Brain regenerative studies require precise visualization of the morphological structures. However, few imaging methods can effectively detect the adult zebrafish brain in real time with high resolution and good penetr...Brain regenerative studies require precise visualization of the morphological structures. However, few imaging methods can effectively detect the adult zebrafish brain in real time with high resolution and good penetration depth. Long-term in vivo monitoring of brain injuries and brain regeneration on adult zebrafish is achieved in this study by using 1325 nm spectral-domain optical coherence tomography（SD-OCT）. The SD-OCT is able to noninvasively visualize the skull injury and brain lesion of adult zebrafish. Valuable phenomenon such as the fractured skull, swollen brain tissues, and part of the brain regeneration process can be conducted based on the SD-OCT images at different time points during a period of 43 days.展开更多
基金supported by MYRG2014-00093-FHS,MYRG 2015-00036-FHS,and MYRG2016-00110-FHS grants from the University of Macao in MacaoFDCT026/2014/A1 and FDCT 025/2015/A1 grants from Macao government
文摘Brain regenerative studies require precise visualization of the morphological structures. However, few imaging methods can effectively detect the adult zebrafish brain in real time with high resolution and good penetration depth. Long-term in vivo monitoring of brain injuries and brain regeneration on adult zebrafish is achieved in this study by using 1325 nm spectral-domain optical coherence tomography（SD-OCT）. The SD-OCT is able to noninvasively visualize the skull injury and brain lesion of adult zebrafish. Valuable phenomenon such as the fractured skull, swollen brain tissues, and part of the brain regeneration process can be conducted based on the SD-OCT images at different time points during a period of 43 days.
