Object: This work explains the theoretical basis of </span><span style="font-family:Verdana;">“Hanshi Zufei Decoction”</span><span style="font-family:""><span styl...Object: This work explains the theoretical basis of </span><span style="font-family:Verdana;">“Hanshi Zufei Decoction”</span><span style="font-family:""><span style="font-family:Verdana;"> for the treatment of Coronavirus Disease 19 (COVID-19) through Western </span><span style="font-family:Verdana;">medical theories. Methods: We analyze the guideline of the “Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia” (Version I to Version VII) made by China, “Clinical</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">Management of Severe Acute Respiratory Infection When Novel Coronavirus (2019-nCoV) Infection is</span><span style="font-family:""> </span><span style="font-family:Verdana;">Suspected—Interim </span><span style="font-family:Verdana;">Guidance” made by WHO, “Therapeutic Guidelines: Gastroenteropathy Section (Version V of Original)” and “Therapeutic Guidelines: Antibiotics Section (Version XV of Original)” published by Australia, and the origin of classical prescription of “Hanshi Zufei Decoction”: “Shanghan Lun (Treatise on Febrile Diseases)”, “Jinkui Yaolue (Synopsis of Golden Chamber)” and “Wenyi Lun (Treatise on Plague). We search the dictionary of traditional Chinese medicine (Version II) manually. Literature </span><span style="font-family:Verdana;">is</span><span style="font-family:Verdana;"> searched from 2001 to 2020 on </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">Wiley online library. We conduct a comparative study on the traditional Chinese medicine</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">(TCM) syndromes of </span><a name="OLE_LINK47"></a><span style="font-family:Verdana;">“Hanshi Zufei Decoction”, the pathogenesis and clinical manifestations of respiratory system diseases and acute gastrointestinal inflammation by COVID-19. And we conduct the pharmacological inquiry of </span><span style="font-family:Verdana;"></span><span style="font-family:Verdana;">“Hanshi Zufei Decoction”. Results: The respiratory and gastrointestinal symptoms of COVID-19 and the basis of the “Hanshi Zufei Decoction” are basically considered to be consistent. “Hanshi Zufei Decoction” can relieve respiratory symptoms, protect gastrointestinal mucosa, promote intestinal emptying, and have anti-inflammatory and antibacterial effects in the form of clusters. The dosage form and dosage used are in line with the range of pharmacological activity of the drug. Conclusions: “Hanshi Zufei Decoction” may have a good performance in reducing toxicity and controlling inflammation through intestinal emptying, and may play an active role in the treatment of COVID-19.展开更多
Objective:To evaluate the effect of heat-clearing and detoxifying method on the macrophages polarization in patients with acute myocardial infarction with heat toxin syndrome after intervention.Methods:Sixty patients ...Objective:To evaluate the effect of heat-clearing and detoxifying method on the macrophages polarization in patients with acute myocardial infarction with heat toxin syndrome after intervention.Methods:Sixty patients with acute myocardial infarction and undergoing percutaneous coronary intervention with heat toxin syndrome were randomly divided into a control group and a test group with 30 cases each.The control group was given conventional treatment,and the test group was given Huanglian Jiedu Decoction,the representative of the method of clearing heat and detoxification,orally on the basis of the control group.The intervention time of both groups was 2 weeks.Comparing The Seattle Angina Pectoris Scale(SAQ)before and after treatment,creatine kinase(CK),creatine kinase MB isoenzyme(CKMB),high-sensitivity troponin I(hs-TnI),and Lipoprotein-associated phospholipaseA2(LPPLA_2)),the phenotype ratio of M1 and M2 macrophages,and observe the adverse reactions.Results:After treatment,the SAQ scores of the two groups of patients were improved,and the levels of CK,CK-MB,hs-TnI,and LP-PLA_2 decreased significantly.The scores of AS,AF,TS,and DP in the SAQ of the test group were all higher than those of the control group,and the hs-TnI and LP-PLA_2 were better than those of the control Group(P<0.05 or P<0.01).After treatment,the proportion of M1 type macrophages in the two groups of patients'macrophages decreased significantly(P<0.05 or P<0.01),the ratio of M2 type macrophages increased(P<0.05),and the M1/M2 ratio decreased.The ratio of M1/M2 in the test group of the control group was significantly lower than that of the control group(P<0.01).There were no obvious adverse reactions in both groups.Conclusions:The method of clearing heat and detoxifying has a definite effect on patients with acute myocardial infarction of heat toxin syndrome after interventional operation.It can reduce myocardial damage,improve myocardial function,and reduce inflammation.And it is safe for clinical treatment without any increasing risk of bleeding or other risk of cardiovascular events.展开更多
文摘Object: This work explains the theoretical basis of </span><span style="font-family:Verdana;">“Hanshi Zufei Decoction”</span><span style="font-family:""><span style="font-family:Verdana;"> for the treatment of Coronavirus Disease 19 (COVID-19) through Western </span><span style="font-family:Verdana;">medical theories. Methods: We analyze the guideline of the “Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia” (Version I to Version VII) made by China, “Clinical</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">Management of Severe Acute Respiratory Infection When Novel Coronavirus (2019-nCoV) Infection is</span><span style="font-family:""> </span><span style="font-family:Verdana;">Suspected—Interim </span><span style="font-family:Verdana;">Guidance” made by WHO, “Therapeutic Guidelines: Gastroenteropathy Section (Version V of Original)” and “Therapeutic Guidelines: Antibiotics Section (Version XV of Original)” published by Australia, and the origin of classical prescription of “Hanshi Zufei Decoction”: “Shanghan Lun (Treatise on Febrile Diseases)”, “Jinkui Yaolue (Synopsis of Golden Chamber)” and “Wenyi Lun (Treatise on Plague). We search the dictionary of traditional Chinese medicine (Version II) manually. Literature </span><span style="font-family:Verdana;">is</span><span style="font-family:Verdana;"> searched from 2001 to 2020 on </span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">Wiley online library. We conduct a comparative study on the traditional Chinese medicine</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">(TCM) syndromes of </span><a name="OLE_LINK47"></a><span style="font-family:Verdana;">“Hanshi Zufei Decoction”, the pathogenesis and clinical manifestations of respiratory system diseases and acute gastrointestinal inflammation by COVID-19. And we conduct the pharmacological inquiry of </span><span style="font-family:Verdana;"></span><span style="font-family:Verdana;">“Hanshi Zufei Decoction”. Results: The respiratory and gastrointestinal symptoms of COVID-19 and the basis of the “Hanshi Zufei Decoction” are basically considered to be consistent. “Hanshi Zufei Decoction” can relieve respiratory symptoms, protect gastrointestinal mucosa, promote intestinal emptying, and have anti-inflammatory and antibacterial effects in the form of clusters. The dosage form and dosage used are in line with the range of pharmacological activity of the drug. Conclusions: “Hanshi Zufei Decoction” may have a good performance in reducing toxicity and controlling inflammation through intestinal emptying, and may play an active role in the treatment of COVID-19.
基金Guangdong Provincial Medical Science and Technology Research Fund Project(No.A2019507)Traditional Chinese Medicine Bureau of Guangdong Provincial Project(No.20191117)+1 种基金Science and Technology Program of Guangzhou(No.202102020927)National Administration of Traditional Chinese Medicine Clinical Research Base Business Construction Research Project(No.JDZX2015241)。
文摘Objective:To evaluate the effect of heat-clearing and detoxifying method on the macrophages polarization in patients with acute myocardial infarction with heat toxin syndrome after intervention.Methods:Sixty patients with acute myocardial infarction and undergoing percutaneous coronary intervention with heat toxin syndrome were randomly divided into a control group and a test group with 30 cases each.The control group was given conventional treatment,and the test group was given Huanglian Jiedu Decoction,the representative of the method of clearing heat and detoxification,orally on the basis of the control group.The intervention time of both groups was 2 weeks.Comparing The Seattle Angina Pectoris Scale(SAQ)before and after treatment,creatine kinase(CK),creatine kinase MB isoenzyme(CKMB),high-sensitivity troponin I(hs-TnI),and Lipoprotein-associated phospholipaseA2(LPPLA_2)),the phenotype ratio of M1 and M2 macrophages,and observe the adverse reactions.Results:After treatment,the SAQ scores of the two groups of patients were improved,and the levels of CK,CK-MB,hs-TnI,and LP-PLA_2 decreased significantly.The scores of AS,AF,TS,and DP in the SAQ of the test group were all higher than those of the control group,and the hs-TnI and LP-PLA_2 were better than those of the control Group(P<0.05 or P<0.01).After treatment,the proportion of M1 type macrophages in the two groups of patients'macrophages decreased significantly(P<0.05 or P<0.01),the ratio of M2 type macrophages increased(P<0.05),and the M1/M2 ratio decreased.The ratio of M1/M2 in the test group of the control group was significantly lower than that of the control group(P<0.01).There were no obvious adverse reactions in both groups.Conclusions:The method of clearing heat and detoxifying has a definite effect on patients with acute myocardial infarction of heat toxin syndrome after interventional operation.It can reduce myocardial damage,improve myocardial function,and reduce inflammation.And it is safe for clinical treatment without any increasing risk of bleeding or other risk of cardiovascular events.
