To investigate the therapeutic effect of nigh-dosage γ-aminobutyric acid （GABA） on acute tetramine （TET） poisoning, 50 Kunming mice were divided into 5 groups at random and the antidotal effects of GABA or sodium...To investigate the therapeutic effect of nigh-dosage γ-aminobutyric acid （GABA） on acute tetramine （TET） poisoning, 50 Kunming mice were divided into 5 groups at random and the antidotal effects of GABA or sodium dimercaptopropane sulfonate （Na-DMPS） on poisoned mice in different groups were observed in order to compare the therapeutic effects of nigh-dosage GABA with those of Na-DMPS. Slices of brain tissue of the poisoned mice were made to examine pathological changes of cells. The survival analysis was employed. Our results showed that both high-dosage GABA and Na-DMPS could obviously prolong the survival time, delay onset of convulsion and muscular twitch, and ameliorate the symptoms after acute tetramine poisoning in the mice. Better effects could be achieved with earlier use of high dosage GABA or Na-DMPS. There was no significant difference in prolonging the survival time between high-dose GABA and Na-DMPS used immediately after poisioning. It is concluded that high-dosage GABA can effectively antagonize acute toxicity of terarnine in mice. And it is suggested that nigh-dosage GABA may be used as an excellent antidote for acute TET poisoning in clinical practice. The indications and correct dosage for clinical use awaits to be further studied.展开更多
基金This project was supported by a grant from Research and Development Program of Science and Technology of Hubei Province (No 2002AA301C93)
文摘To investigate the therapeutic effect of nigh-dosage γ-aminobutyric acid （GABA） on acute tetramine （TET） poisoning, 50 Kunming mice were divided into 5 groups at random and the antidotal effects of GABA or sodium dimercaptopropane sulfonate （Na-DMPS） on poisoned mice in different groups were observed in order to compare the therapeutic effects of nigh-dosage GABA with those of Na-DMPS. Slices of brain tissue of the poisoned mice were made to examine pathological changes of cells. The survival analysis was employed. Our results showed that both high-dosage GABA and Na-DMPS could obviously prolong the survival time, delay onset of convulsion and muscular twitch, and ameliorate the symptoms after acute tetramine poisoning in the mice. Better effects could be achieved with earlier use of high dosage GABA or Na-DMPS. There was no significant difference in prolonging the survival time between high-dose GABA and Na-DMPS used immediately after poisioning. It is concluded that high-dosage GABA can effectively antagonize acute toxicity of terarnine in mice. And it is suggested that nigh-dosage GABA may be used as an excellent antidote for acute TET poisoning in clinical practice. The indications and correct dosage for clinical use awaits to be further studied.
