在不确定信息的复杂环境下进行决策是现实中人们经常面对的困难之一,因此具有能够进行良好决策的能力被视为人工智能的重要能力之一.而游戏类型的博弈作为对现实世界的一种高度抽象,具有良定义、易检验算法优劣等特点,成为研究的主流....在不确定信息的复杂环境下进行决策是现实中人们经常面对的困难之一,因此具有能够进行良好决策的能力被视为人工智能的重要能力之一.而游戏类型的博弈作为对现实世界的一种高度抽象,具有良定义、易检验算法优劣等特点,成为研究的主流.其中以掼蛋为代表的扑克类博弈不仅具有他人手牌未知这样的难点,还由于可选出牌动作与他人手牌情况数量庞大等特点,难以进行高效求解.因此,提出了一种软深度蒙特卡洛(soft deep Monte Carlo,SDMC)求解方法.该方法能够更好地融合领域知识,加快策略学习速度,并采用软动作采样策略调整实时决策,提升策略胜率.所提出的SDMC方法训练出的策略模型参加第2届“中国人工智能博弈算法大赛”时获得冠军.与第1届比赛冠军策略和第2届其他策略模型的实验对比证明了该方法在解决掼蛋扑克博弈中的有效性.展开更多
The exploration and identification of antiproliferative phytochemicals have received increased attention in medicinal chemistry. In particular, research focused on the toxicology of marine natural products has increas...The exploration and identification of antiproliferative phytochemicals have received increased attention in medicinal chemistry. In particular, research focused on the toxicology of marine natural products has increased in recent years. Terpenoids, among many secondary metabolites, have been demonstrated to act as effective anticancer agents. Soft corals, a group of marine invertebrates, produce a variety of terpenoids with biofunctional properties. The current study presents the extraction, purification, and identification of sterol congeners from the soft coral Dendronephthya putteri. The method involves 50% chloroform-methanol extraction, polar column fractionation, and analysis through GC-MSn. Dose-dependent antiproliferative activity was observed within the sterol-rich fraction (DPCMH 2-4), which consisted of 3β-hydroxy-Δ5-steroidal congeners. This fraction inhibited the growth of HL-60 and MCF-7 cells with IC50 values of 25.27±1.43 and 22.81±0.15 μg/mL, respectively. Apoptotic body formation, DNA damage, cell cycle arrest, and apoptotic cell signaling pathway activation were also observed, reinforcing the dose-dependent antiproliferative and apoptosis-inducing activity of 3β-hydroxy-Δ5-steroidal congeners. To our knowledge, this is the first report of anticancer agent identification from the soft coral D. putteri. Based on the observations, these steroidal congeners are promising candidates for the development of anticancer drugs.展开更多
文摘在不确定信息的复杂环境下进行决策是现实中人们经常面对的困难之一,因此具有能够进行良好决策的能力被视为人工智能的重要能力之一.而游戏类型的博弈作为对现实世界的一种高度抽象,具有良定义、易检验算法优劣等特点,成为研究的主流.其中以掼蛋为代表的扑克类博弈不仅具有他人手牌未知这样的难点,还由于可选出牌动作与他人手牌情况数量庞大等特点,难以进行高效求解.因此,提出了一种软深度蒙特卡洛(soft deep Monte Carlo,SDMC)求解方法.该方法能够更好地融合领域知识,加快策略学习速度,并采用软动作采样策略调整实时决策,提升策略胜率.所提出的SDMC方法训练出的策略模型参加第2届“中国人工智能博弈算法大赛”时获得冠军.与第1届比赛冠军策略和第2届其他策略模型的实验对比证明了该方法在解决掼蛋扑克博弈中的有效性.
基金Supported by the "Regional Specialized Industry Development Program",Ministry of Trade,Industry,and Energy(MOTIE),Koreasupervised by the Korea Institute for Advancement of Technology(KIAT)
文摘The exploration and identification of antiproliferative phytochemicals have received increased attention in medicinal chemistry. In particular, research focused on the toxicology of marine natural products has increased in recent years. Terpenoids, among many secondary metabolites, have been demonstrated to act as effective anticancer agents. Soft corals, a group of marine invertebrates, produce a variety of terpenoids with biofunctional properties. The current study presents the extraction, purification, and identification of sterol congeners from the soft coral Dendronephthya putteri. The method involves 50% chloroform-methanol extraction, polar column fractionation, and analysis through GC-MSn. Dose-dependent antiproliferative activity was observed within the sterol-rich fraction (DPCMH 2-4), which consisted of 3β-hydroxy-Δ5-steroidal congeners. This fraction inhibited the growth of HL-60 and MCF-7 cells with IC50 values of 25.27±1.43 and 22.81±0.15 μg/mL, respectively. Apoptotic body formation, DNA damage, cell cycle arrest, and apoptotic cell signaling pathway activation were also observed, reinforcing the dose-dependent antiproliferative and apoptosis-inducing activity of 3β-hydroxy-Δ5-steroidal congeners. To our knowledge, this is the first report of anticancer agent identification from the soft coral D. putteri. Based on the observations, these steroidal congeners are promising candidates for the development of anticancer drugs.
