AIM: To investigate the value of interleukin-8 (IL-8), a pro-inflammatory chemokine, in predicting the prognosis of pancreatic cancer. METHODS: Expression of IL-8 and its receptor CXCR1 was assessed by immunohistochem...AIM: To investigate the value of interleukin-8 (IL-8), a pro-inflammatory chemokine, in predicting the prognosis of pancreatic cancer. METHODS: Expression of IL-8 and its receptor CXCR1 was assessed by immunohistochemistry in pancreatic cancer and chronic pancreatitis samples. Enzyme-linked immunosorbent assay was used to detect the serum IL-8 levels in pancreatic cancer patients. Human pancreatic cancer tissues were heterotopically transplanted to the immune-deficiency mice to evaluate the effect of serum IL-8 on the tumorigenesis of the cancer samples.RESULTS: IL-8 and CXCR1 proteins were both overexpressed in pancreatic adenocarcinoma samples (55.6% and 65.4%, respectively) compared with the matched para-cancer tissues (25.9% and 12.3%, P < 0.01), or chronic pancreatitis (0% and 25%, P < 0.05). Serum IL-8 levels in pancreatic cancer patients (271.1 ± 187.7 ng/mL) were higher than in other digestive system tumors, such as gastric cancer (41.77 ± 9.11 ng/mL, P = 0.025), colorectal carcinoma (78.72 ± 80.60 ng/mL, P = 0.032) and hepatocellular carcinoma (59.60 ± 19.80 ng/mL, P = 0.016). In vivo tumorigenesis analysis further proved that tumor tissues from patients with higher serum IL-8 levels grew faster than those with lower IL-8 levels. CONCLUSION: IL-8 can be a fine serum marker for predicting the prognosis pancreatic cancer.展开更多
目的探究牙痛宁酊辅助根管植入对牙周炎患者血清白细胞介素-8（interleukin 8,IL-8）、白细胞分化抗原4（cluster of differentiation 4,CD4）及热休克蛋白70（heat shock protein 70,HSP70）水平影响。方法收集2013年12月~2015年9月浙...目的探究牙痛宁酊辅助根管植入对牙周炎患者血清白细胞介素-8（interleukin 8,IL-8）、白细胞分化抗原4（cluster of differentiation 4,CD4）及热休克蛋白70（heat shock protein 70,HSP70）水平影响。方法收集2013年12月~2015年9月浙江省余姚市第二人民医院口腔科收治的牙周炎患者64例,根据治疗方法不同分为对照组和治疗组,治疗组33例,对照组31例,2组患者均实施根管植入治疗,治疗组在此基础上实施速效牙痛宁酊治疗方案,治疗结束后对比分析2组患者临床疗效、疼痛发生率、IL-8、CD4及HSP70水平。结果治疗组临床总有效率为96.97%（32例）,显著高于对照组的80.65%（31例）（χ2=4.373,P〈0.05）。治疗组疼痛发生率为30.30%（10例）,显著低于对照组的58.06%（18例）（χ2=5.006,P〈0.05）。治疗后,2组血清IL-8水平均明显升高,CD4、HSP70水平显著降低（P〈0.05）,与对照组相比,治疗组血清IL-8水平显著升高,CD4、HSP70水平显著降低（P〈0.05）。结论牙痛宁酊辅助根管植入提高根管治疗效果,缓解牙组织损伤,改善手术后患者疼痛。展开更多
基金Supported by The National Key Project of Scientific and Technical Supporting Programs of China, No. 2006BAI02A14National Natural Science Foundation of China, No. 30770996 and No. 30901776
文摘AIM: To investigate the value of interleukin-8 (IL-8), a pro-inflammatory chemokine, in predicting the prognosis of pancreatic cancer. METHODS: Expression of IL-8 and its receptor CXCR1 was assessed by immunohistochemistry in pancreatic cancer and chronic pancreatitis samples. Enzyme-linked immunosorbent assay was used to detect the serum IL-8 levels in pancreatic cancer patients. Human pancreatic cancer tissues were heterotopically transplanted to the immune-deficiency mice to evaluate the effect of serum IL-8 on the tumorigenesis of the cancer samples.RESULTS: IL-8 and CXCR1 proteins were both overexpressed in pancreatic adenocarcinoma samples (55.6% and 65.4%, respectively) compared with the matched para-cancer tissues (25.9% and 12.3%, P < 0.01), or chronic pancreatitis (0% and 25%, P < 0.05). Serum IL-8 levels in pancreatic cancer patients (271.1 ± 187.7 ng/mL) were higher than in other digestive system tumors, such as gastric cancer (41.77 ± 9.11 ng/mL, P = 0.025), colorectal carcinoma (78.72 ± 80.60 ng/mL, P = 0.032) and hepatocellular carcinoma (59.60 ± 19.80 ng/mL, P = 0.016). In vivo tumorigenesis analysis further proved that tumor tissues from patients with higher serum IL-8 levels grew faster than those with lower IL-8 levels. CONCLUSION: IL-8 can be a fine serum marker for predicting the prognosis pancreatic cancer.
文摘目的探究牙痛宁酊辅助根管植入对牙周炎患者血清白细胞介素-8（interleukin 8,IL-8）、白细胞分化抗原4（cluster of differentiation 4,CD4）及热休克蛋白70（heat shock protein 70,HSP70）水平影响。方法收集2013年12月~2015年9月浙江省余姚市第二人民医院口腔科收治的牙周炎患者64例,根据治疗方法不同分为对照组和治疗组,治疗组33例,对照组31例,2组患者均实施根管植入治疗,治疗组在此基础上实施速效牙痛宁酊治疗方案,治疗结束后对比分析2组患者临床疗效、疼痛发生率、IL-8、CD4及HSP70水平。结果治疗组临床总有效率为96.97%（32例）,显著高于对照组的80.65%（31例）（χ2=4.373,P〈0.05）。治疗组疼痛发生率为30.30%（10例）,显著低于对照组的58.06%（18例）（χ2=5.006,P〈0.05）。治疗后,2组血清IL-8水平均明显升高,CD4、HSP70水平显著降低（P〈0.05）,与对照组相比,治疗组血清IL-8水平显著升高,CD4、HSP70水平显著降低（P〈0.05）。结论牙痛宁酊辅助根管植入提高根管治疗效果,缓解牙组织损伤,改善手术后患者疼痛。
