Expression of p63 and Cyclooxygenase-2 and Their Correlation in Skin Tumors

To study the expression of p63 and cyclooxygenase-2 （cox-2） in skin tumors and evaluate the correlation between p63 and cox-2, the expressions of cox-2 and p63 were measured by streptavidin-peroxidase complex immunohistochemical technique in 17 cases of skin squamous cell carcinoma （ SCC ） , 19 cases of Bowen＇s disease（Bowen）, 11 cases of actinic keratosis（AK）, 12 cases of seborreic keratosis（SK） and 13 specimens of normal skin. Our results showed that the expression of p63 in skin squamous cell carcinoma, Bowen＇s disease and actinic keratosis were significantly higher than that in seborreic keratosis, while the expression of p63 in seborreic keratosis was significantly higher than that in normal skin. The expression of cox-2 in skin squamous cell carcinoma, Bowen＇s disease and actinic keratosis were significantly higher than that in seborreic keratosis, while no statistical difference was noted in the expression of cox-2 between seborreic keratosis and normal skin. Cox-2 expression was positively correlated with the high p63 expression in malignant skin tu- mors. The increased expression of cox-2 and p63 may play an important role in the development of skin tumors and work synergetically in malignant skin tumors.

Clinical Efficacy and Adverse Reactions of Photodynamic Therapy in the Treatment of Malignant Skin Tumors and Precancerous Skin Diseases

The purpose of the study was to investigate the efficacy and safety of photodynamic therapy in the treatment of malignant skin tumors and precancerous skin diseases.First of all,100 patients with malignant skin tumor and pre-cancer skin disease admitted to our hospital from January 20,2018 to September 18,2018 were selected,and all of them adopted photodynamic therapy.The 100 patients included 40 cases of basal cell carcinoma,14 cases of squamous cell carcinoma,7 cases of proliferative erythema,9 cases of Bowen’s disease and 39 cases of solar keratosis.Among the 100 patients,77 cases had excellent curative effect,18 cases had good effect and 5 cases had poor effect,and the overall effective rate was 95%(95/100).After 6 months of follow-up,5 cases of basal cell carcinoma,2 cases of squamous cell carcinoma,0 cases of proliferative erythra,1 case of Bowen’s disease and 3 cases of solar keratosis recurred,with an overall recurrence rate of 14%(14/100).The adverse reactions of pruritus were 90%(90/100),81%(81/100),90%(90/100)and 3%(3/100).Therefore,the application of photodynamic therapy in the treatment of malignant skin tumors and precancerous skin diseases is not only effective,but also safe and not easy to relapse.

The Frequency of Skin Tumors and Infections in Patients with Autoimmune Diseases

Background: Autoimmune diseases are a vast array of organ-specific as well as systemic diseases, whose pathogenesis results from the activation of B and T lymphocytes reacting against antigens of the body’s own tissues (defined as self). Objective: To record skin tumors and infections in all autoimmune diseases gathered together in a one pathological state, compared with renal transplant recipients and normal control. Patients and Methods: Four hundred patients with different autoimmune diseases were examined. Fifty patients with pemphigus (15 males, 35 females) are aged from 20 - 70 (41.23 ± 3.89) years. Fifty patients with systemic lupus erythematosus (50 females) are aged from 17 - 45 (30.58 ± 10.08) years. One hundred patients with vitiligo (59 males, 41 females) are aged from 9 - 71 (42.89 ± 5.28) years. One hundred patients with alopecia areata (42 males, 58 females) are aged from 7 - 52 (38.67 ± 9.52) years. One hundred patients with psoriasis (56 males, 44 females) are aged from 7 - 71 (47.36 ± 8.62) years were evaluated. One hundred twenty kidney transplant recipients’ (101 males, 19 females) ages ranged from 14 - 70 (45.43 ± 4.63) years. All patients were examined thoroughly for any cutaneous manifestations and tumors and the findings were compared with the general population as a control group, which consisted of 500 healthy control individuals whose ages ranged from 20 - 71 (44.53 ± 11.48) years. This case series, descriptive, controlled study was performed in Baghdad Teaching Hospital from June 2014 to October 2015. Results: In renal transplant recipients, the findings were observed as follow herpetic infection in 30(25%), bacterial 12(10%) while fungal 24(20%) patients. These infections appeared early in the course of immunosuppression. While the tumors were noticed, the benign tumors were the commonest manifestations, which included viral warts in 45(37.5%) followed by actinic keratosis 15(12.5%), seborrheic keratosis 14(11.6%), sebaceous hyperplasia 13(10.8%) and keratoacanthoma 1(0.8%). While the malignant tumors were basal cell carcinoma 4(3.3%) followed by squamous cell carcinoma 3(2.5%), and kaposi’s sarcoma 4(3.3%), Bowen’s disease 1(0.8%). These malignancy usually appeared late in the course of immunosuppression. In pemphigus, viral warts were observed in 4(8%) cases;fungal infection was seen in 4(8%) cases and bacterial infections in 2(4%) of cases and herpetic infection in only 1(2%) of case;no tumors were found in all patients. In vitiligo, viral warts were observed in 2(2%) cases, while seborrhic keratosis and sebaceous hyperplasia were observed in 1(1%) case;herpetic and fungal infections were seen in 3(3%) of cases while bacterial infections were recorded in 2(2%) of cases but no tumors were found in all patients. In alopecia areata viral warts were observed in 9(9%) of cases, sebaceous hyperplasia in 1(1%) case, herpetic and bacterial in 3(3%) of cases and fungal in 4(4%) of cases;no tumors were found in all patients. In systemic lupus erythymatosus (SLE) viral warts were observed in 4(8%) of cases, herpetic infection in 12(12%) of cases, fungal infection in 10(20%) of cases, bacterial infection in 3(3%) of cases and sebaceous hyperplasia in only 1(2%) of case, but no tumors were seen. In psoriasis, viral warts were observed in 14(14%) of cases, herpetic infection in 10(10%) of cases, bacterial infection in 3(3%) of cases, fungal infection in 2(2%) of cases, sebaceous hyperplasia in 2(2%) of cases and seborrhiec hyperkeratosis in 1(1%) case, while no tumors were demonstrated. In healthy control individuals, herpetic infection was present in 36(7.2%) and viral warts in 52(10.4%) individuals, fungal infection in 29(5.8%) of individuals and regarding tumors solar keratosis was present in 24(4.8%);basal cell carcinoma and squamous cell carcinoma were present in 2(0.4%) individuals of each. Conclusions: Patients with autoimmune diseases were protected against infections and tumors while kidney transplant recipients had no such protection although all these groups were on prolonged immunosuppression.

Contour Extraction of Skin Tumors Using Visual Attention and GVF-Snake Model

Contour extraction of skin tumors accurately is an important task for further feature generation of their borders and sur-faces to early diagnose melanomas. An integrated approach, combining visual attention model and GVF-snake, is pro-posed in the paper to provide a general framework for locating tumor boundaries in case of noise and boundaries with large concavity. For any skin image, the visual attention model is implemented to locate the Region of Interests (ROIs) based on saliency maps. Then an algorithm called GVF-snake is utilized to iteratively drive an initial contour, deriving from the extracted ROIs, towards real boundary of skin tumors by minimizing an energy function. It is shown from ex-periments that the proposed approach exceeds in two aspects compared with other contour-deforming methods: 1) ini-tial contours generated from saliency maps are definitely located at neighboring regions of real boundaries of skin tu-mors to speed up converges of contour deformation and achieve higher accuracy;2) the method is not sensitive to nois-es on skins and initial contours extracted.

Evidence-Based Nursing Practice of Reducing Immune-Related Skin Toxicity of Tumor Patients Guided by Sensitive Indicators

Purpose research on nursing sensitive indicators in tumor Patients application effect in immune-related skin toxicity management. Method select our hospital April to June, 202360 cases patients with immune therapy settings as the control group. August-October, 2023 60 cases the patients treated with immune therapy were the experimental group. The control group adopted regular nursing methods, while the experimental group sensitive Indicators, evidence-based give preventive care. The social situation, psychological state, physical function, quality of life score, incidence of skin toxicity caused by immune checkpoint inhibitors, moderate and above of the two groups of patients were compared. Incidence of skin toxicity. Result: experience group SAS score, SDS score higher than the control group, the difference was statistically significant (P < 0.05);The incidence of skin toxic reactions caused by immune checkpoint inhibitors and the incidence of moderate and above skin toxic reactions in the experimental group are lower than those in the control group, and the difference is statistically significant (P < 0.05). Conclusion: sensitive indicator guidance evidence-based preventive care can reduce the degree of immune-related skin toxicity, improve the psychological state and quality of life of tumor patients treated with immune therapy and reduce the incidence of adverse reactions, improve nursing quality and patient satisfaction.

Diagnostic capacity of skin tumor artificial intelligence-assisted decision-making software in real-world clinical settings

Background:Youzhi artificial intelligence(AI)software is the AI-assisted decision-making system for diagnosing skin tumors.The high diagnostic accuracy of Youzhi AI software was previously validated in specific datasets.The objective of this study was to compare the performance of diagnostic capacity between Youzhi AI software and dermatologists in real-world clinical settings.Methods:A total of 106 patients who underwent skin tumor resection in the Dermatology Department of China-Japan Friendship Hospital from July 2017 to June 2019 and were confirmed as skin tumors by pathological biopsy were selected.Dermoscopy and clinical images of 106 patients were diagnosed by Youzhi AI software and dermatologists at different dermoscopy diagnostic levels.The primary outcome was to compare the diagnostic accuracy of the Youzhi AI software with that of dermatologists and that measured in the laboratory using specific data sets.The secondary results included the sensitivity,specificity,positive predictive value,negative predictive value,F-measure,and Matthews correlation coefficient of Youzhi AI software in the real-world.Results:The diagnostic accuracy of Youzhi AI software in real-world clinical settings was lower than that of the laboratory data(P<0.001).The output result of Youzhi AI software has good stability after several tests.Youzhi AI software diagnosed benign and malignant diseases by recognizing dermoscopic images and diagnosed disease types with higher diagnostic accuracy than by recognizing clinical images(P=0.008,P=0.016,respectively).Compared with dermatologists,Youzhi AI software was more accurate in the diagnosis of skin tumor types through the recognition of dermoscopic images(P=0.01).By evaluating the diagnostic performance of dermatologists under different modes,the diagnostic accuracy of dermatologists in diagnosing disease types by matching dermoscopic and clinical images was significantly higher than that by identifying dermoscopic and clinical images in random sequence(P=0.022).The diagnostic accuracy of dermatologists in the diagnosis of benign and malignant diseases by recognizing dermoscopic images was significantly higher than that by recognizing clinical images(P=0.010).Conclusion:The diagnostic accuracy of Youzhi AI software for skin tumors in real-world clinical settings was not as high as that of using special data sets in the laboratory.However,there was no significant difference between the diagnostic capacity of Youzhi AI software and the average diagnostic capacity of dermatologists.It can provide assistant diagnostic decisions for dermatologists in the current state.

Calcium Glucarate Prevents Tumor Formation in Mouse Skin

Objective Calcium Glucarate (Cag), Ca salt of D-glucaric acid is a naturally occurring non-toxic compound present in fruits, vegetables and seeds of some plants, and suppress tumor growth in different models. Due to lack of knowledge about its mode of action its uses are limited in cancer chemotherapy thus the objective of the study was to study the mechanism of action of Cag on mouse skin tumorigenesis. Methods We have estimated effect of Cag on DMBA induced mouse skin tumor development following complete carcinogenesis protocol. We measured, epidermal transglutaminase activity (TG), a marker of cell differentiation after DMBA and/or Cag treatment and [3H] thymidine incorporation into DNA as a marker for cell proliferation. Results Topical application of Cag suppressed the DMBA induced mouse skin tumor development. Topical application of Cag significantly modifies the critical events of proliferation and differentiation TG activity was found to be reduced after DMBA treatment. Reduction of the TG activ

A New Hybrid Model for Segmentation of the Skin Lesion Based on Residual Attention U-Net

Skin segmentation participates significantly in various biomedical applications,such as skin cancer identification and skin lesion detection.This paper presents a novel framework for segmenting the skin.The framework contains two main stages:The first stage is for removing different types of noises from the dermoscopic images,such as hair,speckle,and impulse noise,and the second stage is for segmentation of the dermoscopic images using an attention residual U-shaped Network(U-Net).The framework uses variational Autoencoders(VAEs)for removing the hair noises,the Generative Adversarial Denoising Network(DGAN-Net),the Denoising U-shaped U-Net(D-U-NET),and Batch Renormalization U-Net(Br-U-NET)for remov-ing the speckle noise,and the Laplacian Vector Median Filter(MLVMF)for removing the impulse noise.In the second main stage,the residual attention u-net was used for segmentation.The framework achieves(35.11,31.26,27.01,and 26.16),(36.34,33.23,31.32,and 28.65),and(36.33,32.21,28.54,and 27.11)for removing hair,speckle,and impulse noise,respectively,based on Peak Signal Noise Ratio(PSNR)at the level of(0.1,0.25,0.5,and 0.75)of noise.The framework also achieves an accuracy of nearly 94.26 in the dice score in the process of segmentation before removing noise and 95.22 after removing different types of noise.The experiments have shown the efficiency of the used model in removing noise according to the structural similarity index measure(SSIM)and PSNR and in the segmentation process as well.

Clinical Study of Aminolevulinic Acid-mediated Acid Photodynamic Therapy Combined with Surgical Therapy of Skin Malignant Tumor

The purpose of the study was to analyze the effects of aminolevulinic acid-mediated photodynamic therapy(ALA-PDT)combined with surgery and its prognostic implications.Firstly,70 cases of skin malignant tumors admitted to the dermatology department of our hospital from January 2017 to December 2018 were selected and divided into observation group and control group according to the random number table,with 35 patients in each group.Observation group adopted the ALA-PDT combined with surgery therapy,and control group adopted surgery therapy.Two groups of patients were last follow-up to December 2019.The results showed that the total effective rate of clinical treatment in the observation group was significantly higher than that in the control group(P<0.05),indicating that based on the basis of conventional surgical treatment,combined use of ALA-PDT can effectively improve the clinical therapeutic effect and better promote the patient’s health recovery.Therefore,combined with surgical treatment,ALA-PDT can improve the clinical efficacy of skin malignant tumors with fewer adverse reactions,high safety,low recurrence rate and ideal long-term prognosis.

Investigation of Well-Balanced kV X-Ray Imaging Conditions between Skin Dose and Image Noise for Dynamic Tumor Tracking Irradiation

Purpose: The purposes of this study were to estimate accumulated kV X-ray imaging dose throughout dynamic tumor tracking (DTT) irradiation by Vero 4DRT system and to address an analytical skin dose formula for well-balanced kV X-ray imaging conditions between skin dose and image noise. Method: First, skin dose was measured using kV X-ray tube, chamber, and water-equivalent phantoms. Next, imaging dose for six patients in DTT treatment was computed using log files. Subsequently, scattered dose ratio was calculated by amount of ionization in front of flat panel detector (FPD) for fields with size of maximum and the chamber for 0 - 200 mm-thickness phantoms and tube voltage of 60, 80, 100, 120 kV, respectively. Furthermore, image noise was computed from FPD images. Results: The skin dose was greater by a factor of 1.4 - 1.6 than those in Synergy XVI system. The image noise in FPD, ?was expressed as N = 0.045×(1/QFPDen)0.479, where QFPDen denotes amount of ionization in front of FPD. Then, skin dose, D (N, t, v) was formulated as (0.045/N)(1/0.479)/QFPDen/mAs (t, v) ×D/mAs (v), where QFPDen/mAs (t, v) and D/mAs (v) denote amount of ionization in front of FPD and skin dose per mAs, respectively. Using the formulae, it has been demonstrated that skin dose with 120 kV has become lower than any other tube voltage in this study. Conclusion: Using skin doses for the phantom, the skin dose throughout DTT irradiation was estimated as 0.50 Gy. Furthermore, skin dose by kV X-ray imaging was described as a function of image noise, phantom thickness, and tube voltage, suggesting image noise may be reduced with higher X-ray tube voltage in this phantom study.

改良V-Y推进皮瓣对面部皮肤肿瘤术后缺损患者的修复效果研究

目的探究改良V-Y推进皮瓣对面部皮肤肿瘤术后缺损患者的修复效果。方法前瞻性选取河南宏力医院2020年2月至2023年2月收治的40例面部皮肤肿瘤切除术后皮肤缺损的患者,均接受改良V-Y推进皮瓣修复。结果40例患者皮片和皮瓣全部成活,其中创面为Ⅰ期愈合38例,并发皮瓣边缘部分坏死1例,经局部修剪换药后愈合;切口感染1例,经短期换药后愈合。随访1~12个月,失访1例,于术后1年复发3例,局部肿瘤复发1例,腮腺区淋巴结转移2例,均再次行根治性切除术治疗后行补充放疗,其余患者面部外形、功能均恢复良好36例,伤口美观满意度为94.44%(34/36)。结论改良V-Y推进皮瓣拓宽了V-Y推进皮瓣修复缺损的适应证,降低了术后一期继发性缺损及并发症发生率,皮瓣存活率高,且美观度好。

小檗碱抗皮肤癌药理作用及其机制的研究进展

小檗碱是一种具有广泛药理作用的生物活性物质,除了抗炎、抗菌、抗病毒、抗腹泻、抗高血压、抗缺氧、降血糖和降血脂等作用外,还具有广谱抗肿瘤作用。该文主要从小檗碱一直皮肤癌的形成,以及抑杀皮肤黑色素瘤细胞和人皮肤鳞癌A431细胞等方面进行了综述和分析,为小檗碱在皮肤癌方面的进一步研究提供参考。

肾细胞癌头皮转移一例

头皮发生的肾细胞癌转移较少见,本文报道一例。患者,男,57岁,头顶肿物渐增大半年,6年前行左肾癌根治术。皮肤病理结合免疫组化示:肾细胞癌转移。术后半年随访,在头皮原皮损旁出现新的肿瘤皮损。

不同皮瓣修复术对口腔颌面部肿瘤术后缺损手术时间及口腔功能指标的影响

目的:分析口腔颌面部肿瘤术后缺损患者行不同皮瓣修复术治疗的效果。方法:选择口腔颌面部肿瘤术后缺损患者58例,随机分为对照组和观察组,各29例。两组均施以皮瓣修复手术治疗,对照组胸大肌位置选择皮瓣,观察组为股前外侧皮瓣,比较不同部位皮瓣的效果差异。结果:观察组并发症总发生率低于对照组;手术时间、拔除胃管时间、经口进食时间、皮瓣愈合时间短于对照组;皮瓣制作+显微吻合时间长于对照组;外形修复、正常进食、口腔开合功能、口腔容纳水测试、正常吞咽、咀嚼功能、语言表达能力、正常咬合功能分数,皮瓣成活率和修复满意度高于对照组(P<0.05)。结论:口腔颌面部肿瘤术后皮瓣修复患者行不同皮瓣修复术的效果存在差异,股前外侧皮瓣相对比胸大肌皮瓣更具备优势,可缩短手术时间,改善口腔功能,安全度、患者满意度较高。

基于高分辨率卷积神经网络的皮肤常见肿瘤智能诊断模型构建

目的探究高分辨率卷积神经网络(HRNetW32)模型在皮肤常见肿瘤临床诊断中的应用。方法基于高分辨率特征提取皮肤常见肿瘤智能诊断模型,利用HRNetW32模型,实现统一输入皮肤常见肿瘤皮肤镜图像,自动预测皮肤常见肿瘤类型的诊断结果;同时将构建的模型与VGG16、VGG19、ResNet34等常见卷积神经网络模型进行对比分析。结果HRNetW32模型在训练集和验证集准确率分别为99.72%和95.00%,损失函数值分别为0.15和0.21,表明所构建的模型能准确高效地提取皮肤常见肿瘤皮肤镜图像的高维特征。同时HRNetW32模型表现出了优于VGG16、VGG19、ResNet34模型的精确率、召回率、Micro F1分数、灵敏度、特异度、真正率和假正率。结论HRNetW32模型可用于常见皮肤肿瘤筛检,且诊断准确率较高,具有较高临床诊断价值。

微针递送系统在皮肤肿瘤治疗中的研究进展

微针作为一种新兴的给药技术,可以穿透皮肤角质层,产生微米尺寸的机械通道,无痛、微创和高效地将药物递送至表皮层或真皮层,从而发挥局部或全身治疗作用。该文综述了目前微针用于各类疾病治疗的临床试验进展,并对各类型微针的特点进行阐述,总结了微针在皮肤肿瘤领域的化学药物治疗、光热和光动力治疗、免疫治疗、基因治疗以及联合治疗的最新研究进展,为进一步研究微针用于皮肤肿瘤的治疗提供思路和方向。

Biomedical overview of melanin.1.Updating melanin biology and chemistry,physico-chemical properties,melanoma tumors,and photothermal therapy

Melanins(eumelanin,pheomelanin,and allomelanin)represent a very,if not themost,important group of biological pigments.Their biological roles are multiple,from photoprotection to antioxidant activity,heavy metal disposal or the myriad uses of color in organisms across all Phyla.In the first part of this review,eumelanin biology and some chemical aspects will be presented,as well as key physico-chemical features that make this biological pigment so interesting.The principal characteristics of the melanocyte,the melanin-synthesizing cell in mammals,will also be introduced.Transformed melanocytes are the cause of one of the most devastating known cancers:the malignant melanoma.Epidemiology and molecular signaling aspects will be presented next,as well as the principal advances in promising oncotherapies designed and applied for the treatment of melanoma.In particular,on account of the photo-physical properties of melanin,special details will be provided regarding the use of photothermal therapy for melanoma treatment.

可溶性肿瘤坏死因子样凋亡弱诱导因子在斑秃病人血清及皮损中的表达及临床意义

目的检测可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)在斑秃病人血清及皮损中的表达水平,并探讨其在斑秃发病过程中的作用及临床意义。方法以2017年10月至2018年11月在首都医科大学附属北京友谊医院确诊并治疗的斑秃病人70例为斑秃组,依据病情分为轻症组(44例)、重症组(26例)。同期该院因色素痣或皮肤良性肿瘤进行头皮手术的人群65例作为对照组。比较各组sTWEAK及相关细胞因子白细胞介素(IL)-4、IL-12、γ干扰素(IFN-γ)蛋白及mRNA表达水平;采用Pearson法分析两指标间相关性。多元线性回归分析各指标与sTWEAK或脱发严重度工具(SALT)评分的关系。结果斑秃组血清及皮损中sTWEAK表达水平[(196.73±32.48)ng/L,(2.35±0.62)ng/L]高于对照组[(121.75±19.62)ng/L,(1.49±0.45)ng/L](P<0.05)。斑秃组血清及皮损中细胞因子IL-12、IFN-γ表达水平高于对照组(P<0.05),IL-4表达水平比较差异无统计学意义(P>0.05)。斑秃病人血清及皮损中sTWEAK表达水平与IL-12及IFN-γ呈正相关,与IL-4表达水平无明显相关性。轻症组血清及皮损中sTWEAK[(173.25±26.84)ng/L,(2.04±0.57)ng/L]、IL-12及IFN-γ表达水平低于重症组[(236.47±42.02)ng/L,(2.87±0.70)ng/L](P<0.05);轻症组、重症组血清及皮损中IL-4表达水平差异无统计学意义(P>0.05);斑秃病人血清、皮损处sTWEAK、IL-12、IFN-γ与SALT评分均呈正相关(P<0.05)。多元线性回归分析显示,IL-12、IFN-γ与血清和皮损处sTWEAK呈显著正相关;血清及皮损处sTWEAK、IL-12、IFN-γ与SALT评分存在正相关性(P<0.05)。结论斑秃病人血清及皮损中sTWEAK表达水平增加,与IL-12及IFN-γ呈正相关,sTWEAK、IL-12及IFN-γ均与斑秃病情严重程度密切相关,sTWEAK可能参与斑秃炎症反应过程。

甚高频超声特征对皮肤混合瘤的诊断价值

目的分析皮肤混合瘤(mixed tumor of the skin,MTS)的甚高频超声特征,探讨甚高频超声特征对MTS的诊断价值。方法选取2019年1月至2024年3月于杭州市第三人民医院皮肤科手术并经病理证实为MTS的63例患者为观察组,与同期其他皮肤良性肿瘤63例患者作为对照组,回顾性分析并总结MTS的甚高频超声特征,评价甚高频超声特征对MTS的诊断效能。结果两组患者的肿瘤长径、横径、纵横比,是否伴钙化,有无囊性,血流分级,阻力指数比较,差异无统计学意义(P>0.05)。MTS有更明显的假包膜,且大部分内部回声欠均匀,后方伴增强效应,血流以边缘血流为主,两组比较,差异有统计学意义(P<0.05),受试者操作特征曲线结果显示绘制假包膜、内部回声欠均匀、边缘血流为主及后方增强效应4者联合的诊断效能最高,曲线下面积为0.772,敏感度为77.8%,特异性为71.4%。结论MTS具有特定的甚高频超声特征,甚高频超声可对MTS临床诊断提供帮助。

头皮恶性肿瘤切除后创面局部皮瓣转移联合游离皮片移植术修复11例分析

目的探讨头皮恶性肿瘤切除后形成的创面应用局部皮瓣转移联合游离皮片移植术修复的临床效果。方法回顾分析2017年1月至2022年1月在焦作市人民医院皮肤科治疗并完成随访的11例头皮恶性肿瘤患者资料。患者年龄30~91岁,男4例,女7例,基底细胞癌6例,鳞状细胞癌5例,所有患者均采用局部皮瓣转移联合游离皮片移植术修复头皮恶性肿瘤切除后形成的创面。结果11例患者均一期手术完成,所有转移皮瓣和移植皮片均成活,术后均未出现感染,切口甲级愈合。术后随访6~12个月肿瘤无复发,创面修复良好,患者满意度高。结论局部皮瓣转移联合游离皮片移植术是头皮恶性肿瘤术后创面修复的理想方法,具有手术一期完成、转移皮瓣及游离皮片易于成活、肿瘤复发率低、恢复良好的优点。