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Bioengineered skin organoids:from development to applications
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作者 Zi-Xuan Hong Shun-Tian Zhu +5 位作者 Hao Li Jing-Zhi Luo Yu Yang Yang An Xi Wang Kai Wang 《Military Medical Research》 SCIE CAS CSCD 2024年第3期449-466,共18页
Signifcant advancements have been made in recent years in the development of highly sophisticated skin organoids.Serving as three-dimensional(3D)models that mimic human skin,these organoids have evolved into complex s... Signifcant advancements have been made in recent years in the development of highly sophisticated skin organoids.Serving as three-dimensional(3D)models that mimic human skin,these organoids have evolved into complex structures and are increasingly recognized as efective alternatives to traditional culture models and human skin due to their ability to overcome the limitations of two-dimensional(2D)systems and ethical concerns.The inherent plasticity of skin organoids allows for their construction into physiological and pathological models,enabling the study of skin development and dynamic changes.This review provides an overview of the pivotal work in the progression from 3D layered epidermis to cyst-like skin organoids with appendages.Furthermore,it highlights the latest advancements in organoid construction facilitated by state-of-the-art engineering techniques,such as 3D printing and microfuidic devices.The review also summarizes and discusses the diverse applications of skin organoids in developmental biology,disease modelling,regenerative medicine,and personalized medicine,while considering their prospects and limitations. 展开更多
关键词 skin organoid Organoid generation skin appendage Tissue engineering Disease modelling Regenerative medicine
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Skin appendage-derived stem cells: cell biology and potential for wound repair 被引量:3
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作者 Jiangfan Xie Bin Yao +2 位作者 Yutong Han Sha Huang Xiaobing Fu 《Burns & Trauma》 SCIE 2016年第4期258-263,共6页
Stem cells residing in the epidermis and skin appendages are imperative for skin homeostasis and regeneration.These stem cells also participate in the repair of the epidermis after injuries,inducing restoration of tis... Stem cells residing in the epidermis and skin appendages are imperative for skin homeostasis and regeneration.These stem cells also participate in the repair of the epidermis after injuries,inducing restoration of tissue integrity and function of damaged tissue.Unlike epidermis-derived stem cells,comprehensive knowledge about skin appendage-derived stem cells remains limited.In this review,we summarize the current knowledge of skin appendage-derived stem cells,including their fundamental characteristics,their preferentially expressed biomarkers,and their potential contribution involved in wound repair.Finally,we will also discuss current strategies,future applications,and limitations of these stem cells,attempting to provide some perspectives on optimizing the available therapy in cutaneous repair and regeneration. 展开更多
关键词 skin appendages Stem cells Cell biology Wound healing
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