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Consistent and Specific Multi-View Functional Brain Networks Fusion for Autism Spectrum Disorder Diagnosis
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作者 Chaojun Zhang Chengcheng Wang +1 位作者 Limei Zhang Yunling Ma 《Journal of Applied Mathematics and Physics》 2023年第7期1914-1929,共16页
Functional brain networks (FBN) based on resting-state functional magnetic resonance imaging (rs-fMRI) have become an important tool for exploring underlying organization patterns in the brain, which can provide an ob... Functional brain networks (FBN) based on resting-state functional magnetic resonance imaging (rs-fMRI) have become an important tool for exploring underlying organization patterns in the brain, which can provide an objective basis for brain disorders such as autistic spectrum disorder (ASD). Due to its importance, researchers have proposed a number of FBN estimation methods. However, most existing methods only model a type of functional connection relationship between brain regions-of-interest (ROIs), such as partial correlation or full correlation, which is difficult to fully capture the subtle connections among ROIs since these connections are extremely complex. Motivated by the multi-view learning, in this study we propose a novel Consistent and Specific Multi-view FBNs Fusion (CSMF) approach. Concretely, we first construct multi-view FBNs (i.e., multiple types of FBNs modelling various relationships among ROIs), and then these FBNs are decomposed into a consistent representation matrix and their own specific matrices which capture their common and unique information, respectively. Lastly, to obtain a better brain representation, it is fusing the consistent and specific representation matrices in the latent representation spaces of FBNs, but not directly fusing the original FBNs. This potentially makes it more easily to find the comprehensively brain connections. The experimental results of ASD identification on the ABIDE datasets validate the effectiveness of our proposed method compared to several state-of-the-art methods. Our proposed CSMF method achieved 72.8% and 76.67% classification performance on the ABIDE dataset. 展开更多
关键词 functional Brain Network FUSION CONSISTENCY SPECIFICITY Autism spectrum Disorder
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239Pu alpha spectrum analysis based on PIPS detector response function and variations with vacuum and distance 被引量:7
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作者 Rui Shi Xian-Guo Tuo +3 位作者 Huai-Liang Li Jian-Bo Yang Yi Cheng Hong-Long Zheng 《Nuclear Science and Techniques》 SCIE CAS CSCD 2017年第1期20-26,共7页
Effect factors of the absorption of the source,air,entrance window,and dead layer of a detector must be considered in the measurement of monoenergetic alpha particles,along with statistical noise and other factors tha... Effect factors of the absorption of the source,air,entrance window,and dead layer of a detector must be considered in the measurement of monoenergetic alpha particles,along with statistical noise and other factors that collectively cause the alpha spectrum to exhibit a well-known low-energy tail.Therefore,the estabUshment of an alpha spectrum detector response function from the perspective of a signaling system must consider the various factors mentioned above.The detector response function is the convolution of an alphaparticle pulse function,two exponential functions,and a Gaussian function,followed by calculation of the parameters of the detector response function using the weighted leastsquares fitting method as proposed in this paper.In our experiment,^(239)Pu alpha spectra were measured by a highresolution,passivated implanted planar silicon(PIPS)detector at 10 levels of vacuum and 10 source-detector distances.The spectrum-fitting results were excellent as evaluated by reduced Chi-square(x^2) and correlation coefficients.Finally,the variation of parameters with vacuum level and source-detector distance was studied.Results demonstrate that σ,τ_1,and τ_2 exhibit no obvious trend of variation with vacuum in the range 2000-20,000 mTorr,and at a confidence level of 95%,the values of τ_1 and τ_2 decline in a similar fashion with source-detector distance by the power exponential function,while the value of a declines linearly. 展开更多
关键词 ALPHA spectrum DETECTOR response function WEIGHTED least SQUARES PIPS DETECTOR
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A proposed directional function and wind-wave directional spectrum 被引量:4
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作者 Wen Shengchang Wu Kejian +1 位作者 Guan Changlong Sun Shicai and Zhang Dacuo (Institute of Physical Oceanography, Ocean University of Oingdao, Oingdao 266003, China) 《Acta Oceanologica Sinica》 SCIE CAS CSCD 1995年第2期155-166,共12页
Aproposeddirectionalfunctionandwind-wavedirectionalspectrum¥WenShengchang;WuKejian;GuanChanglong;SunShicaian... Aproposeddirectionalfunctionandwind-wavedirectionalspectrum¥WenShengchang;WuKejian;GuanChanglong;SunShicaiandZhangDacuo(Recei... 展开更多
关键词 Wind-wave directional function directional spectrum
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The Effects of Xbox Kinect Active Video Gaming on Executive Function, Inhibition, in Children with and without Autism Spectrum Disorder: A Pilot Study 被引量:2
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作者 Daphne Golden Ling-Yin Liang Nancy Getchell 《Journal of Behavioral and Brain Science》 2022年第6期287-301,共15页
The purpose of this study was to compare the effects of sedentary video gaming (SVG), active video gaming (AVG), and brisk walking (WLK) on inhibition and reaction time using the Flanker task in boys with and without ... The purpose of this study was to compare the effects of sedentary video gaming (SVG), active video gaming (AVG), and brisk walking (WLK) on inhibition and reaction time using the Flanker task in boys with and without autism spectrum disorder (ASD). We had 9 participants with ASD and 10 age-matched participants without ASD perform 20-minute bouts of each activity, and then had them take the Flanker test. Dependent measures were reaction time (RT) and accuracy (ACC). A Chi-Square analysis revealed that the ASD and TD groups significantly differed in the percent of participants who improved in both of these measures. Next, we looked at each of the conditions exclusively within the ASD group and compared congruent and incongruent trials. In the AVG condition, participants improved a significantly higher percentage on ACC. In the SVG condition, participants improved a significantly higher percentage on incongruent in RT;for ACC, a higher percentage improved on the congruent trials. In WLK, participants improved a significantly higher percentage in RT in the congruent condition. 展开更多
关键词 Autism spectrum Disorder Exergaming Physical Activity Cognitive function
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MODAL PARAMETERS EXTRACTION WITH CROSS CORRELATION FUNCTION AND CROSS POWER SPECTRUM UNDER UNKNOWN EXCITATION 被引量:1
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作者 郑敏 申凡 +1 位作者 陈怀海 鲍明 《Chinese Journal of Aeronautics》 SCIE EI CSCD 2000年第1期19-23,共5页
In most of real operational conditions only response data are measurable while the actual excitations are unknown, so modal parameter must be extracted only from responses. This paper gives a theoretical formulation f... In most of real operational conditions only response data are measurable while the actual excitations are unknown, so modal parameter must be extracted only from responses. This paper gives a theoretical formulation for the cross correlation functions and cross power spectra between the outputs under the assumption of white noise excitation. It widens the field of modal analysis under ambient excitation because many classical methods by impulse response functions or frequency response functions can be used easily for modal analysis under unknown excitation. The Polyreference Complex Exponential method and Eigensystem Realization Algorithm using cross correlation functions in time domain and Orthogonal Polynomial method using cross power spectra in frequency domain are applied to a steel frame to extract modal parameters under operational conditions. The modal properties of the steel frame from these three methods are compared with those from frequency response functions analysis. The results show that the modal analysis method using cross correlation functions or cross power spectra presented in this paper can extract modal parameters efficiently under unknown excitation. 展开更多
关键词 modal analysis cross correlation function cross power spectrum unknown excitation operating modal
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Phase spectrum estimation of the seismic wavelet based on a criterion function 被引量:4
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作者 Yu Yongcai Wang Shangxu +1 位作者 Yuan Sanyi Qi Pengfei 《Petroleum Science》 SCIE CAS CSCD 2012年第2期170-181,共12页
Phase spectrum estimation of the seismic wavelet is an important issue in high-resolution seismic data processing and interpretation. On the basis of two patterns of constant-phase rotation and root transform for wave... Phase spectrum estimation of the seismic wavelet is an important issue in high-resolution seismic data processing and interpretation. On the basis of two patterns of constant-phase rotation and root transform for wavelet phase spectrum variation, we introduce six sparse criteria, including Lu's improved kurtosis criterion, the parsimony criterion, exponential transform criterion, Sech criterion, Cauchy criterion, and the modified Cauchy criterion, to phase spectrum estimation of the seismic wavelet, obtaining an equivalent effect to the kurtosis criterion. Through numerical experiments, we find that when the reflectivity is not a sparse sequence, the estimated phase spectrum of the seismic wavelet based on the criterion function will deviate from the true value. In order to eliminate the influence of non-sparse reflectivity series in a single trace, we apply the method to the multi-trace seismogram, improving the accuracy of seismic wavelet phase spectrum estimation. 展开更多
关键词 地震子波估计 相位谱 谱估计 标准 基础 地震资料处理 柯西准则 高分辨率
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Spectrum Response Estimation for Deep-Water Floating Platforms via Retardation Function Representation 被引量:1
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作者 LIU Fushun LIU Chengcheng +1 位作者 CHEN Jiefeng WANG Bin 《Journal of Ocean University of China》 SCIE CAS CSCD 2017年第4期609-616,共8页
The key concept of spectrum response estimation with commercial software,such as the SESAM software tool,typically includes two main steps:finding a suitable loading spectrum and computing the response amplitude opera... The key concept of spectrum response estimation with commercial software,such as the SESAM software tool,typically includes two main steps:finding a suitable loading spectrum and computing the response amplitude operators(RAOs) subjected to a frequency-specified wave component.In this paper,we propose a nontraditional spectrum response estimation method that uses a numerical representation of the retardation functions.Based on estimated added mass and damping matrices of the structure,we decompose and replace the convolution terms with a series of poles and corresponding residues in the Laplace domain.Then,we estimate the power density corresponding to each frequency component using the improved periodogram method.The advantage of this approach is that the frequency-dependent motion equations in the time domain can be transformed into the Laplace domain without requiring Laplace-domain expressions for the added mass and damping.To validate the proposed method,we use a numerical semi-submerged pontoon from the SESAM.The numerical results show that the responses of the proposed method match well with those obtained from the traditional method.Furthermore,the estimated spectrum also matches well,which indicates its potential application to deep-water floating structures. 展开更多
关键词 估计方法 光谱响应 深水 SESAM 平台 悬置 拉普拉斯 频率分量
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Geant4 simulation of multi-sphere spectrometer response function and the detection of 241Am–Be neutron spectrum
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作者 Xiao-Fei Jiang Jing Cao +1 位作者 Chun-Yu Jiang Ze-Jie Yin 《Nuclear Science and Techniques》 SCIE CAS CSCD 2017年第12期204-208,共5页
This paper is aimed at detecting the neutron spectrum of^(241)Am–Be, a widely used neutron source, with the SP9 ~3He proportional counter, which is a multi-sphere spectrometer system of eight thermal neutron detector... This paper is aimed at detecting the neutron spectrum of^(241)Am–Be, a widely used neutron source, with the SP9 ~3He proportional counter, which is a multi-sphere spectrometer system of eight thermal neutron detectors embedded in eight polyethylene(PE) spheres of varying diameters. The transport processes of a neutron in the multi-sphere spectrometer are simulated using the Geant4 code. Two sets of response functions of the PE spheres are obtained for calculating the^(241)Am–Be neutron spectrum.Response Function 1 utilizes the thermal neutron scattering model G4 Neutron HPThermal Scattering for neutron energies of ≤4 eV, and Response Function 2 has no thermal treatment. Neutron spectra of an^(241)Am–Be neutron source are measured and compared to those calculated by using the response functions. The results show that response function with thermal treatment is more accurate and closer to the real spectrum. 展开更多
关键词 Response function NEUTRON energy spectrum Multi-sphere GEANT4 241Am–Be G4NeutronHPThermalScattering
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Simulation of γ spectrum-shifting based on the parameter adjustment of Gaussian function space 被引量:1
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作者 HUANG Hongquan SHAO qiang +2 位作者 DING Weicheng FANG Fang GONG Dichen 《Nuclear Science and Techniques》 SCIE CAS CSCD 2013年第6期99-104,共6页
Based on the statistical characteristics of energy spectrum and the features of spectrum-shifting in spectrometry,the parameter adjustment method of Gaussian function space was applied in the simulation of spectrum-sh... Based on the statistical characteristics of energy spectrum and the features of spectrum-shifting in spectrometry,the parameter adjustment method of Gaussian function space was applied in the simulation of spectrum-shifting.The transient characteristics of energy spectrum were described by the Gaussian function space,and then the Gaussian function space was transferred by parameter adjustment method.Furthermore,the spectrum-shifting in measurement of energy spectrum was simulated.The applied example shows that the parameters can be adjusted flexibly by this method to meet the various requirements in simulation of energy spectrum-shifting.This method was one parameterized simulation method with good performance for the practical application. 展开更多
关键词 高斯函数 参数调整 空间仿真 基础 Γ谱 仿真应用 函数空间 模拟方法
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A single diffractive optical element implementing spectrum-splitting and beam-concentration functions simultaneously with high diffraction efficiency 被引量:2
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作者 叶佳声 王进泽 +3 位作者 黄庆礼 董碧珍 张岩 杨国桢 《Chinese Physics B》 SCIE EI CAS CSCD 2013年第3期44-49,共6页
In this paper,a novel method is proposed and employed to design a single diffractive optical element(DOE) for implementing spectrum-splitting and beam-concentration(SSBC) functions simultaneously.We develop an optimiz... In this paper,a novel method is proposed and employed to design a single diffractive optical element(DOE) for implementing spectrum-splitting and beam-concentration(SSBC) functions simultaneously.We develop an optimization algorithm,through which the SSBC DOE can be optimized within an arbitrary thickness range according to the limitations of modern photolithography technology.Theoretical simulation results reveal that the designed SSBC DOE has a high optical focusing efficiency.It is expected that the designed SSBC DOE should have practical applications in high-efficiency solar cell systems. 展开更多
关键词 衍射光学元件 衍射效率 浓度 分裂 频谱 优化算法 光刻技术 理论模拟
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The Relationship between Executive Functioning and Emotional Intelligence in Children with Autism Spectrum Disorder
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作者 Jennifer L. Reynolds Alan J. Lincoln +2 位作者 Roya Iravani Varvara Toma Shamayne Brown 《Open Journal of Psychiatry》 2018年第3期253-262,共10页
Children with Autism Spectrum Disorder (ASD) demonstrate marked deficits in the ability to initiate, maintain and sustain meaningful social interaction. While the social-emotional deficits represent a core set of prob... Children with Autism Spectrum Disorder (ASD) demonstrate marked deficits in the ability to initiate, maintain and sustain meaningful social interaction. While the social-emotional deficits represent a core set of problems, persons with ASD also demonstrate significant problems in initiating, sustaining and maintaining appropriate goal directed behaviors. Emotional Intelligence (EI) is a construct that has been successfully applied to a range of skills that allow for the prediction of competent human social behavior. Executive Functions (EF) refer to constructs involving cognitive abilities necessary for initiating, sustaining and maintaining purposeful goal-oriented behavior. While both children and adults with ASD have previously shown to have atypical patterns of EF skills, little is known about EI in either children or adults with ASD. Moreover, there is no study examining the relationship between EI and EF that has been reported in individuals with ASD. The current study examined the relationship between EF and EI in children with ASD. Twenty children with ASD were compared to twenty neurotypical children on self-report and clinical assessments of EI and EF. Although the relationship between EF and EI was not statistically significant, results showed that children with ASD have deficits in interpersonal skills, intrapersonal skills and overall EI when compared to their neurotypical peers. These results suggest that EF and EI are relatively independent domains of development that show compromise in persons with ASD and each may be necessary to support typical socially directed behaviors. 展开更多
关键词 EXECUTIVE functionING EMOTIONAL Intelligence AUTISM spectrum DISORDER
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Correlation between cerebral cortex changes and clinical features in patients with neuromyelitis optica spectrum disorder with normal-appearing brain tissue:a case-control study 被引量:1
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作者 Chuxin Huang Yanyu Li +5 位作者 Yanjing Chen Xuan Liao Huiting Zhang Zhiyuan Wang Jun Liu Wei Lu 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第11期2520-2525,共6页
Neuro myelitis optica spectrum disorder(NMOSD) is an inflammatory demyelinating disease of the central nervous system.However,whether and how cortical changes occur in NMOSD with normal-appearing brain tissue,or wheth... Neuro myelitis optica spectrum disorder(NMOSD) is an inflammatory demyelinating disease of the central nervous system.However,whether and how cortical changes occur in NMOSD with normal-appearing brain tissue,or whether any cortical changes correlate with clinical chara cteristics,is not completely clear.The current study recruited 43 patients with NMOSD who had normal-appearing brain tissue and 45 healthy controls matched for age,sex,and educational background from December 2020 to February 2022.A surface-based morphological analysis of high-resolution T1-weighted structural magnetic resonance images was used to calculate the cortical thickness,sulcal depth,and gyrification index.Analysis showed that cortical thickness in the bilate ral rostral middle frontal gyrus and left superior frontal gyrus was lower in the patients with NMOSD than in the control participants.Subgroup analysis of the patients with NMOSD indicated that compared with those who did not have any optic neuritis episodes,those who did have such episodes exhibited noticeably thinner cortex in the bilateral cuneus,superior parietal co rtex,and pericalcarine co rtex.Correlation analysis indicated that co rtical thickness in the bilateral rostral middle frontal gyrus was positively correlated with scores on the Digit Symbol Substitution Test and negatively correlated with scores on the Trail Making Test and the Expanded Disability Status Scale.These results are evidence that cortical thinning of the bilateral regional frontal cortex occurs in patients with NMOSD who have normal-appearing brain tissue,and that the degree of thinning is correlated with clinical disability and cognitive function.These findings will help im prove our understanding of the imaging chara cteristics in NMOSD and their potential clinical significance. 展开更多
关键词 cognitive function cortical thickness Expanded Disability Status Scale GYRIFICATION magnetic resonance imaging neuromyelitis optica spectrum disorder normal-appearing brain tissue rostral middle frontal gyrus sulcal depth superior frontal gyrus
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GREEN'S FUNCTION AND THE POINTWISE BEHAVIORS OF THE VLASOV-POISSON-FOKKER-PLANCK SYSTEM
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作者 钟明溁 《Acta Mathematica Scientia》 SCIE CSCD 2023年第1期205-236,共32页
The pointwise space-time behaviors of the Green’s function and the global solution to the Vlasov-Poisson-Fokker-Planck(VPFP)system in three dimensional space are studied in this paper.It is shown that the Green’s fu... The pointwise space-time behaviors of the Green’s function and the global solution to the Vlasov-Poisson-Fokker-Planck(VPFP)system in three dimensional space are studied in this paper.It is shown that the Green’s function consists of the diffusion waves decaying exponentially in time but algebraically in space,and the singular kinetic waves which become smooth for all(t,x,v)when t>0.Furthermore,we establish the pointwise space-time behaviors of the global solution to the nonlinear VPFP system when the initial data is not necessarily smooth in terms of the Green’s function. 展开更多
关键词 Vlasov-Poisson-Fokker-Planck system Green’s function pointwise behavior spectrum structure
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Chrestenson Spectrum and Auto-Correlation Function of Inverse Permutations of Quick Trickle Permutations
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作者 WANG Jue LI Zhengchao ZHAO Yaqun 《Wuhan University Journal of Natural Sciences》 CAS 2008年第5期587-590,共4页
In this paper,a sufficient and necessary condition of quick trickle permutations is given from the point of inverse per-mutations. The bridge is built between quick trickle permutations and m-value logic functions. By... In this paper,a sufficient and necessary condition of quick trickle permutations is given from the point of inverse per-mutations. The bridge is built between quick trickle permutations and m-value logic functions. By the methods of the Chrestenson spectrum of m-value logic functions and the auto-correlation func-tion of m-value logic functions to investigate the Chrestenson spectral characteristics and the auto-correlation function charac-teristics of inverse permutations of quick trickle permutations,a determinant arithmetic of quick trickle permutations is given. Us-ing the results,it becomes easy to judge that a permutation is a quick trickle permutation or not by using computer. This gives a new pathway to study constructions and enumerations of quick trickle permutations. 展开更多
关键词 速流排列 光谱 逻辑功能 通讯技术 编码
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Research on Adaptive TSSA-HKRVM Model for Regression Prediction of Crane Load Spectrum
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作者 Dong Qing Qi Song +1 位作者 Shuangyun Huang Gening Xu 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第9期2345-2370,共26页
For the randomness of crane working load leading to the decrease of load spectrum prediction accuracy with time,an adaptive TSSA-HKRVM model for crane load spectrum regression prediction is proposed.The heterogeneous ... For the randomness of crane working load leading to the decrease of load spectrum prediction accuracy with time,an adaptive TSSA-HKRVM model for crane load spectrum regression prediction is proposed.The heterogeneous kernel relevance vector machine model(HKRVM)with comprehensive expression ability is established using the complementary advantages of various kernel functions.The combination strategy consisting of refraction reverse learning,golden sine,and Cauchy mutation+logistic chaotic perturbation is introduced to form a multi-strategy improved sparrow algorithm(TSSA),thus optimizing the relevant parameters of HKRVM.The adaptive updatingmechanismof the heterogeneous kernel RVMmodel under themulti-strategy improved sparrow algorithm(TSSA-HKMRVM)is defined by the sliding window design theory.Based on the sample data of the measured load spectrum,the trained adaptive TSSA-HKRVMmodel is employed to complete the prediction of the crane equivalent load spectrum.Applying this method toQD20/10 t×43m×12mgeneral bridge crane,the results show that:compared with other prediction models,although the complexity of the adaptive TSSA-HKRVMmodel is relatively high,the prediction accuracy of the load spectrum under long periods has been effectively improved,and the completeness of the load information during thewhole life cycle is relatively higher,with better applicability. 展开更多
关键词 Heterogeneous kernel function RVM TSSA adaptive update mechanism equivalent load spectrum
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Estimating Brain Functional Networks Based on Spatiotemporal Higher-Order Correlations for Autism Identification
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作者 Mengxue Pang Limei Zhang +2 位作者 Xueyan Liu Tinglin Zhang Shufeng Zhou 《Journal of Computer and Communications》 2023年第8期149-164,共16页
Brain functional network (BFN) has become an important tool for the analysis and diagnosis of brain diseases, and how to build a high-quality BFN based on resting-state functional magnetic resonance imaging (rs-fMRI) ... Brain functional network (BFN) has become an important tool for the analysis and diagnosis of brain diseases, and how to build a high-quality BFN based on resting-state functional magnetic resonance imaging (rs-fMRI) has become a growing concern in the neuroscience community. Although some methods have been proposed to construct a high-quality BFN, they only encode the spatial characteristics of the ROIs, ignoring the temporal characteristics. As a result, it becomes challenging to accurately capture the true state of the brain. To address this problem, we propose a novel method to construct a higher-order BFN, considering both temporal and spatial domain characteristics. In particular, we get the characteristics of the temporal domain by differentiating the rs-fMRI signal itself, and then we integrate the information of the spatial domain and temporal domain to build a high-order BFN. To evaluate the proposed method, we conduct our experiments on ABIDE database to identify subjects with Autism Spectrum Disorder (ASD) from normal controls. Experimental results show that our method can achieve higher performance than baseline methods. 展开更多
关键词 functional MRI HOFN DIFFERENCE Autism spectrum Disorder
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rTMS联合综合康复干预对孤独症谱系障碍患儿临床症状及语言功能康复的影响
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作者 刘超宇 胡继红 +3 位作者 何金华 罗伟 张玲 黄伊萌 《中国听力语言康复科学杂志》 2024年第2期221-224,共4页
目的探究重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)联合综合康复干预对孤独症谱系障碍(autism spectrum disorder,ASD)患儿临床症状及语言功能康复的影响。方法选取2021年8月~2023年5月在湖南省儿童医院康复... 目的探究重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)联合综合康复干预对孤独症谱系障碍(autism spectrum disorder,ASD)患儿临床症状及语言功能康复的影响。方法选取2021年8月~2023年5月在湖南省儿童医院康复中心接受治疗的141例ASD儿童,采用随机数表法分为观察组(72例)和对照组(69例)。对照组患儿给予常规综合康复治疗,观察组患儿在对照组基础上给予rTMS治疗,并对所有患儿进行5个月跟踪随访。对比相关参数及量表评分。结果治疗后,观察组孤独症行为量表(autism behavior checklist,ABC)和儿童孤独症评定量表(childhood autism rating s cale,CARS)评分均显著低于对照组(P<0.05),对比0~6岁小儿神经心理发育检查表得分,观察组治疗后适应能力、社交能力及语言功能得分均显著高于对照组(P<0.05),两组粗大动作、精细动作得分无显著差异(P>0.05)。末次随访时,观察组患儿的言语行为里程碑评估和安置计划(verbal behavior milestones assessment and placement program,VB-MAPP)得分显著高于对照组(P<0.05)。结论rTMS联合综合康复干预可显著改善ASD症状,提高患儿神经、语言、社交及感知等能力。 展开更多
关键词 重复经颅磁刺激 综合康复干预 孤独症谱系障碍 临床症状 语言功能
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基于模块化思想的航空装备保障设备功能型谱标准研究
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作者 曾照洋 刘敏航 林聪 《中国标准化》 2024年第5期102-109,共8页
为了研究如何将MOSA(模块化开放系统方法)应用于航空装备保障设备的设计研制工作中,本文分析了MOSA的发展历程以及MIL-STD-864如何将模块化设计方法应用于保障设备设计研制领域,阐明了美军保障设备模块化设计方法对我军保障设备发展的... 为了研究如何将MOSA(模块化开放系统方法)应用于航空装备保障设备的设计研制工作中,本文分析了MOSA的发展历程以及MIL-STD-864如何将模块化设计方法应用于保障设备设计研制领域,阐明了美军保障设备模块化设计方法对我军保障设备发展的启示。以此为基础,进一步开展我军航空装备保障设备功能型谱发展建议研究,先后提出了保障设备模块化设计方法以及模块化保障设备功能型谱设计方法,明确了标准化对于保障设备模块化设计的意义,提出了航空装备保障设备功能型谱。为推进保障设备模块化设计思路在我军的应用提供了引导和支撑。 展开更多
关键词 保障设备 航空装备 MOSA 功能型谱
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小剂量利妥昔单抗联合甲泼尼龙序贯治疗视神经脊髓炎谱系疾病疗效观察
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作者 辜忠灵 甘秀红 丁秀英 《中国药业》 CAS 2024年第2期90-93,共4页
目的探讨小剂量利妥昔单抗联合甲泼尼龙序贯治疗视神经脊髓炎谱系疾病(NMOSD)的临床疗效。方法选取医院2017年1月至2020年6月收治的NMOSD患者112例,随机分为观察组和对照组,各56例。两组患者均予注射用甲泼尼龙琥珀酸钠静脉冲击治疗(100... 目的探讨小剂量利妥昔单抗联合甲泼尼龙序贯治疗视神经脊髓炎谱系疾病(NMOSD)的临床疗效。方法选取医院2017年1月至2020年6月收治的NMOSD患者112例,随机分为观察组和对照组,各56例。两组患者均予注射用甲泼尼龙琥珀酸钠静脉冲击治疗(1000μg/d)3~5 d,逐渐减至125 mg/d,后改为口服甲泼尼龙片48 mg/d(继续减量至4 mg/d维持或停用);观察组患者加用利妥昔单抗注射液100 mg静脉滴注,每周1次,连续治疗4周,6~12个月重复使用。结果治疗后,观察组患者年复发率、扩展残疾状态量表(EDSS)评分均显著低于对照组(P<0.05),外周血T淋巴细胞CD_(3)^(+)和CD_(4)^(+)水平及CD_(4)^(+)/CD_(8)^(+)均显著高于对照组(P<0.05),血清白细胞介素6(IL-6)、白细胞介素17(IL-17)及肿瘤坏死因子-α(TNF-α)水平均显著低于对照组(P<0.05)。两组患者治疗后的天门冬氨酸氨基转移酶、丙氨酸氨基转移酶、血尿素氮、血清肌酐水平均无显著改变(P>0.05)。观察组与对照组不良反应发生率相当(7.14%比12.50%,P>0.05)。结论小剂量利妥昔单抗联合甲泼尼龙序贯治疗NMOSD,能有效改善患者的病情及机体炎症状况,提高免疫功能。 展开更多
关键词 视神经脊髓炎谱系疾病 利妥昔单抗 小剂量 甲泼尼龙 序贯治疗 免疫功能 炎性因子:临床疗效
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GaSe/ZnS异质结的结构和界面性质的第一性原理研究
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作者 鲍爱达 马永强 郭鑫 《人工晶体学报》 CAS 北大核心 2024年第4期669-675,共7页
本文设计了一种GaSe/ZnS范德瓦耳斯异质结构(vdWH),并用第一性原理计算系统地分析了该异质结构的几何、电子、输运性质。通过结合能、声子谱、从头算分子动力学(AIMD)模拟验证了所构建GaSe/ZnS范德瓦耳斯异质结构的稳定性。详细计算了Ga... 本文设计了一种GaSe/ZnS范德瓦耳斯异质结构(vdWH),并用第一性原理计算系统地分析了该异质结构的几何、电子、输运性质。通过结合能、声子谱、从头算分子动力学(AIMD)模拟验证了所构建GaSe/ZnS范德瓦耳斯异质结构的稳定性。详细计算了GaSe/ZnS vdWH界面性质中的平面平均电子密度差和平均静电势。结果表明,GaSe/ZnS vdWH是一种直接带隙为2.19 eV,载流子迁移率较高的异质结构。其中,沿x方向的电子迁移率可达1394.63 cm^(2)·V^(-1)·s^(-1),而沿y方向的电子迁移率可达1913.18 cm^(2)·V^(-1)·s^(-1),性能优异,有望应用于电子纳米器件。 展开更多
关键词 第一性原理 密度泛函理论 GaSe/ZnS范德瓦耳斯异质结构 声子色散谱 载流子迁移率
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