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Three Development Stages for the Tibetan Family and Tibet's Modernization——A Survey of Social Changes in Tibet in Last 50 Years
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作者 GELEK 《The Journal of Human Rights》 2010年第2期32-37,共6页
I Since 1990, as a person in charge of key research projects of the China Tibetology Research Center, I have had opportunities almost every year to conduct field surveys on anthropology in Tibet together with my colle... I Since 1990, as a person in charge of key research projects of the China Tibetology Research Center, I have had opportunities almost every year to conduct field surveys on anthropology in Tibet together with my colleagues. Our investigations focus on the family. The purpose of our surveys is to see social changes in Tibet during the 50 years after the Democratic Reform through the study of the family as a social cell. 展开更多
关键词 Three development Stages for the Tibetan Family and Tibet’s Modernization than more time over A Survey of social changes in Tibet in Last 50 Years
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Effects of Social and Economic Development of Regions Surrounding Chao Lake on Water Quality Change of Chao Lake 被引量:1
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作者 赵腾飞 王晴晴 +2 位作者 唐晓先 刘西军 张云华 《Agricultural Science & Technology》 CAS 2015年第12期2866-2869,共4页
The research analyzed social and economic development around Chao Lake as well as changes of water quality in Chao Lake and explored the relation- ships of local population and GDP with water chemical oxygen demand (... The research analyzed social and economic development around Chao Lake as well as changes of water quality in Chao Lake and explored the relation- ships of local population and GDP with water chemical oxygen demand (COD), total phosphorus (TP), total nitrogen (TN), chlorophyll and eutrophication index. The re- sults showed that population around Chao Lake and GDP kept growing from 2001 to 2013, and water quality was improving. In addition, correlation analysis indicated that except of water eutrophication, GDP and population showed inverse correlation with other indices, demonstrating that water quality has been effectively controlled in Chao Lake recently. 展开更多
关键词 Surrounding Chao Lake areas Water quality of Chao Lake social and economic development Correlation analysis
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Analyzing topics in social media for improving digital twinning based product development
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作者 Wenyi Tang Ling Tian +1 位作者 Xu Zheng Ke Yan 《Digital Communications and Networks》 SCIE CSCD 2024年第2期273-281,共9页
Digital twinning enables manufacturers to create digital representations of physical entities,thus implementing virtual simulations for product development.Previous efforts of digital twinning neglect the decisive con... Digital twinning enables manufacturers to create digital representations of physical entities,thus implementing virtual simulations for product development.Previous efforts of digital twinning neglect the decisive consumer feedback in product development stages,failing to cover the gap between physical and digital spaces.This work mines real-world consumer feedbacks through social media topics,which is significant to product development.We specifically analyze the prevalent time of a product topic,giving an insight into both consumer attention and the widely-discussed time of a product.The primary body of current studies regards the prevalent time prediction as an accompanying task or assumes the existence of a preset distribution.Therefore,these proposed solutions are either biased in focused objectives and underlying patterns or weak in the capability of generalization towards diverse topics.To this end,this work combines deep learning and survival analysis to predict the prevalent time of topics.We propose a specialized deep survival model which consists of two modules.The first module enriches input covariates by incorporating latent features of the time-varying text,and the second module fully captures the temporal pattern of a rumor by a recurrent network structure.Moreover,a specific loss function different from regular survival models is proposed to achieve a more reasonable prediction.Extensive experiments on real-world datasets demonstrate that our model significantly outperforms the state-of-the-art methods. 展开更多
关键词 Digital twinning Product development Topic analysis social media
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Constructing a Triangular Linkage Model of Government Audit,Social Audit,and Internal Audit to Promote High-Quality Development of Audit Services
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作者 TANG Pengzhan 《Journal of Modern Accounting and Auditing》 2024年第3期89-98,共10页
It is a complex and important topic to study the linkage mechanism of government audit,social audit,and internal audit in the context of China’s high-quality economic development.The implementation of measures,such a... It is a complex and important topic to study the linkage mechanism of government audit,social audit,and internal audit in the context of China’s high-quality economic development.The implementation of measures,such as establishing a sound and perfect organizational safeguard mechanism,strengthening project collaborative audit mechanism,enhancing the mechanism for utilizing audit results,and establishing an audit and rectification joint mechanism can promote the efficient operation of the audit supervision system and the high-quality development of audit services. 展开更多
关键词 government audit social audit internal audit triangular linkage model high-quality development
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Exploring the Association between Climate Change and Human Development: A Visual Analytics Study
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作者 Dongli Zhang Wullianallur Raghupathi Viju Raghupathi 《Atmospheric and Climate Sciences》 2024年第4期368-395,共28页
This study explores the complex relationship between climate change and human development. The aim is to understand how climate change affects human development across countries, regions, and the global population. Vi... This study explores the complex relationship between climate change and human development. The aim is to understand how climate change affects human development across countries, regions, and the global population. Visual analytics were used to examine the impact of various climate change indicators on different aspects of human development. The study highlights the urgent need for climate change action and encourages policymakers to make decisive moves. Climate change adversely affects numerous aspects of daily life, leading to significant consequences that must be addressed through policy changes and global governance recommendations. Key findings include that regions with higher CO2 emissions experience a significantly higher incidence of life-threatening diseases compared to regions with lower emissions. Additionally, higher CO2 emissions correlate with consistent death rates. Increased pollution exposure is associated with a higher prevalence of life-threatening diseases and higher rates of malnutrition. Moreover, greater mineral depletion is linked to more frequent life-threatening diseases, suggesting that industrialization contributes to adverse health effects. These results provide valuable insights for policy and decision-making aimed at mitigating the impact of climate change on human development. 展开更多
关键词 Air Pollution Climate change CO2 Emissions Death Rate GDP Human development Visual Analytics
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Social development and living environment changes in the Northeast Tibetan Plateau and contiguous regions during the late prehistoric period 被引量:5
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作者 Huihui Cao Guanghui Dong 《Regional Sustainability》 2020年第1期59-67,共9页
The relationship between the evolution of human societies and their living environments has been discussed intensively in recent decades.It is important to understand the patterns and mechanisms of human–environment ... The relationship between the evolution of human societies and their living environments has been discussed intensively in recent decades.It is important to understand the patterns and mechanisms of human–environment interaction and evolution in order to cope with rapidly changing environments in the modern world.We reviewed the results of dating,archaeobotanical,and zooarchaeological studies from 139 prehistoric sites in the Northeast Tibetan Plateau(NETP)and contiguous regions(NETP-CR:i.e.,the Hexi Corridor and western margin of the Chinese Loess Plateau)and compared them with paleoenvironmental records to study variations in spatiotemporal patterns of social development in the area and their relationships with climate and vegetation changes.Our results show that hunter-gatherer groups occupied vast areas of the NETP at low intensities during^15,000–5500 BP(years before present).This was directly related to forest cover and climate change.An increase in temperature and precipitation turnover of vegetation from desert steppe to alpine meadow/subalpine shrub,and recovery of animal population on the Tibetan Plateau created more food resources and space for hunter-gatherers.Millet farmers settled extensively below 2500 m a.s.l.(meters above sea level)in the NETP-CR between^5500 and 3600 BP,and might have coexisted with hunting groups above 2500 m a.s.l.via subsistence exchange.The distribution of human settlements during that period was affected by climate change,with the relatively warm and wet climate promoting the expansion of millet agriculture to the NETP-CR during 5500–4500 BP,while climate deterioration caused humans to retreat to lower altitudes.During 3600–2200 BP,a range of livelihoods emerged in different regions of the NETPCR.This was promoted by early trans-Eurasian exchange and the development of an agro-pastoral economy that utilized cold-tolerant crops and livestock.This eventually promoted the expansion of permanent human settlements to high-altitude areas in the NETP.This study found that human societies adopted various strategies to adapt to the changing living environment throughout late prehistoric times in the NETP-CR.The results provide a long-term perspective on the trajectory of regional socio-environmental co-evolution. 展开更多
关键词 social evolution Climate change Subsistence strategy Late prehistoric period Northeast Tibetan Plateau
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Research on Climate Change and Countermeasure of Agriculture Sustainable Development
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作者 刁军 董晓明 +1 位作者 刘凤芝 贺明慧 《Meteorological and Environmental Research》 CAS 2010年第5期84-88,共5页
Based on the Fourth Intergovernmental Panel on Climate Change(IPCC) Assessment Report and meteorologists' research results of climate change in China,the influences of climate change on agricultural production wer... Based on the Fourth Intergovernmental Panel on Climate Change(IPCC) Assessment Report and meteorologists' research results of climate change in China,the influences of climate change on agricultural production were analyzed from the aspects of temperature,precipitation,sea-level rise and so on.Concrete measures were put forward to reply to climate change.According to the climate change trends,defensive measures were established to enhance the capacity of agriculture coping with climate change,making full use of advantages while avoiding disadvantages,in order to achieve sustainable development. 展开更多
关键词 Climate change Agricultural production COUNTERMEASURE Sustainable development China
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Actively Dealing with Climate Change and Striving to Strengthen the Capability of Sustainable Development
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作者 Zhou Dadi Xu Huaqing 《Chinese Journal of Population,Resources and Environment》 2011年第3期21-27,共7页
Either from the perspective of the finite supply capacity of global resources and energy,or from the perspective of global environment restrictive conditions,developing countries can not repeat the old development roa... Either from the perspective of the finite supply capacity of global resources and energy,or from the perspective of global environment restrictive conditions,developing countries can not repeat the old development road of developed countries,either in view of the international pressure China is currently facing,or in view of China's own resources endowment and stages of development,we must actively face such a challenge of climate change.We must recognize that the issue of climate change may be a great restraint to the present and future eco-social development,and may also be an important driving force and new opportunity to push forward the transformation of development pattern,to take a new road of industrialization and to realize sustainable development.This demands us,on the one hand,to take the Scientific Outlook of Development as the guide to make efforts to control the emission of greenhouse gases and continuously increase the capability of adapting to climatic change,and set up the overall plan to respond to climate change of our country,and on the other hand,we should unswervingly take the road of sustainable development,save energy,optimize energy structure and strengthen biological protection in slowing and adapting to climate change. 展开更多
关键词 climate change sustainable development strategy global resources global energy Scientific Outlook of development
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Global Climate Change and China's Green Development
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作者 Hu Angang 《Chinese Journal of Population,Resources and Environment》 2011年第4期9-15,共7页
For China, green industrial revolution induced by global climate change poses not only the greatest challenge, but also the greatest opportunity. In the perspective of China's basic national conditions, and especi... For China, green industrial revolution induced by global climate change poses not only the greatest challenge, but also the greatest opportunity. In the perspective of China's basic national conditions, and especially its natural conditions, China's green development is the inevitable path of choice for the realization of sustainable development and scientific development. The essence of China's modernization 2050 is green modernization, taking the three-step strategy towards China's own green development and energy conservation and emission reduction. In combination with the 12 th Five Year Plan, its innovative positioning is "green development plan". 展开更多
关键词 global climate change green industrial revolution China's green development green modernization green development plan
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Balancing Carbon Emission Reductions and Social Economic Development for Sustainable Development: Experience from 24 Countries 被引量:6
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作者 KANG Meimei ZHAO Wenwu +1 位作者 JIA Lizhi LIU Yanxu 《Chinese Geographical Science》 SCIE CSCD 2020年第3期379-396,共18页
The impact of human carbon emissions on climate has generated widespread global concern. We selected 24 countries as research objects and analysed the changes in carbon emissions in different countries between the est... The impact of human carbon emissions on climate has generated widespread global concern. We selected 24 countries as research objects and analysed the changes in carbon emissions in different countries between the establishment of emission reduction actions in 1990 and 2014. Then, we selected 19 factors representing four categories(economy, population, technology and energy) to explore the key factors that led to changes in carbon dioxide(CO2) emissions in different countries. Emission reduction actions since 1990 did not lead to marked improvements, and only five countries(Russia, Germany, the United Kingdom, Italy and France) achieved reductions in carbon emissions. The factors that influenced CO2 emissions varied among countries. In most developing countries, reductions in CO2 emissions were caused by reductions in poverty and inherent natural conditions. Moreover, the extent of influence of a given factor on CO2 emissions differed among countries. The global economic crisis may cause similar fluctuations in CO2 emissions in many countries. Adjustments to energy and industrial structures are the main reason for the reduction in carbon emissions, whereas economic growth and urbanization are the two major contributors to the growth of carbon emissions. According to historical carbon emissions data, a green energy revolution must be implemented to address global climate change and ensure the sustainable development of human societies. 展开更多
关键词 carbon dioxide(CO2)emissions climate change economic growth sustainable development
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Coping with climate change and China's wind energy sustainable development 被引量:4
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作者 HE De-Xin 《Advances in Climate Change Research》 SCIE CSCD 2016年第1期3-9,共7页
Greenhouse gas emissions are the main cause of today's climate change. To address this problem, the world is in an era of new round energy transformation, and the existing energy structure is being reformed. In th... Greenhouse gas emissions are the main cause of today's climate change. To address this problem, the world is in an era of new round energy transformation, and the existing energy structure is being reformed. In this paper, according to the Chinese government's action plan for coping with climate change, the China's wind energy sustainable development goals and development route are discussed, and the countermeasures and suggestions are put forward. Wind energy is currently a kind of important renewable energy with matured technology which can be scale-up developed and put into commercial application, and in this transformation, wind energy will play a key role with other non-fossil energy sources. The development and utilization of wind energy is a systematic project, which needs to be solved from the aspects of policy, technology and management. At present, China is in the stage of transferring from "large wind power country" to "strong wind power country", opportunities and challenges coexist, and the advantages of China's socialist system could be fully used, which can concentrate power to do big things and make contribution in the process of realizing global energy transformation. 展开更多
关键词 Climate change Energy transformation Wind energy Sustainable development
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Rural Development Transformation and Social Governance from the Perspective of Specialization:A Case Study of Ruiling Village in Guangzhou City,China 被引量:3
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作者 LIN Yuancheng YANG Ren LI Simeng 《Chinese Geographical Science》 SCIE CSCD 2023年第5期796-812,共17页
The reorganization of the global production network and the increased mobility of urban-rural elements have accelerated the differentiation of rural spaces,resulting in a trend towards specialization in rural areas.Th... The reorganization of the global production network and the increased mobility of urban-rural elements have accelerated the differentiation of rural spaces,resulting in a trend towards specialization in rural areas.This paper focuses on the concept of specialization,and takes a renowned bonsai specialized village in Guangzhou City,China as a typical case to explore its transformation and development process,action logic and coupling mechanism with the social governance.The results show that:1)the development of rural specialization in Ruiling Village is shaped by several key actors,such as local governments,grassroots organizations,villagers,social organizations,policies,markets and infrastructure.The transfer of these key actors and the reconstruction of actor-networks in different stages have an important influence on the transformation and realization of rural development goals.2)Through subjects-driven,organization management and resource connection,social governance supports the specialization of rural industrial organization,operation,technology and mode.The governance structure shifts from decentralization to networking,refinement and integration.A coupling community of social governance and specialization is created by the social governance system of‘local government-grassroots organizationseconomic cooperatives-villagers’,which links industries,industrial chains and cooperatives.3)Social governance integrates into the value chain extension process of rural specialized development with a central,multi-level organizational structure.It promotes the construction of the whole value chain through organizational planning,resource integration and image shaping,thus realizing the value,branding and organization of the industry,as well as the integration of rural sustainable development and governance mechanism.Social governance has a profound impact on the development of rural specialization in terms of subject,structure and mode,and participates in the construction of the whole value chain of rural areas.This paper provides a new perspective for understanding the coupling effect of social governance in the rural development transformation,and promotes the rural sustainable development and governance. 展开更多
关键词 rural specialization rural development transformation social governance rural differentiation actor-network theory(ANT) Ruiling Village
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Coordinative Development Between Land Use Change and Regional Population-Resources-Environment-Development System—A Case Study of Jiangsu Province 被引量:2
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作者 XIAO Sisi HUANG Xianjin PENG Buzhuo 《Chinese Geographical Science》 SCIE CSCD 2007年第4期289-296,共8页
Land use change has significant influence on the operation of the PopulationResources-Environment-De-velopment (PRED) System. Moderate land use is the key factor to ensure the coordinative and sustainable development ... Land use change has significant influence on the operation of the PopulationResources-Environment-De-velopment (PRED) System. Moderate land use is the key factor to ensure the coordinative and sustainable development between land use and PRED system. Based on the internal relationship between land use and PRED system, a PRED evaluation index system and a Press-Status-Response (PSR) model were established in this study. According to the expounding on the mechanism of the PSR model, we investigated the coordinative development between the changes of regional land use and PRED system taking Jiangsu Province as an example. The results showed that the orders of the Synthetic Index of Land Use (SILU) and the Variation of PRED Index (VPI) in Jiangsu are both the southern Jiangsu>the central Jiangsu>the northern Jiangsu. A cubic curve model was used to fit the relationship between the VPI and SILU. The inflection point of VPI was situated in 5.0 of SILU. When SILU was below 5.0, VPI increased with SILU, which will be helpful to the coordinative development between land use and PRED system. Based on those results, it is suggested that the land use degree of the southern Jiangsu, especially that of Nanjing City, should be moderately controlled at present, while land resources of the central Jiangsu and the northern Jiangsu should be further exploited. 展开更多
关键词 land use change Population-Resources-Environment-development (PRED) system Press-Status-Response (PSR) model coordinative development Jiangsu Province China
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Entrepreneurship corporate social responsibility and flexible innovation networks: On the interaction between TNCs' R&D activities and local development 被引量:3
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作者 SHEN Yu-fang 《Chinese Business Review》 2007年第6期1-12,共12页
Entrepreneurship corporate social responsibility is concerned with obligations that should be undertaken by an enterprise or "enterprise citizen" to the society including interrelationship between enterprise and som... Entrepreneurship corporate social responsibility is concerned with obligations that should be undertaken by an enterprise or "enterprise citizen" to the society including interrelationship between enterprise and some related interest dependents. And it is a sense of value, discipline and respect to the people, community and environment-related policies of the enterprise. Obviously, the core of the notion refers to a commitment of the enterprise in order to improve living standard of related interest counterparts. Nowadays, entrepreneurship corporate social responsibility has been not only an ethical call, but also an institutional constraint. The consensus is that in operation process an enterprise should take into account of its economic, social and ethical effects on consumers, staffs, shareholders, communities, local governments and environment and make a better prospect to them. Based on this point of view, by field work and questionnaire method, this paper discusses specifically the interaction between TNCs' R&D activities and local development of the Pudong New Area, a China's largest special economic zone in Shanghai to explore dynamics of the TNCs' R&D activities, growth of the local economy and their roles in promoting flexible innovation networks for sustainable futures. This involves: a. notion of the entrepreneurship corporate social responsibility; b. current state and trend of TNCs' R&D activities; c. mode and linkage tightness between TNCs' R&D activities and the local economy; d. main problems of the TNCs' R&D activities in Pudong; e. the context of flexible innovation networks; and f. manner and ways in creation of flexible innovation networks. 展开更多
关键词 ENTREPRENEURSHIP corporate social responsibility flexible innovation networks TNC R&D local development
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Influence of Social Capital on Rural Tourism Development 被引量:2
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作者 Xiu LI Yuguo WANG 《Asian Agricultural Research》 2020年第11期41-45,共5页
In order to explore the relationship between social capital and rural tourism development effect and improve the development of rural tourism,this study takes Liutai Village in Shandong Province,9 villages of Mangxin ... In order to explore the relationship between social capital and rural tourism development effect and improve the development of rural tourism,this study takes Liutai Village in Shandong Province,9 villages of Mangxin Township and Yuanyi Village in Xinjiang as examples and conducts empirical research.The result of exploratory factor analysis shows that social capital is divided into bonding type and bridging type,which have different characteristics and functions.The result of multiple regression analysis shows that social capital of both the two types has a significant positive impact on the development of rural tourism.In the current process of rural tourism development,the positive influence of bonding social capital is greater than that of bridging social capital.Based on the results of the empirical analysis,this paper puts forward the countermeasures and suggestions for the development of rural tourism. 展开更多
关键词 Rural tourism social capital Rural tourism development achievement
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Socio-economic and energy-environmental impacts of technological change on China's agricultural development under the carbon neutrality strategy 被引量:1
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作者 Hong-Dian Jiang Rui Yu Xiang-Yan Qian 《Petroleum Science》 SCIE EI CAS CSCD 2023年第2期1289-1299,共11页
Promoting agricultural modernisation through technological change is an important strategy for China.China's carbon neutrality strategy is leading to systemic socio-economic changes that could exacerbate the uncer... Promoting agricultural modernisation through technological change is an important strategy for China.China's carbon neutrality strategy is leading to systemic socio-economic changes that could exacerbate the uncertainty of agricultural development.Therefore,applying a computable general equilibrium(CGE)model,this study characterises the agricultural sector in detail,introducing endogenous technological change proxied by research and development(R&D)to assess the impact of different technological change scenarios on agricultural development under the carbon neutrality target.The results show that allocating carbon revenue for R&D inputs can mitigate the significant negative impact of achieving carbon neutrality on knowledge capital and production in agricultural sectors.Overall,using carbon revenue only for R&D input in crop sectors has the optimal effect on increasing the agricultural sectors'knowledge capital,improving crop production and profit,reducing crop external dependence and promoting the synergistic reduction of carbon and pollutant emissions.However,this scenario has the largest negative impact on macro-economics and household welfare.In contrast,allocating carbon revenue to promote technological change in broader non-energy sectors or both crops and non-energy sectors can effectively mitigate negative socio-economic impacts,but the positive impact on agricultural development is minimal.These findings provide practical insights for the rational use of carbon revenue to expand agricultural R&D investment and ensure balanced agricultural and economic development under the carbon neutrality target. 展开更多
关键词 Endogenous technological change R&D investment Agriculture development Computable general equilibrium
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Spatial-temporal characteristics of the coupling coordination of social security and economic development in China during 2002–2018 被引量:3
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作者 Qiong Li Yang Zhao +1 位作者 Songlin Li Lanlan Zhang 《Regional Sustainability》 2021年第2期116-129,共14页
Clarifying the relationship between social security and economic development is helpful to realize the sustainable social security system and the stable function of sustainable economic development.In this paper,the e... Clarifying the relationship between social security and economic development is helpful to realize the sustainable social security system and the stable function of sustainable economic development.In this paper,the entropy method,coupling coordination degree,standard deviation ellipse model,and spatial autocorrelation were used to study the spatial-temporal characteristics of coupling coordination of social security and economic development in China from 2002 to 2018.The results indicate that the relationship between social security and economic development in China has been gradually strengthened in the process of mutual adaptation and common development.The benign interaction between the two was unstable,though the coupling coordination degree gradually transitioned to the primary coupling coordination type.Besides,from a spatial perspective,first,the coupling coordination degree of social security and economic development in China contracted in the east-west and north-south directions,and the coupling coordination clustered in the central region in this period;second,the coupling coordination degree generally presented a positive spatial autocorrelation,and regions with similar coupling coordination degrees were in a state of agglomeration;finally,the hot spots clumped together to form a continuous area in the eastern coastal area while the cold spots expanded toward the northwest and northeast.Furthermore,the random distribution areas exhibited a trend of contraction. 展开更多
关键词 social security Economic development Coupling coordination degree Gravity center Moran index
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Striving for the development of biology——The celebration of Biomagnelism formally changed into Progress in Modem Biomedicine 被引量:2
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作者 Editorial Department of Progress in Modern Biomedicine 《现代生物医学进展》 CAS 2006年第6期F0002-F0002,共1页
关键词 Striving for the development of biology The celebration of Biomagnelism formally changed into Progress in Modem Biomedicine
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Annual change of the gonadal development of the amphioxus in Xiamen 被引量:2
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作者 Fang Yongqiang, Qi Xiang, Liang Ping and Hong GuiyingThird Institute of Oceanography, State Oceanic Administration, Xiamen, China 《Acta Oceanologica Sinica》 SCIE CAS CSCD 1991年第3期477-479,共3页
The study was made by observing the annual change of the gonadal development of amphioxus in Xiamen cohtinuously for two years from November, 1986 to November, 1988. We determined the gonadal diameter, gonadosomatic i... The study was made by observing the annual change of the gonadal development of amphioxus in Xiamen cohtinuously for two years from November, 1986 to November, 1988. We determined the gonadal diameter, gonadosomatic index of each amphioxus, and observed the histological characteristic of the gonadal development of the female and male by cut section, which provided the basis for dividing the stages gonads and the determining level of the gonadal development of amphioxus in each month. 展开更多
关键词 Annual change of the gonadal development of the amphioxus in Xiamen
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The changes of oligodendrocytes induced by anesthesia during brain development 被引量:1
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作者 Danye Jiang Sanghee Lim +2 位作者 Minhye Kwak Yun Kyoung Ryu C.David Mintz 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第9期1386-1387,共2页
With the advent of modern techniques, drugs, and monitoring, general anesthesia has come to be considered an unlikely cause of harm, particularly for healthy patients. While this is largely true, newly emerging clinic... With the advent of modern techniques, drugs, and monitoring, general anesthesia has come to be considered an unlikely cause of harm, particularly for healthy patients. While this is largely true, newly emerging clinical and laboratory studies have sug- gested that exposure to anesthetic agents during early childhood may have long-lasting adverse effects on cognitive function. This concern has been the focus of intense study in the field of anesthesia research. A recent high-profile review by Rappaport et al. (2015) concluded that while many questions remain un- answered, there is strong evidence from laboratory studies that commonly used anesthetics interfere with brain development and that clinical studies suggest a correlation between early childhood exposure to these agents and subsequent effects on learning and cognition. The issue is of sufficient public health importance that a public-private partnership known as Smar- Tots (Strategies for Mitigating Anesthesia-Related Neurotoxicity in Tots) was developed by the FDA to study pediatric anesthetic neurotoxicity. The mechanism of injury underlying this phe- nomenon has yet to be fully elucidated, and there is evidence to suggest that anesthetics may have direct cytotoxic effects on neurons leading to cell death or suppressed neurogenesis (Strat- mann et al., 2010) and that they may interfere with key pro- cesses in neuronal growth and development that underlie brain circuit development (Wagner et al., 2014). 展开更多
关键词 The changes of oligodendrocytes induced by anesthesia during brain development
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