Sphincter of Oddi dysfunction(SOD)encompasses a spectrum of clinical syndromes that are not fully understood,and various diagnostic and therapeutic methods have had varying results depending on the type of dysfunction...Sphincter of Oddi dysfunction(SOD)encompasses a spectrum of clinical syndromes that are not fully understood,and various diagnostic and therapeutic methods have had varying results depending on the type of dysfunction.This review explored various mechanisms that might play a role in SOD and methods of diagnosis and management.It is important to rule out other causes of abdominal pain with laboratory testing,imaging studies,and endoscopic procedures.Medications that affect sphincter motility should be identified as well.Manometry is the gold standard for diagnosis but it is not always required.For example,patients with type I SOD may have symptomatic improvement with sphincterotomy without need for a diagnostic manometry.Hepatobiliary scintigraphy and fatty meal sonography may also have diagnostic utility.Sphincterotomy is not always effective for symptomatic improvement in type II and III SOD.Alternate therapies with calcium channel blockers and botulinum toxin have been studied and might be considered as options after discussing the risks and benefits with the patients.展开更多
目的:探讨跨越壶腹部支架置入后犬胆道压力和Oddi括约肌(sphincter of Oddi,SO)病理学的变化机制。材料与方法:选取成年实验犬5只,建立经皮经肝胆囊穿刺和跨越壶腹部置入金属支架的模型,应用胆道测压的方法比较支架置入前和支架置入5周...目的:探讨跨越壶腹部支架置入后犬胆道压力和Oddi括约肌(sphincter of Oddi,SO)病理学的变化机制。材料与方法:选取成年实验犬5只,建立经皮经肝胆囊穿刺和跨越壶腹部置入金属支架的模型,应用胆道测压的方法比较支架置入前和支架置入5周后十二指肠压(duodenal pressure,DP)、SO基础压(sphincter of Oddi basal pressure,SOBP)、收缩幅度(sphincter of Oddi contractive amplitude,SOCA)、收缩间期(sphincter of Oddi duration,SOD)以及胆总管压(common bile duct pressure,CBDP)的变化。同时,应用胶原纤维染色观察支架置入后SO的病理变化。对实验所获得的计量资料采用配对t检验进行比较,P<0.05为差异有统计学意义。结果:以DP作为零点,获得其他各项指标的相对值结果。支架置入前SOBP、SOCA、SOD、CBDP分别为:13.69±4.29mmHg、42.65±8.50mmHg、6.69±1.46s、12.98±2.86mmHg;支架置入5周后分别为:10.58±3.98mmHg、31.95±9.00mmHg、4.47±1.21s、7.43±2.20mmHg,其中SOCA较支架置入前降低,SOD相比支架置入前缩短,两者的差异均有统计学意义(P<0.05)。而CBDP明显低于支架置入前,差异具有统计学意义(P<0.05)。支架置入5周后,壶腹部SO肌层中发生了不同程度的纤维化、腺体病变和炎性反应等病理变化。结论:跨越壶腹部植入支架5周后,SO运动功能的减弱以紧张性收缩的减弱为主,而基础性收缩仍然存在。CBDP虽然下降,但仍高于正常的DP,并保持与之的压力梯度,从而为抑制肠胆反流提供了可能。而壶腹部SO肌层中则发生了不同程度的纤维化、腺体病变和炎性反应等病理变化。展开更多
目的:探讨肝外胆管结石与O d d i括约肌(sphincter of Oddi,SO)压力的关系.方法:采用前瞻性研究方法,选取2013-01/2014-06南阳医学高等专科学校第一附属医院45例肝外胆管结石患者作为研究对象,根据术中情况,分为松弛组和不松弛组,根据...目的:探讨肝外胆管结石与O d d i括约肌(sphincter of Oddi,SO)压力的关系.方法:采用前瞻性研究方法,选取2013-01/2014-06南阳医学高等专科学校第一附属医院45例肝外胆管结石患者作为研究对象,根据术中情况,分为松弛组和不松弛组,根据手术次数,分为初发组和复发组.所有患者均采用胆总管切开取石T管引流术,术中进行胆道镜探查并进行SO测压.结果:SO松弛的发生率为40%(18/27).松弛组和不松弛组SO基础压(sphincter of O d d i b a s a l p r e s s u r e,S O B P)、S O峰压(sphincter of Oddi amplitude,SOAP)、SO收缩频率(frequency of sphincter of Oddi phasic contraction,SOF)、SO收缩持续时间(duration of sphincter of Oddi contraction,S O D)分别进行比较,差异有统计学意义(P<0.05).初发组S O松弛的发生率为25%(8/32),复发组为76.92%(10/13),两组进行比较,差异有统计学意义(P<0.05);初发组与复发组胆道镜相关指标进行比较,差异有统计学意义(P<0.05).结论:肝外胆管结石患者SO松弛的发生率较高,多次进行胆道手术可能是SO松弛的重要因素.展开更多
An accurate, noninvasive and cost-effective method of in situ tissue evaluation during endoscopy would be highly advantageous for the detection of dysplasia or early cancer and for identifying different disease stages...An accurate, noninvasive and cost-effective method of in situ tissue evaluation during endoscopy would be highly advantageous for the detection of dysplasia or early cancer and for identifying different disease stages. Optical coherence tomography(OCT) is a noninvasive, high-resolution(1-10 μm) emerging optical imaging method with potential for identifying microscopic subsurface features in the pancreatic and biliary ductal system. Tissue microstructure of pancreaticobiliary ductal system has been successfully imaged by inserting an OCT probe through a standard endoscope operative channel. High-resolution OCT images and the technique's endoscopic compatibility have allowed for the microstructural diagnostic of thepancreatobiliary diseases. In this review, we discussed currently available pancreaticobiliary ductal imaging systems to assess the pancreatobiliary tissue microstructure and to evaluate varieties of pancreaticobiliary disorders and diseases. Results show that OCT can improve the quality of images of pancreatobiliary system during endoscopic retrograde cholangiopancheatography procedure, which may be important in distinguishing between the neoplastic and non-neoplastic lesions.展开更多
文摘Sphincter of Oddi dysfunction(SOD)encompasses a spectrum of clinical syndromes that are not fully understood,and various diagnostic and therapeutic methods have had varying results depending on the type of dysfunction.This review explored various mechanisms that might play a role in SOD and methods of diagnosis and management.It is important to rule out other causes of abdominal pain with laboratory testing,imaging studies,and endoscopic procedures.Medications that affect sphincter motility should be identified as well.Manometry is the gold standard for diagnosis but it is not always required.For example,patients with type I SOD may have symptomatic improvement with sphincterotomy without need for a diagnostic manometry.Hepatobiliary scintigraphy and fatty meal sonography may also have diagnostic utility.Sphincterotomy is not always effective for symptomatic improvement in type II and III SOD.Alternate therapies with calcium channel blockers and botulinum toxin have been studied and might be considered as options after discussing the risks and benefits with the patients.
文摘目的:探讨跨越壶腹部支架置入后犬胆道压力和Oddi括约肌(sphincter of Oddi,SO)病理学的变化机制。材料与方法:选取成年实验犬5只,建立经皮经肝胆囊穿刺和跨越壶腹部置入金属支架的模型,应用胆道测压的方法比较支架置入前和支架置入5周后十二指肠压(duodenal pressure,DP)、SO基础压(sphincter of Oddi basal pressure,SOBP)、收缩幅度(sphincter of Oddi contractive amplitude,SOCA)、收缩间期(sphincter of Oddi duration,SOD)以及胆总管压(common bile duct pressure,CBDP)的变化。同时,应用胶原纤维染色观察支架置入后SO的病理变化。对实验所获得的计量资料采用配对t检验进行比较,P<0.05为差异有统计学意义。结果:以DP作为零点,获得其他各项指标的相对值结果。支架置入前SOBP、SOCA、SOD、CBDP分别为:13.69±4.29mmHg、42.65±8.50mmHg、6.69±1.46s、12.98±2.86mmHg;支架置入5周后分别为:10.58±3.98mmHg、31.95±9.00mmHg、4.47±1.21s、7.43±2.20mmHg,其中SOCA较支架置入前降低,SOD相比支架置入前缩短,两者的差异均有统计学意义(P<0.05)。而CBDP明显低于支架置入前,差异具有统计学意义(P<0.05)。支架置入5周后,壶腹部SO肌层中发生了不同程度的纤维化、腺体病变和炎性反应等病理变化。结论:跨越壶腹部植入支架5周后,SO运动功能的减弱以紧张性收缩的减弱为主,而基础性收缩仍然存在。CBDP虽然下降,但仍高于正常的DP,并保持与之的压力梯度,从而为抑制肠胆反流提供了可能。而壶腹部SO肌层中则发生了不同程度的纤维化、腺体病变和炎性反应等病理变化。
文摘目的:探讨肝外胆管结石与O d d i括约肌(sphincter of Oddi,SO)压力的关系.方法:采用前瞻性研究方法,选取2013-01/2014-06南阳医学高等专科学校第一附属医院45例肝外胆管结石患者作为研究对象,根据术中情况,分为松弛组和不松弛组,根据手术次数,分为初发组和复发组.所有患者均采用胆总管切开取石T管引流术,术中进行胆道镜探查并进行SO测压.结果:SO松弛的发生率为40%(18/27).松弛组和不松弛组SO基础压(sphincter of O d d i b a s a l p r e s s u r e,S O B P)、S O峰压(sphincter of Oddi amplitude,SOAP)、SO收缩频率(frequency of sphincter of Oddi phasic contraction,SOF)、SO收缩持续时间(duration of sphincter of Oddi contraction,S O D)分别进行比较,差异有统计学意义(P<0.05).初发组S O松弛的发生率为25%(8/32),复发组为76.92%(10/13),两组进行比较,差异有统计学意义(P<0.05);初发组与复发组胆道镜相关指标进行比较,差异有统计学意义(P<0.05).结论:肝外胆管结石患者SO松弛的发生率较高,多次进行胆道手术可能是SO松弛的重要因素.
文摘An accurate, noninvasive and cost-effective method of in situ tissue evaluation during endoscopy would be highly advantageous for the detection of dysplasia or early cancer and for identifying different disease stages. Optical coherence tomography(OCT) is a noninvasive, high-resolution(1-10 μm) emerging optical imaging method with potential for identifying microscopic subsurface features in the pancreatic and biliary ductal system. Tissue microstructure of pancreaticobiliary ductal system has been successfully imaged by inserting an OCT probe through a standard endoscope operative channel. High-resolution OCT images and the technique's endoscopic compatibility have allowed for the microstructural diagnostic of thepancreatobiliary diseases. In this review, we discussed currently available pancreaticobiliary ductal imaging systems to assess the pancreatobiliary tissue microstructure and to evaluate varieties of pancreaticobiliary disorders and diseases. Results show that OCT can improve the quality of images of pancreatobiliary system during endoscopic retrograde cholangiopancheatography procedure, which may be important in distinguishing between the neoplastic and non-neoplastic lesions.
