Management of Sphenoidal Sinus Lesions by Septal-assisted Approach: Surgical Skills and Advantages

Summary： The aim of this study was to develop a less invasive trans-septal approach for the endo- scopic management of sphenoid sinus lesions. We performed a septal-assisted surgical procedure for endoscopic sphenoidectomy in 38 patients with isolated or combined sphenoidal sinus lesions, including fungal balls, mucoceles, purulent cystic sphenoidal sinusitis, etc. The posterior portion of the nasal sep- turn became flexible after removal of the vomer and the sphenoidal rostrum. The superior portion of the common meatus was expanded to accommodate the endoscope after the septum was repositioned con- tra-laterally. The lesions were individually managed through the enlarged ostiums while damage to the mucosa of the front sphenoidal wall was avoided. All the procedures were completed successfully without intraoperative complications, and the bony ostiums were identified easily and enlarged accu- rately. During the follow-up period of 16 weeks to 2 years, no re-atresia or restenosis was observed. The recurrence rate was 0. No postoperative complications were recorded. All the responses from the pa- tients were satisfactory. It was concluded that endoscopic sphenoidectomy assisted by trans-septal ap- proach is a feasible, safe, effective and minimally invasive approach for selected cases with unilateral or bilateral lesions in the sphenoid sinuses.

Treatment of Organized Hematoma of the Sphenoid Sinus with Pre-Operative Embolization and Endoscopic Resection

The differential diagnosis for expansile masses of the sphenoid sinuses includes both benign and malignant lesions. We herein present a case of a 79-year-old female who presented with chronic epistaxis and an expansile soft tissue mass centered in the sphenoid sinus with erosion of the skull base. Endoscopic resection of the lesion was performed, with histopathological examination revealing organized hematoma. To our knowl- edge, this is the first reported case of sphenoid sinus organizing hematoma treated with pre-operative embolization followed by endoscopic excision.

Study of the relationship between sphenoid sinus volume and protrusions in the sphenoid sinus

The relationship between the volume of sphenoid sinus (SS) and the prevalence of internal carotid artery (ICA) and optic nerve (ON) protrusions in the SS was studied by using high-resolution CT imaging. The ICA and ON protrusions in SS were observed in randomly selected normal head CT scanning images from 350 adult subjects. Ac-cording to the incidence of ICA protrusion, three groups were divided into no ICA protrusion (70.75%), unilateral protrusion (8.68%) and bi-lateral protrusions (20.57%). The ON protrusion accounted for 16% in 350 subjects and accom-panied absolutely with ICA protrusion, but ICA protrusion appeared without accompanying with ON protrusion. The SS volume depended upon the protrusions in it and showed statistical dif-ferences, without ICA protrusion, the smallest size (11.16 ± 1.60) cm3;the unilateral protrusion, medium size (14.20 ± 1.80) cm3 and the bilateral protrusion, the largest size (25.03 ± 2.21) cm3. By observing 3D reconstructed models of ON and SS, we found ON was adjacent to SS (46%) and to posterior ethmoid sinuses (44%). The current study indicates that SS volume is varied with numbers of the protrusions and that ON location varies with the pneumatization of SS. Our results provide an anatomical basis to the surgeries for SS and its surrounding structures.

Application and Care of Two Kinds of Sphenoid Sinus Packing Materials after Pituitary Tumor Resection with the Transnasal Endoscopic Approach

Background: Neuroendoscopic transsphenoidal approach for resection of pituitary adenomas has the advantages of less damage, fewer complications, and a faster recovery than the traditional approach and has beening favored by neurosurgeons. However, there has no standard method of selecting suitable packing materials after the operation to relieve pain in patients and achieve the ideal hemostatic effect. We compared the postoperative complications and treatment effects of two different packing materials in patients with pituitary adenomas. Objective: To investigate the advantages and disadvantages of using a catheter balloon and iodoform gauze for hemostasis in patients undergoing pituitary tumor resection by neuroendoscopic transsphenoidal approach. Materials and Methods: We retrospectively analyzed these data of 48 cases treated with pituitary adenoma resection by the single nasal approach from January 2018 to October 2019 in Sun Yat-sen University Cancer Center. According to the type of sphenoid sinus packing material used, these patients were divided into balloon tamponade oppression group (24 cases) and tela iodoformum oppression group (24 cases), respectively. The balloon tamponade oppression group received catheter balloon tamponade oppression hemostasis, and the tela iodoformum oppression group underwent tela iodoformum oppression hemostasis. The outcomes and complications were compared between the two groups in which two kinds of sphenoid sinus packing materials were used for hemostasis after tumor resection by transnasal endoscopic approach. For the catheter balloon compression hemostasis method, on account of the plasticity of the balloon, the volume of water in the balloon can be adjusted according to the size of the patient’s own sphenoid cavity. The amount of bleeding and several complications in terms of discomfort during placement and removal of the packing material, rebleeding after removal of the packing, cerebrospinal fluid rhinorrhea and electrolyte disturbance are compared between the two groups. Results: 48 patients were enrolled. The two groups’ data of patients were similar in age structure, sex ratio, tumor size at baseline and so on. No complications, such as abscess formation, were found in both groups. The success rate in the compression with catheter balloon group was 100% (24 of 24 patients);and in the iodoform gauze group 83.33% (20 of 24 patients). A catheter balloon was more successful in stopping bleeding at early stage than iodoform gauze. There were no statistically significant differences in the hospitalization stay time, operating day to discharge day and tampon indwelling time (P > 0.05). There were also no significant differences in pairwise comparison between the catheter balloon group and iodoform gauze groups in the incidence of cerebrospinal fluid rhinorrhea or electrolyte disturbance between the two groups (P > 0.05). The incidence of headache in the catheter balloon group was statistically significantly lower than that in the iodoform gauze group (P < 0.05). Conclusion: In patients undergoing endoscopic pituitary tumor resection, compression and hemostasis by means of catheterization expansion lead to lower rates of injury and complications and have a good effect, so this method is worthy of being recommended for clinical practice.

Solitary Fungus Ball of the Sphenoid Sinus

A 50-year-old woman with long standing nonspecific disturbing headaches of the mid-face and rear of the head plus retro-orbital pain for about one year duration was proved to suffer from the fungus ball involvement of the left sphenoid sinus after operation. The diagnosis was established by histopathologic examination of the specimen removed at the time of operation.

蝶窦气化停滞的影像学表现及鉴别诊断

目的分析蝶窦气化停滞的CT和MRI影像学表现,并与蝶骨区骨、软骨源性肿瘤及肿瘤样病变鉴别。方法回顾性分析13例蝶窦气化停滞和20例蝶骨区骨源性肿瘤的CT及MRI资料,包括发生部位、大小、密度、有无膨胀、钙化、骨皮质改变,MRI信号、抑脂后信号改变、强化程度、邻近结构改变等,并进行统计学比较。结果蝶窦气化停滞多见于蝶骨体(4例)、翼突(3例)和多部位受累(6例)。停滞区域以混合密度为主,最长径为0.8~4.1 cm,钙化7例,无膨胀性改变13例,骨皮质完整13例;MRI T1WI高信号11例,等信号2例,T2WI高信号10例,等信号3例,抑脂后信号减低13例,无明显强化10例,轻微强化3例。邻近结构无改变13例。结论蝶窦气化停滞是少见解剖变异,以混合密度为主,骨皮质完整,无膨胀性改变,MRI抑脂信号减低,无明显强化有助于鉴别。

经鼻内镜手术治疗以眼部症状为首发的真菌性蝶窦炎

目的探讨以眼部症状为首发的真菌性蝶窦炎的早期诊断及导航辅助下真菌病变清除术。方法对2007年1月-2022年12月广州市中山大学附属第一医院耳鼻咽喉科收治的17例以眼部症状为首发的真菌性蝶窦炎患者的临床表现、影像学检查、手术方法及术后转归等方面进行回顾性分析,总结临床经验。结果17例患者影像学均符合真菌性鼻窦炎,且术后病理确诊为真菌感染。11例患者术后眼部症状得到不同程度改善,包括视力下降、眼球运动障碍、眼睑下垂等,6例患者术后症状无明显改善。结论临床上病因不明的渐进性视力下降及迁延不愈的头痛,应考虑真菌性蝶窦炎可能,及时完善头颅CT、MRI等检查,一经确诊首选鼻内镜下手术治疗。术中导航技术可辅助准确定位病变并判断病变范围,保障手术安全并提高手术效率。侵袭性真菌性鼻窦炎需要联合系统性抗真菌治疗。

蝶窦解剖对无功能垂体大腺瘤垂直方向生长的影响

目的探讨蝶窦相关解剖对无功能垂体大腺瘤沿垂直方向扩展的影响。方法回顾性分析65例无功能垂体大腺瘤患者影像资料,根据肿瘤鞍上扩展值(suprasellar expansion value,SEV),分为鞍上组(SEV>0)和鞍下组(SEV≤0)。比较蝶窦气化类型、蝶窦主隔偏向、蝶窦体积、蝶窦主隔最大宽度,并进行多因素Logstic回归分析,筛选出有价值的影响因素。结果与鞍下组比较,鞍上组蝶窦气化更好(P=0.016),蝶窦主隔最大宽度更宽(P=0.003),蝶窦主隔更居中(P=0.048),蝶窦体积更小(P=0.040),差异具有统计学意义。多因素Logstic回归分析显示:蝶窦主隔最大宽度(OR=6.23,P=0.013)和蝶窦体积(OR=0.72,P=0.024)是影响无功能垂体大腺瘤沿垂直方向扩展的独立预测因素。结论蝶窦体积越小、蝶窦主隔越宽,无功能垂体大腺瘤越倾向于向鞍上生长。

神经内镜辅助下经鼻蝶窦手术治疗垂体瘤的效果及对嗅觉功能、神经内分泌激素水平的影响

目的:探讨神经内镜辅助下经鼻蝶窦手术治疗垂体瘤的效果及对嗅觉功能、神经内分泌激素水平的影响。方法:回顾性将我院2018年03月至2022年02月收治的垂体瘤患者58例作为此次的研究对象,其中采用显微镜辅助下进行经鼻蝶窦手术的28例作为对照组,神经内镜辅助下进行经鼻蝶窦手术的30例作为观察组,均观察至患者出院,并进行随访1年。比较两组围术期指标,术后1个月视力下降、头痛及性功能障碍缓解率,术前、术后1个月激素水平、T细胞亚群、生活质量评分、嗅觉功能,研究期间并发症发生情况,随访1年后复发情况。结果:与对照组比较,观察组的出血量相对更少,术后住院时间较短,肿瘤全切率相对更高;术后1个月,与对照组进行比较,观察组视力下降、头痛及性功能障碍缓解率均相对更高;相比术前,两组术后1个月血清泌乳素(PRL)、促甲状腺素(TSH)、生长激素(HGH)、促肾上腺皮质激素(ACTh)水平均降低,观察组低于对照组,外周血CD3^(+)、CD4^(+)水平、CD4^(+)/CD8^(+)值、社会功能、躯体功能、心理功能、物质生活状态各项生活质量评分术后1个月则均升高,观察组高于对照组;与术前比较,两组术后1个月嗅觉功能均升高,但观察组低于对照组;研究期间,观察组并发症总发生率3.33%低于对照组的25.00%;随访1年后,观察组的复发率0.00%同样低于对照组的14.29%(P<0.05)。结论:神经内镜辅助下经鼻蝶窦手术可有效提高垂体瘤患者的生活质量以及视力下降、头痛等临床症状缓解率,缩短住院时间,同时还能够改善患者的免疫功能以及嗅觉功能,稳定患者神经内分泌激素水平,降低并发症发生以及复发率。

Microsurgical treatment of cerebrospinal fluid rhinorrhea in sphenoidal sinus

目的将在 sphenoidal 湾穴探索临床的表明，诊断和脑髓的液体 rhinorrhea 的外科的治疗。在从 2007 ～ 2009 的 spenoidal 湾穴的脑髓的液体 rhinorrhea 的九个盒子回顾地被分析由他们的可能的 etiological 因素，临床的表明，漏地点的本地化和处理方法组成的方法。在他们之中，有创伤的 rhinorrhea， 4 手术后的 rhinorrhea 和 2 自发的 rhinorrhea 的 3 个盒子。所有 9 个病人包括所有帕拉鼻音湾穴在 sellar 区域经历了 3-dimensional CT 扫描。漏地点被识别，修理过程通过 trans-sphenoidal 途径被执行。结果所有情况与 trans-sphenoidal microsurgical 过程被治好。他们被跟随在上面为 9 个月 2 年。没有复发，没有感染和癫痫复杂并发症被观察。为在 sphenoidal 湾穴的脑髓的液体 rhinorrhea 的结论，精确地识别漏地点是批评的， trans-sphenoidal 途径是修理漏的 microinvasive 和有效方法，它是值钱的被倡导。

1例蝶窦异位垂体瘤影像学表现

患者男,56岁,枕部间断疼痛伴嗅觉减退、视远物模糊1个月,无视野缺损;既往糖尿病10余年,未规律监测血糖。前鼻镜检查未见明显异常。实验室检查:孕酮0.04ng/ml,睾酮38.67ng/dl,甲状腺素11.60μg/dl,游离甲状腺素1.80ng/dl。颅脑CT/MRI:蝶窦、斜坡处3.9cm×2.5cm×2.3cm等低混杂密度不规则团块,局部骨质破坏(图1A、1B),T1WI以等信号为主(图1C),T2WI呈不均匀高信号(图1D),增强后不均匀强化(图1E),蝶窦偏左部分呈中度强化。

显微镜术和神经内镜下经鼻蝶窦入路切除术治疗垂体瘤的疗效对比

目的分析显微镜术和神经内镜下经鼻蝶窦入路切除术对垂体瘤患者应激反应、性激素的影响及预后的相关因素。方法选取2018-07—2021-02中国人民解放军联勤保障部队第九四〇医院治疗的96例垂体瘤患者为研究对象,分为显微镜组(50例)和神经内镜组(46例),比较显微镜组与神经内镜组患者术前、术后1个月应激指标、性激素水平及并发症发生率、术后2 a复发率。根据随访2 a期间是否复发分为复发组与未复发组,通过单因素与多因素Logistic回归分析影响预后的相关危险因素。结果神经内镜组患者术后1个月的NE、肾上腺素、ATⅡ、PRL、TSH、hGH水平及并发症发生率均低于显微镜组(P<0.05)。2组患者复发率比较差异无统计学意义(P>0.05)。综合单因素与多因素Logistic回归分析,肿瘤直径>3 cm、Hardy分型Ⅳ型、Knosp分级3~4级、非完全切除、未辅助治疗是垂体瘤患者术后复发的独立危险因素(P<0.05)。结论神经内镜下经鼻蝶窦入路切除术相比于显微镜术,能够更有效地平复垂体瘤患者应激反应和性激素水平,并发症更少,但均存在术后复发风险,尤其对于肿瘤直径>3 mm、Hardy分型Ⅳ型、Knosp分级3~4级、非完全切除的高危因素患者,应采取辅助治疗等针对性干预措施。

Invasive sphenoid sinus aspergillosis mimicking sellar tumor: a report of 4 cases and systematic literature review

Background:Invasive sphenoid sinus aspergillosis is a rare but life-threatening condition usually found in immunocompromised patients.When involving cavernous sinus and surrounding structures,patients are frequently misdiagnosed with a neoplasm or sellar abscess.Timely diagnosis and intervention are crucial to patients’outcomes.The objective of this study is to review cases of invasive sphenoid sinus aspergillosis to describe disease manifestations,imaging features,treatment,and outcome.Case presentation:We describe four patients with invasive sphenoid sinus aspergillosis misdiagnosed as sellar tumors preoperatively.The mass was completely removed in three patients and partially removed in one patient microscopically.Pathological examinations confirmed Aspergillus in all cases.All four patients received anti-fungal agents postoperatively.There was no recurrence at the time of each patient’s follow-up date.One patient with complete resection was lost to follow-up while the other three patients’neurologic function improved.Additionally,we performed a systematic review regarding invasive sphenoid sinus aspergillosis of existing English literature.Conclusion:With regard to clinical symptoms,headache,vision impairment,and ophthalmoplegia were observed in over half of the patients in the literature.A sellar mass with bone destruction on CT and involvement of cavernous sinus is highly suggestive of invasive fungal sphenoid sinusitis.Immediate surgical removal of the lesion is recommended for invasive sphenoid sinus aspergillosis to preserve nerve function and increase the likelihood of survival.

艾司氯胺酮在一又二分之一鼻孔-蝶窦入路垂体瘤神经内镜切除术中的应用效果

目的探讨艾司氯胺酮在一又二分之一鼻孔-蝶窦入路垂体瘤神经内镜切除术中的应用效果。方法选择2020年3月至2022年1月中国人民解放军联勤保障部队第九〇四医院98例接受一又二分之一鼻孔-蝶窦入路垂体瘤神经内镜切除术患者,按照随机数字表法将其分为研究组(49例)、对照组(49例)。研究组麻醉诱导前静脉注射艾司氯胺酮0.5 mg/kg,术中持续泵入0.1 mg/(kg·h)艾司氯胺酮至术毕;对照组以相同的方式静脉注射生理盐水。比较两组麻醉诱导前(T_(0))、气管插管后即刻(T_(1))、手术结束时(T_(2))、术后1 h(T_(3))、术后3 h(T_(4))的心率(HR)水平;比较两组T_(3)、T_(4)及术后6 h(T_(5))时视觉模拟评分法(VAS)评分;比较两组瑞芬太尼、丙泊酚用药量;比较两组苏醒期呛咳程度;观察两组苏醒期并发症发生情况。结果两组组内不同时间点HR两两比较,差异有统计学意义(P<0.05);T_(1)~T_(4)时,两组HR比较,差异有统计学意义(P<0.05)。两组组内不同时间点VAS评分两两比较,差异有统计学意义(P<0.05);T_(3)~T_(5)时,研究组VAS评分低于对照组,差异有统计学意义(P<0.05)。研究组瑞芬太尼、丙泊酚用药量低于对照组,差异有统计学意义(P<0.05)。研究组呛咳程度低于对照组,差异有统计学意义(P<0.05)。两组苏醒期并发症总发生率比较,差异无统计学意义(P>0.05)。结论艾司氯胺酮应用于一又二分之一鼻孔-蝶窦入路垂体瘤神经内镜切除术中麻醉效果确切,维持血流动力学稳定,且安全可靠。

The evolution of sinus surgery in England in the last decade - An observational study

Background and objective::Sinus surgery has seen significant changes over the years with advancements in instruments,endoscopes and imaging.This study aimed to use Hospital Episode Statistics(HES)data to review the total number of sinus related procedures performed in both adults and children across England and identify whether there were any trends across the study period.We predicted an increase in endoscopic sinus procedures with a decline in open approaches to the paranasal sinuses.Methods::Data from HES was extracted for the years 2010-2019.The operative(OPCS-4)codes relevant to all sinus procedures between E12.1 and E17.9 were analysed.After examination of overall sinus related procedures,further subgroup analysis was performed with regards to open or endoscopic techniques.Results::The total number of sinus procedures performed between 2010 and 2019 was 89,495.There was an increase in endoscopic surgeries by 21.1%and a decrease of open surgeries 35.3%during this time.There was an overall increase in maxillary,frontal and sphenoid sinus procedures,with a decrease in ethmoid sinus and lateral rhinotomy operations.There was an increase in the proportion of endoscopic cases overall by 5.7%and for all sinuses individually.Conclusion::Overall,we see an increase in sinus surgery over the last 9 years from 2010 to 2019.These findings are in keeping with our initial hypotheses.Although our data set is limited by coding,and lack of patient factors,it represents most,if not all,of the data in England over a large study period.It is therefore useful to add to previous studies when demonstrating the increasing popularity of endoscopic sinus surgery over open procedures.

围术期护理在经单鼻孔蝶窦入路内镜下切除垂体瘤患者中的应用效果

目的:观察围术期护理在经单鼻孔蝶窦入路内镜下切除垂体瘤患者中的应用效果。方法:选取2021年3月—2022年3月贵州医科大学附属医院经单鼻孔蝶窦入路内镜下切除垂体瘤患者60例为观察对象,随机分为对照组和观察组,各30例。对照组予常规护理,观察组给予围术期护理。比较两组生活质量、并发症发生率。结果:护理后,观察组总体健康情况、身体疼痛、活力、生理功能评分均高于对照组,差异有统计学意义(P<0.001);观察组并发症发生率低于对照组,差异有统计学意义(P=0.044)。结论:对经单鼻孔蝶窦入路内镜下切除垂体瘤患者实施围术期护理,能够提升患者生活质量,减少术后并发症的发生。

鼻内镜下经蝶窦蝶鞍区手术中蝶窦前壁的应用解剖

目的：为鼻内镜下经蝶窦蝶鞍区手术准确寻找蝶窦口，避免损伤蝶腭动脉提供解剖学资料。方法：在15例国人头颅标本上，用游标卡尺和角规对30侧蝶窦前壁进行解剖学（走行、位置、外径以及与相关结构的距离）观察和测量。结果：鼻小柱根部至蝶窦口下极及蝶腭孔的距离分别为（60．40±3．21，58．10～72．76）mm和（62．14±1．93，59．50～73．40）mm；蝶腭孔至蝶窦口下极的距离为（12．20±1．10，8．10～16．35）mm，在蝶腭孔处蝶腭动脉的外径为（1．99±0．13，1．50～2．80）mm；蝶窦口下极至鼻中隔后上动脉及鼻中隔后下动脉的距离分别为（3．49±0．24，2．78～5．20）mm和（6．42±1．08，4．30～8．50）mm。结论：蝶窦口是经蝶窦蝶鞍区手术的重要标志；开放蝶窦时宜从蝶窦口内下方开放，以免损伤蝶腭动脉。

内窥镜蝶窦及蝶鞍区手术应用解剖学研究

１１０个头部标本的蝶窦解剖观察测量表明，蝶窦双侧气化相同者占４１．８％，不同者占５８．２％。前鼻棘至蝶窦口和鞍底的距离分别为５４．６ｍｍ和７１．３ｍｍ，蝶窦口和鞍底与鼻底的用度分别为３２．６°和３３．１°。视神经管和颈内动脉在蝶卖内形成隆起的比率分别是５２．７％和５０．９％。文中讨论了蝶窦气化类型、蝶窦膜性开口和中隔，以及蝶窦与视神经管和颈内动脉的毗邻关系在内窥镜蝶窦及蝶鞍区手术时的意义。

内窥镜视神经管减压术应用解剖

观察了１０７具成人尸头标本视神经管及其与蝶窦和筛窦的毗邻关系。所有标本中，视神经管在蝶筛窦外侧壁形成隆起者为７２．４％，视神经管与毗邻结构的关系复杂，但其内壁与后筛窦或／和蝶窦相毗邻最为多见，内壁长１０．２ｍｍ，厚０．４ｍｍ，是内窥镜下行视神经管减压术的关键部位。文中讨论了内窥镜下行视神经管减压术时值得注意的一些问题。

经蝶窦入路显微外科治疗垂体大腺瘤

目的 :探索经蝶窦入路手术治疗垂体大腺瘤的效果。 方法 :1 993年 3月至 1 999年 6月经蝶窦入路手术治疗垂体大腺瘤患者 54例。结果 :全切除 3 6例 ( 66.7% ) ,大部分切除 1 2例 ( 2 2 .2 % ) ,部分切除 6例 ( 1 1 .1 % )。随访 3 5例 ,随访时间 7～3 4个月 ,其中 3 1例视力视野恢复正常 ,MRI扫描鞍上结构恢复 2 9例。主要并发症为尿崩症 9例 ( 1 6.7% )和脑脊液漏 7例( 1 2 .9% )。所有病例术后接受放射治疗。结论 :经蝶窦入路手术切除垂体大腺瘤是安全有效的 ,因为能迅速解除肿瘤对视神经和下丘脑的压迫。术后放疗效果有待长期随访证实。