Effect of TCM Combined with Chemotherapy on Immune Function and Quality of Life of Patients with Non-small Cell Lung Cancer inStage Ⅲ-Ⅳ

Objective: To observe and compare the effect of traditional Chinese medicine (TCM) combined with chemotherapy (CT) on immune function and quality of life (QOL)of patients with non-small cell lung cancer (NSCLC) in stage Ⅲ-Ⅳ. Methods: One hundred cases with stage Ⅲ-Ⅳ NSCLC were randomly divided into two groups. The treated group (n=50) received CT combined with TCM, and the control group received CT alone. The percentage of T lymphocyte subset in peripheral blood and the change of natural killer (NK) cell count were observed after treatment. The QOL and tolerance of CT were also compared between the two groups after treatment. Results: In the treated group, CD3 cell count, CD4 cell count, CD4/ CDg ratio and NK cell activity were higher than those in control group, while CD8 cell count in the treated group was lower than that in the control group (P<0.05), and QOL and tolerance of CT in the treated group were also better (P<0.05). Conclusion: TCM combined with CT could raise the patients' ability in tolerating CT in stage Ⅲ-ⅣNSCLC.

黄芪多糖注射液对Ⅱ-Ⅲ期非小细胞肺癌放疗患者免疫功能影响研究

目的:观察黄芪多糖注射液对Ⅱ-Ⅲ期非小细胞肺癌放疗患者免疫功能的影响。方法:80例随机分为对照组和观察组各40例。两组均进行放疗,观察组加用黄芪多糖注射液治疗。结果:经治疗后观察组CD4+、CD4+/CD8+明显高于对照组,Karnofsky评分、SF-36评分明显高于对照组,组间比较差异有统计学意义(P<0.05)。结论:黄芪多糖注射液可有效改善Ⅱ-Ⅲ期非小细胞肺癌放疗患者免疫功能。