Evaluation of the effects of combined endoscopic variceal ligation and splenectomy with pericardial devascularization on esophageal varices

AIM: To detect the hemodynamic alterations in collateral circulation before and after combined endoscopic variceal ligation (EVL) and splenectomy with pericardial devascularization by ultrasonography, and to evaluate their effect using hemodynamic parameters. METHODS: Forty-three patients with esophageal varices received combined EVL and splenectomy with pericardial devascularization for variceal eradication. The esophageal vein structures and azygos blood flow (AZBF) were detected by endoscopic ultrasonography and color Doppler ultrasound. The recurrence and rebleeding of esophageal varices were followed up. RESULTS: Patients with moderate or severe varices in the esophageal wall and those with severe peri- esophageal collateral vein varices had improvements after treatment, while the percentage of patients with severe para-esophageal collateral vein varices decreased from 54.49% to 2.33%, and the percentage of patients with detectable perforating veins decreased from 79.07% to 4.65% (P < 0.01). Color Doppler flowmetry showed a significant decrease both in AZBF (43.00%, P < 0.05) and in diameter of the azygos vein (28.85%, P < 0.05), while the blood flow rate was unchanged. The recurrence rate of esophageal varices was 2.5% (1/40, mild), while no re-bleeding cases were recorded. CONCLUSION: EVL in combination with splenectomy with pericardial devascularization can block the collateral veins both inside and outside of the esophageal wall, and is more advantagious over splenectomy in combination with pericardial devascularization or EVL in preventing recurrence and re-bleeding of varices.

Comparison of simplified and traditional pericardial devascularisation combined with splenectomy for the treatment of portal hypertension

AIM To compare the clinical outcomes of patients with portal hypertension(PH) who underwent treatment with splenectomy plus simplified pericardial devascularisation(SSPD) or splenectomy plus traditional pericardial devascularisation(STPD).METHODS We conducted a single-centre retrospective study of 1045 PH patients treated with either SSPD(S Group, 357 patients) or STPD(T Group, 688 patients) between January 2002 and February 2017. In all, 37 clinical indicators were compared to evaluate the efficacy of SSPD.RESULTS Perioperative indicators in the S Group were significantly better than those in the T Group(P < 0.05). In both groups, the postoperative long-term portal vein diameter and Model for End-Stage Liver Disease score were significantly lower than those in the preoperative and postoperative short-term groups(P< 0.05). The incidence of complications in the S Group was significantly lower than that in the T Group(P < 0.05). Compared to the T Group, postoperative shortterm WBC(white blood cell) and platelet counts were significantly lower and the short-term Hb(haemoglobin) level was significantly higher in the S Group(P < 0.05). In the S Group, postoperative long-term total bilirubin, direct bilirubin, alanine transaminase, and aspartate transaminase and postoperative serum creatinine and cystatin C levels were significantly lower than those in the T Group(P < 0.05), and postoperative albumin was significantly higher than that in the T Group(P < 0.05).CONCLUSION Compared to STPD, SSPD is a simple and easy procedure resulting in less tissue damage. Patients recovered smoothly and steadily with fewer complications. Short-term liver and kidney function damage was less severe, and long-term liver function recovery was better. Therefore, SSPD is worthy of clinical promotion and application for the treatment of PH.

Indocyanine green retention is a potential prognostic indicator after splenectomy and pericardial devascularization for cirrhotic patients

BACKGROUND：Splenectomy and pericardial devascularization（SPD）is an effective treatment of upper gastrointestinal bleeding and hypersplenism in cirrhotic patients with portal hypertension.Indocyanine green retention at 15 minutes（ICGR15）was reported to offer better sensitivity and specificity than the Child-Pugh classification in hepatectomy,but few reports describe ICGR15 in SPD.The present study was to evaluate the prognostic value of ICGR15 for cirrhotic patients with portal hypertension who underwent SPD.METHODS：From January 2012 to January 2015,43 patients with portal hypertension and hypersplenism caused by liver cirrhosis were admitted in our center and received SPD.The ICGR15,Child-Pugh classification,model for end-stage liver disease（MELD）score,and perioperative characteristics were analyzed retrospectively.RESULTS：Preoperative liver function assessment revealed that 34 patients were Child-Pugh class A with ICGR15 of13.6%-43.0%and MELD score of 7-20;8 patients were class B with ICGR15 of 22.8%-40.7%and MELD score of 7-17;1patient was class C with ICGR15 of 39.7%and MELD score of 22.The optimal ICGR15 threshold for liver function compensation was 31.2%,which offered a sensitivity of 68.4%and a specificity of 70.8%.Univariate analysis showed preoperative ICGR15,MELD score,surgical procedure,intraoperative blood loss,and autologous blood transfusion were significantly different between postoperative liver function compensated and decompensated groups.Multivariate regression analysis revealed that ICGR15 was an independent risk factor of postoperative liver function recovery（P=0.020）.CONCLUSIONS：ICGR15 has outperformed the Child-Pugh classification for assessing liver function in cirrhotic patients with portal hypertension.ICGR15 may be a suitable prognostic indicator for cirrhotic patients after SPD.

Prognosis after splenectomy plus pericardial devascularization vs transjugular intrahepatic portosystemic shunt for esophagogastric variceal bleeding

BACKGROUND Portal hypertension combined with esophagogastric variceal bleeding(EGVB)is a serious complication in patients with hepatitis B virus(HBV)-related cirrhosis in China.Splenectomy plus pericardial devascularization(SPD)and transjugular intrahepatic portosystemic shunt(TIPS)are effective treatments for EGVB.However,a comparison of the effectiveness and safety of those methods is lacking.AIM To compare the prognosis after SPD vs TIPS for acute EGVB after failure of endoscopic therapy or secondary prophylaxis of variceal rebleeding(VRB)in patients with HBV-related cirrhosis combined with portal hypertension.METHODS This retrospective cohort study included 318 patients with HBV-related cirrhosis and EGVB who underwent SPD or TIPS at West China Hospital of Sichuan University during 2009-2013.Propensity score-matched analysis(PSM),the Kaplan-Meier method,and multivariate Cox regression analysis were used to compare overall survival,VRB rate,liver function abnormality rate,and hepatocellular carcinoma(HCC)incidence between the two patient groups.RESULTS The median age was 45.0 years(n=318;226(71.1%)males).During a median follow-up duration of 43.0 mo,18(11.1%)and 33(21.2%)patients died in the SPD and TIPS groups,respectively.After PSM,SPD was significantly associated with better overall survival(OS)(P=0.01),lower rates of abnormal liver function(P<0.001),and a lower incidence of HCC(P=0.02)than TIPS.The VRB rate did not differ significantly between the two groups(P=0.09).CONCLUSION Compared with TIPS,SPD is associated with higher postoperative OS rates,lower rates of abnormal liver function and HCC,and better quality of survival as acute EGVB treatment after failed endoscopic therapy or as secondary prophylaxis of VRB in patients with HBV-related cirrhosis combined with portal hypertension.There is no significant between-group difference in VRB rates.

In situ subtotal spleen resection combined with selective pericardial devascularization for the treatment of portal hypertension

BACKGROUND Hypersplenism and esophageal varices bleeding are the major complications of portal hypertension(PHT).In recent years,increasing attention has been given to spleen preservation operations.The mode and long-term effects of subtotal splenectomy and selective pericardial devascularization for PHT remain controversial.AIM To investigate the clinical efficacy and safety of subtotal splenectomy combined with selective pericardial devascularization for the treatment of PHT.METHODS This was a retrospective study of 15 patients with PHT who underwent subtotal splenectomy not preserving the splenic artery or vein combined with selective pericardial devascularization in the Department of Hepatobiliary Surgery,Qilu Hospital of Shandong University from February 2011 to April 2022.Fifteen propensity score-matched patients with PHT who underwent total splenectomy at the same time served as the control group.The patients were followed for up to 11 years after surgery.We compared the postoperative platelet levels,perioperative splenic vein thrombosis,and serum immunoglobulin levels between the two groups.Abdominal enhanced computed tomography was used to evaluate the blood supply and function of the residual spleen.The operation time,intraoperative blood loss,evacuation time,and hospital stay were compared between the two groups.RESULTS The postoperative platelet level of patients in the subtotal splenectomy group was significantly lower than that in the total splenectomy group(P<0.05),and the postoperative portal system thrombosis rate in the subtotal splenectomy group was also much lower than that in the total splenectomy group.The levels of serum immunoglobulins(IgG,IgA,and IgM)showed no significant differences after surgery compared with before surgery in the subtotal splenectomy group(P>0.05),but serum immunoglobulin IgG and IgM levels decreased dramatically after total splenectomy(P<0.05).The operation time in the subtotal splenectomy group was longer than that in the total splenectomy group(P<0.05),but there were no significant differences in the amount of intraoperative blood loss,evacuation time,or hospital stay between the two groups.CONCLUSION Subtotal splenectomy not preserving the splenic artery or vein combined with selective pericardial devascularization is a safe and effective surgical treatment for patients with PHT,not only correcting hypersplenism but also preserving splenic function,especially immunological function.

腹腔镜脾切除联合贲门周围血管离断术治疗门静脉高压症的临床价值评估

目的:评估腹腔镜脾切除联合贲门周围血管离断术的优越性、安全性,以期为门静脉高压症手术治疗方案的选择提供依据。方法:回顾分析2017年3月至2021年11月收治的215例门静脉高压症患者的临床资料,其中研究组(n=68)行腹腔镜脾切除联合贲门周围血管离断术,从行开腹脾切除联合贲门周围血管离断术的患者中抽取68例作为对照组,比较两组围手术期相关指标、术后并发症等。结果:研究组手术时间长于对照组,术中出血量、术后住院时间、腹腔引流管留置时间、术后并发症均少于对照组,差异有统计学意义(P<0.05);两组术中自体血回输量差异无统计学意义(P>0.05)。结论:腹腔镜脾切除联合贲门周围血管离断术安全、效果显著,与传统开腹脾切除联合贲门周围血管离断术相比,具有创伤更小、术中容易暴露解剖间隙、康复快、住院时间短、并发症少的优点,值得推广应用。

完全腹腔镜下脾切除联合贲门周围血管离断术治疗门脉高压症

目的探讨腹腔镜脾切除联合贲门周围血管离断术的可行性、安全性及有效性。方法 2008年3月-2014年6月,采用完全腹腔镜方法,对45例肝硬化门脉高压并上消化道出血和脾功能亢进的患者行贲门周围血管离断术。术中采用一级脾蒂离断法或者二级脾蒂离断法切脾,断流方法采用选择性或非选择性贲门周围血管离断术。结果 45例在全腔镜下完成（其中28例为选择性贲门周围血管离断术）,其中1例需手助。手术时间110-430 min,平均150 min。术中失血80-1200 ml,平均325 ml。1例术后肝功能衰竭死亡。44例术后住院8-20 d,平均10.6 d。41例术后随访3-60个月,平均36个月,3例再出血,2例原发性肝癌。结论严格把握手术适应证,腹腔镜脾切除联合贲门周围血管离断术安全可行。

全腹腔镜贲门周围血管离断术治疗门脉高压症

目的探讨全腹腔镜下贲门周围血管离断术的技巧和方法。方法 2007年5月~2010年10月,采用完全腹腔镜方法,对34例肝硬化门脉高压并上消化道出血的患者行贲门周围血管离断术。术中切脾方法采用一级脾蒂离断法或者二级脾蒂离断法,断流方法采用选择性或非选择性贲门周围血管离断术。结果 33例在全腔镜下完成（其中2例为选择性贲门周围血管离断术）,1例需手助。手术时间170~430 min,平均250 min。术中失血100~1000 ml,平均533 ml。1例术后肝功能衰竭死亡。33例术后住院8~20 d,平均10.6 d。30例术后随访3~25个月,平均13个月,2例再出血,1例原发性肝癌。结论全腹腔镜下贲门周围血管离断术治疗门脉高压症是一种安全、微创、可行的方法。

内结扎法腹腔镜巨脾切除联合选择性贲门周围血管离断术

目的总结腹腔镜下内结扎法巨脾切除联合选择性贲门周围血管离断术的经验。方法采用丝线结扎结合超声刀或LigaSure，进行腹腔镜巨脾切除和选择性贲门周围血管离断术治疗门静脉高压症并发食管胃底静脉曲张6例。结果6例手术全部镜下顺利完成，术中出血量80-200ml，平均130ml，无输血，无中转开腹，手术时间150-210min平均190min。无并发症，术后5天恢复正常活动。术后随访3—10个月，平均8个月，无再发出血。结论应用内结扎法腹腔镜巨脾切除联合选择性贲门周围血管离断术治疗门静脉高压症安全有效，出血少，微创。

免切割闭合器完全腹腔镜巨脾切除联合贲门周围血管离断术

目的探讨免切割闭合器完全腹腔镜巨脾切除联合贲门周围血管离断术治疗肝硬化门静脉高压症的手术技巧和临床应用价值。方法2005年3月～2006年10月,对23例肝硬化门静脉高压致食道下端静脉曲张患者行完全腹腔镜下巨脾切除联合贲门周围血管离断术治疗,其中18例免切割闭合器应用二级脾蒂离断法切除脾脏,即处理脾蒂时逐支分离脾叶动静脉,边分离边用血管夹夹闭或用丝线结扎后离断血管,并用超声刀离断小网膜后,逐一将贲门周围曲张静脉直接用超声刀或可吸收夹夹闭后离断,将脾脏放入标本袋,拉出扩大的trocar孔外,剪碎后取出。结果18例手术获得成功,手术时间180～320min,平均255min。术中出血量200～1600ml,平均450ml。术后发生胸腔积液2例,左膈下脓肿1例,B超引导穿刺治愈,轻度腹水2例。无死亡病例。术后住院时间6～17d,平均7.5d。18例术后随访5-24个月,平均16.4月,术后20个月再出血1例,经胃镜下注射硬化剂治愈,余17例均无再出血。结论应用二级脾蒂离断法处理脾蒂可以避免腹腔镜巨脾切除联合贲门周围血管离断术应用切割闭合器,不仅节省费用,而且在腹腔镜巨脾切除中有独特的优势。

腹腔镜脾切除加贲门周围血管离断术(附59例报道)

目的探讨微创技术应用于门脉高压症治疗的利弊。方法5例门脉高压症并食管胃底曲张静脉破裂出血病人施行腹腔镜脾切除加贲门周围血管离断术;结合文献报道一并分析。结果全组59例肝功能均为ChildA或B级,脾脏长径14～28cm。全组均择期手术,其中22例全腔镜下完成手术,33例手助,4例中转开腹,无手术死亡。全腔镜下手术最长耗时5.5h,手助术最长耗时5h;术中出血一般200～500mL,最多达2800mL(腔镜下);术后排气及下床活动时间多在3d左右,7～12d出院。结论微创技术应用于门脉高压症并食管胃底曲张静脉破裂出血的择期治疗可行且有利,但应严格筛选合适的病人。

腹腔镜下脾切除联合选择性贲门周围血管离断术

目的探讨腹腔镜下脾切除联合选择性贲门周围血管离断术(laparoscopic splenectomy combined with selectivepericardial devascularization,LSPD)治疗门脉高压症(portal hypertension,PHT)的安全性、可行性及操作技巧。方法回顾性分析2011年3月～2012年3月连续15例因PHT行腹腔镜下脾切除联合LSPD的围手术期资料。观察手术时间、术中出血量、术后排气时间、术后并发症发生率及术后住院时间并随访。结果 15例均顺利完成手术,无中转开腹。术中发现副脾2例。手术时间150～340 min,中位数230 min。术中出血量80～1600 ml,中位数450 ml。腹腔引流管留置时间3～8 d,中位数5 d。术后住院时间7～15 d,中位数10 d。无出血、胰漏等手术并发症。15例随访3～12个月,均存活,2例发生便血。结论LSPD治疗PHT安全、可行。

完全腹腔镜与开腹行贲门周围血管离断术联合脾切除治疗门脉高压症的临床研究

目的探讨完全腹腔镜行贲门周围血管离断术联合脾切除治疗门脉高压症的临床疗效。方法收集2009年1月-2012年1月该院行贲门周围血管离断术联合脾切除的50例门脉高压症患者。其中,完全腹腔镜下行贲门周围血管离断术联合脾切除25例(腹腔镜组)以及同期行开腹贲门周围血管离断术联合脾切除25例(传统开腹组),比较两组的平均手术时间、术中出血量、术后血浆引流量、术后肛门排气时间、术后住院时间、住院总费用以及术后并发症发生率等指标的变化;研究两组患者术后肝脏储备功能、食管曲张静脉复发和上消化道再出血等指标的变化。结果腹腔镜组的平均手术时间及住院费用与传统开腹组比较差异无统计学意义(P>0.05);术中出血量、术后血浆引流量、术后肛门排气时间、术后住院时间和术后并发症发生率腹腔镜组明显少于传统开腹组(P<0.05);术后均随访24个月,两组术后肝脏功能(MELD)评分及Child评分、上消化道再出血率、重度食管胃底静脉曲张发生率差异均无统计学意义(P>0.05)。结论完全腹腔镜下贲门周围血管离断术联合脾切除能有效治疗肝硬化门脉高压症,患者术后恢复快,住院时间短,术后并发症少,同时并不延长手术时间,也不增加费用,安全可行。

手助腹腔镜与开腹脾切除加门奇断流术对机体免疫功能和创伤反应影响临床研究

目的 :研究手助腹腔镜和开腹脾切除加门奇断流两种术式对机体免疫功能及创伤反应的影响 ,探讨其差异及新术式的可行性。方法 :监测 5 0例 (手助腹腔镜及开腹各 2 5例 )肝硬变、门静脉高压症患者术前、术后第1天 ,术后第 3天的外周血淋巴细胞 (PBL)亚群、C -反应蛋白 (CRP)、白细胞介素 6 (IL - 6 )和肿瘤坏死因子(TNF)的变化并进行对比研究。结果 :开腹组术后第 3天成熟的T淋巴细胞 (CD3 )、辅助性T细胞 (CD4)、CD4与抑制性T淋巴细胞 (CD8)比值较术前明显下降 (P <0 .0 5或P <0 .0 1)。且两组相比较开腹组明显低于手助腹腔镜组 (P <0 .0 1)。开腹组术后第 1天或 /和术后第 3天CRP、IL - 6、TNF较术前明显升高 (P <0 .0 1)。且两组比较开腹组明显高于手助腹腔镜组 (P <0 .0 1)。结论 :手助腹腔镜组对机体免疫及细胞因子水平影响较小 ,这构成手助腹腔镜组脾切除加断流术术后恢复较快及创伤反应小的病理、生理基础 ,同时也证明了该新术式治疗肝硬变、门静脉高压症的可行性及优越性。

手助腹腔镜脾切除加门奇静脉断流术对机体应激反应的影响

目的研究手助腹腔镜脾切除加门奇静脉断流术与开腹脾切除加门奇静脉断流术对机体应激反应的影响。方法比较40例肝硬变门静脉高压症患者(腹腔镜组及开腹组各20例)术前及术后第1～3d外周血血糖(BG)、胰岛素(Ins)、三碘甲状腺原氨酸(T3)、四碘甲状腺原氨酸(T4)和皮质醇(CS)的水平及相关临床指标。结果术前2组比较,BG、Ins、T3、T4及CS水平差异均无统计学意义(P>0.05)。2组术后第1dBG及CS均明显升高(P<0.05),至术后第2d腹腔镜组BG及CS恢复至术前水平(P>0.05),开腹组至术后第3d才恢复至术前水平(P>0.05);开腹组术后第2dBG及CS水平均明显高于腹腔镜组(P<0.05)。2组术后第1dIns、T3及T4均明显降低(P<0.05);腹腔镜组该3项指标至术后第2d恢复至术前水平(P>0.05),而开腹组至术后第3d才恢复至术前水平(P>0.05);开腹组术后第2dIns、T3及T4水平均明显低于腹腔镜组(P<0.05)。腹腔镜组平均手术时间与开腹组相比差异无统计学意义(P>0.05),术中出血量明显少于开腹组(P<0.05),胃肠及排尿功能恢复时间明显早于开腹组(P<0.05),住院时间明显短于开腹组(P<0.05)。结论手助腹腔镜脾切除加门奇静脉断流术对机体应激反应影响较小,术后患者恢复快。

腹腔镜下巨脾切除联合贲门周围血管离断术15例

目的探讨腹腔镜巨脾切除联合贲门周围血管离断术的可行性、安全性及有效性。方法 2010年1月～2012年1月行15例腹腔镜下巨脾切除联合贲门周围血管离断术,取右侧斜卧位,超声刀自下向上离断脾结肠、脾胃、脾肾及脾膈韧带,游离脾动脉并结扎,线型切割缝合器(Endo-GIA)离断脾蒂,切除脾脏;切割缝合器切断胃左动静脉,继续游离胃周血管直至食道下端6～8 cm,完成断流。结果 12例腹腔镜下完成巨脾切除,3例因难以控制出血中转开腹。手术时间236～318 min,平均267.2 min;术中出血量200～1000ml,平均400 ml;术后住院时间5～12 d,平均7.8 d。1例出现胰漏,带管引流1个月后漏口愈合,无围手术期死亡。15例术后随访6个月,脾功能亢进纠正,钡餐示5例轻度食管胃底静脉曲张,余10例正常,未再出现呕血、黑便等症状。结论严格把握手术适应证,腹腔镜巨脾切除联合贲门周围血管离断术安全可行。

腹腔镜脾切除联合贲门周围血管离断术治疗肝硬化门静脉高压症效果分析

目的分析腹腔镜脾切除联合贲门周围血管离断术治疗肝硬化门静脉高压症的效果。方法选择2013年12月至2016年3月于河北医科大学第二医院治疗的肝硬化门静脉高压症患者56例。所有患者择期行完全腹腔镜脾切除联合贲门周围血管离断术。记录患者手术相关情况。结果 56例患者均顺利完成腹腔镜脾切除联合贲门周围血管离断术,其中用腹腔镜下切割缝合器(Endo-GIA)将脾蒂钳合后离断或七号线双重结扎后生物夹夹闭离断9例,因脾脏巨大暴露困难改行手助腹腔镜完成2例,其余45例均正常执行。手术时间为150～330 min、平均(221±36)min,术中出血量80～1 400 ml,平均(347±202)ml。所有患者均于术后1～3 d排气,术后引流液量为100～400 ml,平均(204±52)ml,并多于术后3～5 d拔管。其中12例因低蛋白原因出现腹腔积液,无术后出血二次手术病例,无一例出现切口感染、胰漏、胃漏、膈下积液和结肠损伤。24例患者因依从性差,随访丢失。余32例随访成功,脾功能亢进症状完全缓解且血常规三系提示正常。患者术后第1、3、7天血小板计数分别为(45±17)×10~9/L、(157±42)×10~9/L,(299±39)×10~9/L,脾功能亢进逐渐缓解。患者术后住院7～15 d,平均(9.0±1.0)d。其中4例出现门静脉血栓,未再发生呕血或黑便,无死亡病例。结论腹腔镜脾切除联合贲门周围血管离断术是肝硬化门静脉高压症的一种安全有效的治疗方案。

腹腔镜脾切除联合贲门周围血管离断术的临床应用

目的 探讨腹腔镜脾切除联合贲门周围血管离断术的方法、安全性和有效性。 方法 2 0 0 3年 1～ 6月共进行5例腹腔镜脾切除联合贲门周围血管离断术。 结果 5例未行手助术式 ,全部镜下完成 ,手术时间 3 0～ 4 0h ,平均 3 5h。术中出血量 2 5 0～ 4 5 0ml,平均 35 0ml。无手术并发症。 结论 对于脾体积正常至中度肿大的病人进行腹腔镜脾切除联合贲门周围血管离断术安全、微创、有效、可行。

手助腹腔镜下脾切除门奇断流术(附12例报告)

目的 探讨手助腹腔镜脾切除门奇断流术的手术技术。方法 用手助腹腔镜完成 12例脾切除门奇断流术。结果 12例手术全部成功。手术时间 15 0～ 2 6 0min ,平均 2 0 0min。术中出血 2 0 0～ 15 0 0ml,平均 5 80ml。切除脾重 5 0 0～ 2 0 0 0 g ,平均 870g。住院时间 8～ 18d ,平均 11d。术后病人恢复顺利 ,疼痛少 ,5例术后用止痛剂 ,2 4～ 74h排气 ,平均 5 2h。手助切口愈合良好 ,1例出现并发症 ,1例死亡。结论 手助腹腔镜行脾切除门奇断流术不但安全可行 ,而且具有微创手术的优点 ,疗效满意。

手助腹腔镜下脾切除及贲门周围血管离断术的应用研究

目的探讨手助下腹腔镜脾切除及贲门周围血管离断术在肝硬化、门脉高压治疗中的应用价值。方法应用Ligasure及超声刀手助腹腔镜下脾切除10例,贲门周围血管离断术13例。结果23例均完成腹腔镜手术,脾切除手术时间(63±15.5)min,术中出血量(32.4±21.2)ml;贲门周围血管离断术手术时间(115.3±25.5)min,术中出血量(52.4±24.2)ml。术后(12.2±3.8)h离床活动。结论应用Ligasure及超声刀手助腹腔镜下脾切除及贲门周围血管离断术安全性高、出血量小、术后恢复快,可以用于门脉高压、脾功能亢进的手术治疗。