In general,for the majority of men,the amount of exercise is relatively large,so the dress requirements for the men' s trousers gradually have new requirements.It pays more attention to comfort and personality.The th...In general,for the majority of men,the amount of exercise is relatively large,so the dress requirements for the men' s trousers gradually have new requirements.It pays more attention to comfort and personality.The theoretical basis of the clothing loose amount and structural design are both the shape change cased by skin stretch of human body under various movement conditions,the human body has different postures,which will generate different skin stretch data.The combination of static body type and dynamic movements of human body determines clothing structure design,different body movements,different degree of movements and changes in skin stretch all have a direct impact on the form of clothing attached to the human body.展开更多
Background:Currently,various external tissue expansion devices are becoming widely used.Considering the scarcity of relevant application standards,this systematic review was performed to explore the effectiveness and ...Background:Currently,various external tissue expansion devices are becoming widely used.Considering the scarcity of relevant application standards,this systematic review was performed to explore the effectiveness and safety of external tissue expansion techniques for the reconstruction of soft tissue defects.Method:A systematic review and meta-analysis on the efficacy and safety of external tissue expansion technique was conducted.A comprehensive search was performed in the following electronic databases:PubMed/Medline,Embase,Cochrane Library(Wiley Online Library),andWeb of Science.Studies reporting patients with soft tissue defects under the treatment of external tissue expansion technique were included.Results:A total of 66 studies with 22 different types of external tissue expansion devices met the inclusion criteria.We performed a descriptive analysis of different kinds of devices.A single-arm meta-analysis was performed to evaluate the efficacy and safety of the external tissue expansion technique for different aetiologies.The pooled mean wound healing time among patients with defects after fasciotomy was 10.548 days[95%confidence interval(CI)=5.796-15.299].The pooled median wound healing times of patients with defects after excisional surgery,trauma,chronic ulcers and abdominal defects were 11.218 days(95%CI=6.183-16.253),11.561 days(95%CI=7.062-16.060),15.956 days(95%CI=11.916-19.996)and 12.853 days(95%CI=9.444-16.227),respectively.The pooled wound healing rates of patients with defects after fasciotomy,excisional surgery,trauma,chronic ulcers and abdominal defects were 93.8%(95%CI=87.1-98.2%),97.2%(95%CI=92.2-99.7%),97.0%(95%CI=91.2-99.8%),99.5%(95%CI=97.6-100%),and 96.8%(95%CI=79.2-100%),respectively.We performed a subgroup analysis in patients with diabetic ulcers and open abdominal wounds.The pooled median wound healing time of patients with diabetic ulcers was 11.730 days(95%CI=10.334-13.125).The pooled median wound healing time of patients with open abdomen defects was 48.810 days(95%CI=35.557-62.063)and the pooled successful healing rate was 68.8%(95%CI=45.9-88.1%).A total of 1686 patients were included,265(15.7%)of whom experienced complications.The most common complication was dehiscence(n=53,3.14%).Conclusions:Our systematic review is the first to demonstrate the efficacy and safety of external tissue expansion in the management of soft tissue defects.However,we must interpret the meta-analysis results with caution considering the limitations of this review.Large-scale randomized controlled trials and long-term follow-up studies are still needed to confirm the effectiveness and evaluate the quality of healing.展开更多
Aim:Scar prevention and reduction is an area of therapeutic opportunity and unmet medical need.With no current effective scar therapy,patients are often disappointed in their appearance post surgery and re-present to ...Aim:Scar prevention and reduction is an area of therapeutic opportunity and unmet medical need.With no current effective scar therapy,patients are often disappointed in their appearance post surgery and re-present to surgeons,only to be turned away.The purpose of this study was to develop and test a device that produces intermittent parallel stretch on new scars and to analyze its potential to reduce scarring.Methods:Mice were randomized into 5 scar stretch treatment groups:1 control,1 sham,and 3 stretch models(0.5×,1×,or 2×device strength)and treated for 10 days.Scars were scored using the Vancouver Scar Scale.Scar tissue samples were compared by histology and transforming growth factor beta 1(TGF-β1)expression between control and treatment groups.Results:Scar scores of 0.5×and 1×groups were significantly lower than the control group(P<0.05).Scar scores from the 1×treatment group were also significantly lower than the 0.5×group(P<0.05).Sham,control scar and 2×groups showed more collagen deposition and a thicker dermal scar than the 0.5×and 1×groups.Unstretched scars had fewer fibroblasts with more collagen deposition than the 0.5×and 2×groups.TGF-β1 levels were significantly lower in the 0.5×(342.1±9.2)and 1×(254.1±3.1)groups than in the control group(P<0.05).TGF-β1 levels in the 1×treatment group were also significantly lower than the 0.5×treatment group(P<0.05).Conclusion:Intermittent cutaneous tissue stretch parallel to scars during the proliferative phase of wound healing decreases fibrosis on a macroscopic,microscopic and biochemical level.展开更多
文摘In general,for the majority of men,the amount of exercise is relatively large,so the dress requirements for the men' s trousers gradually have new requirements.It pays more attention to comfort and personality.The theoretical basis of the clothing loose amount and structural design are both the shape change cased by skin stretch of human body under various movement conditions,the human body has different postures,which will generate different skin stretch data.The combination of static body type and dynamic movements of human body determines clothing structure design,different body movements,different degree of movements and changes in skin stretch all have a direct impact on the form of clothing attached to the human body.
基金the National Natural Science Foundation of China(81930057,81772076,81971836)the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-076)+1 种基金the Deep Blue Talent Project of Naval Medical University,the 234 Academic Climbing Programme of Changhai Hospitalthe Achievements Supportive Fund(2018-CGPZ-B03).
文摘Background:Currently,various external tissue expansion devices are becoming widely used.Considering the scarcity of relevant application standards,this systematic review was performed to explore the effectiveness and safety of external tissue expansion techniques for the reconstruction of soft tissue defects.Method:A systematic review and meta-analysis on the efficacy and safety of external tissue expansion technique was conducted.A comprehensive search was performed in the following electronic databases:PubMed/Medline,Embase,Cochrane Library(Wiley Online Library),andWeb of Science.Studies reporting patients with soft tissue defects under the treatment of external tissue expansion technique were included.Results:A total of 66 studies with 22 different types of external tissue expansion devices met the inclusion criteria.We performed a descriptive analysis of different kinds of devices.A single-arm meta-analysis was performed to evaluate the efficacy and safety of the external tissue expansion technique for different aetiologies.The pooled mean wound healing time among patients with defects after fasciotomy was 10.548 days[95%confidence interval(CI)=5.796-15.299].The pooled median wound healing times of patients with defects after excisional surgery,trauma,chronic ulcers and abdominal defects were 11.218 days(95%CI=6.183-16.253),11.561 days(95%CI=7.062-16.060),15.956 days(95%CI=11.916-19.996)and 12.853 days(95%CI=9.444-16.227),respectively.The pooled wound healing rates of patients with defects after fasciotomy,excisional surgery,trauma,chronic ulcers and abdominal defects were 93.8%(95%CI=87.1-98.2%),97.2%(95%CI=92.2-99.7%),97.0%(95%CI=91.2-99.8%),99.5%(95%CI=97.6-100%),and 96.8%(95%CI=79.2-100%),respectively.We performed a subgroup analysis in patients with diabetic ulcers and open abdominal wounds.The pooled median wound healing time of patients with diabetic ulcers was 11.730 days(95%CI=10.334-13.125).The pooled median wound healing time of patients with open abdomen defects was 48.810 days(95%CI=35.557-62.063)and the pooled successful healing rate was 68.8%(95%CI=45.9-88.1%).A total of 1686 patients were included,265(15.7%)of whom experienced complications.The most common complication was dehiscence(n=53,3.14%).Conclusions:Our systematic review is the first to demonstrate the efficacy and safety of external tissue expansion in the management of soft tissue defects.However,we must interpret the meta-analysis results with caution considering the limitations of this review.Large-scale randomized controlled trials and long-term follow-up studies are still needed to confirm the effectiveness and evaluate the quality of healing.
文摘Aim:Scar prevention and reduction is an area of therapeutic opportunity and unmet medical need.With no current effective scar therapy,patients are often disappointed in their appearance post surgery and re-present to surgeons,only to be turned away.The purpose of this study was to develop and test a device that produces intermittent parallel stretch on new scars and to analyze its potential to reduce scarring.Methods:Mice were randomized into 5 scar stretch treatment groups:1 control,1 sham,and 3 stretch models(0.5×,1×,or 2×device strength)and treated for 10 days.Scars were scored using the Vancouver Scar Scale.Scar tissue samples were compared by histology and transforming growth factor beta 1(TGF-β1)expression between control and treatment groups.Results:Scar scores of 0.5×and 1×groups were significantly lower than the control group(P<0.05).Scar scores from the 1×treatment group were also significantly lower than the 0.5×group(P<0.05).Sham,control scar and 2×groups showed more collagen deposition and a thicker dermal scar than the 0.5×and 1×groups.Unstretched scars had fewer fibroblasts with more collagen deposition than the 0.5×and 2×groups.TGF-β1 levels were significantly lower in the 0.5×(342.1±9.2)and 1×(254.1±3.1)groups than in the control group(P<0.05).TGF-β1 levels in the 1×treatment group were also significantly lower than the 0.5×treatment group(P<0.05).Conclusion:Intermittent cutaneous tissue stretch parallel to scars during the proliferative phase of wound healing decreases fibrosis on a macroscopic,microscopic and biochemical level.