Effects of Hemp seed soft capsule on colonic ion transport in rats

AIM To investigate the effect of Hemp seed soft capsule(HSCC) on colonic ion transport and its related mechanisms in constipation rats.METHODS Sprague-Dawley male rats were randomly divided into three groups: normal group, constipation group and HSSC group. Rats in the constipation and HSSC groups were administrated loperamide 3 mg/kg per day orally for 12 d to induce the constipation model. Then, the HSSC group was given HSSC 0.126 g/kg per day by gavage for 7 d. The normal and constipation groups were treated with distilled water. After the treatment, the fecal wet weight and water content were measured. The basal short-circuit current(Isc) and resistance were measured by an Ussing Chamber. Besides the in vivo drug delivery experiment above, an in vitro drug application experiment was also conducted. The accumulative concentrations of HSSC(0.1 mg/m L, 0.5 mg/m L, 1.0 mg/m L, 2.5 mg/m L, 5.0 mg/m L, 10.0 mg/m L and 25.0 mg/m L) were added to the normal isolatedcolonic mucosa and the Isc was recorded. Further, after the application of either ion(Cl^-or HCO_3^-) substitution, ion channel-related inhibitor(N-phenylanthranilic acid, glybenclamide, 4,4-diisothiocyano-2,2-stilbenedisulfonic acid or bumetanide) or neural pathway inhibitor [tetrodotoxin(TTX), atropine, or hexamethonium], the Isc induced by HSSC was also measured. RESULTS In the constipation group, the fecal wet weight and the water content were decreased in comparison with the normal group(P < 0.01). After the treatment with HSSC, the fecal wet weight and the water content in the HSSC group were increased, compared with the constipation group(P < 0.01). In the constipation group, the basal Isc was decreased and resistance was increased, in comparison with the normal group(P < 0.01). After the treatment with HSSC, the basal Isc was increased(P < 0.05) and resistance was decreased(P < 0.01) in the HSSC group compared with the constipation group. In the in vitro experiment, beginning with the concentration of 1.0 mg/m L, differences in Isc were found between the experimental mucosa(with HSSC added) and control mucosa. The Isc of experimental mucosa was higher than that of control mucosa under the same concentration(1.0 mg/m L, P < 0.05; 2.5-25 mg/m L, P < 0.01). After the Cl^-or HCO_3^-removal and pretreated with different inhibitors(c AMPdependent and Ca^(2+)-dependent Cl^-channels, Na^+-K^+-2 Cl^-cotransporter(NKCC), Na^+-HCO_3^-cotransporter or Cl^-/HCO_3^-exchanger inhibitor), there were differences between experimental mucosa and control mucosa; the Isc of experimental mucosa was lower than that of control mucosa under the same concentration(P < 0.05). Meanwhile, after pretreatment with neural pathway inhibitor(TTX, atropine, or hexamethonium), there were no differences between experimental mucosa and control mucosa under the same concentration(P > 0.05).CONCLUSION HSSC ameliorates constipation by increasing colonic secretion, which is mediated via the coaction of c AMPdependent and Ca^(2+)-dependent Cl^-channels, NKCC, Na^+-HCO_3^-cotransporter or Cl^-/HCO_3^-exchanger.

Some Mixed Soft Operations and Extremally Soft Disconnectedness via Two Soft Topologies

In this paper, we study the concept of soft sets which is introduced by Molodtsov [5]. We give the definition of (τ1,τ2)-semi open soft (resp. (τ1,τ2)-pre open soft, (τ1,τ2)-α-open soft, (τ1,τ2)-β-open soft, (τ1,τ2)'-semi open soft, (τ1,τ2)'-pre open soft, (τ1,τ2)'-α-open soft, (τ1,τ2)'-βopen soft) set via two soft topologies. Also we introduce (τ1,τ2)-regular open soft and ESDC on two soft topologies. The aim of this paper is to investigate properties of some mixed soft operations and characterizations of ESDC. Finally, we study τ2-ESDC soft topologies τ1.

基于对偶树复小波域图像融合的SAR图像去噪

边缘信息是图像重要的细节信息,保护图像的边缘信息对提高图像质量非常重要。但是在图像去噪的过程中,往往会破坏图像的边缘信息。针对去除噪声和保护边缘信息的双重考虑,提出一种基于对偶树复小波域图像融合的SAR图像阈值去噪。考虑到局部硬阈值和软阈值各自的特点,利用对偶树复小波变换的优点和图像融合的特点,首先在自然对数域对SAR图像进行对偶树复小波分解,然后对小波系数分别执行局部硬阈值去噪和局部软阈值去噪,最后依次通过图像融合,对偶树复小波反变换,指数变换得到去噪以后的图像。实验结果表明,算法融合了两种阈值去噪方法的优点,在明显去噪的同时,更好地保护了图像的边缘信息。

On elastocapillarity:A review

Elastocapillary phenomena involving elastic deformation of solid structures coupled with capillary effects of liquid droplets/films can be observed in a diversity of fields, e.g., biology and microelectromechanical systems （MEMS）. Understanding the physical mechanisms underlying these phenomena is of great interest for the design of new materials and devices by utilizing the effects of surface tension at micro and nano scales. In this paper, some recent developments in the investigations on elastocapillary phenomena are briefly reviewed. Especially, we consider the deformation, adhesion, self-assembly, buckling and wrinkling of ma- terials and devices induced by surface tensions or capillary forces. The main attention is paid to the experimental results of these phenomena and the theoretical analysis meth- ods based on continuum mechanics. Additionally, the applications of these studies in the fields of MEMS, micro/nanometrology, and biomimetic design of advanced materials and devices are discussed.

A Possible Mechanism for the Origin of Ultrastrong Magnetic Field of Magnetars

Growing observations reveal that soft gamma-ray repeaters and anomalous x-ray pulsars are magnetars. Their magnetic fields may achieve 10^14 - 10^15G. We explore the origin of the superstrong magnetic field by considering the magnetization of the ^3P2 superfluid neutrons inside neutron stars （NSs）. By solving the Tolman-Oppenheimer-Volkov equations together with the equation of state adopted by Elgaroy it et al. [Phys. Rev. Lett. 77 （1996） 1428] in the calculation of the neutron pairing gap, we specifically calculate the NS internal structure, the permissible region for ^3P2 superfluid neutrons inside the NS, and the total magnetic moment contributed by the orderly arranged neutron vortexes. The result shows that the induced magnetic field may cover a wide range, which is consistent with the magnetic field predicted by the standard magnetic dipole radiation for pulsar spindown.

俄公司推出硬橡胶聚合物透明3D打印材料

Filamentarno是一家俄罗斯的3D打印材料公司，近日其发布了一系列柔性透明3D打印材料“Prototyper Soft”。据悉，该系列3D打印材料由苯乙烯-丁二烯-苯乙烯这样的硬橡胶聚合物制成。

Dreaming of the Great Rejuvenation of the Chinese Nation

Since the 18th Party Congress in 2012, there has been a steady stream of articles in the Chinese press discussing the ＂Chinese Dream＂ It is a dream of national rejuvenation, of China taking its rightful place in the world. There is no definition of national rejuvenation： nobody knows what it will look like. According to the Chinese leadership, the future models must be found from domestic soil and tradition. Traditionally, China was seen as a civilization at the center of All-Under- Heaven, a non-hegemonic power which relied to force only in order to protect itself against outside aggression. There are two upcoming centennials that serve as major milestones along the way to the rejuvenation, namely the 100th anniversary of the founding of the Communist Party in 2021, and the establishment of the People＇s Republic in 2049. The celebrations then will reveal if China follows this ancient tradition of benevolence, peacefulness and wisdom.

Enhancing China＇s National Image Through Culture Festivals： A Case Study of China Culture Years in Europe

Since the mid-2000s, the PRC has increasingly focused on pursuing cultural diplomacy abroad to improve its national image and enhance cultural soft power. Although China＇s cultural ＂Charm Offensive＂ has not gone unnoticed, a variety of specific activities have not been subject to research so far. This paper, therefore, attempts to fill this research gap by analyzing Chinese state-level cultural diplomacy through a comparative case study of three China Culture Year events held in France （2004）, Italy （2010）, and Germany （2012）. These findings are subsequently compared to the China Culture Year in Australia （2012）, thereby allowing the identification of spatial variations. I argue that the Chinese government applies a general approach of organizing the events abroad by making use of local institu- tions. At the same time, through the strategic selection of events, the festivals portray distinct national images that transmit particular narratives of self-presentation to the European audience and take into account country-specific preferences.