Objective:To investigate the efficacy and safety of Kanglaite injection(KLT)combined with chemotherapy in the treatment of pancreatic cancer.Methods:PubMed,EMBASE,the Cochrane Library,China National Knowledge Infrastr...Objective:To investigate the efficacy and safety of Kanglaite injection(KLT)combined with chemotherapy in the treatment of pancreatic cancer.Methods:PubMed,EMBASE,the Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang Database,VIP Data,and Chinese Biomedical Database(CBM)were searched to get the studies about KLT plus chemotherapy for pancreatic cancer(from established to May 2019).Data extraction and bias risk assessment were carried out by two authors independently according to the retrieval method.RevMan(version 5.3)were employed for data analysis.Results:A total of 151 literatures were retrieved and 11 literatures were finally included.A total of 614 patients were included,including 308 in the treatment group and 306 in the control group.The results of meta-analysis showed that compared with chemotherapy alone,KLT combined with chemotherapy could improve the effective rate[Porr=0.0009,OR=1.96,95%CI(1.32,2.92)]and disease control rate[Pdcr<0.00001,OR=2.53,95%CI(1.76,3.62)],improve KPS score[P<0.00001,OR=3.59,95%CI(2.00,6.44)]and body mass indexes[P=0.0003,OR=3.45,95%CI(1.78,6.69)],prolong progression free survival(PFS)and overall survival(OS),reduce the rate of myelosuppression[P=0.03,OR=0.54,95%CI(0.30,0.95)],but could not reduce the occurrence of neurotoxicity[P=0.49,OR=0.80,95%CI(0.42,1.51)]and digestive tract reaction[P=0.51,OR=0.83,95%CI(0.48,1.44)].Conclusion:KLT combined with chemotherapy can improve the curative effect of pancreatic cancer,improve the quality of life of patients,prolong the survival of patients,and reduce the incidence of bone marrow suppression.However,due to the limitation of the quality and quantity of included literatures,this conclusion needs to be verified by high-quality study.展开更多
基金The study was supported by the National Natural Science Foundation of China(No.81703838)the Key R&D Program of Shandong Province(No.2019GSF108210)+3 种基金Development Project of Traditional Chinese Medicine Science and Technology in Shandong Province(No.2017-027)Key Technology Projects of Key Industries in Shandong Province(No.2016CYJS08A01-4 and 2016CYJS08A01-3)Key Research and Development Plans in Shandong Province(No.2016ZDJS07A12)2018 National SRT Project of Shandong University of Traditional Chinese Medicine(No.201810441008).
文摘Objective:To investigate the efficacy and safety of Kanglaite injection(KLT)combined with chemotherapy in the treatment of pancreatic cancer.Methods:PubMed,EMBASE,the Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang Database,VIP Data,and Chinese Biomedical Database(CBM)were searched to get the studies about KLT plus chemotherapy for pancreatic cancer(from established to May 2019).Data extraction and bias risk assessment were carried out by two authors independently according to the retrieval method.RevMan(version 5.3)were employed for data analysis.Results:A total of 151 literatures were retrieved and 11 literatures were finally included.A total of 614 patients were included,including 308 in the treatment group and 306 in the control group.The results of meta-analysis showed that compared with chemotherapy alone,KLT combined with chemotherapy could improve the effective rate[Porr=0.0009,OR=1.96,95%CI(1.32,2.92)]and disease control rate[Pdcr<0.00001,OR=2.53,95%CI(1.76,3.62)],improve KPS score[P<0.00001,OR=3.59,95%CI(2.00,6.44)]and body mass indexes[P=0.0003,OR=3.45,95%CI(1.78,6.69)],prolong progression free survival(PFS)and overall survival(OS),reduce the rate of myelosuppression[P=0.03,OR=0.54,95%CI(0.30,0.95)],but could not reduce the occurrence of neurotoxicity[P=0.49,OR=0.80,95%CI(0.42,1.51)]and digestive tract reaction[P=0.51,OR=0.83,95%CI(0.48,1.44)].Conclusion:KLT combined with chemotherapy can improve the curative effect of pancreatic cancer,improve the quality of life of patients,prolong the survival of patients,and reduce the incidence of bone marrow suppression.However,due to the limitation of the quality and quantity of included literatures,this conclusion needs to be verified by high-quality study.
