C.L. Chang’s introduction of fuzzy topology in 1981 opened up new avenues for parallel theories in topology. However, Chang’s work appears to focus more on the topology of fuzzy sets rather than fuzzy topology itsel...C.L. Chang’s introduction of fuzzy topology in 1981 opened up new avenues for parallel theories in topology. However, Chang’s work appears to focus more on the topology of fuzzy sets rather than fuzzy topology itself. In 1975, Michálek presented a functional definition of ordinary topology and later developed fuzzy topology as a distinct extension of this idea, setting it apart from Chang’s approach. While there has been significant research on Chang’s fuzzy topology, Michálek’s version has not received as much attention. This paper introduces the concept of fuzzy regularly closed filters, or FRCM filters, within Michálek’s fuzzy topological space and explores some properties of FRCM ultrafilters.展开更多
The ground roll and body wave usually show significant differences in arrival time, frequency content, and polarization characteristics, and conventional polarization filters that operate in either the time or frequen...The ground roll and body wave usually show significant differences in arrival time, frequency content, and polarization characteristics, and conventional polarization filters that operate in either the time or frequency domain cannot consider all these elements. Therefore, we have developed a time-frequency dependent polarization filter based on the S transform to attenuate the ground roll in seismic records. Our approach adopts the complex coefficients of the S transform of the multi-component seismic data to estimate the local polarization attributes and utilizes the estimated attributes to construct the filter function. In this study, we select the S transform to design this polarization filter because its scalable window length can ensure the same number of cycles of a Fourier sinusoid, thereby rendering more precise estimation of local polarization attributes. The results of applying our approach in synthetic and real data examples demonstrate that the proposed polarization filter can effectively attenuate the ground roll and successfully preserve the body wave.展开更多
Octopus skin samples were tested under quasi-static and scissor cutting conditions to measure the in-plane material prop- erties and fracture toughness. Samples from all eight arms of one octopus were tested staticall...Octopus skin samples were tested under quasi-static and scissor cutting conditions to measure the in-plane material prop- erties and fracture toughness. Samples from all eight arms of one octopus were tested statically to investigate how properties vary from arm to arm. Another nine octopus skins were measured to study the influence of body mass on skin properties. In- fluence of specimen location on skin mechanical properties was also studied. Material properties of skin, i.e. the Young's modulus, ultimate stress, failure strain and fracture toughness have been plotted against the position of skin along the length of arm or body. Statistical studies were carried out to help analyzing experimental data obtained. Results of this work will be used as guidelines for the design and development of artificial skins for an octopus-inspired robot.展开更多
As a relatively new method of processing non-stationary signal with high time-frequency resolution, S transform can be used to analyze the time-frequency characteristics of seismic signals. It has the following charac...As a relatively new method of processing non-stationary signal with high time-frequency resolution, S transform can be used to analyze the time-frequency characteristics of seismic signals. It has the following characteristics: its time-frequency resolution corresponding to the signal frequency, reversible inverse transform, basic wavelet that does not have to meet the permit conditions. We combined the threshold method, proposed the S-transform threshold filtering on the basis of S transform timefrequency filtering, and processed airgun seismic records from temporary stations in "Yangtze Program"(the Anhui experiment). Compared with the results of the bandpass filtering, the S transform threshold filtering can improve the signal to noise ratio(SNR) of seismic waves and provide effective help for first arrival pickup and accurate travel time. The first arrival wave seismic phase can be traced farther continuously, and the Pm seismic phase in the subsequent zone is also highlighted.展开更多
A real-time channel flood forecast model was developed to simulate channel flow in plain rivers based on the dynamic wave theory. Taking into consideration channel shape differences along the channel, a roughness upda...A real-time channel flood forecast model was developed to simulate channel flow in plain rivers based on the dynamic wave theory. Taking into consideration channel shape differences along the channel, a roughness updating technique was developed using the Kalman filter method to update Manning's roughness coefficient at each time step of the calculation processes. Channel shapes were simplified as rectangles, triangles, and parabolas, and the relationships between hydraulic radius and water depth were developed for plain rivers. Based on the relationship between the Froude number and the inertia terms of the momentum equation in the Saint-Venant equations, the relationship between Manning's roughness coefficient and water depth was obtained. Using the channel of the Huaihe River from Wangjiaba to Lutaizi stations as a case, to test the performance and rationality of the present flood routing model, the original hydraulic model was compared with the developed model. Results show that the stage hydrographs calculated by the developed flood routing model with the updated Manning's roughness coefficient have a good agreement with the observed stage hydrographs. This model performs better than the original hydraulic model.展开更多
On the basis of preliminary studies,a novel duo-parameter model consisting of amplitude filter factor and frequency filter factor for low-pass S-K filter is presented in this paper.The model is established by applying...On the basis of preliminary studies,a novel duo-parameter model consisting of amplitude filter factor and frequency filter factor for low-pass S-K filter is presented in this paper.The model is established by applying numerical differentiation method.Some simulation experiments and real data tests are carried out to verify the feasibility and superiority of the new algorithm.The results show that this duo-parameter model of low-pass S-K filter can be used to achieve high performance in signal processing and nuclear spectrum smoothing.展开更多
Nicotinamide (NA), a naturally occuring vitamin and a protease inhibitor, has been shown to be effective in treating some skin ailments. It inhibits cell proiferaion and induces cell differentiation. This report shows...Nicotinamide (NA), a naturally occuring vitamin and a protease inhibitor, has been shown to be effective in treating some skin ailments. It inhibits cell proiferaion and induces cell differentiation. This report shows the effects of NA on mouse skin tumor development and on the critical events involved in this process. NA reduced tumor growth, inhibited the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase activity, but induced the transglutaminare activity which was inhibited by TPA under different experimental conditions.The effects of NA on ornithine decarboxylare (ODC) and transglutaminase (TG) indicated that nicotinamide (NA) probably programmmed the cells for their death in the natural course of time, i.e. programed cell death. This observation indicates that NA might be a better agent for the detailed study and for the better use in prevention of cancer alone or in combination with other drugs.展开更多
Long-term exposure to arsenic is associated with cancers of lung, urinary bladder, kidney, liver and skin. Arsenic car-cinogenesis might result from oxidative stress, altered growth factors, chromosomal abnormality, i...Long-term exposure to arsenic is associated with cancers of lung, urinary bladder, kidney, liver and skin. Arsenic car-cinogenesis might result from oxidative stress, altered growth factors, chromosomal abnormality, immune dysregula-tion, and aberrant epigenetic regulations. Bowen’s disease (As-BD) is the most common form of arsenic-induces skin cancers and is characterized by chronicity, multiplicity, and predisposition in sun-spare skin. However, only about 1% of the population exposed to arsenic developped skin cancers, indicating the host immune response plays an important modulatory role in skin carcinogenesis. In this review, we review the pathomechanisms of arsenic skin carcinogenesis and the immune interactions. Arsenic affects innate and adaptive immune responses through CD4+ T cells, monocytes, macrophages, and Langerhans cells. In skin of As-BD, CD4+ T cells undergo selective and differential apoptosis via Fas-FasL interaction. Numbers and dendrites of Langerhans cells are reduced in As-BD lesions. There is a defective homeostasis and aberrant trafficking of Langerhans cells. Such information is essential to understand the molecular mechanism for arsenic carcinogenesis in both skin and in internal organs.展开更多
Temperature (T) and salinity (S) profiles from conductivity-temperature-depth data collected during the Northern South China Sea Open Cruise from August 16 to September 13, 2008 are assimilated using Ensemble Kalm...Temperature (T) and salinity (S) profiles from conductivity-temperature-depth data collected during the Northern South China Sea Open Cruise from August 16 to September 13, 2008 are assimilated using Ensemble Kalman Filter (EnKF). An adaptive observational error strategy is used to prevent filter from diverging. In the meantime, aiming at the limited improvement in some sites caused by the T and S biases in the model, a T-S constraint scheme is adopted to improve the assimilation performance, where T and S are separately updated at these locations. Validation is performed by comparing assimilated outputs with independent in situ data (satellite remote sensing sea level anomaly (SLA), the OSCAR velocity product and shipboard ADCP). The results show that the new EnKF assimilation scheme can significantly reduce the root mean square error (RMSE) of oceanic T and S compared with the control run and traditional EnKF. The system can also improve the simulation of circulations and SLA.展开更多
The prevalence of enterotoxigenic Staphylococcus aureus was investigated among 200 participants working in three different food processing plants in Egypt. Using skin swabs, 75 (38%) of the 200 tested persons were pos...The prevalence of enterotoxigenic Staphylococcus aureus was investigated among 200 participants working in three different food processing plants in Egypt. Using skin swabs, 75 (38%) of the 200 tested persons were positive for the presence of S. aureus. Of the S. aureus positive persons, 28 (14%) harboured S. aureus produced staphylococcal enterotoxins. The serotypes of these enterotoxins were enterotoxin A (68%), enterotoxin B (36%), enterotoxin C (46%) and enterotoxin D (18%). Some of these isolates produced more than one type of enterotoxins namely AB, AC, BC, BD, ABC and ACD. Analysis of risk factors implicated in skin carriage of S. aureus as age, gender, marital status, education, duration in employment, frequency and method of hand wash and incidence of chronic skin infection revealed insignificant association with staphylococcal skin carriage. The obtained results put forth the risk of food contracting contamination with enterotoxigenic strains of S. aureus owing to skin colonization of S. aureus among food handlers.展开更多
Affective filter hypothesis is one of Krashen's five hypotheses on Second Language Acquisition (SLA), and it states that a number of affective variables play a very important role in Second Language Acquisition. B...Affective filter hypothesis is one of Krashen's five hypotheses on Second Language Acquisition (SLA), and it states that a number of affective variables play a very important role in Second Language Acquisition. Based on the introduction of affective filter hypothesis, this paper will analyze the significance and shortcomings of this hypothesis.展开更多
The current use of hearing aids and artificial cochleas for deaf-mute individuals depends on their auditory nerve. Skin-hearing technology, a patented system developed by our group, uses a cutaneous sensory nerve to s...The current use of hearing aids and artificial cochleas for deaf-mute individuals depends on their auditory nerve. Skin-hearing technology, a patented system developed by our group, uses a cutaneous sensory nerve to substitute for the auditory nerve to help deaf-mutes to hear sound. This paper introduces a new solution, multi-channel-array skin-hearing technology, to solve the problem of speech discrimination. Based on the filtering principle of hair cells, external voice sig- nals at different frequencies are converted to current signals at corresponding frequencies using electronic multi-channel bandpass filtering technology. Different positions on the skin can be stimulated by the electrode array, allowing the perception and discrimination of external speech signals to be determined by the skin response to the current signals. Through voice frequen- cy analysis, the frequency range of the band-pass filter can also be determined. These findings demonstrate that the sensory nerves in the skin can help to transfer the voice signal and to dis- tinguish the speech signal, suggesting that the skin sensory nerves are good candidates for the replacement of the auditory nerve in addressing deaf-mutes' hearing problems. Scientific hearing experiments can be more safely performed on the skin. Compared with the artificial cochlea, multi-channel-array skin-hearing aids have lower operation risk in use, are cheaper and are more easily popularized.展开更多
We present some convergence and boundedness theorems with respect to filter convergence for lattice group-valued measures. We give a direct proof, based on the sliding hump argument. Furthermore we pose some open prob...We present some convergence and boundedness theorems with respect to filter convergence for lattice group-valued measures. We give a direct proof, based on the sliding hump argument. Furthermore we pose some open problems.展开更多
Narrowband and high-transmission optical filters are extensively used in color display technology, optical information processing, and high-sensitive sensing. Because of large ohmic losses in metallic nanostructures, ...Narrowband and high-transmission optical filters are extensively used in color display technology, optical information processing, and high-sensitive sensing. Because of large ohmic losses in metallic nanostructures, metallic filters usually exhibit low transmittances and broad bandwidths. By employing both strong field enhancements in metallic nano-slits and the Wood’s anomaly in a periodic metallic grating, an extra-narrowband and high-transmission metallic filter is numerically predicted in an ultrathin single-layer metallic grating. Simulation results show that the Wood’s anomaly in the ultrathin(thickness H = 60 nm) single-layer metallic grating results in large field enhancements in the substrate and low losses in the metallic grating. As a result, the transmission bandwidth(transmittance T > 60%) at λ = 1200 nm is as small as △λFWHM=1.6 nm, which is smaller than 4% of that in the previous thin dielectric and metallic filters. The corresponding quality factor is as high as Q = λ/△λFWHM= 750, which is 40 times greater than that in the previous reports. Moreover, the thickness of our metallic filter(H = 60 nm) is smaller than 40% of that in the previous reports, and its maximum transmittance can reach up to 80%. In experiments, a narrowband metallic filter with a bandwidth of about △λFWHM = 10 nm, which is smaller than 25% of that in the previous metallic filters, is demonstrated.展开更多
Sunscreen application is a common strategy used to prevent the damage induced by UV radiations. In the last 30 years a variety of protective agents against UV exposure have been developed: physical filters, chemical ...Sunscreen application is a common strategy used to prevent the damage induced by UV radiations. In the last 30 years a variety of protective agents against UV exposure have been developed: physical filters, chemical filters and organic filters. Physical filters are the safest: they scatter and reflect UV rays, but are difficult to apply on the skin. Chemical filters are capable of absorbing these rays, they are cosmetically pleasant, but recent studies suggest a toxicological nature for some of these agents. Organic filters are the newest advance in sun products. Since 2003 the COLIPA Index [Europe] has regulated sun product availability on the market. In the USA, the FDA establishes the classification and the safety of sun products, which are considered topical medical drugs. This article summarizes the dermatologist's point of view, according to the patient's request, professional ethics and increasing offer of sun product.展开更多
We developed a novel topical non-steroidal anti-inflammatory drug (NSAID)patch, S(+)-flurbiprofen plaster, (SFPP), containing S(+)-flurbiprofen (SFP), an enantiomer of flurbiprofen (FP). In a previous study conducted ...We developed a novel topical non-steroidal anti-inflammatory drug (NSAID)patch, S(+)-flurbiprofen plaster, (SFPP), containing S(+)-flurbiprofen (SFP), an enantiomer of flurbiprofen (FP). In a previous study conducted in an animal model, we showed good skin absorption and potent analgesic efficacy of SFPP. In this study, to examine the superior features, as an NSAID patch, of SFP as compared to FP and R(-)-flurbiprofen (RFP), we tested the stereospecificity of SFP actions on Prostaglandin E2 (PGE2) inhibition in rat inflammatory leukocytes and in the binding activity of the drug to cells, and also the in vitro skin permeability of the drug in the Yucatan micropig (YMP). SFP showed potent inhibitory activity on PGE2 production from peritoneal leukocytes stimulated with a bacterial suspension, as compared to RFP and FP. The half maximal (50%) inhibitory concentration (IC50) values were 14 nM for SFP, 52 nM for FP, and 17,000 nM for RFP. In the cell binding study, significant and rapid increase of SFP binding to polymorphonuclear leucocytes (PMNs) was observed at 5 min after incubation, eventually reaching a steady state. SFP showed significantly higher binding activity for the inflammatory leucocytes as compared to RFP, suggesting its superior transfer potency. The skin permeability profile of SFP, RFP and FP in the YMP model showed that the rank order of the cumulative amount of permeated compounds in the skin was SFP > RFP > FP. The steady-state permeation rate (Flux) of SFP was significantly higher than that of FP (4.89 and 1.55 mg/cm2/h, respectively, p = 0.0068), indicating the remarkably superior skin permeability of SFP. SFP exerted potent inhibitory activity on PGE2 production and superior binding activity to the PMNs and skin permeability, as compared to FP and RFP. These results suggest that SFP possesses favorable characteristics for use as an active ingredient in the NSAID patch.展开更多
Kalman's Filter Technique for the separation of overlapping incisions of an a.c.oscillopolarogram is presented,the experimental verifications were carried out in various systems with the ions of Pb^(2+),Tl^+,In^(3...Kalman's Filter Technique for the separation of overlapping incisions of an a.c.oscillopolarogram is presented,the experimental verifications were carried out in various systems with the ions of Pb^(2+),Tl^+,In^(3+)and Cd^(2+).The results showed that the concentration of the depolarizer can be determined directly and easily with this technique in the presence of interference elements.展开更多
文摘C.L. Chang’s introduction of fuzzy topology in 1981 opened up new avenues for parallel theories in topology. However, Chang’s work appears to focus more on the topology of fuzzy sets rather than fuzzy topology itself. In 1975, Michálek presented a functional definition of ordinary topology and later developed fuzzy topology as a distinct extension of this idea, setting it apart from Chang’s approach. While there has been significant research on Chang’s fuzzy topology, Michálek’s version has not received as much attention. This paper introduces the concept of fuzzy regularly closed filters, or FRCM filters, within Michálek’s fuzzy topological space and explores some properties of FRCM ultrafilters.
基金supported by the National Science and Technology Major Project of China(Grant No.2011ZX05014 and 2011ZX05008-005)
文摘The ground roll and body wave usually show significant differences in arrival time, frequency content, and polarization characteristics, and conventional polarization filters that operate in either the time or frequency domain cannot consider all these elements. Therefore, we have developed a time-frequency dependent polarization filter based on the S transform to attenuate the ground roll in seismic records. Our approach adopts the complex coefficients of the S transform of the multi-component seismic data to estimate the local polarization attributes and utilizes the estimated attributes to construct the filter function. In this study, we select the S transform to design this polarization filter because its scalable window length can ensure the same number of cycles of a Fourier sinusoid, thereby rendering more precise estimation of local polarization attributes. The results of applying our approach in synthetic and real data examples demonstrate that the proposed polarization filter can effectively attenuate the ground roll and successfully preserve the body wave.
文摘Octopus skin samples were tested under quasi-static and scissor cutting conditions to measure the in-plane material prop- erties and fracture toughness. Samples from all eight arms of one octopus were tested statically to investigate how properties vary from arm to arm. Another nine octopus skins were measured to study the influence of body mass on skin properties. In- fluence of specimen location on skin mechanical properties was also studied. Material properties of skin, i.e. the Young's modulus, ultimate stress, failure strain and fracture toughness have been plotted against the position of skin along the length of arm or body. Statistical studies were carried out to help analyzing experimental data obtained. Results of this work will be used as guidelines for the design and development of artificial skins for an octopus-inspired robot.
基金funded by the National Natural Science Foundation Item (41674068)Seismic Youth Funding of GEC (YFGEC2016001)
文摘As a relatively new method of processing non-stationary signal with high time-frequency resolution, S transform can be used to analyze the time-frequency characteristics of seismic signals. It has the following characteristics: its time-frequency resolution corresponding to the signal frequency, reversible inverse transform, basic wavelet that does not have to meet the permit conditions. We combined the threshold method, proposed the S-transform threshold filtering on the basis of S transform timefrequency filtering, and processed airgun seismic records from temporary stations in "Yangtze Program"(the Anhui experiment). Compared with the results of the bandpass filtering, the S transform threshold filtering can improve the signal to noise ratio(SNR) of seismic waves and provide effective help for first arrival pickup and accurate travel time. The first arrival wave seismic phase can be traced farther continuously, and the Pm seismic phase in the subsequent zone is also highlighted.
基金supported by the Special Fund for Public Welfare (Meteorology) of China (Grants No. GYHY201006037 and GYHY200906007)
文摘A real-time channel flood forecast model was developed to simulate channel flow in plain rivers based on the dynamic wave theory. Taking into consideration channel shape differences along the channel, a roughness updating technique was developed using the Kalman filter method to update Manning's roughness coefficient at each time step of the calculation processes. Channel shapes were simplified as rectangles, triangles, and parabolas, and the relationships between hydraulic radius and water depth were developed for plain rivers. Based on the relationship between the Froude number and the inertia terms of the momentum equation in the Saint-Venant equations, the relationship between Manning's roughness coefficient and water depth was obtained. Using the channel of the Huaihe River from Wangjiaba to Lutaizi stations as a case, to test the performance and rationality of the present flood routing model, the original hydraulic model was compared with the developed model. Results show that the stage hydrographs calculated by the developed flood routing model with the updated Manning's roughness coefficient have a good agreement with the observed stage hydrographs. This model performs better than the original hydraulic model.
基金Supported by branch project of national 863 project(2012AA061804)
文摘On the basis of preliminary studies,a novel duo-parameter model consisting of amplitude filter factor and frequency filter factor for low-pass S-K filter is presented in this paper.The model is established by applying numerical differentiation method.Some simulation experiments and real data tests are carried out to verify the feasibility and superiority of the new algorithm.The results show that this duo-parameter model of low-pass S-K filter can be used to achieve high performance in signal processing and nuclear spectrum smoothing.
文摘Nicotinamide (NA), a naturally occuring vitamin and a protease inhibitor, has been shown to be effective in treating some skin ailments. It inhibits cell proiferaion and induces cell differentiation. This report shows the effects of NA on mouse skin tumor development and on the critical events involved in this process. NA reduced tumor growth, inhibited the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase activity, but induced the transglutaminare activity which was inhibited by TPA under different experimental conditions.The effects of NA on ornithine decarboxylare (ODC) and transglutaminase (TG) indicated that nicotinamide (NA) probably programmmed the cells for their death in the natural course of time, i.e. programed cell death. This observation indicates that NA might be a better agent for the detailed study and for the better use in prevention of cancer alone or in combination with other drugs.
文摘Long-term exposure to arsenic is associated with cancers of lung, urinary bladder, kidney, liver and skin. Arsenic car-cinogenesis might result from oxidative stress, altered growth factors, chromosomal abnormality, immune dysregula-tion, and aberrant epigenetic regulations. Bowen’s disease (As-BD) is the most common form of arsenic-induces skin cancers and is characterized by chronicity, multiplicity, and predisposition in sun-spare skin. However, only about 1% of the population exposed to arsenic developped skin cancers, indicating the host immune response plays an important modulatory role in skin carcinogenesis. In this review, we review the pathomechanisms of arsenic skin carcinogenesis and the immune interactions. Arsenic affects innate and adaptive immune responses through CD4+ T cells, monocytes, macrophages, and Langerhans cells. In skin of As-BD, CD4+ T cells undergo selective and differential apoptosis via Fas-FasL interaction. Numbers and dendrites of Langerhans cells are reduced in As-BD lesions. There is a defective homeostasis and aberrant trafficking of Langerhans cells. Such information is essential to understand the molecular mechanism for arsenic carcinogenesis in both skin and in internal organs.
基金The Strategic Priority Research Program of the Chinese Academy of Sciences under contract No.XDA10010405the Promgram of Guangdong Province Department of Science and Technology No.2012A032100004+1 种基金the National Natural Science Foundation of China under contract Nos 41476012,41521005 and 41406131the Knowledge Innovation Program of the Chinese Academy of Sciences under contract Nos SQ201001 and SQ201205
文摘Temperature (T) and salinity (S) profiles from conductivity-temperature-depth data collected during the Northern South China Sea Open Cruise from August 16 to September 13, 2008 are assimilated using Ensemble Kalman Filter (EnKF). An adaptive observational error strategy is used to prevent filter from diverging. In the meantime, aiming at the limited improvement in some sites caused by the T and S biases in the model, a T-S constraint scheme is adopted to improve the assimilation performance, where T and S are separately updated at these locations. Validation is performed by comparing assimilated outputs with independent in situ data (satellite remote sensing sea level anomaly (SLA), the OSCAR velocity product and shipboard ADCP). The results show that the new EnKF assimilation scheme can significantly reduce the root mean square error (RMSE) of oceanic T and S compared with the control run and traditional EnKF. The system can also improve the simulation of circulations and SLA.
基金Financial support for this research was provided by the Agencia Espanola de Cooperaci’on Internacional para el Desarrollo(A/019106/08,A/025113/09 and A1/035779/11).
文摘The prevalence of enterotoxigenic Staphylococcus aureus was investigated among 200 participants working in three different food processing plants in Egypt. Using skin swabs, 75 (38%) of the 200 tested persons were positive for the presence of S. aureus. Of the S. aureus positive persons, 28 (14%) harboured S. aureus produced staphylococcal enterotoxins. The serotypes of these enterotoxins were enterotoxin A (68%), enterotoxin B (36%), enterotoxin C (46%) and enterotoxin D (18%). Some of these isolates produced more than one type of enterotoxins namely AB, AC, BC, BD, ABC and ACD. Analysis of risk factors implicated in skin carriage of S. aureus as age, gender, marital status, education, duration in employment, frequency and method of hand wash and incidence of chronic skin infection revealed insignificant association with staphylococcal skin carriage. The obtained results put forth the risk of food contracting contamination with enterotoxigenic strains of S. aureus owing to skin colonization of S. aureus among food handlers.
文摘Affective filter hypothesis is one of Krashen's five hypotheses on Second Language Acquisition (SLA), and it states that a number of affective variables play a very important role in Second Language Acquisition. Based on the introduction of affective filter hypothesis, this paper will analyze the significance and shortcomings of this hypothesis.
基金supported by the National Natural Science Foundation of China,No.60672001Special Fund of Education Department of Shaanxi Province,China,No.05JC03
文摘The current use of hearing aids and artificial cochleas for deaf-mute individuals depends on their auditory nerve. Skin-hearing technology, a patented system developed by our group, uses a cutaneous sensory nerve to substitute for the auditory nerve to help deaf-mutes to hear sound. This paper introduces a new solution, multi-channel-array skin-hearing technology, to solve the problem of speech discrimination. Based on the filtering principle of hair cells, external voice sig- nals at different frequencies are converted to current signals at corresponding frequencies using electronic multi-channel bandpass filtering technology. Different positions on the skin can be stimulated by the electrode array, allowing the perception and discrimination of external speech signals to be determined by the skin response to the current signals. Through voice frequen- cy analysis, the frequency range of the band-pass filter can also be determined. These findings demonstrate that the sensory nerves in the skin can help to transfer the voice signal and to dis- tinguish the speech signal, suggesting that the skin sensory nerves are good candidates for the replacement of the auditory nerve in addressing deaf-mutes' hearing problems. Scientific hearing experiments can be more safely performed on the skin. Compared with the artificial cochlea, multi-channel-array skin-hearing aids have lower operation risk in use, are cheaper and are more easily popularized.
文摘We present some convergence and boundedness theorems with respect to filter convergence for lattice group-valued measures. We give a direct proof, based on the sliding hump argument. Furthermore we pose some open problems.
基金National Key Research and Development Program of China(Grant Nos.2018YFA0704401,2017YFF0206103,and 2016YFA0203500)the National Natural Science Foundation of China(Grant Nos.61922002,91850103,11674014,61475005,11527901,11525414,and 91850111)the Beijing Natural Science Foundation,China(Grant No.Z180015).
文摘Narrowband and high-transmission optical filters are extensively used in color display technology, optical information processing, and high-sensitive sensing. Because of large ohmic losses in metallic nanostructures, metallic filters usually exhibit low transmittances and broad bandwidths. By employing both strong field enhancements in metallic nano-slits and the Wood’s anomaly in a periodic metallic grating, an extra-narrowband and high-transmission metallic filter is numerically predicted in an ultrathin single-layer metallic grating. Simulation results show that the Wood’s anomaly in the ultrathin(thickness H = 60 nm) single-layer metallic grating results in large field enhancements in the substrate and low losses in the metallic grating. As a result, the transmission bandwidth(transmittance T > 60%) at λ = 1200 nm is as small as △λFWHM=1.6 nm, which is smaller than 4% of that in the previous thin dielectric and metallic filters. The corresponding quality factor is as high as Q = λ/△λFWHM= 750, which is 40 times greater than that in the previous reports. Moreover, the thickness of our metallic filter(H = 60 nm) is smaller than 40% of that in the previous reports, and its maximum transmittance can reach up to 80%. In experiments, a narrowband metallic filter with a bandwidth of about △λFWHM = 10 nm, which is smaller than 25% of that in the previous metallic filters, is demonstrated.
文摘Sunscreen application is a common strategy used to prevent the damage induced by UV radiations. In the last 30 years a variety of protective agents against UV exposure have been developed: physical filters, chemical filters and organic filters. Physical filters are the safest: they scatter and reflect UV rays, but are difficult to apply on the skin. Chemical filters are capable of absorbing these rays, they are cosmetically pleasant, but recent studies suggest a toxicological nature for some of these agents. Organic filters are the newest advance in sun products. Since 2003 the COLIPA Index [Europe] has regulated sun product availability on the market. In the USA, the FDA establishes the classification and the safety of sun products, which are considered topical medical drugs. This article summarizes the dermatologist's point of view, according to the patient's request, professional ethics and increasing offer of sun product.
文摘We developed a novel topical non-steroidal anti-inflammatory drug (NSAID)patch, S(+)-flurbiprofen plaster, (SFPP), containing S(+)-flurbiprofen (SFP), an enantiomer of flurbiprofen (FP). In a previous study conducted in an animal model, we showed good skin absorption and potent analgesic efficacy of SFPP. In this study, to examine the superior features, as an NSAID patch, of SFP as compared to FP and R(-)-flurbiprofen (RFP), we tested the stereospecificity of SFP actions on Prostaglandin E2 (PGE2) inhibition in rat inflammatory leukocytes and in the binding activity of the drug to cells, and also the in vitro skin permeability of the drug in the Yucatan micropig (YMP). SFP showed potent inhibitory activity on PGE2 production from peritoneal leukocytes stimulated with a bacterial suspension, as compared to RFP and FP. The half maximal (50%) inhibitory concentration (IC50) values were 14 nM for SFP, 52 nM for FP, and 17,000 nM for RFP. In the cell binding study, significant and rapid increase of SFP binding to polymorphonuclear leucocytes (PMNs) was observed at 5 min after incubation, eventually reaching a steady state. SFP showed significantly higher binding activity for the inflammatory leucocytes as compared to RFP, suggesting its superior transfer potency. The skin permeability profile of SFP, RFP and FP in the YMP model showed that the rank order of the cumulative amount of permeated compounds in the skin was SFP > RFP > FP. The steady-state permeation rate (Flux) of SFP was significantly higher than that of FP (4.89 and 1.55 mg/cm2/h, respectively, p = 0.0068), indicating the remarkably superior skin permeability of SFP. SFP exerted potent inhibitory activity on PGE2 production and superior binding activity to the PMNs and skin permeability, as compared to FP and RFP. These results suggest that SFP possesses favorable characteristics for use as an active ingredient in the NSAID patch.
文摘Kalman's Filter Technique for the separation of overlapping incisions of an a.c.oscillopolarogram is presented,the experimental verifications were carried out in various systems with the ions of Pb^(2+),Tl^+,In^(3+)and Cd^(2+).The results showed that the concentration of the depolarizer can be determined directly and easily with this technique in the presence of interference elements.