospital)from May 2022 to May 2023 were selected and randomly divided into two groups,a control group(30 cases)and a study group(31 cases).Both groups received surgical treatment.The control group received conventional treatment and warm water fumigation,sitz bath,and surgical dressing change after surgery,while the research group received XFHM based on the control group.XFHM was taken orally and replaced with warm water for fumigation and sitz bathing.Both groups received treatment for 4 weeks but discontinued sitz bathing after 2 weeks.Various clinical indicators between the two groups were compared.Results:The total clinical effective rate and wound recovery rate of the study group were higher than that of the control group.There were differences in the wound pain scores,surrounding tissue edema,and wound secretions at different time points.Both groups experienced wound pain.The scores of wound pain,surrounding tissue edema,and wound secretions of the study group were lower than those of the control group,7 and 14 days after surgery.The serum interleukin 6(IL-6),tumor necrosis factor-alpha(TNF-α)levels,and pH values of the study group were lower than those of the control group 10 days after surgery(P<0.05).Conclusion:The application of XFHM for treating cutaneous infections and promoting wound healing in patients with perianal abscesses improved the treatment outcome,alleviated clinical symptoms,and promoted healing.

Trying to Explain the Theoretical Basis of Traditional Chinese Medicine “Huashi Baidu Fang” in the Treatment of Coronavirus Disease 2019 with Western Medical Theory: A Review

Purpose: This work is aimed to explain the theoretical basis of “Huashi Baidu Fang” in the treatment of coronavirus disease 2019 (COVID-19) with western medical theory. Methods: We analyze the “Diagnosis and Treatment Protocol for COVID-19 (Version 1 to Version 7)” made by China, “Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected—Interim guidance” made by World Health Organization (WHO), “Therapeutic Guidelines: Respiratory (Version 5)”, “Therapeutic Guidelines: Gastrointestinal (Version 5)” and “Therapeutic Guidelines: Antibiotic (Version 15)” published by Australia, and the origin of classical prescription of “Huashi Baidu Fang”: “Shanghanlun (Treatise on Febrile Diseases)”, “Jinkui Yaolue (Synopsis of Golden Chamber)” and “Wenyi Lun (The Epidemic Febrile Disease)”. We search the dictionary of traditional Chinese medicine (Version II) manually. And we search literatures from 2001 to 2020 on Wiley online library. We conduct a comparative study among the symptoms of TCM formulations in “Huashi Baidu Fang”, the pathogenesis and clinical manifestation of COVID-19 and COPD with acute gastrointestinal inflammation. And we carry out pharmacological inquiry of “Huashi Baidu Fang”. Results: The clinical manifestations of respiratory symptoms and gastrointestinal tract of syndrome of lung obstruction due to epidemic toxin and acute exacerbation of COPD are almost the same;The formulations used in “Huashi Baidu Fang” are consistent with the pharmacological activity of the drug recommended in the Therapeutic Guidelines. Conclusion: “Huashi Baidu Fang” may play a positive role in COVID-19.

The Quest for Haven in Sister Carrie

This essay analyses Theodore Dreiser’s Sister Carrie through the lens of cultural studies,examining the portrayal of domesticity and the quest for an ideal home in late-nineteenth-century America.It explores the complex relationships between the main characters,Carrie and Hurstwood,and their families,as well as their struggles with materialism and alienation.Through close analysis of societal context,the characters’familial backgrounds and emotional yearnings,the essay delves into the characters’longing for stability and belonging and their journey toward understanding the true essence of dwelling amidst the changing urban landscape.It argues that Dreiser’s novel critiques the superficial pursuit of material comforts and highlights the importance of introspection and self-discovery in finding lasting happiness amidst societal turmoil.Ultimately,through the prism of domesticity,the essay delves into broader themes of identity,belonging,and existential fulfillment in a heartless society marked by materialism and alienation.

Lost,Exile and Return-An Analysis of Sheona’s Identity Reconstruction in“Sisters”from the Perspective of Spatial Theory

“Sisters”is the first novel in Irish-American author Colum McCann’s short story collection-Fishing the Sloe-Black River,which tells the story of Sheona’s search for her identity between Ireland and the United States.Colum McCann is skilled in writing about the spiritual dilemmas and identity search of ethnic minorities living in a foreign land.Employing the space theory and Sheona’s perspective,this paper examines her identity loss in Ireland’s patriarchal system,her migration to the US for identity pursuit,and her subsequent transnational journey between the two nations to reconstruct her identity amidst physical and mental trauma.

A Study of the Treatment of Disfiguring Diseases in the “Qian Jin Fang”

Traditional Chinese medicine(TCM)has been passed down for more than 2,000 years.TCM beauty products driven by the principles of identification and treatment with various dosage forms and exhibit mild and safe efficacy are bound to become a main component of the beauty industry in the future.Xu once commented that“Qian Jin Fang”is different from the traditional prescription system,which emphasizes the use of medicines.In this paper,we mainly selected the prescriptions for the treatment of disfigurement diseases such as acne,scarring,black dryness,face hyperpigmentation,black mole,and rosacea from the article titled,“Upper Seven Orifices Disease-Facial Medicine IX”in the Bei Ji Qian Jin Yao Fang[1].By studying and analyzing the original composition of the formula,understanding the etiology and pathogenesis of the disease,and exploring the characteristics of the formula concerning the efficacy of TCM,their properties,flavors,and meridians,we summarized the characteristics of the Qian Jin Fang.It is based on the external treatment of disfigurement diseases,with a wide variety of drugs,flexibility,and accuracy.This method draws upon analogies while utilizing excipients and harmonizers to focus on the combined healing approach of treatment and nourishment.

New Replacement Name for Rana paradoxa Mocquard,1890 with Designations of Lectotypes for Rana paradoxa and Rana conspicillata Günther,1872:Both Synonymized with Limnonectes kuhlii (Tschudi,1838) (Dicroglossidae:Dicroglossinae)

Fanged frogs, now called Limnonectes kuhlii, from Borneo are remotely related to true Javanese L. kuhliL For future taxonomy of Bornean fanged frogs, we fix the nomenclatural status of two existing names, Rana conspicillata Giunther, 1872 and Rana paradoxa Mocquard, 1890. Morphological comparison of the type-series revealed heterospecific relationships of the two species. For R. conspicillata, we designate BMNH 1947.2.29.20 as the lectotype, and for R. para doxa, we also designate MNHN 1889.222 as the lectotype and propose a replacement name Limnonectes mocquardi, in order to stabilize their nomenclature.

Non-genotoxicity of Dental Monomer Siloranes in the Sister Chromatid Exchange Assay with Cultured Mammalian Cells

目的:Siloranes是一种含硅的新型牙科复合树脂环氧乙烷单体,较传统的含碳的环氧乙烷单体具有更好的生物相容性。本研究的目的为用哺乳动物细胞培养检测姐妹染色体交换的方法评估Siloranes的基因毒性,并与传统的环氧乙烷比较。方法:研究所用的传统环氧乙烷为CyracureTM UVR6105。Silorane包括Ph-Sil,TET-Sil和二者50/50(w/w)的混合物(3M-ESPE)。用CHO细胞在有或无S9情况下检测姐妹染色体交换(SCE)。Bonferron post hoc统计分析检测有无显著性差异。结果:与溶剂对照相比,在有或无S9情况下,环氧乙烷UVR6105显著性地增加了培养CHO细胞的SCE数目。3种Silorane单体Ph-Sil,TET-Sil或Sil-Mix均未能增加SCE数目。结论:用哺乳动物细胞培养检测姐妹染色体交换的方法评估显示,3种新型Silorane单体Ph-Sil,TET-Sil或Sil-Mix均未检测出基因毒性效果,提示Silorane单体具有较低基因毒性,是适于研发牙科树脂的新型单体。

On the Treatment of Insomnia with Fang’s Scalp Acupuncture Based on the Therapy of “Regulating Mental Activities and Smoothing the Liver”

As a common clinical disease,insomnia was usually treated with anti-psychotic or sedativehypnotic drugs in Western medicine,which showed a fast efficacy,as well as easy drug tolerance and side effects.In traditional Chinese medicine,the basic and key pathogenesis of insomnia are believed to be“the restlessness of the mind”,as well as“the absence of the mind”;and the treatment mainly focus on“regulating mental activities and smoothing the liver”.By combining the theoretical basis and characteristics of Fang’s scalp acupuncture,this paper aims to explain the advantages of Fang’s scalp acupuncture in the treatment of insomnia,and provide new ideas and methods for its clinical treatment.

The Materialized Lifestyle Under Consumer Culture Reflected in Sister Carrie

In Sister Carrie, Theodore Dreiser depicts a consumer society, where consumption is viewed as an integral part of the social life. Living in such a consumption-dominated context, both Dreiser and his characters in Sister Carrie are unable to avoid its great impact. Consumer culture brands great marks on them, leading them to individualism, pragmatism and hedonism. Under such a context, people are united by their purchases into the web of consumer culture.

Malignant peritoneal mesothelioma presenting umbilical hernia and Sister Mary Joseph's nodule

Malignant peritoneal mesothelioma is a rare aggres-sive tumor of the peritoneum. An increasing number of malignant mesothelioma cases have been reported in recent years. We report here a very rare case of malignant peritoneal mesothelioma with both umbilical hernia and umbilical metastasis which is also called Sister Mary Joseph's nodule. We performed laparoscopy which showed specific laparoscopic findings, and the pathological findings of the biopsy specimen led to the diagnosis. This case was associated with umbilical her-nia which could be induced by massive ascites. A newly developed abdominal hernia should be noted as a primary symptom of malignant peritoneal mesothelioma, as shown in the present case.

Mechanism underlying the protective effect of Kaixin Jieyu Fang on vascular depression following cerebral white matter damage

The Chinese compound Kaixin fieyu Fang can be used to treat vascular depression; however, the underlying mechanism remains unclear. This study established a rat model of chronic cerebral ischemia-caused white matter damage by ligation of the bilateral common carotid arteries. Rats received daily intragastric administration of a suspension of Kaixin ]ieyu Fang powder. After 3, 7 and 21 days of treatment, the degree of white matter damage in the cerebral ischemia rat model was alleviated, Bcl-2 protein and mRNA expression in brain tissue increased, and Bax protein and mRNA expression decreased. These results indicate that Kaixin Jieyu Fang can alleviate cere- bral white matter damage, and the underlying mechanism is associated with regulation of Bcl-2/ Bax protein and mRNA expression, which is one of possible mechanism behind the protective effect of Kaixin Jieyu Fang against vascular depression.

Analysis of the action mechanism of Fang Ji Huang Qi decoction in treating rheumatoid arthritis by network pharmacology

Objective:To explore the pharmacological action mechanism of Fang Ji Huang Qi decoction(FHD)in the treatment of rheumatoid arthritis(RA)by network pharmacology.Methods:The chemical compositions and functional targets of the TCM were retrieved using the systematic pharmacological analysis platform TCMSP,and the gene name of each target protein was obtained from the UniProtKB network platform.The targets of RA were queried through the CTD database.The protein–protein interaction network was constructed in the STRING database,and the network visualization analysis was performed in Cytoscape.The Gene Ontology and Kyoto Gene and Genomic Encyclopedia pathways enrichment analyses of key target proteins were performed using the DAVID data platform.Results:A total of 472 drug active ingredients were screened from the TCMSP database.Seventy-five disease targets from the CTD database were screened.The compound-target network map contained further screened out 98 components and corresponding 75 targets.The key compounds included quercetin and kaempferol.The key targets were prostaglandin G/H synthase 2 and nitric oxide synthase 2.The protein-protein interaction network consisted of 75 proteins,of which 37 were key proteins,including tumor protein 53,JUN and interleukin-6.There were 260 Gene Ontology entries,of which 246 were biological processes.Fifty-five Kyoto Gene and Genomic Encyclopedia pathways were enriched,mainly the cancer pathway,NOD-like receptor signaling pathway,and Toll-like receptor signaling pathway,which are involved in the action mechanism of FHD.Conclusion:The results of this study preliminarily verified the basic pharmacological action mechanism of FHD in the treatment of RA,laying a foundation for elucidating its mechanism of action.

Sister Mary Joseph's nodule as the first sign of pregnancy-associated gastric cancer:A case report

Sister Mary Joseph's nodule is an inconspicuous and uncommon clinical sign of advanced malignant disease, especially gastric cancer. Pregnancy-associated gastric cancer is an extremely rare condition and can be difficult to diagnose, due to the absence or misinterpretation of symptoms as pregnancy-related. Diagnostic aids, such as a basic chemistry panel and imaging techniques, may not show any abnormalities. We present a case of a 37-year-old pregnant patient whose umbilical nodule was the first presenting physical sign of gastric cancer, which had metastasized throughout the abdominal and pelvic regions.

Gan Shen Fu Fang ameliorates liver fibrosis in vitro and in vivo by inhibiting the inflammatory response and extracellular signalregulated kinase phosphorylation

BACKGROUND Liver fibrosis is a common health problem worldwide and there is still a lack of effective medicines.The Chinese herbal medicine,Gan Shen Fu Fang(GSFF)is composed of salvianolic acid B and diammonium glycyrrhizinate.In this study,we observed the effects of GSFF on liver fibrosis in vivo and in vitro in an attempt to provide some hope for the treatment.AIM To observe the effects of GSFF on liver fibrosis in vivo and in vitro and investigate the mechanism from the perspective of the inflammatory response and extracellular signal-regulated kinase(ERK)phosphorylation.METHODS Common bile duct-ligated rats were used for in vivo experiments.Hepatic stellate cells-T6(HSC-T6)cells were used for in vitro experiments.Hematoxylin and eosin staining and Masson staining,biochemical assays,hydroxyproline(Hyp)assays,enzyme-linked immunoasorbent assay and western blotting were performed to evaluate the degree of liver fibrosis,liver function,the inflammatory response and ERK phosphorylation.The CCK8 assay,immunofluorescence and western blotting were applied to test the effect of GSFF on HSC-T6 cell activation and determine whether GSFF had an effect on ERK phosphorylation in HSC-T6 cells.RESULTS GSFF improved liver function and inhibited liver fibrosis in common bile ductligated rats after 3 wk of treatment,as demonstrated by histological changes,hydroxyproline assays and collagen I concentrations.GSFF alleviated inflammatory cell infiltration and reduced the synthesis of pro-inflammatory cytokines[tumor necrosis factor-α(TNF-α)and interlukin-1β]and NF-κB.In addition,GSFF decreased ERK phosphorylation.In vitro,GSFF inhibited the viability of HSC-T6 cells with and without transforming growth factorβ1(TGF-β1)stimulation and decreased the synthesis of collagen I.GSFF had the greatest effect at a concentration of 0.5μmol/L.GSFF inhibited the expression ofα-smooth muscle actin(α-SMA),a marker of HSC activation,in HSC-T6 cells.Consistent with the in vivo results,GSFF also inhibited the phosphorylation of ERK and downregulated the expression of NF-κB.CONCLUSION GSFF inhibited liver fibrosis progression in vivo and HSC-T6 cell activation in vitro.These effects may be related to an alleviated inflammatory response and downregulated ERK phosphorylation.

The Ideological and Artistic Power of “Sister Carrie”

Theodor Dreiser was one of the most important American writers who came from the lower classes and the European immigrants of the 19th century. He was born in a large, poor and intensely religious family in Terre Haute,Indiana and received a good education in an Indiana high school where a teacher found his talent and gave him some money for his going to Indi-

腺癌多发转移合并Sister Mary Joseph结节

报告1例腺癌多发转移合并Sister Mary Joseph结节。患者男,49岁。脐部斑块、结节6个月,腰痛2个月。皮肤科检查:脐部一直径3.5 cm的淡红色浸润性斑块,表面可见多个直径1~5 mm淡红色丘疹、结节,簇集呈菜花样外观,质地坚韧,活动度差。CT检查示纵隔内淋巴结增大,腰3~腰5椎体等多处骨质破坏;锝亚甲基二膦酸盐(^(99m)Tc-MDP)全身骨显像示全身骨骼多处异常放射性浓聚灶。皮损组织病理检查:表皮大致正常,真皮全层致密增生的胶原束间肿瘤细胞呈单个或条索状、列兵样排列,部分肿瘤细胞核大、深染,有明显异形性。免疫组化:细胞角蛋白(CK)、CK7、绒毛蛋白(villin)均阳性表达。腰4椎体针吸组织病理检查符合转移性腺癌,免疫组化示CK及低分子质量细胞角蛋白(CAM)5.2均阳性表达。诊断:腺癌多发转移合并Sister Mary Joseph结节。治疗:患者拒绝接受治疗,随访至13个月时死亡。

The Analysis of Theodore Dreiser's Style from the Love Affairs in Sister Carrie

Theodore Dreiser was a controversial writer whose novel Sister Carrie was condemned hardly. This paper aims to conduct a detailed analysis of Sister Carrie and expose the evil nature of bourgeoisie society. At the same time, Dreiser's great insight and perplexitywere clearly reviewed as a realist and naturalist writer.

Comparison of the Naturalism in Sister Carrie and The Open Boat

Theodore Dreiser's Sister Carrie and Stephen Crane's The Open Boat are American naturalistic works in the 19 th centu-ry.The two novels reveal the writers' awareness of the American people's social situation.This paper will analyze Sister Carrie andThe Open Boat from the point of naturalism.

Lost Women in Social Transitional Period——A Comparative Study of the Tragic Fate of Sister Carrie and Guo Haizao

Sister Carrie and Dwelling depict two heroines who share similarities in many aspects. They all live in the social transitional period and suffer a lot. This paper will make a comparison about the two ladies' tragic fates and aims to investigate the impact on females brought about by the social transition.