A Non-Invasive Skin Treatment Combining LED with Pharmacologic and Ultrasonic Technologies for Facial Rejuvenation

Background: Non-invasive facial treatments have the ability to rejuvenate the facial profile when specific pharmacologic agents and modalities are prescribed and used in combination taking into consideration each patient’s unique skin type and condition. RATIONALE Epinova is a non-invasive skin treatment that combines the correct concentrations and combinations of topicals and modalities to elicit facial rejuvenation with no down-time or side effects. Purpose: This paper focuses on facial rejuvenation improvements combining the RATIONALE Essential Six skincare system (RATIONALE, Victoria, Australia) to protect and repair the skin with the RATIONALE Epinova facial treatment every 4-6 weeks—which uses non-invasive technologies and professional strength active ingredients to deliver visible changes to skin tone and texture. Methods: Subjects underwent a RATIONALE consultation, including taking a skin history and skin imaging, followed by a data analysis and diagnosis of skin condition and prescription of a customized RATIONALE treatement (Epinova), including appropriate pharmacologic agents and treatment with personalized photo/sono therapeutic devices. Results: Subjects reported increased skin hydration, tactile improvements, skin firmness and visible radiance following the RATIONALE Epinova treatment. Further investigations will be initiated to explore the potential for longer term improvements, including connenctive tissue deposition, reduction of erythema etc. Treatments should be performed every 4-6 weeks for patients under 40 and every 3-4 weeks for patients over 40, to support cell differentiation, migration and desquamation to achieve non-invasive facial rejuvenation. Conclusion: This study demonstrated that the synergy of pharmacologic, LED light therapy and ultrasonic technologies when prescribed and administered by a trained skin therapist, can lead to a visible improvement in the signs of facial ageing and photodamage, restoring the appearance of healthy, radiant skin. .

Flow and Ductility of Smectite Clay for Skin Treatment

It is important that pastes and creames for skin treatment have suitable rheological properties and ability to establish a?good contact with the tissues while retaining their tightness. Thixotropy is desired for providing fluidity when agitated and a suitably degree of stiffening thereafter. This requires low shear resistance in the coating phase and microstructural reorganization when leaving the paste to rest. Following the principle of using only mineral components for skin treatment,?use?of expandable hydrophilic clay minerals should be considered. They sorb?cations and positively charged organic molecules and are impermeable to fluids and gas under low pressure, hence providing oxygen-free micro-environment. They can balance pH and are excellent agents for cleaning skin.

Unique Clinical Features of Curaderm when Treating Skin Cancers

Basal cell carcinoma is the most common form of skin cancer and the most frequently occurring form of all cancers. Conventional treatments to remove or destroy basal cell carcinoma are indiscriminate and also remove or destroy normal skin cells resulting in compromised cosmetic outcomes. Consequences of these treatments include body-image issues, anxiety, post-traumatic stress disorder, depression, and poorer quality of social and family life. A progressive topical cream formulation, Curaderm, containing the natural BEC glycoalkaloids, have shown to have advantages over conventional treatments. However, comprehensive clinical features of the skin cancer lesions during treatment with Curaderm have to date not been reported. This report shows that using unpublished data from a large number of patients with varying sizes, types and locations of basal cell carcinomas when treated with Curaderm in a phase 3 trial, an initial increase in size of the lesions occur, followed by a reverse course, leading to complete removal of the skin cancer. The specificity and mode of action of Curaderm explains the superior cosmetic outcomes when compared with conventional therapies.

Atopic eczema treatment now and in the future:Targeting the skin barrier and key immune mechanisms in human skin

The skin facilitates a number of key roles but its functioning can be impaired by disease. Atopic eczema is a chronic inflammatory disease where the skin barrier has become leaky, and inflammation occurs. It affects up to 20% of children and 3% of adults worldwide, manifesting as red itchy patches of skin with varying severity. This review aims to investigate the leaky skin barrier and immune mechanisms from the perspective of potential novel treatments. The complexity of atopic eczema as a disease is what makes it difficult to treat. Genome-wide association studies have highlighted possible genetic variations associated with atopic eczema, however in some cases, individuals develop the disease without these genetic risk factors. Loss of function mutations in the filaggrin gene are one of these associations and this is plausible due to its key role in barrier function. The Th2 immune response is the link with regards to the immune mechanisms as atopic inflammation often occurs through increased levels of interleukin(IL)-4 and IL-13. Eczematous inflammation also creates susceptibility to colonisation and damage by bacteria such as Staphylococcus aureus. Potential novel treatments are becoming ever more specific, offering the hope of fewer side effects and better disease control. The best new treatments highlighted in this review target the immune response with human beta defensin 2, phosphodiesterase-4 inhibitors and monoclonal antibodies all showing promise.

Prevention and Treatment of Radiation Induced Skin Damage in Breast Cancer

Introduction: Skin toxicity is a frequent side effect of radio and chemo-treatments in patients treated for breast cancer after conservative surgery. The aim of this paper is to report our experience in the management of skin toxicity evaluating radiotherapy planning and using preventive local aids. Materials and Methods: We have observed 300 patients undergoing radiotherapy. All received the prescription of a prophylactic moisturizing cream. Skin toxicity was valuated according to Acute Radiation Morbidity Scoring Criteria of the RTOG. Moreover, in a subgroup of 100 patients, we correlated the study of breast volume and features of treatment plans, with the addition of topic prophylactic treatment, using an oral therapy based on Resveratrol, Lycopene, Vitamin C and Anthocyanins (Ixor?). In another subgroup, 100 patients were subjected to corneometry assessing numerically skin hydration before, during and after radiotherapy. Results: In all patients, we related skin toxicity and the type of cream used. All patients completed the radiotherapy treatment, and G4 cutaneous toxicity was not observed in any of them. In patients treated with topic treatment and therapy based on Resveratrol, Lycopene, Vitamin C and Anthocyanins (Ixor?), the protective effect of (Ixor?) is more detected in patients with PTV (Planning Target Volume) <500 ml, when Dmax reaches values lower or equal to 107%, but not exceeding 110% of the prescribed dose, and in patients undergoing adjuvant chemotherapy with anthracyclines and taxanes. The values of corneometry allow us to evaluate the moisturizing effect for products used, and identify cases of skin toxicity in a first phase. Conclusions: Our study confirms the value of moisturizers in the prevention and resolution of radiotherapy-induced skin damage. An instrumental assessment of skin hydration with corneometry can help the radiation oncologist to use strategies that prevent the onset of toxicity of high degree.

The Combined Effect of Botulinum Toxin Type A with a Biorevitalizing Treatment on Forehead Rejuvenation: A Case Series

Background: The forehead is particularly prone to repetitive facial expressions and hyperdynamic activity, resulting in deep wrinkles and a loss of elasticity and hydration. Although botulinum toxin type A (BoNTA) has been shown to reduce the appearance of wrinkles and allow patients to have a smoother and hence younger upper face, it cannot help to improve the other aspects that determine overall skin quality. Objective: This case series aims to evaluate the clinical efficacy of combining BoNTA injections with a biorevitalizing treatment (NCTF®135HA) on skin aging signs and quality using a split face approach. Patients and Methods: A total of eight patients from 30 to 55 years old were treated with botulinum toxin type A combined with NCTF®-135HA or alone. Results: At D60, clinical skin quality scoring showed that NCTF®135HA injection significantly reduced wrinkles and enhanced skin homogeneity, hydration, firmness, and radiance. The Global Aesthetic Improvement Scale (GAIS) by the evaluator at D60 reported mean scores of 2375 (much improved) on the side of the face treated with BoNTA + NCTF®-135HA compared to the side of the face without NCTF®135HA. According to patients, the NCTF®135HA injections resulted in a significantly better aesthetic improvement score on D60 (mean score of 2.5 compared to 0.125 without NCTF®135HA, p 0.001). Conclusions: Our findings show that combining a biorevitalizing treatment with a BoNTA injection can significantly improve the skin’s overall appearance and decrease the wrinkle score when compared to the BoNTA injections alone. The results suggest that the combinatory strategy is effective, safe, and associated with a high level of patient satisfaction.

不同皮片获取方式联合VSD对急诊创伤伴大面积皮肤撕脱病情转归影响

目的探讨不同薄中厚皮片联合负压封闭引流术(vacuum sealing drainage,VSD)对急诊创伤伴大面积皮肤撕脱病情转归影响。方法选取急诊创伤伴大面积皮肤撕脱患者70例,根据皮片获取方式不同分为切取组、反取组,各35例。比较2组愈合情况、换药次数、住院时间、治疗费用、治疗后12 h、治疗后24 h、治疗后48 h、治疗后72 h视觉模拟评分法(visual analogue scale,VAS)评分、温哥华瘢痕量表评分、患处皮肤感觉及并发症。结果反取组Ⅰ期愈合率高于切取组,换药次数少于切取组,住院时间短于切取组(P<0.05);2组术后12~72 h的VAS评分呈降低趋势,组间、时点间、组间时点间交互作用之间差异有统计学意义(P<0.05)。反取组温哥华瘢痕量表色泽、厚度、柔软度评分低于切取组,患处皮肤感觉分级优于切取组(P<0.05);反取组治疗费用、并发症发生率与切取组比较,差异无统计学意义(P>0.05)。结论相比切取薄中厚皮片,反取薄中厚皮片联合VSD治疗急诊创伤伴大面积皮肤撕脱患者Ⅰ期愈合率更高,疼痛度更低,美学效果、皮肤感觉更好,换药次数少、住院时间短,且不会增加并发症发生风险及治疗费用。

色素增加性皮肤病患者治疗中激光与中医药联合应用研究

目的探讨激光联合中医药治疗色素增加性皮肤病的临床效果,为临床研究提供参考。方法选取2019年1月—2022年1月滨州医学院附属医院收治的78例色素增加性皮肤病患者作为研究对象,依据随机数表法将所有患者分为参照组和研究组,每组39例。参照组采用激光治疗,研究组在参照组治疗基础上联合中医药治疗,统计并分析两组患者治疗前后皮肤生理指标[pH、角质层含水量、皮肤经水分丢失(TWEL)]、性激素水平[雌二醇(E2)、黄体生成素(LH)、促卵泡生成素(FSH)、孕酮(Pro)]、色素沉着面积、色素沉着评分改善状况,皮肤的结痂、愈合时间与痂皮脱落时间、治疗总有效率和不良反应发生率。结果治疗前组间角质层含水量、pH、TWEL指标、E2、Pro、LH、FSH水平、色素沉着评分、色素沉着面积及治疗后pH比较,差异无统计学意义(P>0.05),但研究组治疗后的TWEL指标、LH、E2、Pro、FSH水平、色素沉着评分和不良反应发生率均比参照组低,角质层含水量、治疗总有效率高于参照组,且色素沉着面积较参照组小,差异有统计学意义(P<0.05)。结论色素增加性皮肤病患者采用激光联合中医药治疗,不但可以增强皮肤屏障功能,降低患者性激素水平,还能有效避免皮肤色素沉重,加快皮肤结痂、愈合,有效提升治疗效果,且不良反应较少,提高患者的治疗安全性,具有显著的临床疗效,值得临床应用。

钙处理对‘巨峰’葡萄果实品质及果皮解剖结构的影响

为研究钙处理对‘巨峰’葡萄果实品质及果皮解剖结构的影响,该试验以6年生‘巨峰’为试材,定期喷施5g/L氯化钙水溶液,以喷清水为对照,研究钙处理对不同时期(幼果期、转色期、成熟期)果实纵径、横径、单果重、可溶性固形物、果实硬度及果皮解剖结构的影响。结果表明,喷钙明显提高果实品质,果皮厚度明显增加,表皮细胞面积减小,且比对照排列紧实。

老年科护士对皮肤撕裂伤的认知现状及影响因素研究

目的了解老年科护士对皮肤撕裂伤的认知现状,分析其影响因素,为开展相关培训提供参考。方法采用便利抽样法,使用一般资料调查表、皮肤撕裂伤知识评估工具对武汉市3所三级甲等综合医院的286名老年科护士进行横断面调查。结果老年科护士的皮肤撕裂伤认知得分为(9.53±2.02)分。老年科护士对皮肤撕裂伤认知正确率排名前5个条目分属于特殊群体、病因学、分类和观察维度;排名最低的5个条目分属于预防、治疗和风险评估维度。影响老年科护士对皮肤撕裂伤认知水平的主要因素为学历、工作年限、是否为专科护士、皮肤撕裂伤相关培训(均P<0.05),共解释总变异的31.7%。结论老年科护士对皮肤撕裂伤认知水平处于中等偏低水平,对与临床实践相关的预防、治疗和风险评估认知相对不足,应加强相关培训,提高老年科护士对皮肤撕裂伤的关注度,从而提高皮肤撕裂伤整体预防及护理水平。

银屑病与恶性肿瘤相关性研究进展

银屑病是一种慢性、复发性炎症性皮肤病,发病机制还不完全明确,目前认为与遗传、免疫、环境等因素密切相关。研究表明银屑病患者伴发恶性肿瘤风险升高,其恶性风险可能与银屑病的慢性炎症状态或者治疗方式有关,本文就银屑病和其治疗相关的肿瘤疾病的研究进展进行综述。

敏感性皮肤的中医辨治初探

敏感性皮肤发生率较高,国内女性敏感性皮肤发生率在15.93%,男性为8.62%。本文分析了敏感性皮肤的中医病因病机及辨证论治,介绍了肺经风热、肝经湿热、脾虚湿蕴、肝郁血燥、阳虚水饮五型及相应治则、方药,中药湿敷、中药膏/油外用、中药提取物护肤品的应用及体针、放血治疗方案。认为本症可通过中医内服外治联合的方案,以取得促进皮肤屏障修复、降低神经血管高反应性、控制炎症反应、提高皮肤耐受性的效果。

1例免疫检查点抑制剂相关皮疹伴大面积皮肤损伤合并消化道出血病人的护理

总结1例免疫检查点抑制剂治疗相关皮疹伴大面积皮肤损伤合并消化道出血病人的护理过程。护理要点:制定以多学科团队协作为基础的综合护理策略,包括出血与再出血的风险管理、积极处理皮肤损伤部位、加速剥脱皮肤修复、感染的综合预警护理、序贯式营养支持护理、及时评估并促进病人心理康复。治疗28 d后病人病情相对稳定,好转出院。

低温等离子体治疗感染性皮肤病研究进展

低温等离子体作为一种新兴的治疗方式,可产生多种生物医学效应,且具有较高的安全性,在医学领域受到广泛关注。低温等离子体对细菌、真菌、病毒、寄生虫均有一定的杀灭作用,在治疗感染性皮肤病中有着广阔的应用前景。本文综述了低温等离子体杀灭病原体的机制以及低温等离子体治疗感染性皮肤病的研究进展。

基于“以皮治肺”治疗儿童咳嗽

“以皮治肺”即通过内病外治以及皮药内服共同作用于肺。肺外合皮毛,生理功能互通,肺和皮肤细胞同源,通过药物外敷经皮肤入肺;中医法象思维指导运用皮类中草药治疗各类皮肤疾病,通过拓展思考,以皮肤为桥梁,内服皮类中草药治疗儿童咳嗽。在临床中外治法和皮类中草药广泛应用于儿童咳嗽,但并没有医家系统性提出通过“以皮治肺”治疗儿童咳嗽,笔者在“肺合皮毛”及“法象思维”的基础上论述,通过内外合治“以皮治肺”来宣发肺气,散肺中伏热。

Fournier坏疽临床诊断和综合治疗1例报告及文献复习

目的:探讨Fournier坏疽患者临床表现、诊断和治疗方法,以提高临床医生对该病的认识。方法:收集1例Fournier坏疽患者的临床症状、体征、影像学表现和手术结果等临床资料,并复习相关文献,总结Fournier坏疽患者的临床特点、诊断和治疗方法。结果:患者,男,42岁,因会阴、阴囊和肛周感染13 d入院。既往史,急性髓系白血病10个月,于当地医院行化疗8个疗程。腹部CT提示,左侧腹股沟区软组织增厚,密度增高浑浊。血常规,白细胞23.99×10^(9)L^(-1)。创面分泌物培养为大肠埃希菌和阴沟肠杆菌。专科检查,患者阴囊和左臀部近肛门处皮肤坏死,色黑,质硬,坏死皮肤周围溶解,与基底及周围正常皮肤分离,可见少量脓性渗出,无明显异味,创面周围皮肤红肿明显;肛门指诊无出血,未探及窦道。患者入院后当天行急诊清创手术,术后予以换药和多次留置简易负压后行会阴部皮瓣修复及皮肤移植手术,术后患者恢复良好,功能正常,无并发症。结论:Fournier坏疽起病急且进展快,患者临床表现无特异性,感染范围与疾病进展不一致。确诊主要依靠术中探查。反复多次的根治性手术是其主要治疗手段。该病预后较好,复发率低,术后仍需长期随访。

微生物对紫外线辐射的响应机制及其应用研究现状#

紫外线辐射已被世界卫生组织(World Health Organization,WHO)认定为一类致癌物。近年来,由于平流层臭氧的厚度下降和气溶胶、表面反射率、太阳活动和气候的变化,导致到达地球表面的紫外线辐射水平显著增加。皮肤是人体最大、最外层的器官,也是保护机体的第一道屏障。直接暴露在紫外线辐射下会导致晒伤、炎症、光免疫抑制、光老化甚至皮肤癌。机体表面及环境中的微生物都会受到环境中紫外线辐射的影响,改变微生物组的组成和丰度。微生物组也可通过几种重要的光保护机制免受紫外线辐射的损伤。在医学领域,紫外线辐射可通过作用于某些皮肤微生物来进行疾病的治疗。多种微生物及其代谢物通过不同的分子机制也表现出了防治紫外线损伤的作用,具有良好应用前景。本文综述了紫外线辐射对皮肤微生物组产生的光生物学效应、微生物体为抵御紫外线辐射及紫外线辐射应用于临床皮肤病治疗的现状。然而,紫外线辐射对微生物组的影响仍有待进一步阐明,明确微生物对抗紫外辐射的机制,为人类预防紫外线损伤提供全新的思路。

张崇泉从肾论治老年常见皮肤病经验撷要

本文介绍张崇泉教授从肾论治老年常见皮肤病,以带状疱疹、湿疹、银屑病为例,阐述张教授诊疗思路及用药经验,附验案一则,以期为临床应用补肾法治疗常见皮肤病提供新思路。

黄芪对寻常型银屑病的治疗效果及对皮肤屏障功能的影响

目的探讨黄芪对寻常型银屑病的治疗效果以及对皮肤屏障功能的影响。方法回顾性选取2018年2月—2023年2月苏州大学附属第二医院收治的454例寻常型银屑病患者的临床资料,以不同治疗方式分为对照组(218例,外涂卡泊三醇软膏治疗)和观察组(236例,在对照组基础上增加黄芪颗粒治疗)。对比两组血清细胞因子、银屑病皮损面积和严重程度指数(Psoriasis Area and Severity Index,PASI)评分以及皮肤屏障功能。结果观察组白细胞介素-8和肿瘤坏死因子-α水平低于对照组,差异有统计学意义(P均<0.05)。治疗前,两组PASI评分比较,差异无统计学意义(P>0.05);治疗后,观察组PASI评分为(4.24±1.01)分,低于对照组的(11.24±2.35)分,差异有统计学意义(t=7.838,P<0.05)。治疗前,两组患者皮肤屏障功能测定结果比较,差异无统计学意义(P均>0.05);治疗后,观察组皮肤屏障功能优于对照组,差异有统计学意义(P均<0.05)。结论黄芪对寻常型银屑病的治疗效果显著,能够显著降低患者的炎症反应,促进皮肤屏障功能的恢复。

敏感性头皮的发生机制及其评价与治疗研究进展

敏感性皮肤(Sensitive skin,SS)是一种常见的皮肤病理状态,在世界各国发生率均很高。敏感性头皮(Sensitive scalp,SP)同样广泛影响人类头皮健康。本文结合国内外最新研究,对敏感性头皮的流行病学、临床表现、发生机制及评价方法进行了系统阐述,总结发现未来从分子机制等方面针对敏感性头皮的治疗与护理也将成为重要方向。